Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.

abstract：:Hematopoietic stem cell performance and identity, crucial for homeostasis of the blood-forming system, is governed by extrinsic factors found in the bone marrow microenvironment. Communication within hematopoietic stem cell niches occurs via soluble factors or cell-to-cell contacts between niche and blood-forming cell...

journal_title：Mechanisms of ageing and development

authors： Böhm L,Helbing DL,Oraha N,Morrison H

更新日期：2020-10-01 00:00:00

abstract：:To investigate the relationship between immunological potential and advance of age, patterns of humoral immune response in different aged rabbits were compared. In the primary response, the appearance of total antibody and the arrival to its peak level were retarded by advance of age. On the other hand, the appearance...

journal_title：Mechanisms of ageing and development

authors： Nomaguchi T,Okuma-Sakurai Y,Kimura I

更新日期：1976-01-01 00:00:00

abstract：:Food restriction is known to ameliorate many of the adverse physiologic effects of age. In this study, we have examined the effect of food restriction on the induction of the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (PEPCK) in liver and kidney following a 12-h fasting period in young (6 month) and old (...

journal_title：Mechanisms of ageing and development

authors： Van Remmen H,Ward WF

更新日期：1998-09-01 00:00:00

abstract：:Glycosaminoglycan (GAG) distribution has been analyzed in the adhesion sites, left substratum-bound after EGTA-mediated detachment, of various human skin fibroblast populations grown in vitro in the presence (asc+) or absence (asc-) of ascorbate. Examination of these skin fibroblasts during the EGTA treatment by scann...

journal_title：Mechanisms of ageing and development

authors： Beyth RJ,Culp LA

更新日期：1985-02-01 00:00:00

abstract：:The quantification of plasmatic HLA class-I molecules (sHLA-I) was realized by a sandwich ELISA using a monomorphic mAb (W6/32). sHLA-I concentration is significantly increased in the elderly group (>50 years, 0.429+/-0.301 microg ml(-1)) as compared to the young group (<50 years, 0.126+/-0.085 microg ml(-1)). The var...

journal_title：Mechanisms of ageing and development

authors： Le Morvan C,Cogné M,Drouet M

更新日期：2001-03-01 00:00:00

abstract：:Aging is accompanied by the accumulation of cellular damage over time in response to stress, lifestyle and environmental factors ultimately leading to age-related diseases and death. Additionally, the number of senescent cells increases with age. Senescence is most likely not a static endpoint, it represents a series ...

journal_title：Mechanisms of ageing and development

authors： Ott C,Jung T,Grune T,Höhn A

更新日期：2018-03-01 00:00:00

abstract：:The combined grafting of young bone marrow and newborn thymus performed in old mice was effective in restoring the impaired immune functions, but the same treatment performed in middle-aged adult mice had no effect on the life span of C3H/MTV female mice. Sequential multiple newborn thymus graftings starting at young ...

journal_title：Mechanisms of ageing and development

authors： Hirokawa K,Utsuyama M

更新日期：1989-07-01 00:00:00

abstract：:Arteriosclerosis is believed by many to represent the aging process of arteries and to be responsible for the cause-specific deaths at any age in industrialized countries. However, the increasing rate of (A) associated with steadily increasing life expectancy invited studies of the average age at death (AAD) of condit...

journal_title：Mechanisms of ageing and development

authors： Kaunitz H

更新日期：1991-02-01 00:00:00

abstract：:Changes in the T-lymphocyte compartment represent the most critical component of immunological aging. Recent studies have demonstrated that the age-related decline in T-cell-mediated immunity is a multifactorial phenomenon affecting T-cell subset composition as well as several proximal events such as protein tyrosine ...

journal_title：Mechanisms of ageing and development

authors： Chakravarti B,Abraham GN

更新日期：1999-05-17 00:00:00

abstract：:The effect of life-long diets containing different concentrations of selenium and vitamin E on the age pigment accumulation in the rat superior cervical ganglion, vagal ganglion and dorsal root ganglion, was studied using microspectrofluorometry. All types of ganglia showed unchanged amounts of age pigments at low or ...

journal_title：Mechanisms of ageing and development

authors： Koistinaho J,Alho H,Hervonen A

更新日期：1990-01-01 00:00:00

abstract：:Ceramide mediates the effects of several agonists leading to differentiation, apoptosis or senescence. We previously showed that ceramide becomes elevated in senescent fibroblasts. In the present study, senescent cultures of Wi-38 fibroblasts and human umbilical-vein endothelial cells were compared to low-passage cult...

journal_title：Mechanisms of ageing and development

authors： Venable ME,Webb-Froehlich LM,Sloan EF,Thomley JE

更新日期：2006-05-01 00:00:00

abstract：:Two types of age-related cell surface changes could be demonstrated in human diploid fibroblasts with the two methods of the lectin-mediated red blood cell (RBC) adsorption assay: the fibroblast coating method (in which RBCs are adsorbed to lectin-coated fibroblasts) and the RBC coating method (in which lectin-coated ...

journal_title：Mechanisms of ageing and development

authors： Aizawa S,Kurimoto F

更新日期：1979-11-01 00:00:00

abstract：:We determined the number of fibroblastoid progenitors (fibroblastoid colony-forming units, CFU-F) in femurs and spleens derived from (CBA X C57BL)F1 mice of different ages. The femoral CFU-F population size increased from 350 at 1 week of age and plateaued at approximately 1900 CFU-F at 8 weeks of age. The mean incide...

journal_title：Mechanisms of ageing and development

authors： Brockbank KG,Ploemacher RE,van Peer CM

更新日期：1983-05-01 00:00:00

abstract：:Antioxidants and telomere length are potential biomarkers for individuals' exposure and ability to cope with environmental stressors. However, intraspecific variations in antioxidant alterations due to natural, life cycle related stress, have been rarely estimated. We investigated those changes in wild-derived house m...

journal_title：Mechanisms of ageing and development

authors： Stauffer J,Panda B,Ilmonen P

更新日期：2018-01-01 00:00:00

abstract：:The efficient use of nutrients is important in development and aging. In this study, we asked if the protein repair methyltransferase has a related or additional role in energy metabolism and stress response in the nematode Caenorhabditis elegans. Worms lacking the pcm-1 gene encoding this enzyme exhibit reduced longe...

journal_title：Mechanisms of ageing and development

authors： Gomez TA,Banfield KL,Clarke SG

更新日期：2008-12-01 00:00:00

abstract：:In the lung of Rana perezi no differences as a function of age have been found for any of the five major antioxidant enzymes, reduced (GSH), oxidized (GSSG) or glutathione ratio (GSSG/GSH), oxygen consumption (VO2) and for in vivo or in vitro stimulated tissue peroxidation. This frog shows a moderate rate of oxygen co...

journal_title：Mechanisms of ageing and development

authors： Perez-Campo R,López-Torres M,Paton D,Sequeros E,Barja de Quiroga G

更新日期：1990-12-01 00:00:00

abstract：:The effect of the oral administration of 0.150 mg/m2 clonidine on the plasma level of human growth hormone (hGH) was studied in 53 adults (25 males and 28 females) aged from 28 to 68 years, of which 15 were healthy volunteers and 38 were hypertensive. Both the normal and hypertensive subjects of both sexes showed an a...

journal_title：Mechanisms of ageing and development

authors： Gil-Ad I,Gurewitz R,Marcovici O,Rosenfeld J,Laron Z

更新日期：1984-09-01 00:00:00

abstract：:Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead tra...

journal_title：Mechanisms of ageing and development

authors： Xuan Z,Zhang MQ

更新日期：2005-01-01 00:00:00

abstract：:Cyclic AMP levels and activities of adenylate cyclase and phosphodiesterase in the striatum were measured in 4, 12, 24 and 30 month-old rats. No age-related changes were observed either in cyclic AMP levels or basal adenylate cyclase activity. However, there was an age-related decline in dopamine sensitivity of adenyl...

journal_title：Mechanisms of ageing and development

authors： Puri SK,Volicer L

更新日期：1977-01-01 00:00:00

abstract：:We have developed a cell model for loss of differentiated gene expression in cellular aging. Over long periods in culture, bovine adrenocortical cells lose expression of a specialized gene, steroid 17 alpha-hydroxylase. The decline in expression of 17 alpha-hydroxylase in mass cultures and clones of bovine adrenocorti...

journal_title：Mechanisms of ageing and development

authors： Hornsby PJ,Yang LQ

更新日期：1991-04-01 00:00:00

abstract：:The effects of age and nutritional conditions on accumulation of autofluorescent granules in various organs and tissues of male Sprague-Dawley rats were compared morphometrically. The relative intensity of the specific fluorescence of these autofluorescent granules was similar in all tissues and cells examined. In alm...

journal_title：Mechanisms of ageing and development

authors： Sato T,Tokoro Y,Tauchi H,Kohtani K,Mizuno T,Shimasaki H,Ueta N

更新日期：1988-06-01 00:00:00

abstract：:The present study examined the effect of a 40% reduction in caloric intake (CR) versus ad libitum (AL) feeding on retinal aging. CR- and AL-fed Brown Norway (BN) rats were obtained at 12, 24 and 30 months of age from the National Center for Toxicological Research (NCTR). Age-dependent declines in outer nuclear layer (...

journal_title：Mechanisms of ageing and development

authors： Obin M,Pike A,Halbleib M,Lipman R,Taylor A,Bronson R

更新日期：2000-03-13 00:00:00

abstract：:The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of ...

journal_title：Mechanisms of ageing and development

authors： de Vos-Houben JM,Ottenheim NR,Kafatos A,Buijsse B,Hageman GJ,Kromhout D,Giltay EJ

更新日期：2012-06-01 00:00:00

abstract：:Quantitative methods for the study of aging in single organisms of the suctorian protozoan Tokophrya infusionum are described. New cell lines are initiated by metamorphosis of a ciliated embryo to form a sessile adult. The life history of adult cells consists of a sequence of age-related stages, culminating in cessati...

journal_title：Mechanisms of ageing and development

authors： Karakashian SJ,Lanners HN,Rudzinska MA

更新日期：1984-08-01 00:00:00

abstract：:Age-related variations in the stromal cell population of human bone marrow were studied by means of a cloning assay. It was found that these cells are heterogeneous both in division capacity and in morphology. Fibroblast-like progenitor cells could be distinguished from epithelial-like cells, having only a very limite...

journal_title：Mechanisms of ageing and development

authors： Mets T,Verdonk G

更新日期：1981-01-01 00:00:00

abstract：:The survival rate was measured of differently aged rabbit erythrocytes that had been taken from young and old animals, tagged with 51Cr and injected into young and old animals. The survival rate of the donor erythrocytes depends mostly on the age of the recipient animals. The life span of the injected cells found in o...

journal_title：Mechanisms of ageing and development

authors： Vömel T,Platt D

更新日期：1981-11-01 00:00:00

abstract：:Hepatocyte morphology of the three zones of the liver lobule was evaluated by stereological analysis in 3-month-old and 35-month-old virgin female WAG/Rij rats. In the old rats, the volume of the nucleus and cytoplasm, and volume densities of smooth endoplasmic reticulum and lysosomes were increased in all areas of th...

journal_title：Mechanisms of ageing and development

authors： Meihuizen SP,Blansjaar N

更新日期：1980-06-01 00:00:00

abstract：:Age-related changes in the activities of superoxide dismutase, catalase, and glutathione peroxidase were determined in brain, heart, hepatocytes, intestinal mucosa, and kidney from male Fischer F344 rats. Superoxide dismutase activity decreased significantly with age in all five tissues studied. The activity of catala...

journal_title：Mechanisms of ageing and development

authors： Rao G,Xia E,Richardson A

更新日期：1990-03-31 00:00:00

abstract：BACKGROUND:The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper de...

journal_title：Mechanisms of ageing and development

authors： Berendsen A,Santoro A,Pini E,Cevenini E,Ostan R,Pietruszka B,Rolf K,Cano N,Caille A,Lyon-Belgy N,Fairweather-Tait S,Feskens E,Franceschi C,de Groot CP

更新日期：2013-11-01 00:00:00

abstract：:This cross-sectional study was conducted among a rural elderly population of 725 individuals aged over 60 years from Eastern India to assess the association of multiple chronic diseases with frailty and dependence. Multimorbidity, frailty, and dependence were assessed using prevalidated tools. Regression models were u...

journal_title：Mechanisms of ageing and development

authors： Kshatri JS,Palo SK,Bhoi T,Barik SR,Pati S

更新日期：2020-12-01 00:00:00