Cellular dynamics and modulation of WRN protein is DNA damage specific.

abstract：:The activity of rat heart succinate dehydrogenase (SDH) increases 1.7-fold in old animals (Vitorica, J., Cano, J., Satrústegui, J. and Machado, A., Mech. Ageing Dev., 16 (1981) 105-116). This increase is due to an increase in enzyme protein itself because: (a) the activation state of the enzyme does not vary with age;...

journal_title：Mechanisms of ageing and development

authors： Velez M,Machado A,Satrústegui J

更新日期：1985-11-01 00:00:00

abstract：:Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world's top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease,...

journal_title：Mechanisms of ageing and development

authors： Nolen SC,Evans MA,Fischer A,Corrada MM,Kawas CH,Bota DA

更新日期：2017-06-01 00:00:00

abstract：:Hepatocytes isolated from young (1 month) rats were as sensitive to the cytotoxic effects of erythromycin estolate and chlorpromazine as were liver cells obtained from older (3, 10 and 24 months) rats. The hepatocytes from the 24-month-old rats released aspartate transaminase more slowly than did parenchymal cells iso...

journal_title：Mechanisms of ageing and development

authors： Abernathy CO,Lukacs L,Zimmerman HJ

更新日期：1980-01-01 00:00:00

abstract：:Twenty-six institutionalized elderly subjects, selected as healthy according to the SENIEUR protocol, were compared to adult controls to establish correlations between affective disorders and immune abnormalities and to investigate underlying neuroendocrine mechanisms. After an extensive psychodiagnostic examination, ...

journal_title：Mechanisms of ageing and development

authors： Bartoloni C,Guidi L,Frasca D,Antico L,Pili R,Cursi F,Di Giovanni A,Rumi C,Menini E,Carbonin P

更新日期：1991-09-01 00:00:00

abstract：:Age-related loss of hearing and vision are two very common disabling conditions, but the underlying mechanisms are still poorly understood. Damage by reactive oxygen species and other reactive cellular metabolites, which in turn may damage macromolecules such as DNA, has been implicated in both processes. To investiga...

journal_title：Mechanisms of ageing and development

authors： Spoor M,Nagtegaal AP,Ridwan Y,Borgesius NZ,van Alphen B,van der Pluijm I,Hoeijmakers JH,Frens MA,Borst JG

更新日期：2012-02-01 00:00:00

abstract：:Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. This reaction is catalysed by GSH S-transferase (GST) and play a major role in modulation of AFB1 adduct formation to nuclear DNA. Changes recorded in hepatic GST activity during development of rats ca...

journal_title：Mechanisms of ageing and development

authors： Allameh A,Farahani M,Zarghi A

更新日期：2000-05-18 00:00:00

abstract：:In predicting the degree of brain atrophy as measured by CT, the AGP score and a few clinical variables were of some remarkable value. Especially the variables related to memory disorders and lack of insight are easily and reliably assessed during the course of the examination. In comparison to other more widely used ...

journal_title：Mechanisms of ageing and development

authors： Gutzmann H,Avdaloff W

更新日期：1980-11-01 00:00:00

abstract：:Although myocardial actomyosin ATPase specific activity determined at Ca2+ levels of 1 x 10(-3) to 1 x 10(-2) M is consistently higher in two-month old male Fischer rats than in twelve-month old individuals, this difference can be eliminated if the enzyme is assayed at lower calcium concentrations. This suggests that ...

journal_title：Mechanisms of ageing and development

authors： Rockstein M,Chesky JA,Lopez T

更新日期：1978-12-01 00:00:00

abstract：:Ageing is the most complex phenotype currently known, since it becomes manifest in all organs and tissues, affects an organism's entire physiology, impacts function at all levels and increases susceptibility to all major chronic diseases. Insight into the molecular and cellular targets of the ageing process would offe...

journal_title：Mechanisms of ageing and development

authors： Vijg J,Suh Y

更新日期：2003-01-01 00:00:00

abstract：:The DNA repair capabilities of cultured hepatocytes derived from five mammalian species in response to a broad range of ultraviolet light exposures were measured. Differences in the induction of DNA repair synthesis and the proportion of responding cells were noted only for the lowest fluences. These differences appea...

journal_title：Mechanisms of ageing and development

authors： Maslansky CJ,Williams GM

更新日期：1985-02-01 00:00:00

abstract：:Calorie restriction (CR) extends life span and retards many age-related cellular and molecular changes in laboratory rodents. However, neither the breadth of its effects, its underlying mechanisms, nor the limits of its action is fully understood. Expression levels of 588 genes in livers from 3- and 24-month-old ad li...

journal_title：Mechanisms of ageing and development

authors： Han E,Hilsenbeck SG,Richardson A,Nelson JF

更新日期：2000-06-20 00:00:00

abstract：:In this paper, we presented the results of analysis of experimental evidence for the decline of the human immune system functioning with age using mathematical model of immunosenescence. The most prominent changes in this system are related to the decline in the T-cellular immunity. These include the decline in the na...

journal_title：Mechanisms of ageing and development

authors： Romanyukha AA,Yashin AI

更新日期：2003-04-01 00:00:00

abstract：:The strychnine-insensitive binding of [3H]glycine was characterized in purified cerebral cortical membranes from mice aged from 7 days to 22 months. The binding was saturable, exhibiting only one component during the whole life-span studied. The binding constant KD did not change during development and ageing, whereas...

journal_title：Mechanisms of ageing and development

authors： Saransaari P,Oja SS

更新日期：1993-11-01 00:00:00

abstract：:Lymphatic lipid transport in the intestine of adult and ageing rats was compared. Adult (8-10 months old) and old (24-26 months old) male Wistar rats were cannulated into the mesenteric lymph under ethrane anesthesia. On the following day, lipid emulsion containing 35.4 mg/h of olive oil was infused intraduodenally fo...

journal_title：Mechanisms of ageing and development

authors： Hayashi H,Sato Y,Kanai S,Masuda M,Ohta M,Funakoshi A,Nagao K,Imaizumi K,Miyasaka K

更新日期：2000-02-15 00:00:00

abstract：:In a longitudinal design in which each animal was examined repeatedly throughout its life, we used flow cytometry to determine the numbers or proportions of a variety of T lymphocyte subsets in the peripheral blood of mice aged 8-20 months. Half of the 128 mice were given a low calorie diet which is known to extend li...

journal_title：Mechanisms of ageing and development

authors： Miller RA

更新日期：1997-06-01 00:00:00

abstract：:Ascorbic acid content decreased with age in livers of male rats but not in those of female rats. The influence of aging on the regeneration of ascorbic acid from dehydroascorbic acid was investigated as a possible cause of declining ascorbate concentrations. The results demonstrate that hepatic NADPH-dehydroascorbic a...

journal_title：Mechanisms of ageing and development

authors： Rikans LE,Lopez TR,Hornbrook KR

更新日期：1996-11-13 00:00:00

abstract：:This study has characterised the time course of two major transcriptional adaptive responses to exercise (changes in antioxidant defence enzyme activity and heat shock protein (HSP) content) in muscles of adult and old male mice following isometric contractions and has examined the mechanisms involved in the age-relat...

journal_title：Mechanisms of ageing and development

authors： Vasilaki A,McArdle F,Iwanejko LM,McArdle A

更新日期：2006-11-01 00:00:00

abstract：:Lipid peroxidation, one of the most common expressions of oxidative stress, may be altered during normal physiological states including development. We have examined the changes in lipid peroxidation in rat brain, a tissue highly susceptible to oxidative damage, during this physiological state. In vivo lipid peroxidat...

journal_title：Mechanisms of ageing and development

authors： Pushpendran CK,Subramanian M,Devasagayam TP

更新日期：1994-03-01 00:00:00

abstract：:Following a 3 hour in vivo labelling of cytoplasmic RNA in rat liver with orotic acid-6-14C under conditions where ribosomal RNA synthesis was suppressed, the proportion of labelled messenger-like RNA released to the cytoplasm which contained polyadenylate (poly(A)) tracts was about 3.0 times higher in the livers of j...

journal_title：Mechanisms of ageing and development

authors： Yannarell A,Schumm DE,Webb TE

更新日期：1977-07-01 00:00:00

abstract：:This paper is the second one in a series of two papers hypothesizing and testing systemic grounds of reproductive life history in the female fruit fly. In the first paper, we analyzed mechanisms of individual fecundity scheduling and have drawn the following conclusions. Individual fecundity in female flies is endowed...

journal_title：Mechanisms of ageing and development

authors： Novoseltsev VN,Carey RJ,Novoseltseva JA,Papadopoulos NT,Blay S,Yashin AI

更新日期：2004-01-01 00:00:00

abstract：:The human fibroblast cell line WI-38 shows a gradual decline in glutamine synthetase specific activity with increasing age in culture. However, the level of functional enzyme per cell does not change with age. Heat inactivation profiles indicate that glutamine synthetase from younger cell cultures is more heat labile ...

journal_title：Mechanisms of ageing and development

authors： Viceps-Madore D,Cristofalo VJ

更新日期：1978-07-01 00:00:00

abstract：:Confluent late passage WI-38 human diploid fibroblast cultures grown in the presence or absence of hydrocortisone for fifteen population doublings were measured cytochemically for DNA, nuclear RNA, basic nuclear protein and acidic nuclear protein content during a 12-hour interval following a medium-change stimulation....

journal_title：Mechanisms of ageing and development

authors： Docherty PA,Anthony A,Mitchell RB

更新日期：1981-11-01 00:00:00

abstract：:The decline in the lymphoproliferative response to mitogenic stimuli shows marked heterogeneity in elderly individuals. Adequate nutriture is required for optimal immune function, yet nutritional status may be compromised in the elderly. To address whether this variation in the proliferative response of elderly indivi...

journal_title：Mechanisms of ageing and development

authors： Gardner EM,Bernstein ED,Dorfman M,Abrutyn E,Murasko DM

更新日期：1997-03-01 00:00:00

abstract：:Structural changes of glycans are observed in different (patho)physiological conditions. Human placental membrane (glyco)proteins were isolated from the first and third trimester placentas of mothers at different ages. By using lectin microarray, we demonstrated that the placental membrane N-glycome contains several N...

journal_title：Mechanisms of ageing and development

authors： Robajac D,Masnikosa R,Nemčovič M,Križáková M,Belická Kluková Ľ,Baráth P,Katrlík J,Nedić O

更新日期：2019-10-01 00:00:00

abstract：:Functional defects that accumulate in the T cell compartment are thought to be responsible for the pronounced immunodeficiency that develops during ageing, and reduced production of T cells by the thymus as it undergoes involution has been suggested to contribute to this phenomenon. Understanding the mechanisms respon...

journal_title：Mechanisms of ageing and development

authors： Montecino-Rodriguez E,Dorshkind K

更新日期：1997-02-01 00:00:00

abstract：:Morphometric comparison of freeze-fractured mitochondria in flight muscles of adult (37-day-old) and old (68-day-old) houseflies revealed a 28% decrease of cristae in the old flies. The major membrane change with age was an increase in the 90-120-A particles in the inner membrane external face concomitant with a loss ...

journal_title：Mechanisms of ageing and development

authors： Turturro A,Shafiq SA

更新日期：1981-06-01 00:00:00

abstract：:The kidney glomeruli of 9-month-old intact, 23-month-old intact, and 23-month-old hypophysectomized female rats were examined by scanning and transmission electron microscopy. With increasing age, the glomeruli increased in diameter and more podocyte microvilli were found. Hypophysectomy (4 months before sacrifice) re...

journal_title：Mechanisms of ageing and development

authors： Johnson JE Jr,Cutler RG

更新日期：1980-05-01 00:00:00

abstract：:Hepatic growth and protein synthesis in vivo was studied with age in ad libitum-fed and dietary restricted rats in which the mean and maximum lifespan was significantly extended. Livers from underfed rats showed significantly lower DNA, RNA and protein contents, and total protein synthesis. The fractional rate of synt...

journal_title：Mechanisms of ageing and development

authors： Merry BJ,Holehan AM,Lewis SE,Goldspink DF

更新日期：1987-07-01 00:00:00

abstract：:The in vitro replicative potential of human diploid fibroblasts can be increased by polypeptide growth factors such as epidermal growth factor (EGF). Also, the cycle time of EGF-stimulated cells is, on average, decreased and their mitotic cell volume is reduced. Therefore, the regulation of cell size by the duration o...

journal_title：Mechanisms of ageing and development

authors： Angello JC

更新日期：1992-01-01 00:00:00

abstract：:The present review focuses on the effect of aging on flow-mediated outward remodeling (FMR) via alterations in estrogen metabolism, oxidative stress and inflammation. In ischemic disorders, the ability of the vasculature to adapt or remodel determines the quality of the recovery. FMR, which has a key role in revascula...

journal_title：Mechanisms of ageing and development

authors： Chehaitly A,Vessieres E,Guihot AL,Henrion D

更新日期：2020-12-14 00:00:00