Endothelin-1 promotes neointima formation after balloon angioplasty in the rat.

abstract：:Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the effects of torasemi...

journal_title：Journal of cardiovascular pharmacology

authors： Harada K,Izawa H,Nishizawa T,Hirashiki A,Murase Y,Kobayashi M,Isobe S,Cheng XW,Noda A,Nagata K,Yokota M,Murohara T

更新日期：2009-06-01 00:00:00

abstract：:Hypertension is associated with dyslipidemia, which is a significant risk factor for cardiovascular complications. This study was undertaken to investigate the effects of veratric acid (VA) on blood pressure, plasma, and tissue lipid profile in N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Hypert...

journal_title：Journal of cardiovascular pharmacology

authors： Saravanakumar M,Raja B

更新日期：2012-06-01 00:00:00

abstract：:Antiarrhythmic concentrations of disopyramide in canine plasma and myocardium were determined by gas chromatography. Ventricular tachycardia was incuded in anesthetized dogs by the intravenous administration of ouabain. Disopyramide phosphate was then administered by a two-stage continuous infusion method. A rapid inf...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Stetson P,Lucchesi BR

更新日期：1979-09-01 00:00:00

abstract：:The regulation of coronary hemodynamics is a complex process. One important factor that interferes with the regulation of coronary tone is the pathophysiological state of the vessels: stimuli that in normal vessels provoke no or only a slight vasoconstriction may cause a severe vasoconstriction in diseased vessels. Th...

journal_title：Journal of cardiovascular pharmacology

authors： van Gilst WH,Tio RA,van Wijngaarden J,de Graeff PA,Wesseling H

更新日期：1992-01-01 00:00:00

abstract：:Spirapril (SCH 33844; 7-N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-(S)-alanyl-1,4-dithia- 7-azaspiro[4,4]-nonane-8(S)-carboxylic acid) is a new angiotensin-converting enzyme (ACE) inhibitor. SCH 33844 diacid inhibited hydrolysis of hip-his-leu by rabbit lung ACE in a potent (Ki = 0.74 nM), selective, and noncompetitive fa...

journal_title：Journal of cardiovascular pharmacology

authors： Sybertz EJ,Watkins RW,Ahn HS,Baum T,La Rocca P,Patrick J,Leitz F

更新日期：1987-01-01 00:00:00

abstract：:The effects of angiotensin-converting enzyme inhibitor captopril on infarct size and cardiovascular hemodynamics were studied in 35 conscious dogs subjected to 24 h of coronary occlusion. Following occlusion of the left anterior descending coronary artery, 10 dogs were infused with captopril 0.25 mg/kg/h i.v. (group 1...

journal_title：Journal of cardiovascular pharmacology

authors： Daniell HB,Carson RR,Ballard KD,Thomas GR,Privitera PJ

更新日期：1984-11-01 00:00:00

abstract：:Forty patients (aged 28-66 years) with essential hypertension were randomized to 14 weeks of treatment with diltiazem or hydrochlorothiazide (HCTZ) in a double-blind, parallel study design. A significant reduction in supine body weight (-6.0 +/- 1.5 lb; p less than 0.001) and increase in pulse (+6 +/- 2 beats/min; p l...

journal_title：Journal of cardiovascular pharmacology

authors： Swartz SL

更新日期：1987-04-01 00:00:00

abstract：:The antihypertensive effect of the combination of ketanserin, a new antiserotonergic agent, and thiazide has been evaluated in 35 patients with arterial hypertension of mild to moderate degree in the greater than 50-year-old age group. Twenty patients were given ketanserin (20 mg) + hydrochlorothiazide (25 mg) (treatm...

journal_title：Journal of cardiovascular pharmacology

authors： Ferrara LA,Fasano ML,Soro S,Pasanisi F,Mancini M

更新日期：1987-01-01 00:00:00

abstract：:Coronary arteries from animals on normal diets (ND) exhibit well-maintained responses to dilators under ischemic conditions. The reported altered metabolic requirements and K+-currents in blood vessels from hypercholesterolemic animals fed high-fat diets (HF) led us to hypothesize that under metabolically depressed co...

journal_title：Journal of cardiovascular pharmacology

authors： Franke R,Yang Y,Rubin LJ,Magliola L,Jones AW

更新日期：2004-04-01 00:00:00

abstract：:Qiliqiangxin (QL), a traditional Chinese medicine, has been used in the treatment of chronic heart failure. However, whether QL can benefit cardiac remodeling in the hypertensive state is unknown. We here examined the effects of QL on the development of cardiac hypertrophy through comparing those of losartan in C57BL/...

journal_title：Journal of cardiovascular pharmacology

authors： Zou Y,Lin L,Ye Y,Wei J,Zhou N,Liang Y,Gong H,Li L,Wu J,Li Y,Jia Z,Wu Y,Zhou J,Ge J

更新日期：2012-03-01 00:00:00

abstract：:Endothelin-1[1-31] is a recently discovered member of the endothelin family with vasoactive properties in several animal models and in man in vivo. It is generated from big endothelin-1 by human mast cell chymase and may be a novel intermediary peptide in the production of endothelin-1[1-21]. Given that both big endot...

journal_title：Journal of cardiovascular pharmacology

authors： Leslie SJ,Johnston N,Strachan FE,Bagnall A,Gray GA,Newby DE,Denvir MA,Webb DJ

更新日期：2004-11-01 00:00:00

abstract：:We conducted an intracardiac study of the electrophysiologic effects and kinetics of intravenous nicardipine (N) in 16 patients with or without impaired cardiac conduction, using a randomized, double-blind, crossover design versus placebo (P). N or P were infused intravenously over 5 min: the dose of N was 9.46 +/- 3....

journal_title：Journal of cardiovascular pharmacology

authors： David D,Guize L,Leheuzey JY,Lavergne T,Loria Y,Ourbak P

更新日期：1990-01-01 00:00:00

abstract：:Chronic rapid right ventricular pacing (RRVP) at 250 beats/min produces low cardiac output (CO) heart failure, marked reduction in total vascular capacitance, and a shift in volume centrally. The effect of converting enzyme inhibition with captopril on cardiac preload was investigated in this model of heart failure. E...

journal_title：Journal of cardiovascular pharmacology

authors： Ogilvie RI,Zborowska-Sluis D

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Factor Xa (FXa) has been a target of considerable interest for drug development efforts aimed at suppressing thrombosis. In this report, a new orally active, small molecule, active-site directed FXa inhibitor, GW813893, has been profiled in a succession of in vitro and in vivo assays involved in its preclini...

journal_title：Journal of cardiovascular pharmacology

authors： Abboud MA,Needle SJ,Burns-Kurtis CL,Valocik RE,Koster PF,Amour AJ,Chan C,Brown D,Chaudry L,Zhou P,Patikis A,Patel C,Pateman AJ,Young RJ,Watson NS,Toomey JR

更新日期：2008-07-01 00:00:00

abstract：:The main therapeutic strategies for treating atrial fibrillation include rate control, maintenance of sinus rhythm, and antiembolic treatment. Current antiarrhythmic drugs are effective in about 50% of patients and are often associated with adverse effects. Multiple trials suggest that rate control with proper anticoa...

journal_title：Journal of cardiovascular pharmacology

authors： Naccarelli GV,Gonzalez MD

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that endogenous sex hormones regulate vascular reactivity, and testosterone may contribute to the worse prognosis for renal disease in men. Male Zucker diabetic rats exhibit improved renal hemodynamic responses after castration. It is, however, unclear whether endogenous testoste...

journal_title：Journal of cardiovascular pharmacology

authors： Ajayi AA,Fidelis P

更新日期：2006-11-01 00:00:00

abstract：:Amlodipine, a new long-acting dihydropyridine calcium antagonist, was compared with hydrochlorothiazie (HCTZ) in 145 patients with mild to moderate hypertension. After 4 weeks of single-blind placebo runin, patients were randomly allocated to receive amlodipine (2.5-10 mg once daily, n = 97) or HCTZ (25-100 mg once da...

journal_title：Journal of cardiovascular pharmacology

authors： Burris JF,Ames RP,Applegate WB,Ram CV,Davidov ME,Mroczek WJ

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Genetic loci predict <5% of variation in low-density lipoprotein cholesterol (LDL-C) response to statins. Cholestanol and desmosterol are plasma markers of cholesterol absorption and synthesis, respectively. Because statins lower LDL-C by inhibiting cholesterol synthesis, we studied the relationship between c...

journal_title：Journal of cardiovascular pharmacology

authors： Hoenig MR,Walker PJ,Gurnsey C,Beadle K,Johnson L

更新日期：2010-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) and ATP are considered cotransmitters with norepinephrine (NE) in sympathetic neurons innervating some blood vessels, including those of the mesentery. A prominent action of NPY is to potentiate the postjunctional contractile effect of NE as well as that of other vasoactive agents. We wished to in...

journal_title：Journal of cardiovascular pharmacology

authors： Westfall TC,Yang CL,Curfman-Falvey M

更新日期：1995-11-01 00:00:00

abstract：:Dobutamine is frequently used for acute therapy in heart failure. In the present study, the hemodynamic effects of long-term intermittent dobutamine therapy were investigated in conscious rats with heart failure. Rats with healed myocardial infarctions received two i.p. injections of dobutamine per day for 2 weeks. He...

journal_title：Journal of cardiovascular pharmacology

authors： Schoemaker RG,Debets JJ,Struyker-Boudier HA,Smits JF

更新日期：1991-06-01 00:00:00

abstract：:Heart failure after myocardial infarction (MI) is associated with endothelial dysfunction. There is conflicting evidence on the exact nature of this endothelial dysfunction and how endothelium-dependent vasodilation is affected by angiotensin-converting enzyme inhibitor (ACE-I) therapy. Furthermore, consequences of ac...

journal_title：Journal of cardiovascular pharmacology

authors： Westendorp B,Schoemaker RG,van Gilst WH,Buikema H

更新日期：2005-12-01 00:00:00

abstract：:Traditionally, antihypertensive medications were used in few children or adolescents, usually just those with underlying renal or other organ system disease. However, with recent data suggesting that the incidence of primary hypertension may be increasing in the young, it is possible that more children and adolescents...

journal_title：Journal of cardiovascular pharmacology

authors： Flynn JT

更新日期：2011-08-01 00:00:00

abstract：:Labedipinedilol-A is a novel 1, 4-dihydropyridine type calcium antagonist with alpha-receptor blocking activity. This study investigates the effects of labedipinedilol-A on mitogen-induced proliferation of rat vascular smooth muscle cells (VSMCs). Labedipinedilol-A's inhibition on cell proliferation was measured by th...

journal_title：Journal of cardiovascular pharmacology

authors： Liou SF,Yeh JL,Liang JC,Chiu CC,Lin YT,Chen IJ

更新日期：2004-11-01 00:00:00

abstract：:Erythropoietin (EPO) has been linked to cardioprotective effects. However, its effects during the aging process are little known. We investigated the effect of EPO administration on hemodynamic parameters, cardiac function, oxidative damage, and erythropoietin receptor (EPOR) expression pattern in the hypovolemic stat...

journal_title：Journal of cardiovascular pharmacology

authors： Puchulu MB,Arreche N,Zotta E,Donato M,Ogonowski N,Fellet A,Balaszczuk AM

更新日期：2019-05-01 00:00:00

abstract：:Peripheral vascular resistance, arterial blood pressure, and left ventricular hypertrophy (LVH) are closely related. In systemic hypertension, hemodynamic changes in systolic and diastolic function accompany LVH. Both of these cardiac functions are detected with echocardiography and were measured during this study in ...

journal_title：Journal of cardiovascular pharmacology

authors： Moisejev VS,Ivleva AY,Gurochkin AB,Kobalava ZD

更新日期：1994-01-01 00:00:00

abstract：:To investigate the effects of endothelin blockade initiated immediately after the onset of myocardial infarction on survival and left ventricular remodeling, treatment with the nonselective receptor antagonist TAK-044 (n = 22) or saline (n = 19) for 3 weeks was initiated immediately after coronary ligation in rats. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi C,Kagaya Y,Namiuchi S,Takeda M,Fukuchi M,Otani H,Ninomiya M,Yamane Y,Kohzuki M,Watanabe J,Shirato K

更新日期：2001-07-01 00:00:00

abstract：:In this study we compared the antithrombotic and anticoagulant properties of sodium and calcium derivatives of pentosan polysulfate (Na-PPS, Ca-PPS), unfractionated heparin (UFH), and low-molecular-weight heparin (Fraxiparin). The antithrombotic effects of these agents have been investigated in an experimental thrombo...

journal_title：Journal of cardiovascular pharmacology

authors： Giedrojć J,Klimiuk M,Radziwon P,Kłoczko J,Bielawiec M,Breddin HK

更新日期：1999-09-01 00:00:00

abstract：:The signaling impact of a human beta1-adrenergic receptor (beta1 AR) polymorphism at residue 49 of the aminoterminus (Ser-to-Gly substitution) was studied by recombinantly expressing each receptor. The two receptors displayed identical agonist and antagonist binding affinities. Furthermore, basal and agonist-stimulate...

journal_title：Journal of cardiovascular pharmacology

authors： Rathz DA,Brown KM,Kramer LA,Liggett SB

更新日期：2002-02-01 00:00:00

abstract：:Three consecutive periods in the natural history of atherosclerosis are amenable to medical treatment. Plaque development is the main target of prevention, which also aims at slowing the progression of already existing plaques. The control of several established risk factors (high blood cholesterol, high blood pressur...

journal_title：Journal of cardiovascular pharmacology

authors： Capron L

更新日期：1995-01-01 00:00:00

abstract：:The short half-life, low plasma concentrations, and extensive biotransformation of prazosin suggest that it might be subject to extensive first-pass metabolism. Bioavailability, disposition, and hepatic extraction were studied in the dog. In conscious dogs whole blood prazosin concentrations were measured after oral a...

journal_title：Journal of cardiovascular pharmacology

authors： Rubin P,Yee YG,Anderson M,Blaschke T

更新日期：1979-11-01 00:00:00