Introduction to EDRF research.

abstract：:The aim of this study was to determine whether a quantitative relation exists between changes in regional myocardial blood flow (RMBF) and those in electrophysiologic determinants recorded via left ventricular endocardial and epicardial bipolar electrograms after administration of disopyramide (DP) and a class III ant...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe T,Iwamoto T,Iwata O,Aikawa M,Kusuzaki S,Handa S,Shinozaki Y,Mori H

更新日期：1999-08-01 00:00:00

abstract：:Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type 1 receptor (AT1R) mediates the established actions of angiotensin II (Ang II), and changes in its expression have been reported in cardiac fibroblasts after myocardial infarc...

journal_title：Journal of cardiovascular pharmacology

authors： Vivar R,Soto C,Copaja M,Mateluna F,Aranguiz P,Muñoz JP,Chiong M,Garcia L,Letelier A,Thomas WG,Lavandero S,Díaz-Araya G

更新日期：2008-08-01 00:00:00

abstract：:Disruption of atherosclerotic plaques with associated thrombus is responsible for the majority of the acute coronary syndromes. Plaque instability is related closely to the degree of inflammation. Inflammatory cells within the plaque produce cytokines that inhibit collagen production by vascular smooth muscle cells an...

journal_title：Journal of cardiovascular pharmacology

authors： Kinlay S,Selwyn AP,Libby P,Ganz P

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the effect of a combination of bone marrow mononuclear cell (BM-MNC) implantation and sarpogrelate, a selective 5-HT(2A) antagonist, on endothelial function in patients with critical limb ischemia (CLI). METHODS:We evaluated the leg blood flow (LBF) responses to ac...

journal_title：Journal of cardiovascular pharmacology

authors： Higashi Y,Miyazaki M,Goto C,Sanada H,Sueda T,Chayama K

更新日期：2010-01-01 00:00:00

abstract：:Numerous studies have demonstrated that immune effector mechanisms cause serious heart diseases, among which are heart transplant rejection, myocarditis, and the resulting dilated cardiomyopathy, as well as Chagas' disease. Whereas different effectors of the immune system can affect cardiac function, this review prima...

journal_title：Journal of cardiovascular pharmacology

authors： Binah O

更新日期：2001-08-01 00:00:00

abstract：:Low density lipoprotein (LDL) oxidation plays a crucial role in the development and progression of atherosclerosis and is enhanced in patients with essential hypertension. This finding has stimulated a search for antihypertensive drugs with high intrinsic antioxidant properties. We investigated the antihypertensive an...

journal_title：Journal of cardiovascular pharmacology

authors： Maggi E,Marchesi E,Covini D,Negro C,Perani G,Bellomo G

更新日期：1996-04-01 00:00:00

abstract：:Endothelin-1 (ET-1) not only causes potent vasoconstriction but also leads to fluid retention, both actions mediated by ET(A)- and/or ET(B)-receptors. Selective ET(A)- and combined ET(A)/ET(B)-receptor antagonists improve hemodynamics in heart failure; however, it is also important to evaluate the effects of these ant...

journal_title：Journal of cardiovascular pharmacology

authors： Ohnishi M,Wada A,Tsutamoto T,Sawaki M,Fujii M,Matsumoto T,Kinoshita M

更新日期：2000-11-01 00:00:00

abstract：:To determine whether the pattern of alcohol consumption, intake, and withdrawal modulates the incidence of malignant ventricular arrhythmias and sudden cardiac death due to beta-adrenergic stimulation in a species susceptible to administration of isoproterenol alone, a regimen was formulated in which both continuous a...

journal_title：Journal of cardiovascular pharmacology

authors： Guideri G,Gutstein WH,Olivetti G,Anversa P

更新日期：1988-10-01 00:00:00

abstract：:Bezafibrate, a potent hypolipidemic agent, was studied as potentially preventive in the atherosclerosis-associated vascular hyperresponsiveness to alpha-adrenoceptors agonists in rats. Contractile responses to norepinephrine (NE) were determined in isolated tail arteries of rats fed an atherogenic or a standard diet. ...

journal_title：Journal of cardiovascular pharmacology

authors： Trzeciak HI,Okopień B,Kozłowski A,Chociłowska D,Bara A

更新日期：1993-11-01 00:00:00

abstract：:We undertook a systematic comparison of the effects of diltiazem and nifedipine and a nonspecific vasodilator, sodium nitroprusside, on renal perfusion, function, and activation of potentially relevant neurohormonal systems in the anesthetized dog. These agents were employed to reduce blood pressure to two levels, a m...

journal_title：Journal of cardiovascular pharmacology

authors： Blackshear JL,Orlandi C,Williams GH,Hollenberg NK

更新日期：1986-01-01 00:00:00

abstract：:beta 2-Adrenoceptor function may be decreased in primary hypertension, resulting in increased peripheral resistance. To study the beta 2-adrenoceptor function, we used circulating mononuclear leukocytes (MNL) as a model system. Twenty untreated hypertensive subjects [(HT) 10 men and 10 women] and 20 age- and sex-match...

journal_title：Journal of cardiovascular pharmacology

authors： Blankesteijn WM,Willems PH,Graafsma SJ,de Pont JJ,Thien T

更新日期：1993-11-01 00:00:00

abstract：:We investigated the role of peripheral sympathetic neurons and the adrenal medulla in the cardiovascular responses to cocaine in conscious, unrestrained Sprague-Dawley rats. Surgical adrenal demedullation (ADM) and/or chemical peripheral sympathectomy was used to eliminate one or both components of the sympathoadrenal...

journal_title：Journal of cardiovascular pharmacology

authors： Chen BX,Myles J,Wilkerson RD

更新日期：1995-05-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is a widely used vehicle for water-insoluble substances and exerts a wide range of pharmacologic effects including anti-inflammatory and free radical scavenging properties. Additionally, in an animal model, DMSO inhibited cholesterol-induced atherosclerosis. Despite such profound pharmacologi...

journal_title：Journal of cardiovascular pharmacology

authors： Laskar A,Yuan XM,Li W

更新日期：2010-09-01 00:00:00

abstract：:To elucidate the pathophysiologic significance of endothelin-1 (ET-1) in adrenal and the mechanism for reduced responsiveness to exogenous ET-1 in aldosterone-producing adenoma (APA), we have investigated ET-1 receptors by radioligand binding assay (RBA) in human normal adrenal (NA), APA, idiopathic hyperaldosteronism...

journal_title：Journal of cardiovascular pharmacology

authors： Zeng Z,Tang X,Yang D,Li H,Zhang R,Zeng Q,Li M,Chen J,Lu Z,Demura H,Naruse M,Shi Y

更新日期：1998-01-01 00:00:00

abstract：:We isolated two candidates for endogenous digitalis-like factors from human urine based on the inhibition of [3H]ouabain binding to intact human erythrocytes. The more-polar ouabain-displacing compound-1 (ODC-1) closely resembled ouabain in biological, physicochemical, and chromatographic properties. Moreover, anti-ou...

journal_title：Journal of cardiovascular pharmacology

authors： Goto A,Yamada K,Yagi N,Hui C,Nagoshi H,Sasabe M,Yoshioka M

更新日期：1993-01-01 00:00:00

abstract：:We compared platelet function results obtained with the VerifyNow P2Y12 (VN-P2Y12) point-of-care device and the light transmission aggregometry (5 and 20 microM adenosine diphosphate) method using an integrated database of eight clinical trials with a total of 591 subjects. The study was performed in healthy subjects,...

journal_title：Journal of cardiovascular pharmacology

authors： Jakubowski JA,Li YG,Small DS,Payne CD,Tomlin ME,Luo J,Winters KJ

更新日期：2010-07-01 00:00:00

abstract：:The calcium channel blocker nifedipine and the new phosphodiesterase (PDE) inhibitor enoximone are used in the treatment of cardiovascular diseases. Since both substances are acting on slow calcium channels and because systemic elimination of these two agents is dependent on oxidative drug metabolizing enzyme activity...

journal_title：Journal of cardiovascular pharmacology

authors： Boldt J,Kling D,Dietevich HA,Hempelmann G

更新日期：1990-01-01 00:00:00

abstract：:Dihydropyridine calcium antagonists play an important role in the treatment of arterial hypertension. In many centers, they are used as first-line treatment. Since impaired renal function can be a complication of long-standing blood pressure elevation, the usefulness of dihydropyridine calcium antagonists in hypertens...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson LH

更新日期：1989-01-01 00:00:00

abstract：:The primary purpose of the arterial baroreflex is to keep blood pressure close to a particular set point over a relatively short period of time. The rapid resetting of arterial baroreceptor afferents toward any sustained new level of blood pressure ensures that the reflex acts as an effective buffer of short-term bloo...

journal_title：Journal of cardiovascular pharmacology

authors： Head GA

更新日期：1995-01-01 00:00:00

abstract：:Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, are synthesized from membrane phospholipids in the heart and other cardiovascular tissues. They activate cannabinoid CB1 and CB2 receptors, transient receptor potential V1 (TRPV1), peroxisome proliferator-activated receptors, and perhaps a novel vascular...

journal_title：Journal of cardiovascular pharmacology

authors： Hiley CR

更新日期：2009-04-01 00:00:00

abstract：:One possible mechanism that accounts for the alterations observed in varicose veins is the activation of endothelial cells by ischemia occurring in the leg veins during blood stasis and the cascade of reactions that follows. Because in vitro data suggest that endothelium alteration is a key event in the development of...

journal_title：Journal of cardiovascular pharmacology

authors： Janssens D,Michiels C,Guillaume G,Cuisinier B,Louagie Y,Remacle J

更新日期：1999-01-01 00:00:00

abstract：:The "Oxford" system for continuous monitoring of the ambulatory blood pressure was used to assess the changes in blood pressure following therapy with the calcium ion antagonists verapamil and nifedipine in two separate groups of patients. In the first group 16 patients were studied on both no therapy and following a ...

journal_title：Journal of cardiovascular pharmacology

authors： Gould BA,Hornung RS,Mann S,Balasubramanian V,Raftery EB

更新日期：1982-01-01 00:00:00

abstract：ABSTRACT:Establishing efficient perfusion into the myocardium is the main purpose in patients with acute coronary syndrome, but the process of reperfusion is not without risk and can damage the myocardium paradoxically. Unfortunately, there is no effective treatment for reperfusion injury, and efforts to find an effici...

journal_title：Journal of cardiovascular pharmacology

authors： Kakavand H,Aghakouchakzadeh M,Coons J,Talasaz AH

更新日期：2021-01-04 00:00:00

abstract：:We compared the effects of angiotensin II (AII), enalapril, and losartan given by acute intravenous (i.v.) injection, on cardiac baroreflex sensitivity in two groups of conscious normotensive rabbits bred for high gain [> 5 beats/min/mm Hg] (group I) and low gain [< 4 beats/min/mm Hg] (group II) of the mean arterial b...

journal_title：Journal of cardiovascular pharmacology

authors： Weinstock M,Gorodetsky E

更新日期：1995-03-01 00:00:00

abstract：:Data are presented that define the risks of elevated blood pressure, both systolic and diastolic, and support the recent recommendations of the Third Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure in the United States that a consistently elevated pressure level above 140/90 mm ...

journal_title：Journal of cardiovascular pharmacology

authors： Moser M

更新日期：1985-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH), an increase in the muscle mass of the left ventricle, has been identified as a powerful risk factor for future cardiovascular morbidity and mortality. The risk of acute myocardial infarction, congestive heart failure, sudden death, and other cardiovascular events increases sixfold t...

journal_title：Journal of cardiovascular pharmacology

authors： Messerli FH,Ketelhut R

更新日期：1993-01-01 00:00:00

abstract：:Recently, we have reported two cases with endothelin (ET)-secreting tumor presenting with hypertension and elevated plasma endothelin-1 (ET-1) levels. The present study examines the histopathology of the ET-secreting tumor in one of these cases. The neoplasm was located in the skin and microscopically characterized as...

journal_title：Journal of cardiovascular pharmacology

authors： Yokokawa K,Tahara H,Kohno M,Murakawa K,Yasunari K,Nakagawa K,Hamada T,Otani S,Yanagisawa M,Takeda T

更新日期：1991-01-01 00:00:00

abstract：:To examine the role of sulfhydryl (-SH) group in improvement of endothelial dysfunction with angiotensin-converting enzyme (ACE) inhibitors in experimental high dose of methionine dieted rats. We compared the effects of Captopril (an ACE inhibitor with -SH group), enalapril (an ACE-inhibitor without -SH group), N-acet...

journal_title：Journal of cardiovascular pharmacology

authors： Liu YH,Liu LY,Wu JX,Chen SX,Sun YX

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:This study was designed to assess whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could prevent the recurrence of atrial fibrillation (AF). METHODS:A systemic literature search of PubMed, EMBASE, and Cochrane Controlled Trials Register till 2012 was performed...

journal_title：Journal of cardiovascular pharmacology

authors： Han M,Zhang Y,Sun S,Wang Z,Wang J,Xie X,Gao M,Yin X,Hou Y

更新日期：2013-10-01 00:00:00

abstract：:Endothelin-1 reduces the chronotropic and inotropic effects of the beta-adrenoceptor agonist isoproterenol in rabbit isolated atria. Vascular interactions between endothelin-1 and isoproterenol have not been reported. Rings of the rabbit aorta without endothelium were mounted on myographs to measure isometric tension....

journal_title：Journal of cardiovascular pharmacology

authors： Gilbert P,Thorin E

更新日期：2003-10-01 00:00:00