Mechanisms of bombesin on growth of gastrinoma (PT) in vivo.

Abstract:

:The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). The mechanism is not known, and a potent and specific GRP-R antagonist BIM26226, which has low affinity for NMB-R, was used in vivo in athymic nude mice bearing gastrinoma subcutaneously. Both the BBS and BIM26226 stimulated the growth of PT, and the growth stimulation was even greater when given together. RT-PCR study of gastrinoma revealed the presence of both GRP-R and NMB-R mRNA, but much more abundant NMB-R mRNA. We conclude that BBS-stimulated growth of gastrinoma involves both GRP-R and NMB-R, and our findings suggest that GRP-R mediates negative and NMB-R produces positive growth effects on gastrinoma.

journal_name

Dig Dis Sci

authors

Chu KU,Ishizuka J,Battey JF,Uchida T,Beauchamp RD,Townsend CM Jr,Thompson JC

doi

10.1007/BF02071398

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

2180-6

issue

11

eissn

0163-2116

issn

1573-2568

journal_volume

41

pub_type

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