Comparison of human immunodeficiency virus type 1 RNA sequence heterogeneity in cerebrospinal fluid and plasma.

Abstract:

:The source of human immunodeficiency virus type 1 (HIV-1) RNA in cerebrospinal fluid (CSF) during HIV-1 infection is uncertain. The sequence heterogeneity of HIV-1 RNA in simultaneous CSF and plasma samples was characterized for five patients at the baseline and during the first week of antiretroviral therapy by two commercial genotyping methodologies. In individual subjects, the sequences in CSF samples differed significantly from those in plasma. In contrast, the viral sequences in CSF at the baseline did not differ from the sequences in CSF during treatment. Similarly, viral sequences in plasma did not vary over this interval. This study provides evidence that HIV-1 RNA in CSF and plasma arise from distinct compartments.

journal_name

J Clin Microbiol

authors

Tang YW,Huong JT,Lloyd RM Jr,Spearman P,Haas DW

doi

10.1128/JCM.38.12.4637-4639.2000

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

4637-9

issue

12

eissn

0095-1137

issn

1098-660X

journal_volume

38

pub_type

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