Effects of flestolol, an ultra-short acting beta-adrenoceptor antagonist, on hemodynamic changes produced by treadmill exercise or isoprenaline stimulation in conscious dogs.

abstract：:Hyperhomocysteinemia is a risk factor for atherosclerosis, and is found in the heterozygous form in approximately one-third of all individuals with coronary artery disease. The sulfhydryl group of homocysteine has been viewed as contributing to the atherogenic effects of this low-molecular-weight thiol, largely as a c...

journal_title：Journal of cardiovascular pharmacology

authors： Stamler JS,Loscalzo J

更新日期：1992-01-01 00:00:00

abstract：:Activity in central sympathetic pathways can be modified by stimulating central alpha 2-adrenoceptors, e.g., with clonidine, or, more recently, by stimulating central 5-hydroxytryptamine (5-HT1A) receptors. Stimulation of 5-HT1A receptors causes central sympathoinhibition and an increase in cardiac vagal drive, which ...

journal_title：Journal of cardiovascular pharmacology

authors： Ramage AG

更新日期：1990-01-01 00:00:00

abstract：:The electrophysiologic effects of acutely and chronically administered amiodarone on canine Purkinje fibers were assessed using microelectrode techniques to record intracellular action potentials. Chronically treated dogs received amiodarone for 3 weeks (serum levels, 0.91 +/- 0.09 microgram/ml or 1.42 X 10(-6) M). Ac...

journal_title：Journal of cardiovascular pharmacology

authors： Gallagher JD,Bianchi J,Gessman LJ

更新日期：1989-05-01 00:00:00

abstract：:Carthamin yellow (CY) is a flavonoid compound isolated from safflower, which is widely used clinically in China. It has various pharmacological effects including promoting blood circulation to remove blood stasis and alleviating pain. Ischemic heart disease is one of the main culprits of illness and death. Here, in th...

journal_title：Journal of cardiovascular pharmacology

authors： Lu QY,Ma JQ,Duan YY,Sun Y,Yu S,Li B,Zhang GM

更新日期：2019-09-01 00:00:00

abstract：:To elucidate the pathophysiologic significance of endothelin-1 (ET-1) in adrenal and the mechanism for reduced responsiveness to exogenous ET-1 in aldosterone-producing adenoma (APA), we have investigated ET-1 receptors by radioligand binding assay (RBA) in human normal adrenal (NA), APA, idiopathic hyperaldosteronism...

journal_title：Journal of cardiovascular pharmacology

authors： Zeng Z,Tang X,Yang D,Li H,Zhang R,Zeng Q,Li M,Chen J,Lu Z,Demura H,Naruse M,Shi Y

更新日期：1998-01-01 00:00:00

abstract：:Intravenous injections of the indirect sympathetic amine, tyramine, are used as a test of peripheral adrenergic function. The authors measured the time course of increases in ejection fraction, heart rate, systolic and diastolic pressure, popliteal artery flow, and greater saphenous vein diameter before and after an i...

journal_title：Journal of cardiovascular pharmacology

authors： Meck JV,Martin DS,D'Aunno DS,Waters WW

更新日期：2003-01-01 00:00:00

abstract：:The relationship between adrenergic nerve activity and neuronal uptake was investigated. Helically cut strips of rat tail artery were mounted in organ chambers and isometric contractions were recorded. Spontaneous contractions were occasionally observed and these contractions were blocked by phentolamine. Cumulative a...

journal_title：Journal of cardiovascular pharmacology

authors： Webb RC,Vanhoutte PM,Bohr DF

更新日期：1980-01-01 00:00:00

abstract：:This study determined whether flavin adenine dinucleotide (FAD) may elicit vasodilation in conscious rats via release of preformed endothelium-derived nitrosyl factors. Injections 1-6 (inj(1-6)) of FAD (2.5 micromol/kg, IV) elicited pronounced and equivalent vasodilator responses in saline-treated rats. Inj(1) of FAD ...

journal_title：Journal of cardiovascular pharmacology

authors： Hashmi-Hill MP,Sandock K,Bates JN,Robertson TP,Lewis SJ

更新日期：2007-08-01 00:00:00

abstract：:Although the importance of adenosine (Ado)-receptor activation in preconditioning (PC) has been established, it is unclear whether cardioprotection afforded by PC is determined by the Ado level during PC ischemia or by that during sustained ischemia. Accordingly, we tested whether the PC effect is modified by augmenti...

journal_title：Journal of cardiovascular pharmacology

authors： Suzuki K,Miura T,Miki T,Tsuchida A,Shimamoto K

更新日期：1998-01-01 00:00:00

abstract：:Foods and beverages rich in flavonoids are being heralded as potential preventive agents for a range of pathologic conditions, ranging from hypertension to coronary heart disease to stroke and dementia. We and others have demonstrated that short-term ingestion of cocoa, particularly rich in the subclass of flavonoids ...

journal_title：Journal of cardiovascular pharmacology

authors： Fisher ND,Sorond FA,Hollenberg NK

更新日期：2006-01-01 00:00:00

abstract：:We have previously reported that production of endothelin (ET)-1 is markedly increased in failing hearts of rats with chronic heart failure (CHF). It was also reported that the production of angiotensin II (Ang II) is increased in the failing heart. In this study we investigated both converting enzymes of the ET-1 sys...

journal_title：Journal of cardiovascular pharmacology

authors： Kobayashi T,Miyauchi T,Sakai S,Yamaguchi I,Goto K,Sugishita Y

更新日期：1998-01-01 00:00:00

abstract：:In this study, the authors sought to evaluate the mechanisms responsible for echocardiographically determined differences in cardiac structure and function between conscious and anesthetized mice to determine whether such differences were more or less evident in diseased states. Cardiac parameters were determined by t...

journal_title：Journal of cardiovascular pharmacology

authors： Tan TP,Gao XM,Krawczyszyn M,Feng X,Kiriazis H,Dart AM,Du XJ

更新日期：2003-08-01 00:00:00

abstract：:Insulin resistance is associated with endothelial dysfunction and increased production of the pro-inflammatory vasoconstrictor peptide endothelin-1 (ET-1). The aim of this study was to test the hypothesis that blockade of ET receptors results in enhanced endothelium-dependent vasodilatation (EDV) in individuals with i...

journal_title：Journal of cardiovascular pharmacology

authors： Shemyakin A,Böhm F,Wagner H,Efendic S,Båvenholm P,Pernow J

更新日期：2006-03-01 00:00:00

abstract：:The benefit of thrombolytic agents to reduce myocardial infarct size, improve left ventricular (LV) function, and prolong survival in human subjects is generally recognized, although the precise mechanism is poorly defined. This study was designed to evaluate the cardioprotective effects of streptokinase (SK) in rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Smith EF 3rd,Nichols AJ,Sellers TS,O'Brien SR,Griswold DE,Egan JW,Hillegass LM,Vasko JA,Slivjak MJ,Davis PA

更新日期：1991-11-01 00:00:00

abstract：:An attempt was made to study possible interaction between neuromodulation by adenosine and nicotine stimulatory effects. Dose-effect curves were made double blind in 7 nonsmoking, nonsnuffing healthy volunteers (25-49 years) before and during exposition to nicotine roughly corresponding to the nicotine of one cigarett...

journal_title：Journal of cardiovascular pharmacology

authors： Sylvén C,Beermann B,Kaijser L,Jonzon B

更新日期：1990-12-01 00:00:00

abstract：:Simvastatin (SV), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity inhibits migration and proliferation of vascular smooth muscle cells (SMC). To investigate whether these effects of SV are related to inhibition of cell calcium mobilization, cultured SMC obtained from rat aorta were l...

journal_title：Journal of cardiovascular pharmacology

authors： Escobales N,Castro M,Altieri PI,Sanabria P

更新日期：1996-03-01 00:00:00

abstract：:To slow ventricular rate during supraventricular tachycardia, a drug must have a strong rate-dependent depressant effect on atrioventricular (AV) conduction. We investigated the frequency-dependent effects of verapamil, amiodarone, digoxin, and diltiazem on AV conduction time (AVCT) in isolated guinea pig heart perfus...

journal_title：Journal of cardiovascular pharmacology

authors： Stark G,Schulze-Bauer C,Stark U,Kasper K,Decrinis M,Tritthart HA

更新日期：1995-02-01 00:00:00

abstract：:The purpose of this study was to investigate the renal effects of aranidipine, a novel calcium channel blocker of the dihydropyridine type, and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats (SHRs). When infused into the renal artery in anesthetized dogs, aranidipine (0.03 mic...

journal_title：Journal of cardiovascular pharmacology

authors： Ichihara K,Okumura K,Kamei H,Nagasaka M,Kanda A,Kanno T,Miyoshi K,Miyake H

更新日期：1998-02-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：:We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

journal_title：Journal of cardiovascular pharmacology

authors： Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

更新日期：1996-08-01 00:00:00

abstract：:In response to acetylcholine, endothelial cells were shown to release a nonprostanoid factor, called endothelium-derived relaxing factor (EDRF), which caused relaxation of vascular smooth muscle. Since this discovery in 1980, many additional agents have been shown to stimulate release of EDRF from endothelium. Biologi...

journal_title：Journal of cardiovascular pharmacology

authors： Furchgott RF

更新日期：1993-01-01 00:00:00

abstract：:Studies were undertaken to establish the regional hemodynamic profile and dose-response relation of the adenosine triphosphate (ATP)-dependent potassium channel activator lemakalim in anesthetized rats. In addition, the ability of the sulphonylurea potassium channel blocker glybenclamide to reverse the hemodynamic eff...

journal_title：Journal of cardiovascular pharmacology

authors： Smits GJ,Perrone MH,Cox BF

更新日期：1997-01-01 00:00:00

abstract：:In this study the effects of a new calcium entry blocking agent, 2,6-dimethyl-3-methoxycarbonyl-4-(2-nitrophenyl)-5-(2-furoyl)-1, 4-dihydropyridine (MDL 72567), were compared with those of nifedipine on blood pressure, heart rate, ECG, and cardiac contractility indices in conscious sinoaortic baroreceptor-denervated (...

journal_title：Journal of cardiovascular pharmacology

authors： Petty MA,Spedding M,Di Francesco GF

更新日期：1987-10-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an important role in blood pressure control and in water and salt homeostasis. It is involved in the pathophysiology of hypertension and structural alterations of the vasculature, kidney, and heart, including neointima formation, nephrosclerosis, postinfarction remodeling, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Stroth U,Unger T

更新日期：1999-01-01 00:00:00

abstract：:The disposition of amlodipine, a new calcium-channel blocker with a slow onset and long duration of action, has been investigated in humans and in the animal species used in the evaluation of drug efficacy and safety. Pharmacokinetic studies were conducted with nonlabeled drug using specific high-pressure liquid chrom...

journal_title：Journal of cardiovascular pharmacology

authors： Stopher DA,Beresford AP,Macrae PV,Humphrey MJ

更新日期：1988-01-01 00:00:00

abstract：:The effects of a newly synthesized antiarrhythmic agent, TYB-3823 on the transmembrane action potential were examined in isolated papillary muscles of guinea pig. TYB-3823 (3 x 10(-6)-3 x 10(-5)M) caused a dose-dependent decrease in the maximum upstroke velocity (Vmax) and a shortening of action potential duration (AP...

journal_title：Journal of cardiovascular pharmacology

authors： Kodama I,Morimoto M,Toyama J,Shibata S

更新日期：1989-04-01 00:00:00

abstract：:We examined the involvement of the oxidative stress in high glucose-induced suppression of human aortic endothelial cell proliferation. Chronic glucose treatment for 72 h concentration-dependently (5.6-22.2 mol/l) inhibited human coronary endothelial cell proliferation. Temocaprilat, an angiotensin-converting enzyme i...

journal_title：Journal of cardiovascular pharmacology

authors： Yasunari K,Maeda K,Watanabe T,Nakamura M,Asada A,Yoshikawa J

更新日期：2003-12-01 00:00:00

abstract：:Diabetes mellitus is associated with significant morbidity and mortality caused by the micro- and macro-vascular complications that all too frequently develop during the lifetime of the diabetic patient. In attempts to treat the complications of diabetes, several different treatment strategies have been investigated. ...

journal_title：Journal of cardiovascular pharmacology

authors： Savage S,Miller LA,Schrier RW

更新日期：1991-01-01 00:00:00

abstract：:Adenosine A1 receptor (A1AR) activation contracts smooth muscle, although signaling mechanisms are not thoroughly understood. Activation of A1AR leads to metabolism of arachidonic acid, including the production of 20-hydroxyeicosatetraenoic acid (20-HETE) by cytochrome P4504a (CYP4a). The 20-HETE can activate protein ...

journal_title：Journal of cardiovascular pharmacology

authors： Kunduri SS,Mustafa SJ,Ponnoth DS,Dick GM,Nayeem MA

更新日期：2013-07-01 00:00:00

abstract：:Doxazosin has been shown to lower serum cholesterol levels in the cholesterol-fed (0.75% in a synthetic diet that contains sucrose and cholic acid) C57BR/cdJ mouse. These studies show that the drug's main effect is to lower low-density lipoprotein (LDL) cholesterol and leave high-density lipoprotein (HDL) cholesterol ...

journal_title：Journal of cardiovascular pharmacology

authors： Krupp MN,Hoover KW,Valentine JJ

更新日期：1989-01-01 00:00:00