Electrophysiologic effects of a class I antiarrhythmic agent, cibenzoline, on the refractoriness and conduction of the human atrium in vivo.

abstract：:Nicorandil, a potent coronary vasorelaxant used in the treatment of angina, has differential effects on arteries and veins in vivo. To explain this phenomenon, experiments were designed to characterize the relaxant and inhibitory actions of this compound on canine isolated arteries and veins. Paired rings of canine co...

journal_title：Journal of cardiovascular pharmacology

authors： Morrison KJ,Flavahan NA,Vanhoutte PM

更新日期：1990-05-01 00:00:00

abstract：:As a receptor for transforming growth factor-β, nodal and activin, activin receptor-like kinase 7 (ALK7) previously acts as a suppressor of tumorigenesis and metastasis, which has emerged to play a key role in cardiovascular diseases. However, the potential effect and molecular mechanism of ALK7 on vascular smooth mus...

journal_title：Journal of cardiovascular pharmacology

authors： Gong FH,Cheng WL,Zhang Q,Chen XL,Cao JL,Yang T,Song WH,Zhao F

更新日期：2020-08-01 00:00:00

abstract：:This study investigated the role of perivascular adipose tissue (PVAT) in the beneficial effects of andrographolide on vascular reactivity in endotoxaemic rats. After being challenged by lipopolysaccharide (4 mg/kg intraperitoneally), the rats were treated with andrographolide (1 mg/kg intraperitoneally). The response...

journal_title：Journal of cardiovascular pharmacology

authors： Hai-Mei L,Song-Yin H,Run-Mei L,Xiao-Huang X,Le-Quan Z,Xiao-Ping L,Jin-Wen X

更新日期：2013-08-01 00:00:00

abstract：:The elimination of an acute oral saline load is markedly blunted in adult Sabra hypertension-prone (SBH) rats compared with hypertension-resistant Sabra normotensive (SBN) rats. Within 2 h, urinary output and the excretion of sodium and potassium are significantly reduced, while urine osmolality is markedly elevated i...

journal_title：Journal of cardiovascular pharmacology

authors： Mekler J,Ben-Ishay D,Garthoff B,Kazda S

更新日期：1987-01-01 00:00:00

abstract：:Coronary arteries from animals on normal diets (ND) exhibit well-maintained responses to dilators under ischemic conditions. The reported altered metabolic requirements and K+-currents in blood vessels from hypercholesterolemic animals fed high-fat diets (HF) led us to hypothesize that under metabolically depressed co...

journal_title：Journal of cardiovascular pharmacology

authors： Franke R,Yang Y,Rubin LJ,Magliola L,Jones AW

更新日期：2004-04-01 00:00:00

abstract：:Ranolazine was previously shown to stimulate cardiac glucose oxidation. Dichloroacetate (DCA) also does and was shown to improve exercise capacity in animals, but it has long-term toxicity problems. To test the hypothesis that ranolazine would increase exercise performance in the chronic heart failure (CHF) condition,...

journal_title：Journal of cardiovascular pharmacology

authors： Aaker A,McCormack JG,Hirai T,Musch TI

更新日期：1996-09-01 00:00:00

abstract：:Hypertension is a major disease in the black population of sub-Saharan Africa and the U.S. The prevalence of hypertension varies from 1-30% of the adult population. Differences in blood pressure (BP) between black and white patients have been documented. In this review, genetic, endocrine, and environmental characteri...

journal_title：Journal of cardiovascular pharmacology

authors： Seedat YK

更新日期：1990-01-01 00:00:00

abstract：:The beta-blocking activity of flestolol was established during increasing isoprenaline infusions and during graded physical exercise in conscious, chronically instrumented dogs. After a control cycle, flestolol was infused at three doses (1, 2.67, and 10 micrograms/kg/min). Flestolol has an extremely short half-life, ...

journal_title：Journal of cardiovascular pharmacology

authors： Grohs JG,Fischer G,Raberger G

更新日期：1990-02-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors have been extensively studied and established in the treatment of hypertension, heart failure, and ventricular dysfunction. They have various cardiac and vascular protective effects, but the relevant mechanisms of action in these areas remain to be fully understood. Possible ef...

journal_title：Journal of cardiovascular pharmacology

authors： Sharpe N

更新日期：1993-01-01 00:00:00

abstract：:Several reports suggest that when diuretics are added to nifedipine (N), they do not exert any additional hypotensive effect to that produced by N alone. We present the first double-blind, crossover trial to investigate this interaction. Twenty-four black patients with moderate to severe essential hypertension entered...

journal_title：Journal of cardiovascular pharmacology

authors： Poulter N,Thompson AV,Sever PS

更新日期：1987-01-01 00:00:00

abstract：:The effect of two dihydropyridine derivatives, nifedipine and felodipine, on myocardial blood flow distribution 1 h after ligation of the left anterior descending coronary artery (LAD) was studied in open-chest dogs by means of radioactive microspheres. The myocardium normally perfused from the LAD was first labeled w...

journal_title：Journal of cardiovascular pharmacology

authors： Sjöquist PO,Duker G,Almgren O

更新日期：1985-07-01 00:00:00

abstract：:Prazosin, in daily doses of 6--16 mg, was used along with furosemide and polythiazide in 11 hypertensive heart failure patients. Average supine and standing blood pressures were reduced from 180/108 and 171/106 to 130/84 and 135/86, respectively. Average heart rate decreased from 83 to 73 supine and from 84 to 75 stan...

journal_title：Journal of cardiovascular pharmacology

authors： Antani JA

更新日期：1979-11-01 00:00:00

abstract：:The renin-angiotensin system (RAS) has been proposed to play a major role in causing the heart to hypertrophy during pressure overload. We examined whether blockade of this system by the angiotensin-converting enzyme (ACE) inhibitors enalapril (0.5 to 20 mg/kg p.o.) or ramipril (1.0 mg/kg p.o.) or the angiotensin rece...

journal_title：Journal of cardiovascular pharmacology

authors： Mohabir R,Young SD,Strosberg AM

更新日期：1994-02-01 00:00:00

abstract：:Erythropoietin (EPO) has been linked to cardioprotective effects. However, its effects during the aging process are little known. We investigated the effect of EPO administration on hemodynamic parameters, cardiac function, oxidative damage, and erythropoietin receptor (EPOR) expression pattern in the hypovolemic stat...

journal_title：Journal of cardiovascular pharmacology

authors： Puchulu MB,Arreche N,Zotta E,Donato M,Ogonowski N,Fellet A,Balaszczuk AM

更新日期：2019-05-01 00:00:00

abstract：:We evaluated the antiischemic effects of nifedipine in isolated working rat hearts from age-matched normotensive Wistar-Kyoto rats (WKY), diabetic WKY, spontaneously hypertensive rats (SHR), and diabetic SHR. Diabetes was induced by streptozotocin. First, we constructed concentration-response curves for the negative i...

journal_title：Journal of cardiovascular pharmacology

authors： Pijl AJ,Hendriks MG,Kam KL,Pfaffendorf M,van Zwieten PA

更新日期：1994-03-01 00:00:00

abstract：:A brief review is given of the vasodilators that require an intact vascular endothelium to exert their relaxing effect. Then some major issues of the phenomenon of endothelium-dependent smooth muscle relaxation are discussed in more detail: The chemical structure of the endothelium-derived relaxing factor (EDRF), whic...

journal_title：Journal of cardiovascular pharmacology

authors： Förstermann U

更新日期：1986-01-01 00:00:00

abstract：:On the basis of animal studies, it has been proposed that calcium antagonists selectively interfere with the pressor response to alpha 2-adrenoceptor antagonists and have less direct action on alpha 1-adrenoceptor mechanisms. In placebo-controlled randomized studies in healthy normotensives, we have found that verapam...

journal_title：Journal of cardiovascular pharmacology

authors： Reid JL,Pasanisi F,Meredith PA,Elliott HL

更新日期：1985-01-01 00:00:00

abstract：:Heart failure after myocardial infarction (MI) is associated with endothelial dysfunction. There is conflicting evidence on the exact nature of this endothelial dysfunction and how endothelium-dependent vasodilation is affected by angiotensin-converting enzyme inhibitor (ACE-I) therapy. Furthermore, consequences of ac...

journal_title：Journal of cardiovascular pharmacology

authors： Westendorp B,Schoemaker RG,van Gilst WH,Buikema H

更新日期：2005-12-01 00:00:00

abstract：:The effects of 5-hydroxypropafenone (5-OH-P), the main metabolite of propafenone, were studied in guinea pig papillary muscles obtained from untreated animals and from animals pretreated with 5-OH-P, 3 mg/kg for 24 days. In untreated muscles perfused with 2.7 and 5.4 mM K+, 5-OH-P depressed action potential amplitude ...

journal_title：Journal of cardiovascular pharmacology

authors： Valenzuela C,Delgado C,Tamargo J

更新日期：1987-11-01 00:00:00

abstract：:Chronic diabetes mellitus finally leads to serious vascular dysfunction. Diosgenin is a natural steroidal saponin with potential cardiovascular protective effect. In this study, the protective effect of diosgenin was checked on the aorta from streptozotocin-induced diabetic rats. Diabetic rats received diosgenin (40 m...

journal_title：Journal of cardiovascular pharmacology

authors： Roghani-Dehkordi F,Roghani M,Baluchnejadmojarad T

更新日期：2015-12-01 00:00:00

abstract：:We compared the beta-adrenoceptor blocking actions of bupuranolol and propranolol using the response to isoprenaline of the strength of contraction of the canine blood-perfused ventricular muscle, of the rate and strength of contraction of the isolated guinea pig heart and of a guinea pig tracheal ring preparation. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Hashimoto K,Tsukada T,Matsuda H,Nakagawa Y,Imai S

更新日期：1979-03-01 00:00:00

abstract：:Beta-blocker therapy has been shown to be associated with an increase in the plasma concentration of A-type natriuretic peptide (ANP). Whether the plasma concentration of B-type natriuretic peptide (BNP), which is mainly derived from ventricular tissue, is also increased and whether this increase is caused by increase...

journal_title：Journal of cardiovascular pharmacology

authors： van den Meiracker AH,Lameris TW,van de Ven LL,Boomsma F

更新日期：2003-10-01 00:00:00

abstract：:The aim of this study was to investigate whether the HMG-CoA reductase inhibitor cerivastatin alters the nitric oxide (NO) bioavailability of porcine aortic endothelial cell cultures and of native porcine coronary endothelium, after short-term (minutes) and long-term (24-hour) treatment with cerivastatin (electrochemi...

journal_title：Journal of cardiovascular pharmacology

authors： Berkels R,Nouri SK,Taubert D,Bartels H,Roesen P,Roesen R,Klaus W

更新日期：2003-09-01 00:00:00

abstract：:Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. However, this hormone has a ubiquitous influence and has specific effects on the heart. Although diff...

journal_title：Journal of cardiovascular pharmacology

authors： Pelletier JS,Dicken B,Bigam D,Cheung PY

更新日期：2014-07-01 00:00:00

abstract：:We studied the kinetics of amiodarone in three healthy volunteers after single oral (400 mg) and intravenous (150 mg) doses and in six patients with supraventricular tachycardia. Three patients were studied after the first oral dose (400 mg) and during subsequent therapy (200 mg/day); the other three after 5 mg/kg of ...

journal_title：Journal of cardiovascular pharmacology

authors： Riva E,Gerna M,Latini R,Giani P,Volpi A,Maggioni A

更新日期：1982-03-01 00:00:00

abstract：:We have recently shown that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and store-operated Ca2+ channel (SOCC). These channels can be pharmacologically discriminated using 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1-H-imidazoe l h...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang XF,Iwamuro Y,Okamoto Y,Kawanabe Y,Masaki T,Miwa S

更新日期：2000-11-01 00:00:00

abstract：:The modification of tumor blood flow resulting from administration of endothelin-1 (ET-1) and sarafotoxin S6c (SX6c) was examined in female CBH rats. Blood flow in subcutaneous HSN tumors and normal tissues was measured by tissue uptake of 125I-labeled iodoantipyrine ([125I])IAP). A 75% increase in tumor blood flow wa...

journal_title：Journal of cardiovascular pharmacology

authors： Bell KM,Prise VE,Chaplin DJ,Tozer GM

更新日期：1995-01-01 00:00:00

abstract：:The hypothesis that local release of prostanoids may contribute to the pharmacologic effect of nitroglycerin (NTG) has long been debated. Results of prostanoid blockade by indomethacin on NTG-induced effects, to date, have been inconclusive. To quantitate the effects of intravenous indomethacin on NTG-induced myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Bednarcyzk EM,Furniss SM,Green JA,Munger MA

更新日期：1997-12-01 00:00:00

abstract：:To evaluate the possible role of endothelin in the development and/or maintenance of hypertension in Dahl rats, we examined the responsiveness of isolated vascular smooth muscle and glomerular mesangial cells, as well as deendothelialized vascular ring preparations to endothelin-1 (ET-1). Production of immunoreactive ...

journal_title：Journal of cardiovascular pharmacology

authors： Goligorsky MS,Iijima K,Morgan M,Yanagisawa M,Masaki T,Lin L,Nasjletti A,Kaskel F,Frazer M,Badr KF

更新日期：1991-01-01 00:00:00

abstract：:The cholinergic anti-inflammatory pathway has been found to exert a protective role in myocardial ischemia-reperfusion injury (MIRI). Alpha7 nicotinic acetylcholine receptor (α7nAChR) is a regulator of cholinergic anti-inflammatory pathway; however, little information is available on the effect of α7nAChR on MIRI. In ...

journal_title：Journal of cardiovascular pharmacology

authors： Li H,Zhang ZZ,Zhan J,He XH,Song XM,Wang YL

更新日期：2012-06-01 00:00:00