Abstract:
:Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty-five male mice were divided into 5 groups and treated with different dose of EGCG, Vitamin C (VitC) to mice as a positive control. All groups except vehicle were established aging model induced by d-galactose (200mg/kg/day) that was subcutaneously injected to mice for 8 weeks. Two weeks after injection of d-galactose, EGCG and Vit C groups were simultaneously administered once a day by subcutaneously inject after 5h for injecting d-galactose. The results show that EGCG can be absorbed by the skin. Overall, the conditions of the skin of EGCG-treatment groups were improved, the whole structure of skin were better than control groups, and the levels of oxidative stress and the expression of relate with EGFR proteins were significantly higher than control group after EGCG treatment. All these findings suggest that EGCG can resist skin senility effectively. And the EGFR with relate of downstream proteins are implicated in the skin aging.
journal_name
Mech Ageing Devjournal_title
Mechanisms of ageing and developmentauthors
Chen J,Li Y,Zhu Q,Li T,Lu H,Wei N,Huang Y,Shi R,Ma X,Wang X,Sheng Jdoi
10.1016/j.mad.2017.03.007subject
Has Abstractpub_date
2017-06-01 00:00:00pages
1-7eissn
0047-6374issn
1872-6216pii
S0047-6374(16)30260-3journal_volume
164pub_type
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pub_type: 杂志文章
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