Effects of endothelin-1 in isolated perfused rat heart.

abstract：:We conducted a double-blind, placebo-controlled parallel study of the effect of the aldosterone antagonist spironolactone, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, and transmembrane cation transport systems and plasma or urinary variables. Af...

journal_title：Journal of cardiovascular pharmacology

authors： Lijnen P,Petrov V

更新日期：1996-04-01 00:00:00

abstract：:Vasopressin is the primary physiological factor regulating renal water reabsorption in mammals. Inhibitors of vasopressin-stimulated water reabsorption have previously been used as water diuretic agents in both experimental animals and man. The present studies describe and characterize the pharmacological effects of t...

journal_title：Journal of cardiovascular pharmacology

authors： Kinter LB,Dytko G,Ashton D,McDonald J,Huffman W,Stassen F

更新日期：1986-01-01 00:00:00

abstract：:Isolated perfused rat kidney was used to examine the possible mechanisms involved in the hypotensive/vasodilator actions of cryptolepine. In kidneys preconstricted by phenylephrine (PE 5-7.5 x 10(-7) M), cryptolepine at bolus doses of 2.5, 5, and 10 micrograms elicited dose-dependent reductions in perfusion pressure b...

journal_title：Journal of cardiovascular pharmacology

authors： Oyekan AO

更新日期：1994-04-01 00:00:00

abstract：:To study the effects of chronic in vivo inhibition of NO synthase on endothelium-dependent hyperpolarization, cell-membrane potential (in individual vascular smooth-muscle cells) and changes in tension (in isolated rings) were recorded from isolated canine coronary arteries and guinea-pig carotid arteries and aortas. ...

journal_title：Journal of cardiovascular pharmacology

authors： Corriu C,Félétou M,Puybasset L,Bea ML,Berdeaux A,Vanhoutte PM

更新日期：1998-12-01 00:00:00

abstract：:The complementary antihypertensive effects of the beta-blocker/calcium antagonist combination has to be weighed against their additive and potentially detrimental negative inotropic, chronotropic, and dromotropic effects inherent in both classes of drugs. We reviewed the main adversity, particularly electrophysiologic...

journal_title：Journal of cardiovascular pharmacology

authors： Brouwer RM,Follath F,Bühler FR

更新日期：1985-01-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:Hypertension, atherosclerosis, arteriosclerosis, and cardiomyopathy account for 80% of all diabetic deaths. A paucity of data exists concerning reactivity of the diabetic vasculature to vasopressor substances. The purpose of this investigation was to determine the influence of short-term (4-5 weeks) diabetes on the re...

journal_title：Journal of cardiovascular pharmacology

authors： Jackson CV,Carrier GO

更新日期：1983-03-01 00:00:00

abstract：:Cilnidipine has a blocking action against N-type calcium channels as well as L-type calcium channels. We studied the effect of morning and bedtime dosing on circadian variation of blood pressure (BP), heart rate (HR), and activity of the autonomic nervous system, using an open randomized crossover study in 13 essentia...

journal_title：Journal of cardiovascular pharmacology

authors： Kitahara Y,Saito F,Akao M,Fujita H,Takahashi A,Taguchi H,Hino T,Otsuka Y,Kushiro T,Kanmatsuse K

更新日期：2004-01-01 00:00:00

abstract：:The understanding of blood pressure (BP) and heart rate (HR) variation, circadian changes, and the responses to nonclinical situations has been improved by automated ambulatory recordings. The antihypertensive efficacy of a once-daily regimen (10/20 mg) of nitrendipine was evaluated in detail using the lightest availa...

journal_title：Journal of cardiovascular pharmacology

authors： Meyer-Sabellek W,Schulte KL,Streitberg B,Gotzen R,Distler A

更新日期：1988-01-01 00:00:00

abstract：:To assess dose-related effects of enalapril, we treated eight hospitalized hypertensive patients receiving constant sodium intake with incremental doses of this new angiotensin converting-enzyme blocking drug. After a few days of placebo treatment, enalapril was given in single daily doses, starting with 1.25 mg and i...

journal_title：Journal of cardiovascular pharmacology

authors： de Leeuw PW,Birkenhäger WH

更新日期：1986-01-01 00:00:00

abstract：:Guinea pig papillary muscles were preincubated in the presence of 5 x 10(-9) mol/L unlabeled noradrenaline or adrenaline then incubated with (3H)-noradrenaline and superfused. Electrical field stimulation with 180 pulses delivered at 1 or 3 Hz was used to induce overflow of radioactivity. Comparison of the effects of ...

journal_title：Journal of cardiovascular pharmacology

authors： Valenta B,Singer EA

更新日期：1991-02-01 00:00:00

abstract：:The acute effects of daunomycin on the mechanical and energetic outputs of rabbit papillary muscles have been examined at 27 degrees C using a myothermic technique. Contrary to expectations, daunomycin, in concentrations ranging from 10 to 160 micrograms/ml, acted as a positive inotropic agent in terms of peak stress ...

journal_title：Journal of cardiovascular pharmacology

authors： Gibbs CL

更新日期：1985-05-01 00:00:00

abstract：:The effects of various doses of creatine phosphate have been examined in a rat model of acute myocardial ischaemia. When given directly into the lumen of the left ventricle in pentobarbitone-anaesthetised male rats, creatine phosphate (50 and 100 mg/kg) markedly reduced the incidence of ventricular ectopic beats, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Fagbemi O,Kane KA,Parratt JR

更新日期：1982-01-01 00:00:00

abstract：:We investigated the interaction between nitroxy groups and angiotensin-converting enzyme (ACE) inhibitors to assess the role of sulfhydryl groups and adenosine triphosphate (ATP)-sensitive potassium channels in vasodilation of human coronary resistance vessels in vitro. Coronary resistance vessels were resected from t...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Ohyanagi M,Kobayashi S,Iwasaki T,Miyamoto T

更新日期：2000-10-01 00:00:00

abstract：:The pressor responses to selective alpha 1-adrenoceptor agonists (cirazoline and methoxamine) and to alpha 2-adrenoceptor agonists (UK-14,304 and B-HT 933) were investigated in pithed, streptozotocin-induced diabetic rats and age-matched control animals. Three months after induction of diabetes, the basal values of di...

journal_title：Journal of cardiovascular pharmacology

authors： Heijnis JB,Mathy MJ,Pfaffendorf M,van Zwieten PA

更新日期：1992-10-01 00:00:00

abstract：:The antiarrhythmic effects of R56865 were characterized both in vivo and in vitro. Four groups (n = 12 per group) of anesthetized rats, subjected to 5- or 30-min coronary artery ligation and reperfusion, were studied: saline, dimethyl sulfoxide (DMSO) carrier, and R56865 (0.5 or 2 mg/kg) were administered as an intrav...

journal_title：Journal of cardiovascular pharmacology

authors： Garner JA,Hearse DJ,Bernier M

更新日期：1990-09-01 00:00:00

abstract：:Inhibition of angiotensin-converting enzyme (ACEI) after myocardial infarction reduces remodeling of the surviving myocardium. The cellular signaling mechanisms contributing to remodeling are not fully elucidated. Goal of the current study was to test whether protein kinase C (PKC) is regulated in the surviving myocar...

journal_title：Journal of cardiovascular pharmacology

authors： Simonis G,Braun MU,Kirrstetter M,Schön SP,Strasser RH

更新日期：2003-05-01 00:00:00

abstract：:Oxidative stress might exert deleterious cardiovascular effects. The aim of the present study was to compare the antioxidative effects of carvedilol and atenolol. Levels of oxidized low-density lipoprotein cholesterol (ox-LDL), vitamin E, and thiobarbituric acid reactive substances (TBARS) were measured. In a prospect...

journal_title：Journal of cardiovascular pharmacology

authors： Jonsson G,Abdelnoor M,Seljeflot I,Arnesen H,Hostmark AT,Kjeldsen SE,Os I,Westheim AS

更新日期：2007-01-01 00:00:00

abstract：:The equilibrating process of catecholamines (CAs) between plasma and red blood cells (RBC) was studied by measuring their erythrocyte/plasma concentration gradient (E/P ratio); ratio of E/P > 1 for a given amine was considered the consequence of its accumulation in or on RBC. We studied in vitro human blood obtained f...

journal_title：Journal of cardiovascular pharmacology

authors： Azoui R,Vignon D,Safar M,Cuche JL

更新日期：1994-04-01 00:00:00

abstract：:The safety of concomitant use of angiotensin-converting enzyme (ACE) inhibitors and potassium-sparing diuretics (PSD) in severe heart failure remains a controversial issue. The database of the recently reported double-blind international trial, "Xamoterol in Severe Heart Failure," was investigated to elucidate this qu...

journal_title：Journal of cardiovascular pharmacology

authors： Bergler-Klein J,Sochor H,Pouleur H,Pacher R,Porenta G,Glogar D

更新日期：1994-08-01 00:00:00

abstract：:beta-Adrenoceptor antagonists such as propranolol and atenolol ameliorate the symptoms of human hyperthyroidism. We wished to define whether the cardiac changes of hyperthyroidism are attenuated by treatment with the beta-adrenoceptor antagonist atenolol. Rats were treated with triiodothyronine (T3) [1 mg/kg/day subcu...

journal_title：Journal of cardiovascular pharmacology

authors： Amos G,Kerr D,Sernia C,Brown L

更新日期：1994-08-01 00:00:00

abstract：:Nitrates are beneficial in post-myocardial infarction patients with stable, unstable, and Prinzmetal's variant angina and as adjunctive therapy in congestive heart failure. They are available in multiple formulations that differ in chemical structure, pharmacokinetics, onset and duration of activity, and peak effect; ...

journal_title：Journal of cardiovascular pharmacology

authors： Scardi S

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The goal of this study was to determine whether an Angiotensin II receptor antagonist, candesartan, prevents myocardial fibrosis more effectively than enalapril in animals with a non-ACE pathway during the progression of congestive heart failure (CHF). METHODS AND RESULTS:Dogs were randomly assigned to one ...

journal_title：Journal of cardiovascular pharmacology

authors： Onishi K,Dohi K,Koji T,Funabiki K,Kitamura T,Imanaka-Yoshida K,Ito M,Nobori T,Nakano T

更新日期：2004-06-01 00:00:00

abstract：:This investigation demonstrates an increase in endothelin (ET)-mediated vascular tone in peri-ischemic areas after experimental focal cerebral ischemia (middle cerebral artery occlusion) in the cat. Adventitial application of the butenolide antagonist PD155080 (30 microM), after MCA occlusions resulted in marked incre...

journal_title：Journal of cardiovascular pharmacology

authors： Patel TR,Galbraith SL,McAuley MA,Doherty AM,Graham DI,McCulloch J

更新日期：1995-01-01 00:00:00

abstract：:The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Erdmann E

更新日期：1988-04-01 00:00:00

abstract：:The potential therapeutic value of a new prostacyclin analogue, (4z, 16s)-4,5,18,18,19,19-hexadehydro-16,20-dimethyl-delta 6(9a)- 9-(O)-methano-PGI1 (KP-10614), was studied in acute myocardial infarction in rats. Myocardial infarction was induced by ligation of the left coronary artery and ischemic injury was followed...

journal_title：Journal of cardiovascular pharmacology

authors： Kanayama T,Kimura Y,Tamao Y,Mizogami S

更新日期：1992-10-01 00:00:00

abstract：:Neonatal exposure to a selective serotonin reuptake inhibitor (SSRI) leads to decreased left ventricular volumes and sympathetic activation in adult mice. We hypothesized this neonatal SSRI exposure-induced small left heart syndrome would increase post-myocardial infarction (MI) morbidity and mortality. C57BL/6 mice r...

journal_title：Journal of cardiovascular pharmacology

authors： Haskell SE,Peotta VA,Reinking BE,Hermann GM,Roghair RD

更新日期：2013-11-01 00:00:00

abstract：:In fetal human left ventricular endocardial endothelial cells (EECLs), both plasma membrane (PM) ET(A)R and ET(B)R were reported to mediate ET-1-induced increase of intracellular calcium [Ca](i); however, this effect was mediated by ET(A)R in right EECs (EECRs). In this study, we verified whether, as for the PM, nucle...

journal_title：Journal of cardiovascular pharmacology

authors： Jules F,Avedanian L,Al-Khoury J,Keita R,Normand A,Bkaily G,Jacques D

更新日期：2015-07-01 00:00:00

abstract：:Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of ca...

journal_title：Journal of cardiovascular pharmacology

authors： de Leiris J,de Lorgeril M,Boucher F

更新日期：2009-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission. We investigated the manner by which ET-1 exerts this action. ET-1 administered intracerebroventricularly produced a dose-dependent antinociceptive effect in a thermal pain test that utilized a spin...

journal_title：Journal of cardiovascular pharmacology

authors： Hasue F,Kuwaki T,Yamada H,Fukuda Y,Shimoyama M

更新日期：2004-11-01 00:00:00