Effect of ranitidine on intragastric pH and stress-related upper gastrointestinal bleeding in patients with severe head injury.

Abstract:

:We conducted a double-blind, placebo-controlled study to evaluate the effects of ranitidine on intragastric pH and upper gastrointestinal tract bleeding in severe head injury patients. Within 24 hr of the precipitating trauma, 34 adults with Glasgow coma scale scores < or = 10 were randomized to a 6.25 mg/hr ranitidine continuous infusion or placebo for a maximum of 72 hr. Intragastric pH was recorded via an intragastric pH electrode. Patients with hematemesis, hematochezia, bright red blood, or "coffee ground" nasogastric tube aspirates plus a 5% decrease from baseline in hematocrit were considered to have gastrointestinal bleeding. Ranitidine patients maintained a significantly greater mean pH than placebo patients (placebo 2.2, ranitidine 4.1; P < 0.01). All patients had at least two bleeding risk factors at study entry. No ranitidine patients (0/16) developed bleeding compared with five (5/18) placebo patients (P < 0.05). Ranitidine continuous infusion provided consistent intragastric pH control and significant protection from stress-related upper gastrointestinal tract bleeding in a high-risk patient population.

journal_name

Dig Dis Sci

authors

Burgess P,Larson GM,Davidson P,Brown J,Metz CA

doi

10.1007/BF02064385

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

645-50

issue

3

eissn

0163-2116

issn

1573-2568

journal_volume

40

pub_type

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