Abstract:
:The preferred positions for meiotic double-strand breakage were mapped on Saccharomyces cerevisiae chromosomes I and VI, and on a number of yeast artificial chromosomes carrying human DNA inserts. Each chromosome had strong and weak double-strand break (DSB) sites. On average one DSB-prone region was detected by pulsed-field gel electrophoresis per 25 kb of DNA, but each chromosome had a unique distribution of DSB sites. There were no preferred meiotic DSB sites near the telomeres. DSB-prone regions were associated with all of the known "hot spots" for meiotic recombination on chromosomes I, III and VI.
journal_name
Chromosomajournal_title
Chromosomaauthors
Klein S,Zenvirth D,Dror V,Barton AB,Kaback DB,Simchen Gdoi
10.1007/BF02524645subject
Has Abstractpub_date
1996-12-01 00:00:00pages
276-84issue
5eissn
0009-5915issn
1432-0886journal_volume
105pub_type
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