Simvastatin releases Ca2+ from a thapsigargin-sensitive pool and inhibits InsP3-dependent Ca2+ mobilization in vascular smooth muscle cells.

abstract：:Forty patients (aged 28-66 years) with essential hypertension were randomized to 14 weeks of treatment with diltiazem or hydrochlorothiazide (HCTZ) in a double-blind, parallel study design. A significant reduction in supine body weight (-6.0 +/- 1.5 lb; p less than 0.001) and increase in pulse (+6 +/- 2 beats/min; p l...

journal_title：Journal of cardiovascular pharmacology

authors： Swartz SL

更新日期：1987-04-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:Among other mediators, platelet-derived serotonin (5-HT) may contribute to thromboembolic complications of atherosclerosis. We determined whether long-term oral treatment with the 5-HT2 antagonist naftidrofuryl (NAF, 50 mg/kg daily for 12 weeks) alters platelet function in cholesterol-fed (1%) rabbits. Hypercholestero...

journal_title：Journal of cardiovascular pharmacology

authors： Weber AA,Hohlfeld T,Strobach H,Schrör K

更新日期：1993-02-01 00:00:00

abstract：:The role of pressure-sensitive mechanoreceptors (PSMRs) in histamine-stimulated nitric oxide release from cultured human endothelial cells was investigated, using our new method (helium pack method). PSMRs were stimulated by various levels of pressure applied in addition to atmospheric pressure (40, 80, 120, and 160 m...

journal_title：Journal of cardiovascular pharmacology

authors： Hishikawa K,Nakaki T,Suzuki H,Saruta T,Kato R

更新日期：1992-01-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors have been extensively studied and established in the treatment of hypertension, heart failure, and ventricular dysfunction. They have various cardiac and vascular protective effects, but the relevant mechanisms of action in these areas remain to be fully understood. Possible ef...

journal_title：Journal of cardiovascular pharmacology

authors： Sharpe N

更新日期：1993-01-01 00:00:00

abstract：:Serotonin, applied to helical strips of larger vessels such as coronary arteries, acts as a potent vasoconstrictor in vitro. In contrast, in vivo serotonin causes a remarkable decrease in total peripheral resistance. To differentiate the influence of serotonin on resistances of large and small vessels, experiments wer...

journal_title：Journal of cardiovascular pharmacology

authors： Meschig R,Breuer J,Arnold G

更新日期：1985-01-01 00:00:00

abstract：:We compared the beta-adrenoceptor blocking actions of bupuranolol and propranolol using the response to isoprenaline of the strength of contraction of the canine blood-perfused ventricular muscle, of the rate and strength of contraction of the isolated guinea pig heart and of a guinea pig tracheal ring preparation. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Hashimoto K,Tsukada T,Matsuda H,Nakagawa Y,Imai S

更新日期：1979-03-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanisms involved in the angiotensin II-induced increase in the contractile response of the hypertensive wall after prolonged incubation in the organ-bath buffer. In 5-h incubated rings, the contractile response to angiotensin II in aortic rings with endothelium from ...

journal_title：Journal of cardiovascular pharmacology

authors： Zerrouk A,Auguet M,Chabrier PE

更新日期：1998-04-01 00:00:00

abstract：:Anesthesia inhibits arterial baroreflex functions such as baroreflex sensitivity (BRS). The main objective of the present study was to determine the time course of BRS recovery from anesthesia and to determine whether BRS recovery is synchronous with the recovery of consciousness and blood pressure (BP). Experiments w...

journal_title：Journal of cardiovascular pharmacology

authors： Yi-Ming W,Shu H,Miao CY,Shen FM,Jiang YY,Su DF

更新日期：2004-01-01 00:00:00

abstract：:In a multicenter, randomized, double-blind, placebo-controlled study, we evaluated the efficacy and tolerability of the combination of benazepril, 10 mg, and amlodipine, 2.5 or 5 mg once daily, compared with benazepril, 10 mg, monotherapy in patients with hypertension inadequately controlled with angiotensin-convertin...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Corea L,Cardoni O,Cosmi F,Porcellati C,Innocenti P,Provvidenza M,Timio M,Bentivoglio M,Bertocchi F,Zoppi A

更新日期：1997-10-01 00:00:00

abstract：:Salusin-alpha and salusin-beta are newly identified bioactive peptides with hemodynamic and mitogenic activities. Recent studies have shown that salusins improve calcium uptake and protein synthesis in neonatal rat cardiomyocytes, suggesting that salusins may be regulatory factors for myocardial growth and hypertrophy...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao-Hong Y,Li L,Yan-Xia P,Hong L,Wei-Fang R,Yan L,An-Jing R,Chao-Shu T,Wen-Jun Y

更新日期：2006-08-01 00:00:00

abstract：:The vascular effects of cardamonin and alpinetin from Alpinia henryi K. Schum. were examined in the rat isolated mesenteric arteries. 1H and 13C nuclear magnetic resonance spectra showed that cardamonin is present in trans-form, and single-crystal radiographic structure revealed that alpinetin is present in S configur...

journal_title：Journal of cardiovascular pharmacology

authors： Wang ZT,Lau CW,Chan FL,Yao X,Chen ZY,He ZD,Huang Y

更新日期：2001-05-01 00:00:00

abstract：:In this study the contribution of alternating architecture and Ca2+ handling of mitochondria to cytosolic Ca2+ homeostasis was elucidated under normoglycemic and hyperglycemic (HGC) conditions in the human endothelial cell line EA.hy926. Exposure of endothelial cells to hyperglycemic medium elevated basal cytosolic fr...

journal_title：Journal of cardiovascular pharmacology

authors： Paltauf-Doburzynska J,Malli R,Graier WF

更新日期：2004-10-01 00:00:00

abstract：:The effects of bPTH-(1-34), a synthetic preparation of bovine parathyroid hormone containing the first 34 amino acids, on electromechanical activity of isolated rabbit sinus node cells and guinea pig papillary muscles were examined by microelectrode techniques. In sinus node cells, bPTH-(1-34) (10(-7) M) decreased the...

journal_title：Journal of cardiovascular pharmacology

authors： Kondo N,Shibata S,Tenner TE Jr,Pang PK

更新日期：1988-05-01 00:00:00

abstract：:The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris. Hemodynamic indices were measured by impedance cardiography and echocardiography and bicyc...

journal_title：Journal of cardiovascular pharmacology

authors： Andreyev N,Bichkov I,Skutelis A,Andreyeva T

更新日期：1991-01-01 00:00:00

abstract：:The effects of local myocardial administration of lactic acid and low-dose edaravone were investigated to determine if this combination provides benefits similar to mechanical postconditioning. We randomly divided 108 rats into 6 groups: sham, reperfusion injury, postconditioning (Post), lactic acid (Lac), low-dose ed...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang G,Sun Y,Wang Y,Li X,Li T,Su S,Xu L,Shen H

更新日期：2013-10-01 00:00:00

abstract：:Endothelium-dependent relaxations can be evoked by a variety of stimuli, among them substance P (SP), which is found in sensory nerve fibers supplying the adventitia-media junction of most muscular arteries. This study determined the role of endothelium-derived nitric oxide as a mediator of endothelium-dependent relax...

journal_title：Journal of cardiovascular pharmacology

authors： Fiscus RR,Gross DR,Hao H,Wang X,Arden WA,Maley RH,Salley RK

更新日期：1992-01-01 00:00:00

abstract：:Nitric oxide (NO) is a potent inhibitor of platelet aggregation. However, the benefits of NO-based therapies can be confounded by concomitant hypotension. Monophosphoryl lipid A (MLA) is a nontoxic derivative of endotoxin that purportedly increases nitric oxide synthase (NOS) activity and, presumably, NO production, y...

journal_title：Journal of cardiovascular pharmacology

authors： Przyklenk K,Hata K,Whittaker P,Elliott GT

更新日期：2000-03-01 00:00:00

abstract：:The effects of 3 quinazoline alpha-adrenoreceptor antagonists, prazosin, trimazosin, and UK-33,274, on lying blood pressure (BP), BP response to 60 degrees tilt, pressor response to noradrenaline, phenylephrine, and exercise (isometric and dynamic) were measured in a double-blind study in 6 volunteers. There was no di...

journal_title：Journal of cardiovascular pharmacology

authors： Singleton W,Saxton CA,Hernandez J,Prichard BN

更新日期：1982-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha) is an inflammatory cytokine involved in atherogenesis. Adipose tissue is an important source of endogenous TNFalpha production. The aim of this study was to evaluate the effect of atorvastatin on TNFalpha serum concentration and mRNA expressions of subcutaneous adipose in hyperch...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao SP,Wu ZH,Wu J,Hong SC,Deng P

更新日期：2005-08-01 00:00:00

abstract：:In urban Australia, the risk of retiring with hypertension is greater than 40%, and the basic abnormality--a rise in blood pressure (BP) with age--is almost universal. A hypothesis linking this with salt, therefore, concerns everyone. The diet of early humans was unsalted, and the Na content of breast milk (6 mmol/kg)...

journal_title：Journal of cardiovascular pharmacology

authors： Beard TC

更新日期：1990-01-01 00:00:00

abstract：:The acute phase of myocardial infarction promotes an inflammatory response that stimulates inducible nitric oxide synthase (iNOS). We investigated the iNOS role on the rat tail vascular bed reactivity 3 days after myocardial infarction. Vasodilator and vasoconstrictor responses were determined in isolated caudal vascu...

journal_title：Journal of cardiovascular pharmacology

authors： Sartório CL,Pinto VD,Cutini GJ,Vassallo DV,Stefanon I

更新日期：2005-04-01 00:00:00

abstract：:Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) ...

journal_title：Journal of cardiovascular pharmacology

authors： Ivanov AV,Alexandrin VV,Paltsyn AA,Virus ED,Nikiforova KA,Bulgakova PO,Sviridkina NB,Svetlana Alexandrovna Apollonova,Kubatiev AA

更新日期：2018-10-01 00:00:00

abstract：:The present article reviews the experience with amiodarone therapy in life-threatening ventricular tachyarrhythmias. In 13 studies, 1,594 patients were treated with amiodarone in average doses of 300 mg/day. The mean annual death rate was 6.2%; the annual withdrawal rate averaged 8%. Risk factors for arrhythmia recurr...

journal_title：Journal of cardiovascular pharmacology

authors： Burckhardt D

更新日期：1992-01-01 00:00:00

abstract：:Long-term exposure of endothelial cells to molsidomine in vivo and in vitro improves the thromboresistance of endothelial cells, judging from the inhibition of platelet aggregation by endothelial cells in autologous plasma. In cultured endothelial cells, the present studies attempted (a) to show that platelets influen...

journal_title：Journal of cardiovascular pharmacology

authors： Berenger-Bahuet FP,Rolland PH

更新日期：1989-01-01 00:00:00

abstract：:This study investigated the role of perivascular adipose tissue (PVAT) in the beneficial effects of andrographolide on vascular reactivity in endotoxaemic rats. After being challenged by lipopolysaccharide (4 mg/kg intraperitoneally), the rats were treated with andrographolide (1 mg/kg intraperitoneally). The response...

journal_title：Journal of cardiovascular pharmacology

authors： Hai-Mei L,Song-Yin H,Run-Mei L,Xiao-Huang X,Le-Quan Z,Xiao-Ping L,Jin-Wen X

更新日期：2013-08-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is increasingly used in the clinical evaluation of hypertension. However, a number of limitations restrict its routine use. One of the limitations is a lack of definite conclusions about ambulatory blood pressure normality, because of the shortcomings of previous studies on ...

journal_title：Journal of cardiovascular pharmacology

authors： Sega G,Bravi C,Cesana G,Valagussa F,Mancia G,Zanchetti A

更新日期：1994-01-01 00:00:00

abstract：:In a prospective randomized study, we assessed the electrophysiologic effects and the efficacy of ajmaline versus propafenone in patients with accessory pathways (APs). During initiated atrioventricular (AV) reentrant tachycardia or atrial fibrillation (AF), ajmaline (1 mg/kg as bolus followed by infusion of 15 microg...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Borggrefe M,Martinez-Rubio A,Hief C,Haverkamp W,Hindricks G,Breithardt G

更新日期：1994-10-01 00:00:00

abstract：:The aim of this study was to determine whether tumor necrosis factor (TNF)-alpha would impair basal and stimulated endothelium-dependent vasomotion in human resistance vessel. Changes in baseline and acetylcholine (ACh)-induced forearm vascular resistance (FVR) were measured plethysmographically before and after a low...

journal_title：Journal of cardiovascular pharmacology

authors： Nakamura M,Yoshida H,Arakawa N,Saitoh S,Satoh M,Hiramori K

更新日期：2000-10-01 00:00:00

abstract：:We investigated the impact of respiratory syncytial virus (RSV) infection, an important asthma precipitant, on endothelin receptor function and release in sheep bronchial explants. RSV infection was confirmed using polymerase chain reaction and immunohistochemistry. Since sheep airway smooth muscle contains only endot...

journal_title：Journal of cardiovascular pharmacology

authors： Fernandes LB,D'Aprile AC,Self GJ,Harnett GB,Goldie RG

更新日期：2004-11-01 00:00:00