Effects of hypophysectomy on age-related changes in the rat kidney glomerulus: observations by scanning and transmission electron microscopy.

abstract：:Alpha-synuclein (syn) is the main component of proteinaceous inclusions known as Lewy bodies (LBs), which are implicated in the pathogenesis of the neurodegenerative diseases known as synucleinopathies, like Parkinson's disease (PD). Aging is a major risk factor for PD and thus, interventions that delay aging will hav...

journal_title：Mechanisms of ageing and development

authors： Guedes A,Ludovico P,Sampaio-Marques B

更新日期：2017-01-01 00:00:00

abstract：:Some observations on cellular senescence are discussed regarding the possibility that the postulated genes, which bring about the DNA synthesis block of senescent fibroblasts, might be similar to those designated as anti-oncogenes or tumour suppressor genes. The latter genes have been defined by tumorogenicity tests o...

journal_title：Mechanisms of ageing and development

authors： Ferluga J

更新日期：1990-04-30 00:00:00

abstract：:The health status of the oldest old, the fastest increasing population segment worldwide, progressively becomes more heterogeneous, and this peculiarity represents a major obstacle to their classification. We compared the effectiveness of four previously proposed criteria (Franceschi et al., 2000; Evert et al., 2003; ...

journal_title：Mechanisms of ageing and development

authors： Cevenini E,Cotichini R,Stazi MA,Toccaceli V,Scurti M,Mari V,Berardelli M,Passarino G,Jeune B,Franceschi C,GEHA Project Consortium.

更新日期：2013-11-01 00:00:00

abstract：:A subset of 43 [35S]methionine labeled mitochondrial proteins, identified on two dimensional electrophoresis gels of whole body extracts of adult Drosophila, were compared between two age groups. These flies, which except for their spermatocytes consist entirely of postmitotic cells, were 6 days old and 38 days old, w...

journal_title：Mechanisms of ageing and development

authors： Fleming JE,Melnikoff PS,Latter GI,Chandra D,Bensch KG

更新日期：1986-03-01 00:00:00

abstract：:The observations of the loss of cholinergic function in neocortex and hippocampus in Alzheimer's disease (AD) developed the hypothesis that replacement of cholinergic function may be of therapeutic benefit to AD patients. The different approaches proposed or tested included intervention with acetylcholine (ACh) precur...

journal_title：Mechanisms of ageing and development

authors： Amenta F,Parnetti L,Gallai V,Wallin A

更新日期：2001-11-01 00:00:00

abstract：:Steroid-receptor complexes (SRCs) (glucocorticoids, estrogens and progestins) are isolated from rat liver and purified 1500-2000-fold. Both the initial cytosol complexes and those purified 2000-fold were characterized by gel filtration on Sephadex G-100 and DEAE-cellulose chromatography. The purified rat liver SRCs we...

journal_title：Mechanisms of ageing and development

authors： Konoplya EF,Luksha GL,Savateev SK,Naumov AD

更新日期：1986-07-01 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of Marie-Ange Teste, Isabelle Léger-Silvestre, Jean M François and Jean-Luc Parrou. Marjorie Petitjean could not b...

journal_title：Mechanisms of ageing and development

authors： Petitjean M,Teste MA,Léger-Silvestre I,François JM,Parrou JL

更新日期：2017-01-01 00:00:00

abstract：:Although myocardial actomyosin ATPase specific activity determined at Ca2+ levels of 1 x 10(-3) to 1 x 10(-2) M is consistently higher in two-month old male Fischer rats than in twelve-month old individuals, this difference can be eliminated if the enzyme is assayed at lower calcium concentrations. This suggests that ...

journal_title：Mechanisms of ageing and development

authors： Rockstein M,Chesky JA,Lopez T

更新日期：1978-12-01 00:00:00

abstract：:The intertwining between epilepsy, sleep disorders and beta amyloid pathology has been progressively highlighted, as early identification and stratification of patients at high risk of cognitive decline is the need of the hour. Modification of the sleep-wake activity, such as sleep impairment or excessive daytime slee...

journal_title：Mechanisms of ageing and development

authors： Liguori C,Spanetta M,Romoli M,Placidi F,Nardi Cesarini E,Mercuri NB,Costa C

更新日期：2021-01-11 00:00:00

abstract：:Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty...

journal_title：Mechanisms of ageing and development

authors： Chen J,Li Y,Zhu Q,Li T,Lu H,Wei N,Huang Y,Shi R,Ma X,Wang X,Sheng J

更新日期：2017-06-01 00:00:00

abstract：:Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof, including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha-synuclein disorders, such as Parkinson'...

journal_title：Mechanisms of ageing and development

authors： Butterfield DA,Kanski J

更新日期：2001-07-15 00:00:00

abstract：:The lifespan of the nematode, Caenorhabditis elegans, can be extended by mutations affecting components of the insulin-like growth factor (IGF) signaling cascade or by overexpression of SIR2, an NAD+-dependent protein deacetylase. The mammalian homologue of SIR2, Sirt1, has been shown to modulate the activity of FoxO,...

journal_title：Mechanisms of ageing and development

authors： Lemieux ME,Yang X,Jardine K,He X,Jacobsen KX,Staines WA,Harper ME,McBurney MW

更新日期：2005-10-01 00:00:00

abstract：:Glycosaminoglycan (GAG) distribution has been analyzed in the adhesion sites, left substratum-bound after EGTA-mediated detachment, of various human skin fibroblast populations grown in vitro in the presence (asc+) or absence (asc-) of ascorbate. Examination of these skin fibroblasts during the EGTA treatment by scann...

journal_title：Mechanisms of ageing and development

authors： Beyth RJ,Culp LA

更新日期：1985-02-01 00:00:00

abstract：:Human diploid fibroblasts, TIG-1, were serially subcultivated at low inoculation densities thus maintaining the cultures in log phase throughout their in vitro lifespan. Their lifespan was shortened in calendar time without decreasing the cumulative number of population doublings when compared with the lifespan of cel...

journal_title：Mechanisms of ageing and development

authors： Kaji K,Matsuo M

更新日期：1980-07-01 00:00:00

abstract：:An age-related decline in blood-brain barrier transport of thyroid hormones may contribute to the central nervous system changes with aging. To test this hypothesis, the brain uptake index (BUI) of levo (L) and dextro (D) triiodothyronine (T3) was determined in male Fischer 344 rats at 6 months of age (young) and 26 m...

journal_title：Mechanisms of ageing and development

authors： Mooradian AD

更新日期：1990-03-15 00:00:00

abstract：:Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate the decline in functions. Various aspects of physiological deterioration are controlled by the hypothalamus, a critical brai...

journal_title：Mechanisms of ageing and development

authors： Kim K,Choe HK

更新日期：2019-01-01 00:00:00

abstract：:Possible alterations in the population of poly(A)(+)mRNA during ageing were investigated by translation in vitro of poly(A)(+)mRNA from the liver, kidney and brain of male ddY mice of different ages. [35S]Methionine-labeled translation products were analysed by two-dimensional polyacrylamide gel electrophoresis follow...

journal_title：Mechanisms of ageing and development

authors： Anzai K,Imazato C,Goto S

更新日期：1983-10-01 00:00:00

abstract：:Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-as...

journal_title：Mechanisms of ageing and development

authors： van de Ven M,Andressoo JO,Holcomb VB,Hasty P,Suh Y,van Steeg H,Garinis GA,Hoeijmakers JH,Mitchell JR

更新日期：2007-01-01 00:00:00

abstract：:It has been previously well documented that partial pressure of oxygen (PO2) and weight-specific rate of O2 consumption in chick embryo (Gallus gallus domesticus) transiently increase midway through the 21-day in ovo incubation period. The present study found that these oxidative changes were paralleled by the concent...

journal_title：Mechanisms of ageing and development

authors： Wilson JX,Lui EM,Del Maestro RF

更新日期：1992-08-01 00:00:00

abstract：:Overproduction of oxidants and free radicals in ageing tissues induces nitro-oxidative stress, which has recently been implicated in the pathogenesis of cardiovascular dysfunction associated with ageing. Peroxynitrite, a strong cytotoxic oxidant damages proteins and DNA and activates several pathways causing tissue in...

journal_title：Mechanisms of ageing and development

authors： Radovits T,Seres L,Gero D,Lin LN,Beller CJ,Chen SH,Zotkina J,Berger I,Groves JT,Szabó C,Szabó G

更新日期：2007-02-01 00:00:00

abstract：:The kinetics of accumulation and loss of zinc from the liver following subcutaneous administration of 10 mg of zinc per kg were examined in young adult (6 months old) and old (24 months old) male C57BL/6J mice. After zinc treatment, total liver zinc concentrations rose equally in both groups and returned to basal leve...

journal_title：Mechanisms of ageing and development

authors： Thomas DJ,Winchurch RA,Adler WH

更新日期：1989-03-01 00:00:00

abstract：:We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in the spleen, CD5(+) B cells in...

journal_title：Mechanisms of ageing and development

authors： Watanabe K,Watanabe M,Maruoka H,Amino N,Iwatani Y

更新日期：2001-10-01 00:00:00

abstract：:The current increase in life expectancy observed in industrialized societies underscores the need to achieve a better understanding of the aging process that could help the development of effective strategies to achieve healthy aging. This will require not only identifying genes involved in the aging process, but also...

journal_title：Mechanisms of ageing and development

authors： Lai CQ,Parnell LD,Lyman RF,Ordovas JM,Mackay TF

更新日期：2007-03-01 00:00:00

abstract：:Expression of dystrophin and the dystrophin-related protein utrophin has been studied in the human fetal brain both in vivo and in vitro. Results showed that both these proteins were developmentally regulated, even if their expression followed a different pattern. Utrophin was found since very early stages of developm...

journal_title：Mechanisms of ageing and development

authors： Sogos V,Curto M,Reali C,Gremo F

更新日期：2002-03-15 00:00:00

abstract：:Type I and II macrophage scavenger receptors are implicated in the pathologic deposition of cholesterol during the atherogenesis. There is a charged collagen structure of type I and II receptors identified as a ligand binding domain, which can recognize a wide range of negatively charged macromolecules including oxidi...

journal_title：Mechanisms of ageing and development

authors： Shirai H,Murakami T,Yamada Y,Doi T,Hamakubo T,Kodama T

更新日期：1999-11-01 00:00:00

abstract：:The purpose of these studies was to analyze the role of different immune cell populations in the immune response against Trypanosoma cruzi antigens in aged mice. Mice of different ages (3 and 12 months old) were immunized i.d. with S-105 plus Bordetella pertussis as adjuvant and we compared the activities of the lymph...

journal_title：Mechanisms of ageing and development

authors： Maletto BA,Gruppi A,Moron G,Pistoresi-Palencia MC

更新日期：1996-07-05 00:00:00

abstract：:Ageing is the most complex phenotype currently known, since it becomes manifest in all organs and tissues, affects an organism's entire physiology, impacts function at all levels and increases susceptibility to all major chronic diseases. Insight into the molecular and cellular targets of the ageing process would offe...

journal_title：Mechanisms of ageing and development

authors： Vijg J,Suh Y

更新日期：2003-01-01 00:00:00

abstract：:Age-specific mortality from carcinoma of the prostate was analyzed by drawing a line between the value at age 52 years and that at age 87. Slope of the line was relatively constant for the pooled years 1962-1966, 1967-1971 and 1972-1976 (maximum variation from the mean of 4.5%). However, the slope was 17.7% greater fo...

journal_title：Mechanisms of ageing and development

authors： Clive JM,Spencer RP

更新日期：1995-08-31 00:00:00

abstract：:The effect of age on potassium (K+)-induced norepinephrine release in the heart was studied in 6- and 24-month-old male Fischer-344 rats. Isolated hearts were perfused with Krebs-Ringer solution according to Langendorff method. K+ was employed as 2 ml bolus at the concentrations, of 70, 90, 100 and 120 microM. Norepin...

journal_title：Mechanisms of ageing and development

authors： Tumer N,Ryan PJ,Roberts J

更新日期：1990-03-01 00:00:00

abstract：:A quantitative ultrastructural study of the posterior pituitary was undertaken. The posterior pituitary is the storage of the hormones vasopressin and oxytocin. Female C57BL/Icrfat mice which were under conditions of normal hydration were sampled at 8 and 32 months of age. There was a slight age-related decline in the...

journal_title：Mechanisms of ageing and development

authors： Wilkinson A,Davies I

更新日期：1981-02-01 00:00:00