Endothelium-derived relaxing factor modulates the atherothrombogenic effects of homocysteine.

abstract：:One of the earliest structural changes in the heart adapting to hypertension is left ventricular hypertrophy, which can now be exactly measured by echocardiography. Left ventricular hypertrophy increases the incidence of coronary artery disease, heart failure, and sudden death severalfold, independent of the blood pre...

journal_title：Journal of cardiovascular pharmacology

authors： Schmieder RE

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Paraquat poisoning is one of leading intoxication worldwide without an effective antidote and treatment protocol. Among the other organs, cardiotoxicity of paraquat has been frequently reported. AIM:The protective effects of atorvastatin (STN) on paraquat-induced cardiotoxicity and the role of peroxisome pr...

journal_title：Journal of cardiovascular pharmacology

authors： Malekinejad M,Masoumi Verki M,Khoramjouy M,Alenabi A,Hallaj-Salahipour M,Malekinejad H

更新日期：2019-11-01 00:00:00

abstract：:To investigate the antianginal action of nitroglycerin and nifedipine, systemic and right heart pressures, cardiac output, oxygen consumption, and radionuclide left ventricular ejection fraction and volume were measured in 14 men with stable effort angina and a positive exercise electrocardiogram. Exercise tests were ...

journal_title：Journal of cardiovascular pharmacology

authors： Choong CY,Freedman SB,Roubin GS,Shen WF,Bautovich GJ,Harris PJ,Kelly DT

更新日期：1989-03-01 00:00:00

abstract：INTRODUCTION:Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by increasing the density of natriuretic peptide receptor A, leading to a potent diuresis and a renal function improvement in patients with acute decompensated heart failure (ADHF). Therefore, glucocorticoid t...

journal_title：Journal of cardiovascular pharmacology

authors： Liu C,Liu K,COPE-ADHF Study Group.

更新日期：2014-04-01 00:00:00

abstract：:To study the role of medullary alpha-adrenoceptors in hypertension, we compared specific binding of [3H]prazosin and [3H]clonidine in different brain regions of spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and normotensive Wistar-Kyoto rats (WKY). As compared with age-matched WKY, Bmax values for s...

journal_title：Journal of cardiovascular pharmacology

authors： Yamada S,Ashizawa N,Nakayama K,Tomita T,Hayashi E

更新日期：1989-03-01 00:00:00

abstract：:Recent in vitro experiments have shown that amrinone enhances the release of nitric oxide (NO) from the endothelium and induces NO mediated vasodilatation. This in vivo study examined whether amrinone causes vasodilatation mediated by endothelium-derived NO, and whether this effect is attenuated in patients with endot...

journal_title：Journal of cardiovascular pharmacology

authors： Sakane T,Ishibashi Y,Shimada T,Takahashi N,Sugamori T,Hirano Y,Ohata S,Inoue SI,Nakamura K,Murakami Y

更新日期：2000-08-01 00:00:00

abstract：:Hypertension is a well-known risk factor that predisposes to the development of left ventricular hypertrophy, coronary flow abnormalities, and systolic and diastolic dysfunction. This complex of abnormalities is known as hypertensive heart disease and eventually leads to heart failure. Structural lesions underlying th...

journal_title：Journal of cardiovascular pharmacology

authors： de Leeuw PW,Kroon AA

更新日期：1998-01-01 00:00:00

abstract：:Chloride (Cl-) efflux induces depolarization and contributes to contraction of cerebral arteries. We tested the effect of endothelin-1 and 5-hydroxytryptamine on isometric tension in rabbit basilar artery by inhibition of Na+-K+-2Cl- co-transporter and Cl-/HCO3- exchanger to decrease Cl-, by decreasing extracellular C...

journal_title：Journal of cardiovascular pharmacology

authors： Dai Y,Zhang J

更新日期：2004-11-01 00:00:00

abstract：:Increased sodium absorption in the gut is one mechanism contributing to hypertensive blood pressure values. The sodium-proton-exchanger subtype 3 (NHE3) is an important mediator of intestinal sodium absorption. The compound SAR is a new specific NHE3 inhibitor with extremely low oral absorbability leading to decreased...

journal_title：Journal of cardiovascular pharmacology

authors： Linz B,Hohl M,Reil JC,Böhm M,Linz D

更新日期：2016-03-01 00:00:00

abstract：:The CARTAGOMAX study assessed the safety and efficacy of bivalirudin during real-world cardiac intervention. This was a single-center prospective study. Patients with acute coronary syndrome undergoing percutaneous coronary intervention were anticoagulated with bivalirudin alone or unfractionated heparin plus a glycop...

journal_title：Journal of cardiovascular pharmacology

authors： Cascón-Pérez JD,Abellán-Huerta J,Giner-Caro JA,Dau-Villareal DF,Mármol-Lozano R,Jaulent-Huertas L,Bonilla-Pacheco YI,Ruiz-Abellón Mdel C,Picó-Aracil F,Castillo-Moreno JA

更新日期：2016-09-01 00:00:00

abstract：:Arrhythmias occur 24 h after occlusion of the left anterior descending (LAD) coronary artery in the canine heart and have been attributed to the abnormal spontaneous activity in subendocardial Purkinje fibers, which are markedly depolarized. The major current underlying normal automaticity in these fibers is i(f). Alt...

journal_title：Journal of cardiovascular pharmacology

authors： Lasker SM,Han D,Kline RP

更新日期：1997-05-01 00:00:00

abstract：:To establish a model of hypertension in marmosets, increasing doses of the immune-modulator cyclosporin (from 3 to 30 mg/kg/day) were given orally to marmosets for 31 days. Cyclosporin consistently induced hypertension with doses greater than or equal to 10 mg/kg/day. Time course and level of hypertension reached were...

journal_title：Journal of cardiovascular pharmacology

authors： Clozel JP,Fischli W

更新日期：1989-07-01 00:00:00

abstract：:To evaluate a possible mechanism for the chronic regulation of MAPK/ERK kinase-1 (MEK-1) and p42 mitogen-activated protein kinase (MAPK) we studied the long-term effects of the G-protein-coupled receptor agonist endothelin-1 (ET-1) and the protein tyrosine kinase-coupled receptor agonist platelet-derived growth factor...

journal_title：Journal of cardiovascular pharmacology

authors： Schramek H,Sorokin A,Watson RD,Dunn MJ

更新日期：1995-01-01 00:00:00

abstract：:The long-term efficacy of percutaneous transluminal coronary angioplasty (PTCA) is severely limited by the high incidence of vascular restenosis. Endothelin-1 (ET-1) has been implicated in the pathogenesis of this response, since circulating levels of this potent smooth-muscle mitogen are elevated after PTCA. Therefor...

journal_title：Journal of cardiovascular pharmacology

authors： Douglas SA,Ohlstein EH

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of long-term monotherapy with four beta-blockers provided with different pharmacological properties on plasma lipids in both normocholesterolemic and hypercholesterolemic hypertensive patients. After a 1-month run-in period on placebo, 70 hypertensive patients with bas...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Zoppi A,Tettamanti F,Poletti L,Lazzari P,Pasotti C,Corradi L

更新日期：1990-01-01 00:00:00

abstract：:The beta-blocking activity of flestolol was established during increasing isoprenaline infusions and during graded physical exercise in conscious, chronically instrumented dogs. After a control cycle, flestolol was infused at three doses (1, 2.67, and 10 micrograms/kg/min). Flestolol has an extremely short half-life, ...

journal_title：Journal of cardiovascular pharmacology

authors： Grohs JG,Fischer G,Raberger G

更新日期：1990-02-01 00:00:00

abstract：:The electrophysiologic effects of acutely and chronically administered amiodarone on canine Purkinje fibers were assessed using microelectrode techniques to record intracellular action potentials. Chronically treated dogs received amiodarone for 3 weeks (serum levels, 0.91 +/- 0.09 microgram/ml or 1.42 X 10(-6) M). Ac...

journal_title：Journal of cardiovascular pharmacology

authors： Gallagher JD,Bianchi J,Gessman LJ

更新日期：1989-05-01 00:00:00

abstract：:Our aim was to characterize and determine the function of endothelin (ET) receptor subtypes in human vascular tissue. Reverse transcriptase-polymerase chain reaction with nested oligonucleotide primers detected the presence of mRNA encoding both ETA and ETB receptors in the media from aorta and pulmonary and coronary ...

journal_title：Journal of cardiovascular pharmacology

authors： Davenport AP,O'Reilly G,Molenaar P,Maguire JJ,Kuc RE,Sharkey A,Bacon CR,Ferro A

更新日期：1993-01-01 00:00:00

abstract：:The prevention of coronary disease in hypertensive patients will see progress in the years to come. It is clearly too much, however, to expect this progress to come exclusively from the application of new therapies, as the incidence of coronary disease in hypertensive patients depends on several factors, which are, es...

journal_title：Journal of cardiovascular pharmacology

authors： Djian J

更新日期：1990-01-01 00:00:00

abstract：:Current drug screening methods are insufficiently predictive of clinical toxicity and efficacy. Recent advances in stem cell technology have the potential to improve drug screening. For tests of cardiotoxicity and efficacy of cardioactive drugs, cardiomyocytes derived from human embryonic stem cells and/or human induc...

journal_title：Journal of cardiovascular pharmacology

authors： Laposa RR

更新日期：2011-09-01 00:00:00

abstract：:Relative DA1-dopamine-receptor agonist and alpha-adrenoceptor antagonist activities of fenoldopam were determined in pentobarbital anesthetized dogs. The renal vasodilating effect of intravenous infusions of fenoldopam was used as an index of its DA1-agonist activity. Inhibition by fenoldopam of femoral vasoconstricti...

journal_title：Journal of cardiovascular pharmacology

authors： Kohli JD,Glock D,Goldberg LI

更新日期：1988-01-01 00:00:00

abstract：:Cilazapril (CLZ) is a new, long-acting nonsulfhydril converting enzyme inhibitor (ACE-I). Its effect on peak and trough sitting diastolic blood pressure (SDBP) was studied in a total of 85 patients with uncomplicated, essential hypertension at three centers. After 4 weeks of a single-blind placebo (PLA) run-in period,...

journal_title：Journal of cardiovascular pharmacology

authors： Güntzel P,Kobrin I,Pasquier C,Zimlichman R,Viskoper JR

更新日期：1991-01-01 00:00:00

abstract：:The signaling pathways of endothelin-1-induced contraction, including the role of protein tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK), protein kinase C (PKC) and RhoA/Rho-kinase were studied using rabbit basilar arteries by isometric tension and Western blot. The following results were observed: (1)...

journal_title：Journal of cardiovascular pharmacology

authors： Zubkov A,Miao L,Zhang J

更新日期：2004-11-01 00:00:00

abstract：:Myocardial alpha 1-adrenoceptor number has been reported to increase during ischaemia in myocytes consequent to an increase in acyl carnitine levels. We investigated whether this phenomenon occurs in vivo and whether the novel antiischaemic agent ranolazine will protect against it. Thirty-minute occlusion of the left ...

journal_title：Journal of cardiovascular pharmacology

authors： Allely MC,Brown CM,Kenny BA,Kilpatrick AT,Martin A,Spedding M

更新日期：1993-06-01 00:00:00

abstract：:At present, there is no information on endothelin-1 (ET-1)-mediated vascular effects in the human spleen. The objectives of this study were to investigate the in vitro vascular responses to ET-1 using pharmacologic probes (selective ET receptor agonists/antagonists) and to characterize the ET receptor population in th...

journal_title：Journal of cardiovascular pharmacology

authors： Faro R,Grassi-Kassise DM,Boin I,Withrington PG,Opgenorth TJ,Ferraz JG,Antunes E,de Nucci G

更新日期：1998-01-01 00:00:00

abstract：:Felodipine, a dihydropyridine calcium antagonist, was used to treat eight patients with severe uncontrolled hypertension: five had essential hypertension, two had renovascular disease, and one chronic pyelonephritis. Mean blood pressure (BP) was 221 +/- 14/120 +/- 4 mm Hg despite treatment with three or more antihyper...

journal_title：Journal of cardiovascular pharmacology

authors： Herlitz H,Granérus G,Aurell M

更新日期：1990-01-01 00:00:00

abstract：:Among other mediators, platelet-derived serotonin (5-HT) may contribute to thromboembolic complications of atherosclerosis. We determined whether long-term oral treatment with the 5-HT2 antagonist naftidrofuryl (NAF, 50 mg/kg daily for 12 weeks) alters platelet function in cholesterol-fed (1%) rabbits. Hypercholestero...

journal_title：Journal of cardiovascular pharmacology

authors： Weber AA,Hohlfeld T,Strobach H,Schrör K

更新日期：1993-02-01 00:00:00

abstract：:During ischemia-reperfusion an imbalance between endothelin (ET) and nitric oxide (NO) can be responsible for microcirculatory disturbances. The aim of this study was to restore the ET/NO balance to reduce the ischemia-reperfusion injury. Hepatic ischemia was induced for 30 min in 56 Wistar rats. Sham operation, ische...

journal_title：Journal of cardiovascular pharmacology

authors： Uhlmann D,Uhlmann S,Spiegel HU

更新日期：2000-11-01 00:00:00

abstract：:We investigated the effect of gallopamil on cardiac sarcoplasmic reticulum (SR) function. Heavy SR was prepared from bovine ventricular muscle. Oxalate-supported calcium uptake was stimulated by gallopamil at concentrations ranging from 10 to 300 nM, whereas higher concentrations were ineffective. Peak stimulation ave...

journal_title：Journal of cardiovascular pharmacology

authors： Zucchi R,Ronca-Testoni S,Limbruno U,Yu G,Galbani P,Ronca G,Mariani M

更新日期：1992-01-01 00:00:00

abstract：UNLABELLED:The role of mitochondrial transporters in the cardioprotection of rat hearts exposed to high [K+]-low [Ca2+]-cardioplegia (CPG) and ischemia and reperfusion (I/R) was studied through the mechano-energetic consequences of target drugs. The total heat rate (Ht) and the left intraventricular pressure (LVP) were...

journal_title：Journal of cardiovascular pharmacology

authors： Ragone MI,Consolini AE

更新日期：2009-09-01 00:00:00