Transgenic methods for increasing Drosophila life span.

abstract：:Metabolite concentrations in gastrocnemius and soleus muscles were compared in young-adult (4 months), mature (12 months) and senescent (24 months) rats after continuous (72 consecutive hours) exposure to normobaric hypoxia or normoxia with the intraperitoneal administration of the vasodilator naftidrofuryl or saline ...

journal_title：Mechanisms of ageing and development

authors： Pastoris O,Dossena M,Allorio F,Vercesi L

更新日期：1990-06-01 00:00:00

abstract：:In mammals, proliferation is rapid in many tissues during early postnatal life, causing rapid somatic growth. This robust proliferation is then suppressed as the animal approaches adult size, bringing many tissues to a quiescent state where proliferation occurs only as needed to replace dying cells. Recent evidence su...

journal_title：Mechanisms of ageing and development

authors： Lui JC,Chen W,Barnes KM,Baron J

更新日期：2010-10-01 00:00:00

abstract：:Age-related changes in intestinal glucose absorption were studied using everted intestinal sacs and brush border membrane vesicles prepared from male F344 rats. Glucose uptake by everted intestinal sacs was greatest in young (2-3-month-old) as compared with adult (12-14-month-old) and old (24-month-old) rats. The grea...

journal_title：Mechanisms of ageing and development

authors： Doubek WG,Armbrecht HJ

更新日期：1987-06-01 00:00:00

abstract：:The present study was designed to determine whether the memory sparing effects of dietary restriction during aging could be through an effect on ionotropic glutamate receptors. Quantitative autoradiography was performed on 3, 10, and 26 month old mice to examine the density changes of NMDA, AMPA and kainate binding si...

journal_title：Mechanisms of ageing and development

authors： Magnusson KR

更新日期：1997-05-01 00:00:00

abstract：:Antioxidants and telomere length are potential biomarkers for individuals' exposure and ability to cope with environmental stressors. However, intraspecific variations in antioxidant alterations due to natural, life cycle related stress, have been rarely estimated. We investigated those changes in wild-derived house m...

journal_title：Mechanisms of ageing and development

authors： Stauffer J,Panda B,Ilmonen P

更新日期：2018-01-01 00:00:00

abstract：:Different theories of ageing exist. Oxidative stress by generating neo-antigens and affecting cellular communications may precipitate immune disregulation, and both may concur in the whole ageing process. In the present study, we have analysed the effect of dietary high doses of vitamin E, a free radical scavenger, on...

journal_title：Mechanisms of ageing and development

authors： Brohée D,Nève P

更新日期：1994-10-20 00:00:00

abstract：:We have developed a cell model for loss of differentiated gene expression in cellular aging. Over long periods in culture, bovine adrenocortical cells lose expression of a specialized gene, steroid 17 alpha-hydroxylase. The decline in expression of 17 alpha-hydroxylase in mass cultures and clones of bovine adrenocorti...

journal_title：Mechanisms of ageing and development

authors： Hornsby PJ,Yang LQ

更新日期：1991-04-01 00:00:00

abstract：:Impaired lymphocyte and granulocyte function in the aged may, in part, reflect intrinsic aged-related biochemical alterations. In this study we compared the ribonucleotide contents of lymphocytes and granulocytes from young and old subjects evaluated by means of an HPLC-anion exchange method. We found that in general ...

journal_title：Mechanisms of ageing and development

authors： Borzì RM,Dal Monte P,Uguccioni M,Meliconi R,Facchini A

更新日期：1992-06-01 00:00:00

abstract：:It has been shown that enhanced levels of p53 activity contribute to reduced cancer susceptibility in mice, however longevity is compromised due to the onset of an early-ageing phenotype. The effects of enhanced levels of p53 in these in mice could therefore have implications for human premature ageing disorders. We e...

journal_title：Mechanisms of ageing and development

authors： O'Neill M,Núñez F,Melton DW

更新日期：2003-05-01 00:00:00

abstract：:Human diploid fibroblasts, TIG-1, were serially subcultivated at low inoculation densities thus maintaining the cultures in log phase throughout their in vitro lifespan. Their lifespan was shortened in calendar time without decreasing the cumulative number of population doublings when compared with the lifespan of cel...

journal_title：Mechanisms of ageing and development

authors： Kaji K,Matsuo M

更新日期：1980-07-01 00:00:00

abstract：:Alpha-synuclein (syn) is the main component of proteinaceous inclusions known as Lewy bodies (LBs), which are implicated in the pathogenesis of the neurodegenerative diseases known as synucleinopathies, like Parkinson's disease (PD). Aging is a major risk factor for PD and thus, interventions that delay aging will hav...

journal_title：Mechanisms of ageing and development

authors： Guedes A,Ludovico P,Sampaio-Marques B

更新日期：2017-01-01 00:00:00

abstract：:Several alternative mortality models fit Swedish old-age mortality data equally well. The models build on two different concepts of the heterogeneity of individuals in a population. The first concept concerns fixed, genetic differences among individuals in their risk of death. The second concept involves acquired susc...

journal_title：Mechanisms of ageing and development

authors： Yashin AI,Vaupel JW,Iachine IA

更新日期：1994-05-01 00:00:00

abstract：:Food intake, body weight and serum LH, FSH, progesterone and oestradiol-17 beta were monitored from weaning to puberty in fully fed females housed in groups of four or individually and in females individually housed and dietary restricted. Restriction of food intake from weaning delayed the onset of puberty (34-39 day...

journal_title：Mechanisms of ageing and development

authors： Holehan AM,Merry BJ

更新日期：1985-11-01 00:00:00

abstract：:Cellular senescence is a fundamental trait of many eukaryotic organisms. Senescent cells participate both in the developmental program and in normal ageing and age-related diseases. Senescence of proliferation-prone cells is a state of permanent cell cycle arrest accompanied by metabolic activity manifested by high se...

journal_title：Mechanisms of ageing and development

authors： Bielak-Zmijewska A,Mosieniak G,Sikora E

更新日期：2018-03-01 00:00:00

abstract：:DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, v...

journal_title：Mechanisms of ageing and development

authors： Vijg J

更新日期：2008-07-01 00:00:00

abstract：:The decreased immune response associated with aging may, in part, reflect intrinsic age-related biochemical alterations in lymphocytes from older animals. We measured levels of lymphocyte adenosine triphosphate (ATP) and continuous [3H]thymidine incorporation in phytohemagglutinin-stimulated lymphocytes from young and...

journal_title：Mechanisms of ageing and development

authors： Verity MA,Tam CF,Cheung MK,Mock DC,Walford RL

更新日期：1983-09-01 00:00:00

abstract：:Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-as...

journal_title：Mechanisms of ageing and development

authors： van de Ven M,Andressoo JO,Holcomb VB,Hasty P,Suh Y,van Steeg H,Garinis GA,Hoeijmakers JH,Mitchell JR

更新日期：2007-01-01 00:00:00

abstract：:This review addresses a novel facet of human T cell biology that constitutes a fundamental problem for long-term maintenance of immunological memory against viruses. The finite proliferative capacity of human T lymphocytes is sufficiently great to accommodate the waves of clonal expansion associated with primary and e...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2000-12-20 00:00:00

abstract：:Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty...

journal_title：Mechanisms of ageing and development

authors： Chen J,Li Y,Zhu Q,Li T,Lu H,Wei N,Huang Y,Shi R,Ma X,Wang X,Sheng J

更新日期：2017-06-01 00:00:00

abstract：:Human diploid cells, TIG-7, were serially cultivated under 1%, 5% or 21% (air) oxygen. The limit of their cumulative population doublings was extended by 16% or 10% under 1% or 5% oxygen, respectively, as compared with that under 21% oxygen. When TIG-7 cells were serially cultivated in the presence of 10 mM or 20 mM 3...

journal_title：Mechanisms of ageing and development

authors： Yuan H,Kaneko T,Matsuo M

更新日期：1995-07-14 00:00:00

abstract：:During experiments on the molecular basis of morphological and functional changes observed in rat liver mitochondria upon aging, we found that the buoyant density profile of mitochondrial DNA (mtDNA) shows a wide distribution pattern especially in the lighter region than that of young rat liver mtDNA. The heterogeneou...

journal_title：Mechanisms of ageing and development

authors： Asano K,Amagase S,Matsuura ET,Yamagishi H

更新日期：1991-11-01 00:00:00

abstract：:Previous reports suggest that 33 degrees C is the optimum temperature for the long-term culture of murine bone marrow in vitro. We found that horse serum was an important variable determining our ability to culture marrow from immature (less than 10 weeks) mice at 37 degrees C. While some batches supported growth othe...

journal_title：Mechanisms of ageing and development

authors： Lipschitz DA,Udupa KB

更新日期：1984-01-01 00:00:00

abstract：:Age-specific mortality from carcinoma of the prostate was analyzed by drawing a line between the value at age 52 years and that at age 87. Slope of the line was relatively constant for the pooled years 1962-1966, 1967-1971 and 1972-1976 (maximum variation from the mean of 4.5%). However, the slope was 17.7% greater fo...

journal_title：Mechanisms of ageing and development

authors： Clive JM,Spencer RP

更新日期：1995-08-31 00:00:00

abstract：:In an attempt to understand the molecular mechanisms of age-dependent degenerative alteration in human periodontal tissues, we examined mRNA level and DNA methylation of collagen alpha1(I) gene. Using healthy periodontal ligament tissues from humans aged 9-76 years, we found that the collagen alpha1(I) mRNA level decr...

journal_title：Mechanisms of ageing and development

authors： Takatsu M,Uyeno S,Komura J,Watanabe M,Ono T

更新日期：1999-10-01 00:00:00

abstract：:The decline in phytohemagglutinin (PHA) responsiveness of spleen cells from aged mice was studied in an effort to determine the nature of the depressed PHA reactivity. The reduced response of DNA synthesis (thymidine incorporation) to PHA stimulation could not be attributed to a decreased viability of spleen lymphocyt...

journal_title：Mechanisms of ageing and development

authors： Hung CY,Perkins EH,Yang WK

更新日期：1975-01-01 00:00:00

abstract：:DNA methylation (DNAm) is a fundamental biochemical modification which occurs over the lifespan of an individual and it is a significant component in the aging process. Methylation level of CpG sites plays an important role in finding the age of a person. Different approaches were used to extract age-related CpG (AR-C...

journal_title：Mechanisms of ageing and development

authors： Goel N,Karir P,Garg VK

更新日期：2017-09-01 00:00:00

abstract：:Ageing of WI-38 fibroblasts in culture was used as a model in order to investigate the evolution and the alteration of the key antioxidant enzyme glutathione peroxidase. The activity of glutathione peroxidase is influenced by the presence of selenium in the culture medium and we have also shown that the specific activ...

journal_title：Mechanisms of ageing and development

authors： Pigeolet E,Remacle J

更新日期：1991-04-01 00:00:00

abstract：:T cells in vivo have been shown to accumulate DNA damage with age. To investigate the effects of DNA damage on T cell biology we have utilised an in vitro human CD4+ T cell clone model. Levels and types of DNA damage were determined in 11 independent T cell clones as a function of their in vitro lifespan. Increased le...

journal_title：Mechanisms of ageing and development

authors： Hyland P,Barnett C,Pawelec G,Barnett Y

更新日期：2001-08-01 00:00:00

abstract：:The proto-oncogene c-fos (the cellular homolog of v-fos, Finkel-Biskis-Jenkins (FBJ) murine osteogenic sarcoma virus) encodes a major component of the activator protein-1 (AP-1) transcription factor. Serum stimulation as well as oxidizing treatments induce transitory increases in c-fos mRNA abundance. The induction of...

journal_title：Mechanisms of ageing and development

authors： Keogh BP,Tresini M,Cristofalo VJ,Allen RG

更新日期：1996-03-29 00:00:00

abstract：:This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the...

journal_title：Mechanisms of ageing and development

authors： Moldoveanu E,Klein R,Bartoc R,Bruhis S,Oeriu I

更新日期：1975-09-01 00:00:00