Abstract:
:The specificity of polymerase chain reaction monoclonality in the diagnosis of gastric lymphoma was prospectively evaluated. Gastric mucosal tissue from normal gastric mucosa (N = 13), benign gastric ulcers (N = 3), chronic Helicobacter pylori gastritis (N = 3), gastric mucosa-associated lymphoid tissue (N = 16), and gastric lymphoma (N = 15) was obtained. Polymerase chain reaction amplification of the heavy-chain framework 2A gene was performed. The sensitivity and specificity of heavy-chain clonality, in the detection of gastric lymphoma, were 73.3% and 45.7%, respectively. Determination of monoclonality by polymerase chain reaction methodology is not an acceptable technique for confirming the diagnosis of gastric lymphoma as it is too sensitive, detecting minute populations of clonal lymphocytes that occur in benign diseases as well as larger populations of clonal lymphocytes associated with malignant gastric lymphoproliferative diseases. Southern blot gene rearrangement testing should be utilized to determine clonality in the evaluation of gastric lymphocytic infiltrates.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Weston AP,Banerjee SK,Horvat RT,Cherian R,Campbell DR,Zoubine MNdoi
10.1023/a:1018842002926subject
Has Abstractpub_date
1998-02-01 00:00:00pages
290-9issue
2eissn
0163-2116issn
1573-2568journal_volume
43pub_type
杂志文章abstract::This study tested the hypothesis that (alginic) acid may have a preferential effect on reflux in the upright position. We evaluated the effect of a compound containing alginic acid plus antacid (extra-strength Gaviscon) versus active control antacid with equal acid-neutralizing capacity on intraesophageal acid exposur...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01307584
更新日期:1992-04-01 00:00:00
abstract::Our objective was to study the predictive value of the family history in the initial diagnosis of hereditary hemochromatosis. Sixty five hemochromatosis proband patients and 66 control patients with chronic liver disease were assessed for a family history of hemochromatosis, cirrhosis, diabetes, and arthritis. There w...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018878813075
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Relative adrenal insufficiency (RAI) is frequently observed in patients with cirrhosis. We sought to identify evidence in the literature regarding the impact of RAI on clinical outcomes in cirrhotic patients. METHODS:We conducted a systematic review (SR) and meta-analysis (MA) using the Ovid-MEDLINE, EMBASE...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10620-017-4471-8
更新日期:2017-04-01 00:00:00
abstract::This study set out to evaluate the effects of dietary fiber on cancer development in the large bowel under in vivo experimental conditions as similar as possible to those under which this cancer develops in vivo in humans. Forty-eight Sprague-Dawley rats were divided into three groups that were fed either a nonfiber d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1015310211821
更新日期:2002-06-01 00:00:00
abstract::To evaluate the frequency and type of gastroduodenal mucosal inflammatory changes in patients with symptomatic acid peptic disease and nonulcer dyspepsia, 100 patients with gastrointestinal symptoms indicative of acid peptic disease or dyspepsia and 10 control subjects were clinically evaluated and underwent radiograp...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308325
更新日期:1980-09-01 00:00:00
abstract::Although transient increases in intracellular Ca2+ ([Ca2+]i) underlie a number of important physiological processes, sustained elevations in [Ca2+]i mediate damage to a number of tissues and cell types including gastric mucosal cells. Increases in [Ca2+]i can activate phospholipid hydrolysis via increases in phospholi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026688819939
更新日期:1999-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) as an indication to liver transplant (LT) started as palliative treatment, then moved to potentially curative anti-cancer therapy and more recently entered the era of competition with non-cancer indications, consequent to the need of the society to target equal distribution of the limite...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-019-05538-1
更新日期:2019-04-01 00:00:00
abstract::The susceptibility to sepsis in obstructive jaundice may be related to bacterial translocation (BT) from the gastrointestinal tract. We evaluated BT to visceral organs and morphological changes of the intestinal mucosa in a rat model of obstructive jaundice. Animals were randomly divided into two groups: in group A th...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1014733226337
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression. METHODS:Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specime...
journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-008-0418-4
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02208653
更新日期:1995-09-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3438-2
更新日期:2015-07-01 00:00:00
abstract::The aim of this study was to compare the additive effect of rebamipide with that of teprenone in combination with dual therapy on H. pylori eradication. A total of 102 H. pylori-positive gastric ulcer patients were assigned at random to two groups; in addition to dual therapy (amoxicillin 500 mg thrice daily and lanso...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-09-01 00:00:00
abstract::The gastroprotective agent ecabet sodium (ecabet, 12-sulfodehydroabietic acid monosodium salt) increases the formation of prostaglandin (PG) E2 and I2 by gastric mucosa. In the present study, we examined the effect of ecabet on metabolism of arachidonic acid (AA) in rat gastric mucosal cells. Ecabet (0.1-10 mM) concen...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018885005109
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Proton pump inhibitors (PPIs) may reduce the risk of esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus. PPIs are prescribed for virtually all patients with Barrett's esophagus, irrespective of the presence of reflux symptoms, and represent a de facto chemopreventive agent in this populatio...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3186-3
更新日期:2014-06-01 00:00:00
abstract::The study investigated the effect of either nocturnal acid suppression by the H2 antagonist nizatidine 300 mg at night or prolonged acid suppression by the proton- pump inhibitor omeprazole 20 mg in the morning, during four weeks, on intragastric pH profile, occurrence of bacterial growth in gastric fluid and biopsies...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02093609
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Both colorectal neoplasms and atherosclerosis can be induced by common visceral fat accumulation. However, the association between these diseases at the advanced stage, colorectal cancer and cardiovascular/cerebrovascular diseases, has not been elucidated. AIMS:This study aimed to investigate the associatio...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4041-5
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Data regarding early atherosclerosis and inflammatory bowel disease are limited and conflicting results are present. AIMS:The purpose of this study was to evaluate serological and sonographical evidence of subclinical vascular involvement in patients with inflammatory bowel disease. METHODS:Thirty-nine pat...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2148-x
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Autofluorescence imaging (AFI), which is a "red flag" technique during Barrett's surveillance, is associated with significant false positive results. The aim of this study was to assess the inter-observer agreement (IOA) in identifying AFI-positive lesions and to assess the overall accuracy of AFI. METHODS:...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-012-2358-2
更新日期:2013-02-01 00:00:00
abstract::We compared changes in gastric mucosal blood flow (GMBF) and left gastric artery blood flow (LGABF) in response to pharmacological, physiological, and pathological stimuli. GMBF and LGABF were measured by the hydrogen gas clearance and perivascular ultrasonic transit time techniques, respectively, under baseline condi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018807009266
更新日期:1997-09-01 00:00:00
abstract::Epidemiological studies have demonstrated a variety of potential environmental factors that may alter susceptibility to chronic pancreatitis (CP) through oxidative/xenobiotic stress; however, a direct causal and mechanistic role has not been established. We aimed (1) to determine the prevalence of functional genetic p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2790-7
更新日期:2005-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) arises from a number of cirrhosis-related and non-cirrhosis-related exposures and is one of the leading causes of cancer-related deaths worldwide. Achieving a durable cure currently relies on either resection or transplantation, but since most patients will be diagnosed with inoperable d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3483-x
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND AND AIM:Second harmonic generation (SHG) is a novel imaging technology that could provide optical biopsy during endoscopy with advantages over current technology. SHG has the unique ability to evaluate the amount of extracellular matrix collagen protein and its alignment. METHODS:Hematoxylin- and eosin-stai...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3121-7
更新日期:2014-07-01 00:00:00
abstract::A novel peptide, submandibular gland peptide-T (SGP-T), which reduces allergen-induced hypotension, was examined for effects on intestinal anaphylaxis. Hooded-Lister rats were sensitized to egg albumin and prepared for the measurement of in vivo myoelectric activity of the jejunum. The disruption of migrating myoelect...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018847608184
更新日期:1997-11-01 00:00:00
abstract::The possible role of Saccharomyces boulardii, a nonpathogenic yeast with beneficial effects on the human intestine, in the maintenance treatment of Crohn's disease has been evaluated. Thirty-two patients with Crohn's disease in clinical remission (CDAI < 150) were randomly treated for six months with either mesalamine...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1023/a:1005588911207
更新日期:2000-07-01 00:00:00
abstract::Infection with Helicobacter pylori is associated with the development of gastric cancer. To study whether the infection with H. pylori strains expressing the vacuolating cytotoxin (VacA) and/or the cytotoxin-associated protein (CagA) is associated with an increased risk of developing gastric adenocarcinoma, sera of 90...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018849112533
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome contributing to nonalcoholic fatty liver disease (NAFLD) can lead to hepatic dysfunction, steatohepatitis, cirrhosis, and hepatocellular carcinoma. AIMS:In this study, we tested whether diet-induced fatty liver in a mouse model physiologically mimicked human NAFLD, and whether transcripti...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5398-4
更新日期:2019-05-01 00:00:00
abstract::Chemiluminescence (CL) analysis of monocytes and polymorphonuclear cells (PMNs) was performed on 13 patients with Crohn's disease (CD) and 10 healthy volunteers. The percentages of monocyte populations in mononuclear cells obtained from the patients with CD were greater than those from the healthy volunteers, but the ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01535990
更新日期:1988-08-01 00:00:00
abstract::Serum biochemical tests were observed for about three weeks following oral cholecystography with fractionated high doses (6 g) of iopanoic acid (Telepaque) or sodium ipodate (Biloptin) in 24 and 29 patients, respectively. Both agents produced similar effects. No significant changes were seen in renal or hepatic functi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308063
更新日期:1980-05-01 00:00:00
abstract::Technological developments have greatly promoted interest in the use of computer systems for recording findings and images at endoscopy and creating databases. The aim of this study was to develop a comprehensive WHO-approved code system for gastrointestinal endoscopic terminology. The International Classification of ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9272-4
更新日期:2007-04-01 00:00:00