Neuropeptide-Y-ATP interactions at the vascular sympathetic neuroeffector junction.

abstract：:The influence of isoniazid (ISO) preincubation on the relaxant effects of a group of nitrovasodilators was examined in norepinephrine-contracted rat aortic rings with and without endothelium. ISO displaced to the left the dose-response curves to all nitrovasodilators and increased the negative logarithm of their media...

journal_title：Journal of cardiovascular pharmacology

authors： Vidrio H,Fernández G

更新日期：1998-09-01 00:00:00

abstract：:Spirapril is a new angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug with a resorption of about 50%. The active metabolite spiraprilat reaches maximal plasma concentration within 2-3 h after oral administration. Spirapril can be administered once daily because of its long duration of action caused by an e...

journal_title：Journal of cardiovascular pharmacology

authors： Hayduk K,Kraul H

更新日期：1999-08-01 00:00:00

abstract：:Endothelin-1 (ET-1) not only causes potent vasoconstriction but also leads to fluid retention, both actions mediated by ET(A)- and/or ET(B)-receptors. Selective ET(A)- and combined ET(A)/ET(B)-receptor antagonists improve hemodynamics in heart failure; however, it is also important to evaluate the effects of these ant...

journal_title：Journal of cardiovascular pharmacology

authors： Ohnishi M,Wada A,Tsutamoto T,Sawaki M,Fujii M,Matsumoto T,Kinoshita M

更新日期：2000-11-01 00:00:00

abstract：:Meobentine (sulfate) has antifibrillatory and antiarrhythmic activity in canine models. The antiarrhythmic, pharmacokinetic, and adrenergic neuronal blocking effects of meobentine were assessed in 15 patients with chronic, high-frequency ventricular ectopic depolarizations (VEDs). Eleven of the 15 patients had recurre...

journal_title：Journal of cardiovascular pharmacology

authors： Duff HJ,Oates JA,Roden DM,Woosley RL

更新日期：1984-07-01 00:00:00

abstract：:Atherosclerosis is a complex vascular disease initiated by abnormal accumulation of plasma lipoproteins in the subendothelial space. Elevated levels of plasma triglycerides (TG) and low-density lipoprotein (LDL)-cholesterol as well as low concentrations of high-density lipoprotein (HDL) play a causal role in the devel...

journal_title：Journal of cardiovascular pharmacology

authors： Declercq V,Yeganeh B,Moshtaghi-Kashanian GR,Khademi H,Bahadori B,Moghadasian MH

更新日期：2005-07-01 00:00:00

abstract：:In conscious, spontaneously hypertensive rats (SHR) oral prazosin (0.03-3.0 mg/kg) resulted in dose-related reductions of systolic blood pressure measured with a tail cuff. In SHR whose tail artery blood pressure was continuously monitored the antihypertensive effect of prazosin (1.0 mg/kg, p.o.) was accompanied by a ...

journal_title：Journal of cardiovascular pharmacology

authors： Lefèvre-Borg F,Roach AG,Gomeni R,Cavero I

更新日期：1979-01-01 00:00:00

abstract：SUMMARY:The present study reports the effects of apomorphine (APO) on blood pressure and the principal site of action of this agonist in 4-week deoxycorticosterone-acetate (DOCA)-hypertensive conscious rats. In these preprations, intravenous (i.v.) administration of APO (0.50-1 mg/kg) induced short-lasting and dose-dep...

journal_title：Journal of cardiovascular pharmacology

authors： Toscano CF,Lahlou S

更新日期：2003-12-01 00:00:00

abstract：:In this retrospective study, a group of 435 patients provided meaningful analyses of blood pressure and dosage data for treatment periods of up to 4.5 years. The protocol, study objectives, and pretreatment demographic characteristics of the group are summarized in this report, which is the first in a series in this i...

journal_title：Journal of cardiovascular pharmacology

authors： Itskovitz HD,Menduke H

更新日期：1981-01-01 00:00:00

abstract：:The area of vulnerability (AOV) to ventricular fibrillation (VF) induction by high-voltage shocks has been proposed as a measure of vulnerability to VF. Biphasic shocks spanning the T wave and ranging between 50 V and the upper limit of vulnerability (ULV) to VF were delivered before and after terikalant (1 mg/kg) and...

journal_title：Journal of cardiovascular pharmacology

authors： Qi X,Varma P,Newman D,Mamalias N,Dorian P

更新日期：2002-02-01 00:00:00

abstract：:The pharmacokinetics of losartan and EXP3174, an active metabolite of losartan, were evaluated in the anesthetized pig after both a single intravenous dose (3 mg/kg) and during constant intravenous infusion. The pharmacodynamic activities of losartan and EXP3174 were determined during constant intravenous infusion as ...

journal_title：Journal of cardiovascular pharmacology

authors： Lankford SM,Plummer D,Hellyer P,Christ DD,Bai SA

更新日期：1997-11-01 00:00:00

abstract：:Nicorandil, a potent coronary vasorelaxant used in the treatment of angina, has differential effects on arteries and veins in vivo. To explain this phenomenon, experiments were designed to characterize the relaxant and inhibitory actions of this compound on canine isolated arteries and veins. Paired rings of canine co...

journal_title：Journal of cardiovascular pharmacology

authors： Morrison KJ,Flavahan NA,Vanhoutte PM

更新日期：1990-05-01 00:00:00

abstract：:The purpose of this study was to examine the sympathetic-parasympathetic interactions on heart rate through release of neuropeptide Y (NPY) and its action on prejunctional NPY Y2 receptors on vagal and sympathetic nerve fibers. In other studies on various preparations and in various organs, attenuation of transmitter ...

journal_title：Journal of cardiovascular pharmacology

authors： Ilebekk A,Björkman JA,Nordlander M

更新日期：2005-10-01 00:00:00

abstract：:To determine whether differential release of nitric oxide underlies the diversity of regional kidney blood flow responses to vasoactive agents, this study examined how nitric oxide synthase blockade with IV N(G)-nitro-L-arginine (L-NNA), and also IV L-NNA plus co-infusion of glyceryl trinitrate, affected responses to ...

journal_title：Journal of cardiovascular pharmacology

authors： Rajapakse NW,Oliver JJ,Evans RG

更新日期：2002-08-01 00:00:00

abstract：:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 > nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >...

journal_title：Journal of cardiovascular pharmacology

authors： Bossaller C,Auch-Schwelk W,Graf K,Gräfe M,Catadelgirmen G,Ennker J,Fleck E

更新日期：1992-01-01 00:00:00

abstract：:The integration of the needs of children into the legal drug development process since 1997 in the United States and since 2007 in the European Union has improved health and stimulated innovative approaches in the design of clinical trials and will benefit both current and future populations. According to the US Food ...

journal_title：Journal of cardiovascular pharmacology

authors： Läer S

更新日期：2011-09-01 00:00:00

abstract：:It has been suggested that isosorbide dinitrate (ISDN)-induced venodilation could be ascribed to preferential accumulation of the agent in venous tissues, resulting in higher concentrations of nitric oxide (NO). Here, the authors investigated whether the venodilating effect of ISDN is associated with a preferential in...

journal_title：Journal of cardiovascular pharmacology

authors： Ishibashi T,Himeno M,Kubota K,Matsubara T,Hori T,Ozaki K,Yamazoe M,Aizawa Y,Yoshida J,Nishio M

更新日期：2003-01-01 00:00:00

abstract：:We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-induced myocardial systolic shortening and malonylaldehyde production an...

journal_title：Journal of cardiovascular pharmacology

authors： Kim YD,Farhat MY,Myers AK,Kouretas P,DeGroot KW,Pacquing A,Ramwell PW,Suyderhoud JP,Lees DE

更新日期：1998-09-01 00:00:00

abstract：:We investigated the potential role of atorvastatin, given at reperfusion, to improve survival of the ischemic/reperfused myocardium by activation of p44/42 MAPK and p38 MAPK with its downstream effector, HSP27. We have previously shown that atorvastatin attenuates lethal reperfusion-induced injury via activation of th...

journal_title：Journal of cardiovascular pharmacology

authors： Efthymiou CA,Mocanu MM,Yellon DM

更新日期：2005-03-01 00:00:00

abstract：:Endothelin-1 (ET-1) is an endothelium-derived peptide with powerful vasoconstrictor and mitogenic properties. A pathophysiologic role for ET-1 has been suggested, because increased plasma and tissue levels of this peptide have been described in a number of disease states, including atherosclerosis. Immunocytochemistry...

journal_title：Journal of cardiovascular pharmacology

authors： Timm M,Kaski JC,Dashwood MR

更新日期：1995-01-01 00:00:00

abstract：:The relationship between adrenergic nerve activity and neuronal uptake was investigated. Helically cut strips of rat tail artery were mounted in organ chambers and isometric contractions were recorded. Spontaneous contractions were occasionally observed and these contractions were blocked by phentolamine. Cumulative a...

journal_title：Journal of cardiovascular pharmacology

authors： Webb RC,Vanhoutte PM,Bohr DF

更新日期：1980-01-01 00:00:00

abstract：:We examined whether the activation of the renin-angiotensin system after intramuscular isoprenaline injection contributes to the simultaneous increase in vasopressin release. Plasma concentrations of vasopressin and angiotensin II were measured in conscious rats using specific radioimmunoassays. Intravenous infusions ...

journal_title：Journal of cardiovascular pharmacology

authors： Knepel W,Meyer DK

更新日期：1980-11-01 00:00:00

abstract：:Erythrocyte lithium-sodium countertransport, a mode of ouabain-insensitive monovalent cation metabolism, is increased in human essential hypertension, but no pathophysiological link to hypertension has yet been established. Similarities between red cell lithium-sodium countertransport and renal proximal tubular sodium...

journal_title：Journal of cardiovascular pharmacology

authors： Weder AB,Fitzpatrick MA

更新日期：1986-01-01 00:00:00

abstract：:Pinacidil is one of a number of new antihypertensive agents possessing an action that involves an enhanced potassium efflux in cardiac and vascular smooth muscle. An associated feature of pinacidil is a shortening of the cardiac action potential duration, which may constitute a potentially proarrhythmic effect. The pr...

journal_title：Journal of cardiovascular pharmacology

authors： Chi L,Uprichard AC,Lucchesi BR

更新日期：1990-03-01 00:00:00

abstract：:Nebivolol is a highly selective and lipophilic beta1-adrenergic receptor antagonist with vasodilating characteristics attributed mainly to endothelial generation of nitric oxide (NO). Coincidently, rapid vascular vasodilating effects of estradiol are also widely reported and membrane-initiated signaling by estrogen re...

journal_title：Journal of cardiovascular pharmacology

authors： Garbán HJ,Buga GM,Ignarro LJ

更新日期：2004-05-01 00:00:00

abstract：:The vasodilator action of organic nitrates can be severely impaired by induction of drug tolerance. A critical depletion of sulfhydryl groups has been proposed to play a key role in impairment of the biotransformation of organic nitrates to nitric oxide (NO). We studied the effects of the new cysteine-containing nitra...

journal_title：Journal of cardiovascular pharmacology

authors： Zanzinger J,Feelisch M,Bassenge E

更新日期：1994-05-01 00:00:00

abstract：:Studies were undertaken to establish the regional hemodynamic profile and dose-response relation of the adenosine triphosphate (ATP)-dependent potassium channel activator lemakalim in anesthetized rats. In addition, the ability of the sulphonylurea potassium channel blocker glybenclamide to reverse the hemodynamic eff...

journal_title：Journal of cardiovascular pharmacology

authors： Smits GJ,Perrone MH,Cox BF

更新日期：1997-01-01 00:00:00

abstract：:In anesthetized and ventilated guinea pigs, intravenous injection of ET-1, ET-2, or ET-3 induced similar rapid and dose-related increases in pulmonary inflation pressure (PIP) and mean arterial blood pressure (MABP). Indomethacin inhibited the increase in PIP evoked by ET-1, ET-2, or ET-3, whereas the changes in MABP ...

journal_title：Journal of cardiovascular pharmacology

authors： Pons F,Touvay C,Lagente V,Mencia-Huerta JM,Braquet P

更新日期：1991-01-01 00:00:00

abstract：:The effects of the thromboxane A2 (TXA2)/prostaglandin endoperoxide (TP) receptor antagonist ifetroban (BMS-180291) on infarct size (IS) resulting from coronary occlusion/reperfusion was determined in anesthetized dogs and ferrets. In dogs, ifetroban (1 + 1 mg/kg/h, intravenously, i.v.) or vehicle administration was i...

journal_title：Journal of cardiovascular pharmacology

authors： Gomoll AW,Grover GJ,Ogletree ML

更新日期：1994-12-01 00:00:00

abstract：:The potential therapeutic value of a new prostacyclin analogue, (4z, 16s)-4,5,18,18,19,19-hexadehydro-16,20-dimethyl-delta 6(9a)- 9-(O)-methano-PGI1 (KP-10614), was studied in acute myocardial infarction in rats. Myocardial infarction was induced by ligation of the left coronary artery and ischemic injury was followed...

journal_title：Journal of cardiovascular pharmacology

authors： Kanayama T,Kimura Y,Tamao Y,Mizogami S

更新日期：1992-10-01 00:00:00

abstract：:We studied the effects of maprotiline, a tetracyclic antidepressant agent, on transmembrane potentials recorded from papillary muscles of guinea pigs and sinoatrial nodes of rabbits, using standard microelectrode techniques. Maprotiline (10-100 microM) produced dose-dependent decreases in the maximum rate of rise (Vma...

journal_title：Journal of cardiovascular pharmacology

authors： Igawa O,Kotake H,Kurata Y,Saitoh M,Fujimoto Y,Hasegawa J,Mashiba H

更新日期：1988-02-01 00:00:00