Effect of endothelin-1 on arterioles and venules in vivo.

Abstract:

:The vasoconstrictor effects of endothelin-1 (ET-1) and norepinephrine (NE) were compared in the exteriorized rat mesentery in situ. ET-1 was 1,000 times more potent than NE in constricting both arterioles and venules. Vasoconstrictions induced by ET-1 lasted much longer than those caused by the catecholamine. At nonrelaxant doses, acetylcholine and sodium nitroprusside antagonized the constrictive response of microvessels to ET-1 and NE. However, larger doses of acetylcholine were necessary to inhibit the response to ET-1 than that to NE.

journal_name

J Cardiovasc Pharmacol

authors

Fortes ZB,de Nucci G,Garcia-Leme J

doi

10.1097/00005344-198900135-00056

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

S200-1

eissn

0160-2446

issn

1533-4023

journal_volume

13 Suppl 5

pub_type

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