Cardioprotective Effects of Atorvastatin Are Mediated Through PPARγ in Paraquat-Exposed Rats.

abstract：:Recently, we have reported two cases with endothelin (ET)-secreting tumor presenting with hypertension and elevated plasma endothelin-1 (ET-1) levels. The present study examines the histopathology of the ET-secreting tumor in one of these cases. The neoplasm was located in the skin and microscopically characterized as...

journal_title：Journal of cardiovascular pharmacology

authors： Yokokawa K,Tahara H,Kohno M,Murakawa K,Yasunari K,Nakagawa K,Hamada T,Otani S,Yanagisawa M,Takeda T

更新日期：1991-01-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is generally thought to be a central nervous system depressant; however, GHB also has sympathomimetic cardiovascular actions. Radio telemetry was used to record the cardiovascular responses elicited by GHB (180-1000 mg/kg IV) in conscious rats. GHB elicited increases in mean arterial pressu...

journal_title：Journal of cardiovascular pharmacology

authors： Hicks AR,Kapusta DR,Varner KJ

更新日期：2004-12-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is known to alter the pharmacokinetics of several antiarrhythmic agents. To study the effects of AMI on the kinetics of mexiletine (MEX), a single intravenous dose of 200 mg MEX HCl was infused over 30 min in 11 patients with AMI. The study was performed within 24 h of the onset of pa...

journal_title：Journal of cardiovascular pharmacology

authors： Pentikäinen PJ,Halinen MO,Helin MJ

更新日期：1984-01-01 00:00:00

abstract：:The exact mechanism of mechano-electrical feedback and stretch-induced arrhythmias is unknown, but the role of stretch-activated ion channels and specific calcium channels has been proposed. The aim of the present study was to test the hypothesis that stretch-activated ion channels and not calcium channels contribute ...

journal_title：Journal of cardiovascular pharmacology

authors： Eckardt L,Kirchhof P,Mönnig G,Breithardt G,Borggrefe M,Haverkamp W

更新日期：2000-12-01 00:00:00

abstract：:Kinins locally synthesized in the cardiovascular tissue are believed to contribute to the regulation of cardiovascular homeostasis by stimulating the endothelial cells to release nitric oxide, prostacyclin, or a hyperpolarizing factor via autocrine-paracrine mechanisms. This study was designed to investigate the actio...

journal_title：Journal of cardiovascular pharmacology

authors： Kanna T,Akata T,Izumi K,Nakashima M,Yonemitsu Y,Hashizume M,Takahashi S

更新日期：2002-11-01 00:00:00

abstract：:A brief review is given of the vasodilators that require an intact vascular endothelium to exert their relaxing effect. Then some major issues of the phenomenon of endothelium-dependent smooth muscle relaxation are discussed in more detail: The chemical structure of the endothelium-derived relaxing factor (EDRF), whic...

journal_title：Journal of cardiovascular pharmacology

authors： Förstermann U

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Telmisartan is an angiotensin II receptor blocker, which acts as a partial agonist of peroxisome proliferator activator receptor-γ (PPAR-γ). Because PPAR-γ initiates a variety of antiinflammatory responses, the effect on myocardial ischemia is to be elucidated. METHODS AND RESULTS:The left anterior descendi...

journal_title：Journal of cardiovascular pharmacology

authors： Nagashima A,Watanabe R,Ogawa M,Suzuki J,Masumura M,Hishikari K,Shimizu T,Takayama K,Hirata Y,Nagai R,Isobe M

更新日期：2012-08-01 00:00:00

abstract：:The complementary antihypertensive effects of the beta-blocker/calcium antagonist combination has to be weighed against their additive and potentially detrimental negative inotropic, chronotropic, and dromotropic effects inherent in both classes of drugs. We reviewed the main adversity, particularly electrophysiologic...

journal_title：Journal of cardiovascular pharmacology

authors： Brouwer RM,Follath F,Bühler FR

更新日期：1985-01-01 00:00:00

abstract：:We have recently shown that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and store-operated Ca2+ channel (SOCC). These channels can be pharmacologically discriminated using 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1-H-imidazoe l h...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang XF,Iwamuro Y,Okamoto Y,Kawanabe Y,Masaki T,Miwa S

更新日期：2000-11-01 00:00:00

abstract：:N-[3,5-Dichlorophenyl] 4-[4-hydroxy-2-methoxy-phenyl] piperazine carboxamidine dihydrochloride (RS-87337) is a chemically novel antiarrhythmic agent with an electrophysiologic profile characteristic of both class III and class Ia compounds as defined by Vaughan-Williams and Campbell. In isolated superfused guinea pig ...

journal_title：Journal of cardiovascular pharmacology

authors： Dumez D,Patmore L,Ferrandon P,Allely M,Armstrong JM

更新日期：1989-08-01 00:00:00

abstract：:Experiments were carried out on isolated canine right atria to investigate the effects of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil, SG-75) and its interaction with beta-adrenoceptor stimulation on the cyclic nucleotide levels accompanying inotropic changes. The results were compared with those during muscari...

journal_title：Journal of cardiovascular pharmacology

authors： Endoh M,Iijima T

更新日期：1983-09-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of long-term monotherapy with four beta-blockers provided with different pharmacological properties on plasma lipids in both normocholesterolemic and hypercholesterolemic hypertensive patients. After a 1-month run-in period on placebo, 70 hypertensive patients with bas...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Zoppi A,Tettamanti F,Poletti L,Lazzari P,Pasotti C,Corradi L

更新日期：1990-01-01 00:00:00

abstract：:The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris. Hemodynamic indices were measured by impedance cardiography and echocardiography and bicyc...

journal_title：Journal of cardiovascular pharmacology

authors： Andreyev N,Bichkov I,Skutelis A,Andreyeva T

更新日期：1991-01-01 00:00:00

abstract：:A randomized, double-blind, parallel-group study comparing the efficacy and tolerability of once-daily diltiazem capsules with amlodipine tablets in patients with stable angina. After a run-in period of 1 to 3 weeks, 34 patients received once-daily diltiazem and 33 patients received amlodipine. Patients received eithe...

journal_title：Journal of cardiovascular pharmacology

authors： Chugh SK,Digpal K,Hutchinson T,McDonald CJ,Miller AJ,Lahiri A

更新日期：2001-09-01 00:00:00

abstract：:Prostaglandin E1 (PGE1) has been reported to be a coronary vasodilator and has been considered clinically in the treatment of coronary vasospasm, but its mechanism of action is not known. To evaluate the vasomotor effect of PGE1, epicardial coronary and distal resistance vessel responses were compared by PGE1 and nitr...

journal_title：Journal of cardiovascular pharmacology

authors： Miller WL,Bove AA

更新日期：1989-08-01 00:00:00

abstract：:Vasoconstrictor responses to intraluminal and extraluminal 5-hydroxytryptamine (5-HT) were studied in isolated mesenteric resistance arteries of Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). Third-order branches of mesenteric arteries were dissected free and mounted on glass cannulae in organ cha...

journal_title：Journal of cardiovascular pharmacology

authors： Dohi Y,Lüscher TF

更新日期：1991-08-01 00:00:00

abstract：:The effects of bilateral sinoaortic denervation were examined in rabbits in vivo and in vitro. In the in vivo studies the effects of intravenous administration of the alpha-adrenoceptor agonists phenylephrine and guanabenz and the antagonists prazosin and phentolamine on mean arterial pressure, heart rate, and plasma ...

journal_title：Journal of cardiovascular pharmacology

authors： Berthelot A,Hamilton CA,Petty MA,Reid JL

更新日期：1982-07-01 00:00:00

abstract：:The elderly are reported to be less sensitive to the beta-blocking effects of propranolol. However, age-related changes in the stereoselective pharmacokinetics or protein binding of propranolol enantiomers could have confounded the results of previous studies because only 1-propranolol contributes significantly to the...

journal_title：Journal of cardiovascular pharmacology

authors： Tenero DM,Bottorff MB,Burlew BS,Williams JB,Lalonde RL

更新日期：1990-11-01 00:00:00

abstract：:The aim of this study was to determine whether tumor necrosis factor (TNF)-alpha would impair basal and stimulated endothelium-dependent vasomotion in human resistance vessel. Changes in baseline and acetylcholine (ACh)-induced forearm vascular resistance (FVR) were measured plethysmographically before and after a low...

journal_title：Journal of cardiovascular pharmacology

authors： Nakamura M,Yoshida H,Arakawa N,Saitoh S,Satoh M,Hiramori K

更新日期：2000-10-01 00:00:00

abstract：:This study was undertaken to determine and confer the cardioprotective effects of the adenosine A2 receptor (A2AR) and its impact on myocardial autophagy in the setting of reperfusion. We established a rat ischemia model by subjecting rats to 30 minutes of ischemia (I) and 120 minutes of reperfusion (R). The A2AR agon...

journal_title：Journal of cardiovascular pharmacology

authors： Ke J,Yao B,Li T,Cui S,Ding H

更新日期：2015-07-01 00:00:00

abstract：:During myocardial ischemia, the extracellular potassium concentration increases in a triphasic pattern, an initial early increase, a constant phase, and a late increasing phase. The aim of this study was to determine whether diltiazem inhibits the late increasing phase by maintaining glycolytic adenosine triphosphate ...

journal_title：Journal of cardiovascular pharmacology

authors： Sakamoto K,Yamazaki J,Nagao T

更新日期：1997-10-01 00:00:00

abstract：:Experiments were designed to examine mechanisms of relaxations to nitric oxide (NO) in venous smooth muscle. Rings of canine femoral veins without endothelium were suspended for measurement of isometric force in organ chambers. Concentration-response curves to NO and 8-Br-cyclic guanosine monophosphate (cGMP) were obt...

journal_title：Journal of cardiovascular pharmacology

authors： Bracamonte MP,Burnett JC Jr,Miller VM

更新日期：1999-09-01 00:00:00

abstract：:alpha-Adrenoceptor agonists and antagonists are widely used perioperatively for internal mammary artery (IMA)-coronary artery bypass operations. To determine subtypes of alpha-adrenoceptors in the human IMA, we studied responses of isolated human IMA segments to alpha-adrenoceptor agonists, antagonists, and electrical...

journal_title：Journal of cardiovascular pharmacology

authors： He GW,Shaw J,Hughes CF,Yang CQ,Thomson DS,McCaughan B,Hendle PN,Baird DK

更新日期：1993-02-01 00:00:00

abstract：:We compared left ventricular (LV) hemodynamics, LV muscle mass (LVMM), and LV geometry of 13 spontaneously hypertensive rats (SHRs) treated for 20 weeks with nifedipine (30 mg/kg/day) with those of 11 age-matched untreated SHRs. LVMM, LVMM related to end-diastolic volume (LVMM/EDV), LV pressure (PLV), systolic wall st...

journal_title：Journal of cardiovascular pharmacology

authors： Motz W,Ploeger M,Ringsgwandl G,Goeldel N,Garthoff B,Kazda S,Strauer BE

更新日期：1983-01-01 00:00:00

abstract：:Dilevalol, the stereoisomer of labetalol, was given in repeated incremental intravenous bolus injections to 10 patients with severe hypertension requiring urgent blood pressure lowering. The mean cumulative dose of dilevalol was 445 +/- 165 mg. Blood pressure was reduced from 201 +/- 33/131 +/- 13 to 150 +/- 12/109 +/...

journal_title：Journal of cardiovascular pharmacology

authors： Bursztyn M,Gavras I,Blasucci DJ,Gavras H

更新日期：1989-05-01 00:00:00

abstract：:Twenty-three patients [mean age 49.7 +/- 5.6 years (WHO II-III)] with severe hypertension and not responding to previous drug treatment were included in the study to evaluate the effect of nitrendipine (NTP) as monotherapy and also in combination with propranolol (PRO). After a control period of 10 days, NTP was start...

journal_title：Journal of cardiovascular pharmacology

authors： Faulhaber HD,Gruner R,Homuth V,Naumann E,Menz M,Hartrodt W,Schmidt J,Mohnike W

更新日期：1988-01-01 00:00:00

abstract：:We investigated the effects of sodium 2[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (POCA) on regional myocardial function and metabolism in anesthetized, thoracotomized dogs subjected to a 53.5% reduction in flow through the circumflex branch of the left coronary artery (LCX). Regional function in the area suppl...

journal_title：Journal of cardiovascular pharmacology

authors： Seitelberger R,Kraupp O,Winkler M,Brugger G,Raberger G

更新日期：1985-03-01 00:00:00

abstract：:This review deals with cellular factors that contribute to individualities of vascular smooth-muscle function in different organ systems and at different levels of the vascular tree. Particular attention has been given to: membrane receptors responsive to catecholamines, serotonin, angiotensin II, dopamine, and acetyl...

journal_title：Journal of cardiovascular pharmacology

authors： Bell DR,Webb RC,Bohr DF

更新日期：1985-01-01 00:00:00

abstract：:Endothelins (ETs) are a family of peptide hormones that act on G protein-coupled ET(A) and ET(B) receptors. ETs exert inotropic and chronotropic actions in the heart. Myocardial ischemia is associated with increased plasma levels of ET and cell swelling. We examined the effect of ETs on dog atrial swelling-induced chl...

journal_title：Journal of cardiovascular pharmacology

authors： Du XY,Sorota S

更新日期：2000-05-01 00:00:00

abstract：:The advent of biologic therapy has enhanced our ability to augment disease in an increasingly targeted manner. The use of biologics in cardiovascular disease (CVD) has steadily increased over the past several decades. Much of the early data on biologics and CVD were derived from their use in rheumatologic populations....

journal_title：Journal of cardiovascular pharmacology

authors： Van Taunay JS,Albelda MT,Frias JC,Lipinski MJ

更新日期：2018-08-01 00:00:00