Genetics beyond Mendel. Understanding nontraditional inheritance patterns.

Abstract:

:Many medical conditions that clearly have a strong genetic component are not transmitted in a straightforward dominant, recessive, or X-linked pattern. Recent progress in understanding other modes of inheritance, such as imprinting, trinucleotide repeat expansion, mitochondrial inheritance, and mosaicism, has allowed us to solve many of these hereditary puzzles. Such advances have led to improvements in diagnosis and genetic counseling for patients affected with these disorders and should be valuable in development of effective therapies for some of these disorders in the future.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Wagstaff J

doi

10.3810/pgm.2000.09.1.1210

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

131-3, 137-8

issue

3

eissn

0032-5481

issn

1941-9260

journal_volume

108

pub_type

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