Lifespan of rabbit erythrocytes and activity of the reticulohistiocyte system.

abstract：:Oxidative stress may contribute to the cellular alterations, which occur as the result of aging, and the nervous system is particularly vulnerable to aging associated oxidative injury. The multicatalytic proteasome (MCP) is responsible for the majority of protein degradation and is sensitive to oxidative stress. To de...

journal_title：Mechanisms of ageing and development

authors： Keller JN,Hanni KB,Markesbery WR

更新日期：2000-01-24 00:00:00

abstract：:The effects of ageing and of exercise on muscle mass, fiber cross-sectional area, and fiber type composition of a weight-bearing muscle, the soleus and a non-weight-bearing muscle, the extensor digitorum longus (EDL) were investigated in female Long-Evans rats. The animals were exercised by means of voluntary wheel ru...

journal_title：Mechanisms of ageing and development

authors： Brown M,Ross TP,Holloszy JO

更新日期：1992-03-15 00:00:00

abstract：:With recent sequencing of the genome and development of high-density array technology, it is now possible to assess global gene expression in cells/tissues by a technique that is sensitive, quantitative, and rapid. Gene expression array technology is extremely useful in studying a complex, multigenetic process, such a...

journal_title：Mechanisms of ageing and development

authors： Han E,Hilsenbeck SG

更新日期：2001-07-31 00:00:00

abstract：:Cultured epiphyseal-chondrocytes from embryonic chick may serve as a useful in vitro model to study aging processes in cartilage. The accelerated aging process in cultured chondrocytes is completed within a month and is manifested by typical changes in both cellular and extracellular compartments. Under common mainten...

journal_title：Mechanisms of ageing and development

authors： Nevo Z,Beit-Or A,Eilam Y

更新日期：1988-11-14 00:00:00

abstract：:This paper presents evidence derived from the selective use of codons in ca. 40 eukaryotic genes (or messages derived from them) that codon usage is one of the most conserved features of messages for specific cell products. The theory has been developed by several investigations that the kinds of products of many if n...

journal_title：Mechanisms of ageing and development

authors： Strehler B,North D

更新日期：1982-04-01 00:00:00

abstract：:Impaired lymphocyte and granulocyte function in the aged may, in part, reflect intrinsic aged-related biochemical alterations. In this study we compared the ribonucleotide contents of lymphocytes and granulocytes from young and old subjects evaluated by means of an HPLC-anion exchange method. We found that in general ...

journal_title：Mechanisms of ageing and development

authors： Borzì RM,Dal Monte P,Uguccioni M,Meliconi R,Facchini A

更新日期：1992-06-01 00:00:00

abstract：:In order to gain a better understanding of tissue plasticity with aging, we investigated the adaptive responses of young and adult animals to both 7 and 28 days of hypobaric hypoxia. Senescence is associated with a decreased tolerance to hypoxia that may be related to an age-associated decline in glucose transporter s...

journal_title：Mechanisms of ageing and development

authors： Dill RP,Chadan SG,Li C,Parkhouse WS

更新日期：2001-05-15 00:00:00

abstract：:Food restriction (FR) may increase longevity by increasing the efficiency of energy utilization by some organs. We tested whether any effect of FR on the energy efficiency of isolated, isovolumically beating hearts could be observed, by studying four groups of rats: (1). AL fed (AL) 10-13-month-old rats, (2). age matc...

journal_title：Mechanisms of ageing and development

authors： Klebanov S,Herlihy JT,Freeman GL

更新日期：2002-07-01 00:00:00

abstract：:Certain anatomic and functional parameters of the eye change with increasing chronological age. They may, therefore, serve as potential biomarkers of ageing. We investigated associations between four such ocular parameters (lens density, retinal vessel calibre, corneal endothelial cells and retinal nerve fibre layer t...

journal_title：Mechanisms of ageing and development

authors： Pathai S,Gilbert CE,Lawn SD,Weiss HA,Peto T,Cook C,Wong TY,Shiels PG

更新日期：2013-07-01 00:00:00

abstract：:Rats from one month to 22 months of age were subjected to in vivo brain microdialysis under a free-moving condition. The 3,4-dihydroxyphenylacetic acid level in the striatum reached a maximum at 3 months old. However, both basal and potassium-induced dopamine release were maximal at 1.5 months, which represents sexual...

journal_title：Mechanisms of ageing and development

authors： Nakano M,Mizuno T

更新日期：1996-02-24 00:00:00

abstract：:While deviations from the optimal phenotype are deleterious, increased variation can prevent population extinction under severe stresses. Cell division asymmetry is an important source of microbial phenotypic heterogeneity. A consecutive set of asymmetric divisions can cause the gradual accumulation of deleterious fac...

journal_title：Mechanisms of ageing and development

authors： Knorre DA,Azbarova AV,Galkina KV,Feniouk BA,Severin FF

更新日期：2018-12-01 00:00:00

abstract：:Social isolation (SI) is a major health risk in older people leading to cognitive decline. This study examined how SI and age influence performance in the novel object recognition (NOR) and elevated plus maze (EPM) tasks in C57BL/6 mice aged 3 or 24 months. Mice were group-housed (groups of 2-3) or isolated for 2 week...

journal_title：Mechanisms of ageing and development

authors： Panossian A,Cave MW,Patel BA,Brooks EL,Flint MS,Yeoman MS

更新日期：2020-10-01 00:00:00

abstract：:In an attempt to determine the relevance of the free radical theory of ageing to age changes discernible in connective tissue parameters, a small colony of C3H/He and LAF1 mice was set up, with sample culled at intervals throughout the lifespan to provide experimental samples. To half of the stock a dietary supplement...

journal_title：Mechanisms of ageing and development

authors： Blackett AD,Hall DA

更新日期：1980-11-01 00:00:00

abstract：:The microtubule-associated protein tau, and the cytoplasmic protein ubiquitin, are constituents of pathological neurofibrillary tangles found in Alzheimer's disease. In order to see if there is any physiological relationship between these proteins in a functioning human system, human neuroblastoma (LAN-5) cells were g...

journal_title：Mechanisms of ageing and development

authors： Mesco ER,Timiras PS

更新日期：1991-11-15 00:00:00

abstract：:Age-specific mortality rates from stomach cancer (SC) in Japan from 1950 through 1993 were subjected to longitudinal Gompertzian analysis. Age-specific SC mortality rate distributions between ages 45 and 75 years were highly Gompertzian for each- and every year for both men and women. Between 1950 and 1993, age-adjust...

journal_title：Mechanisms of ageing and development

authors： Imaizumi Y

更新日期：1995-11-24 00:00:00

abstract：:A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In additio...

journal_title：Mechanisms of ageing and development

authors： Ishi N,Suzuki N,Hartman PS,Suzuki K

更新日期：1993-05-01 00:00:00

abstract：:The dynamics of in vitro uptake of [14C]-ascorbic acid into intact lenses of young (50 days old) and old (730 days old) guinea pigs was evaluated in this study. Two-dimensional protein gel analysis of [35S]-methionine labeled proteins provided evidence that the isolated lenses were viable throughout the culture period...

journal_title：Mechanisms of ageing and development

authors： Fleming JE,Choi S,Bensch KG

更新日期：1990-08-01 00:00:00

abstract：:The efficient use of nutrients is important in development and aging. In this study, we asked if the protein repair methyltransferase has a related or additional role in energy metabolism and stress response in the nematode Caenorhabditis elegans. Worms lacking the pcm-1 gene encoding this enzyme exhibit reduced longe...

journal_title：Mechanisms of ageing and development

authors： Gomez TA,Banfield KL,Clarke SG

更新日期：2008-12-01 00:00:00

abstract：:Cyclic AMP levels and activities of adenylate cyclase and phosphodiesterase in the striatum were measured in 4, 12, 24 and 30 month-old rats. No age-related changes were observed either in cyclic AMP levels or basal adenylate cyclase activity. However, there was an age-related decline in dopamine sensitivity of adenyl...

journal_title：Mechanisms of ageing and development

authors： Puri SK,Volicer L

更新日期：1977-01-01 00:00:00

abstract：:DNA synthesis is a remarkably vulnerable phase in the cell cycle. In addition to introduction of errors during semi-conservative replication, the inherently labile structure of the replication fork, as well as numerous pitfalls encountered in the course of fork progression, make the normally stable double stranded mol...

journal_title：Mechanisms of ageing and development

authors： Ruzankina Y,Asare A,Brown EJ

更新日期：2008-07-01 00:00:00

abstract：:The development and aging of the nucleolus and nucleus in layer V pyramidal cells in the hamster cerebrum were studied by light and electron microscopy. The nucleoli appeared in the newborn as occasional fibrillar masses adjacent to peripherally placed bodies of chromatin. By maturity, a single, generally central, nuc...

journal_title：Mechanisms of ageing and development

authors： Buschmann MB,LaVelle A

更新日期：1981-04-01 00:00:00

abstract：:Aging and HIV disease show certain immunological similarities. In both situations, control over viral infection is diminished, and there is an increase in certain types of cancer. The immune cell type responsible for controlling viral infections and cancer is the so-called CD8 or cytotoxic T cell. In elderly persons a...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2004-02-01 00:00:00

abstract：:MARK-AGE aims at the identification of biomarkers of human aging capable of discriminating between the chronological age and the effective functional status of the organism. To achieve this, given the structure of the collected data, a proper statistical analysis has to be performed, as the structure of the data are n...

journal_title：Mechanisms of ageing and development

authors： Giampieri E,Remondini D,Bacalini MG,Garagnani P,Pirazzini C,Yani SL,Giuliani C,Menichetti G,Zironi I,Sala C,Capri M,Franceschi C,Bürkle A,Castellani G

更新日期：2015-11-01 00:00:00

abstract：:The bone marrow of old adult mice ( approximately 2 years old) has reduced B lymphopoiesis; however, whether the B1 pathway in adult bone marrow is also compromised in senescence is not known. Herein, we show that phenotypic (IgM(-)Lin(-)CD93(+)[AA4.1(+)] CD19(+)B220(low/-)) B1 progenitors are retained in old bone mar...

journal_title：Mechanisms of ageing and development

authors： Alter-Wolf S,Blomberg BB,Riley RL

更新日期：2009-06-01 00:00:00

abstract：:A comparison was made of the resting membrane potential (MP) as well as the MP responses to K+, ACTH and gamma-MSH of superfused adrenocortical, zona fasciculata cells from young (Y) and old (O) male rats. The resting MP of these cells did not vary with age. However, the MP responses to altered extracellular [K+] vari...

journal_title：Mechanisms of ageing and development

authors： Lymangrover JR,Valego NK,Shilling RD

更新日期：1988-06-01 00:00:00

abstract：:T cell responses are altered in the aged in a manner usually interpreted as detrimental to host defences against infectious agents and possibly also against cancer. T cell dysregulation may be caused by any or a combination of stem cell deficits, compromised T cell differentiation, inefficient antigen processing and p...

journal_title：Mechanisms of ageing and development

authors： Pawelec G,Hirokawa K,Fülöp T

更新日期：2001-09-30 00:00:00

abstract：OBJECTIVES:To investigate whether systemic inflammation in acutely admitted older medical patients (age >65 years) is associated with physical performance and organ dysfunction. Organ dysfunction´s association with physical performance, and whether these associations are mediated by systemic inflammation, was also inve...

journal_title：Mechanisms of ageing and development

authors： Klausen HH,Bodilsen AC,Petersen J,Bandholm T,Haupt T,Sivertsen DM,Andersen O

更新日期：2017-06-01 00:00:00

abstract：:The effects of age on estrogen stimulated nuclear RNA polymerase II activity were studied in uteri of ovariectomized mature (6-8 months) and senescent (24 months) rats. Basal levels of RNA polymerase II activity were the same in both age groups. Following 17 beta-estradiol (E2) administration, RNA polymerase II activi...

journal_title：Mechanisms of ageing and development

authors： Haji M,Roth GS

更新日期：1984-04-01 00:00:00

abstract：:Apoptosis plays a central role in the homeostasis of the immune system. During aging, there is an altered regulation of pivotal molecules that are responsible for the regulation of this type of cell death, such as those of the Fas/FasL system. Understanding the regulation of these genes can help to clarify, at least i...

journal_title：Mechanisms of ageing and development

authors： Pinti M,Troiano L,Nasi M,Monterastelli E,Moretti L,Bellodi C,Mazzacani A,Mussi C,Salvioli G,Cossarizza A

更新日期：2003-04-01 00:00:00

abstract：:Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world's top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease,...

journal_title：Mechanisms of ageing and development

authors： Nolen SC,Evans MA,Fischer A,Corrada MM,Kawas CH,Bota DA

更新日期：2017-06-01 00:00:00