Asynchronism of the recovery of baroreflex sensitivity, blood pressure, and consciousness from anesthesia in rats.

abstract：:Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems are evolutionarily conserved throughout species. As a result, the immune response and metabolic regulation are highly integrated and the proper fu...

journal_title：Journal of cardiovascular pharmacology

authors： Sokolova M,Ranheim T,Louwe MC,Halvorsen B,Yndestad A,Aukrust P

更新日期：2019-10-01 00:00:00

abstract：UNLABELLED:The role of mitochondrial transporters in the cardioprotection of rat hearts exposed to high [K+]-low [Ca2+]-cardioplegia (CPG) and ischemia and reperfusion (I/R) was studied through the mechano-energetic consequences of target drugs. The total heat rate (Ht) and the left intraventricular pressure (LVP) were...

journal_title：Journal of cardiovascular pharmacology

authors： Ragone MI,Consolini AE

更新日期：2009-09-01 00:00:00

abstract：:At present, endothelin (ET) receptor classification remains controversial. We investigated the presence of atypical ETA receptors in human saphenous veins (SV). Human SV was obtained from 24 patients undergoing coronary artery bypass grafting. Vessels were set up in organ baths, stretched to a tension of 6 g, and left...

journal_title：Journal of cardiovascular pharmacology

authors： Pate MA,Chester AH,Brown TJ,Roach AG,Yacoub MH

更新日期：1998-01-01 00:00:00

abstract：:Intravenous diltiazem (10-300 micrograms/kg), verapamil (10-300 micrograms/kg), nifedipine (1-100 micrograms/kg) and nicardipine (1-100 micrograms/kg) inhibited the tachycardia caused by cardiac sympathetic nerve stimulation (SNS, 0.5-4 Hz) in decentralized hearts of anesthetized dogs. The dose range of each drug requ...

journal_title：Journal of cardiovascular pharmacology

authors： Satoh E,Mukaiyama O,Kimura T,Satoh S

更新日期：1990-10-01 00:00:00

abstract：:Studies were undertaken to establish the regional hemodynamic profile and dose-response relation of the adenosine triphosphate (ATP)-dependent potassium channel activator lemakalim in anesthetized rats. In addition, the ability of the sulphonylurea potassium channel blocker glybenclamide to reverse the hemodynamic eff...

journal_title：Journal of cardiovascular pharmacology

authors： Smits GJ,Perrone MH,Cox BF

更新日期：1997-01-01 00:00:00

abstract：:Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney. A similar distribution of ETA receptors was found in ETB-deficient mice (25 +/- 2 days old) but the density was reduced in...

journal_title：Journal of cardiovascular pharmacology

authors： Davenport AP,Kuc RE

更新日期：2004-11-01 00:00:00

abstract：:Sixty patients with mild to moderate essential hypertension, uncontrolled with diuretics alone, were evaluated in a double-blind randomized study that compared the effect of indoramin plus hydrochlorothiazide with that of pindolol plus hydrochlorothiazide. Following a 2-week period during which the patients were treat...

journal_title：Journal of cardiovascular pharmacology

authors： Luomanmäki K,Hartikainen M

更新日期：1986-01-01 00:00:00

abstract：:To investigate the electrophysiological effects of propranolol in vivo over a wide range of plasma concentrations and to distinguish effects due to beta-blockade from those due to a direct membrane action, His bundle electrograms were recorded, and ventricular effective refractory periods (VERP) and monophasic action ...

journal_title：Journal of cardiovascular pharmacology

authors： Brorson L,Reele S,Dupont W,Woosley R,Shand D,Smith R

更新日期：1981-07-01 00:00:00

abstract：:The antiarrhythmic agent propafenone and its primary electropharmacologically active metabolite, 5-hydroxypropafenone, are known inhibitors of cardiac myocyte repolarizing currents. We recently documented potent propafenone inhibition of the transient outward potassium current (Ito) in human atrial myocytes from patie...

journal_title：Journal of cardiovascular pharmacology

authors： Cahill SA,Kirshenbaum LA,Gross GJ

更新日期：2001-09-01 00:00:00

abstract：:Since the end of 1976 ten orally active converting enzyme inhibitors [SQ 14,225 (captopril), MK 421 (enalapril), MK 422, MK 521 (lysinopril), RHC 3659, CGS 13945, CGS 13928C, CGS 14824A, Hoe 498, S 9490-3, and Ro 31-2848] have been evaluated by our group in normal volunteers. Their ability to blunt the pressor respons...

journal_title：Journal of cardiovascular pharmacology

authors： Brunner HR,Nussberger J,Waeber B

更新日期：1985-01-01 00:00:00

abstract：:We used isolated superior mesenteric arteries (SMAs) from hemorrhagic-shock rats and hypoxia-treated vascular smooth muscle cells (VSMCs; mimicking the shock state) to observe the effects of platelet-derived growth factor (PDGF; Rac1 stimulator) and NSC23766 (Rac1 antagonist) on vascular reactivity and the relationshi...

journal_title：Journal of cardiovascular pharmacology

authors： Li T,Yang G,Xu J,Zhu Y,Liu L

更新日期：2011-06-01 00:00:00

abstract：:Heart failure is associated with attenuation of parasympathetic nervous function and enhanced renin-angiotensin activity. We tested whether there was a dysfunction in the efferent cholinergic neurotransmission in the heart of rats with chronic myocardial infarction (MI) and the potential role of angiotensin II (Ang II...

journal_title：Journal of cardiovascular pharmacology

authors： Du XJ,Cox HS,Dart AM,Esler MD

更新日期：1998-06-01 00:00:00

abstract：:Doxazosin has been shown to lower serum cholesterol levels in the cholesterol-fed (0.75% in a synthetic diet that contains sucrose and cholic acid) C57BR/cdJ mouse. These studies show that the drug's main effect is to lower low-density lipoprotein (LDL) cholesterol and leave high-density lipoprotein (HDL) cholesterol ...

journal_title：Journal of cardiovascular pharmacology

authors： Krupp MN,Hoover KW,Valentine JJ

更新日期：1989-01-01 00:00:00

abstract：:In this study we compared the antithrombotic and anticoagulant properties of sodium and calcium derivatives of pentosan polysulfate (Na-PPS, Ca-PPS), unfractionated heparin (UFH), and low-molecular-weight heparin (Fraxiparin). The antithrombotic effects of these agents have been investigated in an experimental thrombo...

journal_title：Journal of cardiovascular pharmacology

authors： Giedrojć J,Klimiuk M,Radziwon P,Kłoczko J,Bielawiec M,Breddin HK

更新日期：1999-09-01 00:00:00

abstract：:We examined four commercially available human cell lines for endothelin-converting-enzyme-(ECE) like activity and compared the results with primary porcine aortic endothelial cell enzymes. The cells that were investigated were 293 (transformed primary human embryonal kidney), Hep G2 (human hepatocellular carcinoma), H...

journal_title：Journal of cardiovascular pharmacology

authors： Knap AK,Wigg AM

更新日期：1993-01-01 00:00:00

abstract：:We previously reported that i.v. DAMGO (Tyr-D-Ala-Gly-NMePhe-Gly-ol), a selective mu-opioid agonist, causes an increase in blood pressure with no change in heart rate in unanesthetized sheep and subsequently demonstrated that DAMGO attenuates baroreflex-mediated bradycardia. To determine the site and mechanism by whic...

journal_title：Journal of cardiovascular pharmacology

authors： Omoniyi AT,Kett A,Wu D,Soong Y,Clapp JF 3rd,Szeto HH

更新日期：2000-02-01 00:00:00

abstract：:The autonomic nervous system exerts broad control over the involuntary functions of the human body through complex equilibrium between sympathetic and parasympathetic tone. Imbalance in this equilibrium is associated with a multitude of cardiovascular outcomes, including mortality. The cardiovascular static state of t...

journal_title：Journal of cardiovascular pharmacology

authors： Sigurdsson MI,Waldron NH,Bortsov AV,Smith SB,Maixner W

更新日期：2018-03-01 00:00:00

abstract：:Arterial vascular resistance is established by myogenic mechanisms and is modulated both by local factors such as vasodilator metabolites and by remote controls of neurogenic and hormonal origin. This paper reports on the effects of felodipine and hydralazine on the myogenic tone and the neurogenic control of the vasc...

journal_title：Journal of cardiovascular pharmacology

authors： Nordlander M,Thalén P

更新日期：1987-01-01 00:00:00

abstract：:The vasoconstrictor effects of endothelin-1 (ET-1) and norepinephrine (NE) were compared in the exteriorized rat mesentery in situ. ET-1 was 1,000 times more potent than NE in constricting both arterioles and venules. Vasoconstrictions induced by ET-1 lasted much longer than those caused by the catecholamine. At nonre...

journal_title：Journal of cardiovascular pharmacology

authors： Fortes ZB,de Nucci G,Garcia-Leme J

更新日期：1989-01-01 00:00:00

abstract：:We conducted an intracardiac study of the electrophysiologic effects and kinetics of intravenous nicardipine (N) in 16 patients with or without impaired cardiac conduction, using a randomized, double-blind, crossover design versus placebo (P). N or P were infused intravenously over 5 min: the dose of N was 9.46 +/- 3....

journal_title：Journal of cardiovascular pharmacology

authors： David D,Guize L,Leheuzey JY,Lavergne T,Loria Y,Ourbak P

更新日期：1990-01-01 00:00:00

abstract：:The long-term efficacy of percutaneous transluminal coronary angioplasty (PTCA) is severely limited by the high incidence of vascular restenosis. Endothelin-1 (ET-1) has been implicated in the pathogenesis of this response, since circulating levels of this potent smooth-muscle mitogen are elevated after PTCA. Therefor...

journal_title：Journal of cardiovascular pharmacology

authors： Douglas SA,Ohlstein EH

更新日期：1993-01-01 00:00:00

abstract：:Diazepam (DZP) is commonly used in treatment of patients with acute ischemic syndromes to allay anxiety, but benzodiazepines reduce myocardial contractility and increase myocardial blood flow. To investigate the antiischemic effect of DZP, we studied 13 patients with a positive exercise test and angiographically docum...

journal_title：Journal of cardiovascular pharmacology

authors： Rossetti E,Fragasso G,Xuereb RG,Xuereb M,Margonato A,Chierchia SL

更新日期：1994-07-01 00:00:00

abstract：:Possible enhancement by free fatty acids (FFA) of the arrhythmogenic actions of ouabain was studied in rabbits. The mean dose of ouabain required for inducing ventricular tachycardia or fibrillation in conscious animals was significantly lowered by intravenous injection of 5 ml of a 20% fat emulsion (Lipofundin), whic...

journal_title：Journal of cardiovascular pharmacology

authors： Sánchez-Serrano D,Alvarez JL,García-Barreto D

更新日期：1980-01-01 00:00:00

abstract：:We examined the effects of the vasoconstrictor peptide endothelin-1 in the isolated heart and defined interactions of endothelin-1 with other hormone systems. Isolated isovolumic rat hearts were perfused with Krebs-Henseleit buffer at constant pressure. First, the effect of a single bolus of endothelin-1 (4-400 pmol) ...

journal_title：Journal of cardiovascular pharmacology

authors： Neubauer S,Ertl G,Haas U,Pulzer F,Kochsiek K

更新日期：1990-07-01 00:00:00

abstract：:We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2 diabetes with increased body...

journal_title：Journal of cardiovascular pharmacology

authors： Huang JP,Hsu SC,Li DE,Chen KH,Kuo CY,Hung LM

更新日期：2018-11-01 00:00:00

abstract：:Halothane opposes cardiotoxicity of neutral-sugar digitalis compounds in intact animals, presumably by depressing a sympathetic component of arrhythmogenesis. However, halothane also produces a dose-related reduction in arrhythmogenicity of ouabain in isolated canine Purkinje fibers, suggesting that the anesthetic may...

journal_title：Journal of cardiovascular pharmacology

authors： Heerdt PM,Gallagher JD,Caldwell RW

更新日期：1994-06-01 00:00:00

abstract：:Gangliosides, sialic acid-containing glycosphigolipids, are localized mostly to the outer leaflet of the lipid bilayer in the plasma membrane, particularly in brain. Gangliosides reduce edema formation, restore glucose metabolism, and increase cerebral blood flow after focal ischemia in the rat brain. We wished to det...

journal_title：Journal of cardiovascular pharmacology

authors： Maulik N,Das DK,Gogineni M,Cordis GA,Avrova N,Denisova N

更新日期：1993-07-01 00:00:00

abstract：:The bronchopulmonary and pressor effects of endothelin-1 (ET-1), a newly described vasoconstrictor peptide produced by endothelial cells, were investigated in the guinea pig. Intravenous injection of ET-1 (1 nmol/kg) induced an increase in pulmonary inflation pressure (PIP) as well as an important and sustained increa...

journal_title：Journal of cardiovascular pharmacology

authors： Braquet P,Touvay C,Lagente V,Vilain B,Pons F,Hosford D,Chabrier PE,Mencia-Huerta JM

更新日期：1989-01-01 00:00:00

abstract：:Selection of the appropriate dose of a new drug for initiation of treatment and then for maintenance is a complicated task. It requires the careful assessment and weighing of benefit vs. risk. A series of studies was carried out with lacidipine to determine the optimal initial dose in a general hypertensive population...

journal_title：Journal of cardiovascular pharmacology

authors： Perelman M

更新日期：1991-01-01 00:00:00

abstract：:In a previous experiment, (-)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine-induced locomotor activity and stereotyped behaviors and inhibited caffeine-induced neuronal stimulant activity. This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant effects in animals...

journal_title：Journal of cardiovascular pharmacology

authors： Han JY,Kim CS,Lim KH,Kim JH,Kim S,Yun YP,Hong JT,Oh KW

更新日期：2011-10-01 00:00:00