当前位置： SCI文献检索 > MECHANISMS OF AGEING AND DEVELOPMENT期刊下所有文献 > Excess male mortality and age-specific mortality trajectories under different mortality conditions: a lesson from the heat wave of summer 2003.

Excess male mortality and age-specific mortality trajectories under different mortality conditions: a lesson from the heat wave of summer 2003.

Abstract：

INTRODUCTION:Our objective was to study the impact of an identical additional stress on male and female mortality with a quasi-experimental study design, using natural variations in summer mortality, including the massive heat wave that struck Europe in 2003. MATERIAL AND METHODS:The summer daily mortality rates of the population aged 65 and over living in 16 European countries were computed by single age from 1998 to 2003. Using the method of Tukey, we established five categories summarizing the summer daily conditions of mortality (exceptionally high values, minor extremely high values, common values, minor extremely low values, and exceptionally low values). RESULTS:Whatever the mortality conditions during the summer months, the mortality trajectories by age are exponential for both sexes: males die twice more than females at the age of 65 and their level of mortality linearly converges around the age of 97 to that of the females. DISCUSSION:Being male remains a major risk factor of mortality during heat waves. This issue was missed by previous epidemiological studies because almost all of them focused only on the relative increase in mortality and not on the sex specific mortality rates which implies being able to estimate the population at risk.

journal_name

Mech Ageing Dev

journal_title

Mechanisms of ageing and development

authors

Robine JM,Michel JP,Herrmann FR

doi

10.1016/j.mad.2012.04.004

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

378-86

issue

6

eissn

0047-6374

issn

1872-6216

pii

S0047-6374(12)00071-1

journal_volume

133

pub_type

杂志文章

相关文献

MECHANISMS OF AGEING AND DEVELOPMENT文献大全
  • Stromal hemopoietic microenvironment in aging.

    abstract：:The bone marrow content, proliferative potential and proliferative activity of precursor cells for stromal fibroblast colony forming cells (CFC-F) were investigated in young and old CBA mice. The relationship between CFC-F and the number of bone marrow nucleated cells and granulocytic-macrophagal precursors (GM-CFC) w...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(90)90061-j

    authors： Sidorenko AV,Andrianova LF,Macsyuk TV,Butenko GM

    更新日期：1990-05-30 00:00:00

  • Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing.

    abstract：:Mitochondrial reactive oxygen species (ROS) and oxidative damage are associated with a range of age-related human pathologies. It is also likely that mitochondrial ROS generation is a factor in stress response and signal transduction pathways. However, current methods for measuring and influencing mitochondrial ROS pr...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章,评审

    doi：10.1016/j.mad.2005.03.026

    authors： James AM,Cochemé HM,Murphy MP

    更新日期：2005-09-01 00:00:00

  • Developmental changes of proteoglycan synthesis in rat liver and isolated hepatocytes.

    abstract：:The synthesis of sulfated proteoglycans in late fetal (19th to 22nd day of intrauterine life), early postnatal, and adult liver tissue as well as in hepatocytes and their distribution in plasma membranes were studied. Overall proteoglycan production is enhanced two-fold in fetal as compared with adult liver tissue. In...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(85)90097-1

    authors： Gressner AM,Vasel A

    更新日期：1985-09-01 00:00:00

  • The role of DNA damage and repair in aging: new approaches to an old problem.

    abstract：:DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, v...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章,评审

    doi：10.1016/j.mad.2008.02.009

    authors： Vijg J

    更新日期：2008-07-01 00:00:00

  • Related age changes in the elastase and lipid contents of normal and hemiplegic subjects of various ages.

    abstract：:Elastase and lipid levels of the plasmas of subjects and of those who have suffered a stroke have been measured, and it has been shown that the normal age related fall in elastase content is mirrored more closely by the fall in high density lipoprotein cholesterol than by changes in total cholesterol. After a stroke a...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(80)90003-2

    authors： Hall DA,Elridi SS,Zajac A,Middleton RS

    更新日期：1980-11-01 00:00:00

  • In K562 and HL60 cells membrane ageing during cell growth is associated with changes in cholesterol concentration.

    abstract：:In a cell culture model of aging we have previously shown that there is an age-related decrease in the lipid dynamics of the proerythropoetic K562 cell membranes, as determined by the generalized polarization (GP) of the phase-sensitive lipid probe 2-dimethylamino-6-lauroylnaphthalene (Laurdan) (T. Parasassi, M. Di St...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/s0047-6374(97)00047-x

    authors： Levi M,Wilson P,Nguyen S,Iorio E,Sapora O,Parasassi T

    更新日期：1997-08-01 00:00:00

  • Chromosomal alterations and sister chromatid exchanges induced by zirconium oxychloride in human lymphocytes in vitro with relation to age of donors.

    abstract：:Aqueous solutions of zirconium oxychloride were added to human peripheral blood lymphocyte culture. Cultures were set up from healthy donors of both sexes belonging to age groups of 0-10, 11-20, 21-30, 31-40, 41-50 and 51-60 years. Airdried Giemsa schedule was followed for preparation of chromosomal aberrations and mi...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(92)90110-y

    authors： Ghosh S,Talukder G,Sharma A

    更新日期：1992-03-01 00:00:00

  • Age-dependent IGF-1 regulation of gene transcription of Ca2+ channels in skeletal muscle.

    abstract：:In the present work, we investigated whether IGF-1 regulates the transcription of the genes encoding the L-type Ca2+ channel (DHPR) channel and RyR1 in young adult and senescent mice. To this end, a transgenic mouse model overexpressing IGF-1 exclusively in skeletal muscle (S1S2) was studied at different ages and the ...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/s0047-6374(00)00236-0

    authors： Zheng Z,Messi ML,Delbono O

    更新日期：2001-04-15 00:00:00

  • Renal failure causes early death of bcl-2 deficient mice.

    abstract：:BCL-2 functions as a death repressor molecule in an evolutionary conserved cell death pathway. Inactivation of bcl-2 in mice results in pleiotropic effects including postnatal growth retardation, massive apoptosis in lymphoid tissues, polycystic kidney disease (PKD) and shortened lifespan. To evaluate the influence of...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/j.mad.2006.02.009

    authors： Fedorov LM,Schmittwolf C,Amann K,Thomas WH,Müller AM,Schubert H,Domen J,Kneitz B

    更新日期：2006-07-01 00:00:00

  • Multihormonal control of enzyme clusters in rat liver ontogenesis. II. Role of glucocorticosteroid and thyroid hormone and of glucagon and insulin.

    abstract：:The role of glucocorticosteroid and thyroid hormone and of glucagon and insulin in the pre- and postnatal developmental formation of carbamoyl-phosphate synthase, ornithine transcarbamoylase, arginase, glutamate dehydrogenase, tyrosine aminotransferase, glucose-6-phosphatase, hexokinase and glucokinase activities in r...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(81)90010-5

    authors： Lamers WH,Mooren PG

    更新日期：1981-01-01 00:00:00

  • Rhythmic variations of different hemopoietic cell lines and maturation stages in aging mice.

    abstract：:Non-proliferative and proliferative myeloid, and lymphoid and erythroid bone marrow cells were studied in aging female C3H mice. A chronobiological approach was used and mice aged 16, 21 and 26 months were examined vs. 3 month-old mice every 3 h during the 24-h period in three different experiments. Significant circad...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(88)90065-6

    authors： Sletvold O,Laerum OD,Riise T

    更新日期：1988-01-01 00:00:00

  • Influence of aging and neurodegenerative disease on changes in band 3-like proteins in white blood cells.

    abstract：:Fluorescent microspheres were used to measure antibody-induced capping of leukocyte membrane proteins that are immunologically related to band 3, the anion exchanger of the erythrocyte. The degree of capping was found to increase with donor age. Surface labeling and capping characteristics of cells from healthy, age-m...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(94)01553-x

    authors： Bosman GJ,Steetzel BD,De Man AJ,Van Kalmthout PJ,Visser FE,De Grip WJ

    更新日期：1995-04-21 00:00:00

  • Diminished axonal transport of glycoproteins in the senescent rat brain.

    abstract：:At various time intervals (10, 15, 20, 25, 30 min) after injection of 3H-fucose into the medial septal nucleus of young adult (3 months old) and senescent (25 months old) Fischer-344 rats, the specific activities of trichloroacetic acid-phosphotungstic acid (TCA-PTA) soluble and insoluble fractions were determined in ...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(77)90038-0

    authors： Geinisman Y,Bondareff W,Telser A

    更新日期：1977-09-01 00:00:00

  • Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.

    abstract：:The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mouse accelerated agi...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/j.mad.2009.01.001

    authors： Hinkal GW,Gatza CE,Parikh N,Donehower LA

    更新日期：2009-04-01 00:00:00

  • Effect of dietary high doses of vitamin E on lymphocyte subsets in young and old CBA mice.

    abstract：:Different theories of ageing exist. Oxidative stress by generating neo-antigens and affecting cellular communications may precipitate immune disregulation, and both may concur in the whole ageing process. In the present study, we have analysed the effect of dietary high doses of vitamin E, a free radical scavenger, on...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(94)91593-8

    authors： Brohée D,Nève P

    更新日期：1994-10-20 00:00:00

  • Age related changes in population of peripheral T cells: towards a model of immunosenescence.

    abstract：:In this paper, we presented the results of analysis of experimental evidence for the decline of the human immune system functioning with age using mathematical model of immunosenescence. The most prominent changes in this system are related to the decline in the T-cellular immunity. These include the decline in the na...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/s0047-6374(03)00019-8

    authors： Romanyukha AA,Yashin AI

    更新日期：2003-04-01 00:00:00

  • Lysosomal activity in aging rat liver: I. Variation in enzyme activity within the liver lobule.

    abstract：:The intralobular distribution of three lysosomal enzymes, acid phosphatase, N-acetyl-beta-D-glucosaminidase, and beta-D-glucuronidase, was investigated in hepatocytes of 3-, 12-, 24-, and 36-month-old rats. The distribution pattern changed with age. In young rats, the activity was higher in the peripheral area than in...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(83)90109-4

    authors： van Manen R,de Priester W,Knook DL

    更新日期：1983-06-01 00:00:00

  • Transplanted mammary epithelium grows in association with host stroma: aging of serially transplanted mammary gland is intrinsic to epithelial cells.

    abstract：:Mouse mammary gland displays an irreversible decline in growth rate when propagated by serial transplantation in gland-free mammary fat pads of isogeneic mice. Because transplanted fragments of gland contain both mammary epithelial and stromal elements, the present study was undertaken to distinguish between two possi...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(83)90026-x

    authors： Daniel CW,Shannon JM,Cunha GR

    更新日期：1983-11-01 00:00:00

  • Patho-physiologic findings after chronic tryptophan deficiency in rats: a model for delayed growth and aging.

    abstract：:Long-Evans female rats three weeks, three months and 13-14 months of age were placed on tryptophan-deficient diets for periods ranging from a few months to nearly two years. Growth was interupted during the period of tryptophan-deficiency, but when the animals were returned to a complete diet, they gained weight and g...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(76)90012-9

    authors： Segall PE,Timiras PS

    更新日期：1976-03-01 00:00:00

  • Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria.

    abstract：:To gain insight into the anti-ageing mechanisms of caloric restriction (CR), liver mitochondria were isolated from male Brown-Norway rats of different ages (fully fed control and CR) and various specific markers of non-enzymatic protein modification (by oxidative, glyco- and lipoxidative-reactions) were measured by GC...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/j.mad.2004.06.002

    authors： Lambert AJ,Portero-Otin M,Pamplona R,Merry BJ

    更新日期：2004-08-01 00:00:00

  • Changes in intestinal glucose transport over the lifespan of the rat.

    abstract：:Age-related changes in intestinal glucose absorption were studied using everted intestinal sacs and brush border membrane vesicles prepared from male F344 rats. Glucose uptake by everted intestinal sacs was greatest in young (2-3-month-old) as compared with adult (12-14-month-old) and old (24-month-old) rats. The grea...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(87)90089-3

    authors： Doubek WG,Armbrecht HJ

    更新日期：1987-06-01 00:00:00

  • With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions.

    abstract：:Ageing is a complex multifactorial process that results in many changes in physiological changes processes that ultimately increase susceptibility to a wide range of diseases. As such an ageing population is resulting in a pressing need for more and improved treatments across an assortment of diseases. Such treatments...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章,评审

    doi：10.1016/j.mad.2016.07.005

    authors： Drechsler S,Lynch MA,Novella S,González-Navarro H,Hecimovic S,Barini E,Tucci V,Castro RE,Vandenbroucke RE,Osuchowski M,Potter PK

    更新日期：2016-12-01 00:00:00

  • Comparison of telomere length between population-specific mitochondrial haplogroups among different age groups in a Latvian population.

    abstract：:Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geograph...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/j.mad.2015.01.002

    authors： Zole E,Elferts D,Kimsis J,Krumina A,Narels K,Pole I,Ranka R,Pliss L

    更新日期：2015-01-01 00:00:00

  • Influence of age upon the metabolism of zinc in livers of C57BL/6J mice.

    abstract：:The kinetics of accumulation and loss of zinc from the liver following subcutaneous administration of 10 mg of zinc per kg were examined in young adult (6 months old) and old (24 months old) male C57BL/6J mice. After zinc treatment, total liver zinc concentrations rose equally in both groups and returned to basal leve...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(89)90036-5

    authors： Thomas DJ,Winchurch RA,Adler WH

    更新日期：1989-03-01 00:00:00

  • Does glycosylation of lysosomal proteins show age-related changes in rat liver?

    abstract：:We studied the pattern of lectins binding by liver lysosomal proteins from rats between 18 days of gestation and 72 weeks of age. An analysis of the carbohydrate structure was carried out after an electrophoresis and blotting, followed by a very sensitive detection system with highly specific digoxigenin-labelled lect...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/s0047-6374(98)00006-2

    authors： Lityńska A,Przybyło M

    更新日期：1998-05-01 00:00:00

  • Influence of age on accumulation of alpha-actin in satellite-cell-derived myotubes in vitro.

    abstract：:Because muscle satellite cells have been implicated in the process of muscle growth and mass regulation, as well as regeneration, alterations in the capacity of satellite cells to differentiate and accumulate muscle specific proteins during aging could play a role in the process of senile muscle atrophy. Skeletal musc...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(82)90033-1

    authors： Allen RE,McAllister PK,Masak KC,Anderson GR

    更新日期：1982-01-01 00:00:00

  • Aged lymphocyte proliferation following incorporation and retention of dietary omega-3 fatty acids.

    abstract：:T cell activation involves events at the plasma membrane; therefore, molecules such as long chain omega-3 fatty acids that alter the structure of the plasma membrane may affect the activation of aged T cells. In this project we investigated whether the incorporation of omega-3 fatty acids (from fish oil), in the prese...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(94)90079-5

    authors： VanMeter AR,Ehringer WD,Stillwell W,Blumenthal EJ,Jenski LJ

    更新日期：1994-08-01 00:00:00

  • Effect of vitamin E and selenium supplement on the aging peripheral neurons of the male Sprague-Dawley rat.

    abstract：:The effect of life-long diets containing different concentrations of selenium and vitamin E on the age pigment accumulation in the rat superior cervical ganglion, vagal ganglion and dorsal root ganglion, was studied using microspectrofluorometry. All types of ganglia showed unchanged amounts of age pigments at low or ...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(90)90162-9

    authors： Koistinaho J,Alho H,Hervonen A

    更新日期：1990-01-01 00:00:00

  • Amyloid peptide attenuates the proteasome activity in neuronal cells.

    abstract：:Previous studies have suggested a possible relationship between the ubiquitin-proteasome pathway and some pathological manifestations of Alzheimer's disease (AD). This study investigated the possibility that the Abeta peptides interact with the ubiquitin-proteasome pathway inside neuronal cells. The ubiquitin-proteaso...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/j.mad.2005.07.006

    authors： Oh S,Hong HS,Hwang E,Sim HJ,Lee W,Shin SJ,Mook-Jung I

    更新日期：2005-12-01 00:00:00

  • Rat adrenal zona fasciculata cell electrophysiological responses to ACTH and gamma-MSH vary with age.

    abstract：:A comparison was made of the resting membrane potential (MP) as well as the MP responses to K+, ACTH and gamma-MSH of superfused adrenocortical, zona fasciculata cells from young (Y) and old (O) male rats. The resting MP of these cells did not vary with age. However, the MP responses to altered extracellular [K+] vari...

    journal_title：Mechanisms of ageing and development

    pub_type： 杂志文章

    doi：10.1016/0047-6374(88)90036-x

    authors： Lymangrover JR,Valego NK,Shilling RD

    更新日期：1988-06-01 00:00:00