Acute energetic effects of daunomycin on rabbit heart muscle.

abstract：:This study assessed the possible local nociceptive and hyperalgesic properties of endothelin-1 (ET-1) in the rat knee-joint incapacitation test, in which animals are placed for 1 min/h on a revolving (3 rpm) metal cylinder and nociception is measured as the time the hindpaw of the injected limb was off the cylinder (i...

journal_title：Journal of cardiovascular pharmacology

authors： De-Melo JD,Tonussi CR,D'Orléans-Juste P,Rae GA

更新日期：1998-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) has been proven to activate two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC) in rabbit internal carotid artery vascular smooth muscle cells (ICA VSMCs). Ca2+ influx through these channels plays an essential role for ET-...

journal_title：Journal of cardiovascular pharmacology

authors： Kawanabe Y,Hashimoto N,Masaki T

更新日期：2002-08-01 00:00:00

abstract：:The beta-blocking activity of flestolol was established during increasing isoprenaline infusions and during graded physical exercise in conscious, chronically instrumented dogs. After a control cycle, flestolol was infused at three doses (1, 2.67, and 10 micrograms/kg/min). Flestolol has an extremely short half-life, ...

journal_title：Journal of cardiovascular pharmacology

authors： Grohs JG,Fischer G,Raberger G

更新日期：1990-02-01 00:00:00

abstract：:In this study, we used the spontaneously beating, isolated rat right atrium as an in vitro model to study arrhythmogenic effects of electrical stimulation. A tetrapolar platinum electrode was used for stimulation and recording of atrial electrical activity at 36.5 degrees C (spontaneous rate, 4.9+/-0.3 Hz). A flutter-...

journal_title：Journal of cardiovascular pharmacology

authors： Godoy CM,Bassani RA,Bassani JW

更新日期：1999-10-01 00:00:00

abstract：:Kinins locally synthesized in the cardiovascular tissue are believed to contribute to the regulation of cardiovascular homeostasis by stimulating the endothelial cells to release nitric oxide, prostacyclin, or a hyperpolarizing factor via autocrine-paracrine mechanisms. This study was designed to investigate the actio...

journal_title：Journal of cardiovascular pharmacology

authors： Kanna T,Akata T,Izumi K,Nakashima M,Yonemitsu Y,Hashizume M,Takahashi S

更新日期：2002-11-01 00:00:00

abstract：:To elucidate the pathophysiologic significance of endothelin-1 (ET-1) in adrenal and the mechanism for reduced responsiveness to exogenous ET-1 in aldosterone-producing adenoma (APA), we have investigated ET-1 receptors by radioligand binding assay (RBA) in human normal adrenal (NA), APA, idiopathic hyperaldosteronism...

journal_title：Journal of cardiovascular pharmacology

authors： Zeng Z,Tang X,Yang D,Li H,Zhang R,Zeng Q,Li M,Chen J,Lu Z,Demura H,Naruse M,Shi Y

更新日期：1998-01-01 00:00:00

abstract：:In this study, we compared the effect of the essential oil of Citrus bergamia Risso [bergamot, bergamot essential oil (BEO)] on the intracellular Ca levels in vascular endothelial (EA) and mouse vascular smooth muscle (MOVAS) cells, using the fura-2 fluorescence technique. BEO caused an initial transient increase in i...

journal_title：Journal of cardiovascular pharmacology

authors： You JH,Kang P,Min SS,Seol GH

更新日期：2013-04-01 00:00:00

abstract：:Trimetazidine has no hemodynamic/antithrombotic actions. Hence, its anti-ischemic properties have been mostly attributed to its metabolic effects. However, this issue is not completely elucidated. We investigated whether inhibition of neutrophil activation may also contribute to its cardioprotective action. We first s...

journal_title：Journal of cardiovascular pharmacology

authors： Tritto I,Wang P,Kuppusamy P,Giraldez R,Zweier JL,Ambrosio G

更新日期：2005-07-01 00:00:00

abstract：:We have previously demonstrated that cocaine induces apoptosis in primary cultures of fetal rat cardiomyocytes. The current study was designed to determine whether cocaine administered to the mother during pregnancy induced apoptosis in fetal rat heart. Pregnant rats were treated with cocaine subcutaneously (30 and 60...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao Y,Xiao D,He J,Zhang L

更新日期：2001-06-01 00:00:00

abstract：:The effects of a newly synthesized antiarrhythmic agent, TYB-3823 on the transmembrane action potential were examined in isolated papillary muscles of guinea pig. TYB-3823 (3 x 10(-6)-3 x 10(-5)M) caused a dose-dependent decrease in the maximum upstroke velocity (Vmax) and a shortening of action potential duration (AP...

journal_title：Journal of cardiovascular pharmacology

authors： Kodama I,Morimoto M,Toyama J,Shibata S

更新日期：1989-04-01 00:00:00

abstract：:[125I]Endothelin-1 (ET-1) was administered intravenously into rats, and binding sites in various tissues were examined by electron-microscopic radioautography. Labeling was observed predominantly on the glomerular fenestrated endothelial cells of kidney, alveolar capillary endothelial cells of lung, fat-storing cells ...

journal_title：Journal of cardiovascular pharmacology

authors： Furuya S,Naruse S,Nakayama T,Furuya K,Nokihara K

更新日期：1991-01-01 00:00:00

abstract：:As a receptor for transforming growth factor-β, nodal and activin, activin receptor-like kinase 7 (ALK7) previously acts as a suppressor of tumorigenesis and metastasis, which has emerged to play a key role in cardiovascular diseases. However, the potential effect and molecular mechanism of ALK7 on vascular smooth mus...

journal_title：Journal of cardiovascular pharmacology

authors： Gong FH,Cheng WL,Zhang Q,Chen XL,Cao JL,Yang T,Song WH,Zhao F

更新日期：2020-08-01 00:00:00

abstract：:To assess dose-related effects of enalapril, we treated eight hospitalized hypertensive patients receiving constant sodium intake with incremental doses of this new angiotensin converting-enzyme blocking drug. After a few days of placebo treatment, enalapril was given in single daily doses, starting with 1.25 mg and i...

journal_title：Journal of cardiovascular pharmacology

authors： de Leeuw PW,Birkenhäger WH

更新日期：1986-01-01 00:00:00

abstract：:The aim of the present work was to examine the effects of 4'-N-benzoyl staurosporine (CGP 41251), a protein kinase C inhibitor with broad antiproliferative activity in many cell lines, on the rat isolated heart contractility under normoxic and hypoxic conditions. Additionally, we examined the effects of CGP 41251, WB-...

journal_title：Journal of cardiovascular pharmacology

authors： Kocic I,Dworakowska D,Dworakowski R,Petrusewicz J

更新日期：2001-06-01 00:00:00

abstract：:The phosphodiesterase inhibitor UK 61260 exhibits positive inotropic activity in animal studies and is under clinical investigation for treatment of congestive heart failure (CHF). We examined the lusitropic and inotropic responses to UK 61260 in electrically driven (1 Hz, 37 degrees C) human auricular trabeculae (AUT...

journal_title：Journal of cardiovascular pharmacology

authors： Schwinger RH,Böhm M,La Rosée K,Schmidt U,Erdmann E

更新日期：1992-06-01 00:00:00

abstract：:During ischemia-reperfusion an imbalance between endothelin (ET) and nitric oxide (NO) can be responsible for microcirculatory disturbances. The aim of this study was to restore the ET/NO balance to reduce the ischemia-reperfusion injury. Hepatic ischemia was induced for 30 min in 56 Wistar rats. Sham operation, ische...

journal_title：Journal of cardiovascular pharmacology

authors： Uhlmann D,Uhlmann S,Spiegel HU

更新日期：2000-11-01 00:00:00

abstract：:Several studies suggested that dopamine may be one of the inhibitory modulators of aldosterone secretion. Metoclopramide, a selective antagonist for dopamine D-2 receptors, increases both basal plasma aldosterone levels and the aldosterone response to angiotensin II (Ang II) in rats and humans kept on a high sodium in...

journal_title：Journal of cardiovascular pharmacology

authors： Missale C,Lombardi C,De Cotiis R,Memo M,Carruba MO,Spano PF

更新日期：1989-01-01 00:00:00

abstract：:Erythropoietin (EPO) has been linked to cardioprotective effects. However, its effects during the aging process are little known. We investigated the effect of EPO administration on hemodynamic parameters, cardiac function, oxidative damage, and erythropoietin receptor (EPOR) expression pattern in the hypovolemic stat...

journal_title：Journal of cardiovascular pharmacology

authors： Puchulu MB,Arreche N,Zotta E,Donato M,Ogonowski N,Fellet A,Balaszczuk AM

更新日期：2019-05-01 00:00:00

abstract：:Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underly...

journal_title：Journal of cardiovascular pharmacology

authors： Zhu Y,Wang DH

更新日期：2008-05-01 00:00:00

abstract：:The relationship between sodium sensitivity and borderline hypertension was explored in 63 subjects. Thirty percent of those with borderline hypertension and 15% of normal subjects increased mean arterial pressure by more than 5% when daily sodium intake was increased from 10 to 200 mEq. While most displayed an increa...

journal_title：Journal of cardiovascular pharmacology

authors： Sullivan JM

更新日期：1986-01-01 00:00:00

abstract：:This article reviews the relation of cardiac cellular Na+ load and increased force of contraction. Digitalis glycosides and naturally occurring Na+ channel activators are considered. DPI201-106 was described as the first synthetic organic molecule with cardioselective Na+ channel-activating properties and investigated...

journal_title：Journal of cardiovascular pharmacology

authors： Scholtysik G

更新日期：1989-01-01 00:00:00

abstract：:Vasopeptidase inhibitors are single molecules that inhibit neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) simultaneously. Omapatrilat, the first in this new class of cardiovascular agents, potentiates vasodilatory and cardioprotective peptides and represses angiotensin II. This study compared the ...

journal_title：Journal of cardiovascular pharmacology

authors： Trippodo NC,Fox M,Monticello TM,Panchal BC,Asaad MM

更新日期：1999-12-01 00:00:00

abstract：:Therapeutic response to angiotensin-converting enzyme (ACE) inhibitors was reported to be better related to tissular than to circulating levels of ACE inhibition, especially during chronic therapy. We studied the relations between plasma concentrations of angiotensin I (AI), plasma renin activity (PRA), angiotensin II...

journal_title：Journal of cardiovascular pharmacology

authors： Schaison FH,Fernando Ramirez-Gil J,Ciferri S,Bernard M,Baudin B,Mougenot N,Carayon A,Lechat P

更新日期：1996-07-01 00:00:00

abstract：:Reviewed herein are data supporting the hypothesis that insulin and the sympathoadrenal system are involved in the pathogenesis of hypertension in the obese. Data from the Normative Aging Study, a population-based cohort followed in Boston, confirm other epidemiologic reports of a direct relationship between upper-bod...

journal_title：Journal of cardiovascular pharmacology

authors： Landsberg L

更新日期：1994-01-01 00:00:00

abstract：:The cardioprotective effects of betaxolol were studied in a rat model with heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization, Lewis rats were divided into four groups; 0.1 mg/kg betaxolol per day (group 0.1), 1.0 mg/kg betaxolol per day (group 1), 10 mg/kg betaxolol per day (group 1...

journal_title：Journal of cardiovascular pharmacology

authors： Watanabe K,Juan W,Narasimman G,Ma M,Inoue M,Saito Y,Wahed MI,Nakazawa M,Hasegawa G,Naito M,Tachikawa H,Tanabe N,Kodama M,Aizawa Y,Yamamoto T,Yamaguchi K,Takahashi T

更新日期：2003-01-01 00:00:00

abstract：:Spirapril is a new angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug with a resorption of about 50%. The active metabolite spiraprilat reaches maximal plasma concentration within 2-3 h after oral administration. Spirapril can be administered once daily because of its long duration of action caused by an e...

journal_title：Journal of cardiovascular pharmacology

authors： Hayduk K,Kraul H

更新日期：1999-08-01 00:00:00

abstract：:Endothelium-derived relaxing factors (EDRFs) and prostacyclin (PGI2) released from endothelial cells are potent vasodilators; endothelin-1 and thromboxane A2 may be their physiological antagonists. Interactions between these vasodilators and vasoconstrictors were studied in isolated intramyocardial porcine coronary ar...

journal_title：Journal of cardiovascular pharmacology

authors： Noll G,Bühler FR,Yang Z,Lüscher TF

更新日期：1991-07-01 00:00:00

abstract：:The effects of prenylamine (PNL) and AQ-A 39 on sustained ventricular tachycardia (SVT) were studied by programmed stimulation in conscious dogs 4-10 days after ligation of the left anterior descending (LAD) coronary artery. In 8 of 16 dogs developing SVT in the control, PNL (3 mg/kg intravenously, i.v.) suppressed in...

journal_title：Journal of cardiovascular pharmacology

authors： Aidonidis I,Egel E,Hilbel T,Kuebler W,Brachmann J

更新日期：1993-09-01 00:00:00

abstract：:We investigated the potential role of atorvastatin, given at reperfusion, to improve survival of the ischemic/reperfused myocardium by activation of p44/42 MAPK and p38 MAPK with its downstream effector, HSP27. We have previously shown that atorvastatin attenuates lethal reperfusion-induced injury via activation of th...

journal_title：Journal of cardiovascular pharmacology

authors： Efthymiou CA,Mocanu MM,Yellon DM

更新日期：2005-03-01 00:00:00

abstract：:To establish the clinical efficacy of pilsicainide, we evaluated its electrophysiologic and hemodynamic effects after a single oral administration to 18 patients with documented supraventricular tachycardia (SVT). To determine the minimal effective blood level, changes in efficacy with time were evaluated by serial re...

journal_title：Journal of cardiovascular pharmacology

authors： Ino T,Atarashi H,Kuruma A,Onodera T,Saitoh H,Hayakawa H

更新日期：1998-01-01 00:00:00