Novel organic nitrates are potent dilators of large coronary arteries with reduced development of tolerance during long-term infusion in dogs: role of the sulfhydryl moiety.

abstract：:We recently found that TGF-beta increases ET-1 secretion in MDCK, a renal tubular cell line. The secretion of ET-1, by a confluent monolayer of MDCK cells grown on a filter, to the basolateral side of the epithelium was two times greater than that to the apical side. However, TGF-beta-increased ET-1 and big ET-1 secre...

journal_title：Journal of cardiovascular pharmacology

authors： Uchida S,Horie M,Yanagisawa M,Matsushita Y,Kurokawa K,Ogata E

更新日期：1991-01-01 00:00:00

abstract：:Cardiac hypertrophy occurs in response to increased workload, such as hypertension or valvular heart disease. Oxidative stress has been implicated in cardiac hypertrophy and in its transition to heart failure. This study was taken up with the objective to evaluate the role of oxidative stress in cardiomyoblast hypertr...

journal_title：Journal of cardiovascular pharmacology

authors： Sankar V,Pangayarselvi B,Prathapan A,Raghu KG

更新日期：2013-01-01 00:00:00

abstract：:Stroke is a major clinical problem in hypertension. Cerebral hemorrhage has become considerably less frequent since treatment of hypertension has become more widely used. Antihypertensive treatment has also reduced the incidence of lacunar stroke, which is a result of hypertensive vascular disease of small arteries. C...

journal_title：Journal of cardiovascular pharmacology

authors： Doyle AE,Donnan GA

更新日期：1990-01-01 00:00:00

abstract：:We observed that heterozygous knockout (+/-, KO) of either endothelin-A- (ET(A)) or -B- (ET(B)) receptors significantly reduced the pressor responses to systemically administered endothelin-1 (ET-1) in ET(A) or ET(B) (+/-) KO mice when compared to wild-type (WT) mice (data not shown). Also, we observed that basal mean...

journal_title：Journal of cardiovascular pharmacology

authors： Berthiaume N,Yanagisawa M,D'Orléans-Juste P

更新日期：2000-11-01 00:00:00

abstract：:Cultured vascular smooth muscle cells derived by enzymatic dissociation of rabbit aortic media were used for study of alpha 1-adrenergic receptors (AAR) and receptor-coupled calcium flux. AAR were characterized by binding of the alpha 1-selective radioligand [3H]prazosin, and norepinephrine-stimulated 45calcium efflux...

journal_title：Journal of cardiovascular pharmacology

authors： Colucci WS,Brock TA,Atkinson WJ,Alexander RW,Gimbrone MA Jr

更新日期：1985-01-01 00:00:00

abstract：:The effect of chronic inhibition of nitric oxide (NO) synthesis by NG-nitro-L-arginine methyl ester (L-NAME) on cutaneous ear blood flow (EBF) in the rabbit was examined in vivo with use of laser Doppler flowmetry. Additionally, the efficacy of inhibition of NO by L-NAME was studied ex vivo in isolated preparations of...

journal_title：Journal of cardiovascular pharmacology

authors： Khan F,Palacino JJ,Coffman JD,Cohen RA

更新日期：1993-08-01 00:00:00

abstract：:We have previously reported the production of endothelin-1 (ET-1) by the cerebral microvessel endothelia and suggested an important role of ET-1 and microvessel endothelia in the regulation of local blood flow within the brain. In the present study, radioimmunoassay of ET-1 revealed that ET-1, produced by cultured cer...

journal_title：Journal of cardiovascular pharmacology

authors： Yoshimoto S,Ishizaki Y,Mori A,Sasaki T,Takakura K,Murota S

更新日期：1991-01-01 00:00:00

abstract：:Activation of polymorphonuclear neutrophils (PMNs) during cardiopulmonary bypass (CPB) is a wellknown phenomenon. This study aimed to determine if activated PMNs are sequestered and degranulated within the myocardium at reperfusion in patients undergoing coronary artery bypass grafting (CABG). Nineteen patients underg...

journal_title：Journal of cardiovascular pharmacology

authors： Dhôte-Burger P,Vuilleminot A,Lecompte T,Pasquier C,Bara L,Julia P,Chardigny C,Fabiani JN

更新日期：1995-01-01 00:00:00

abstract：:Pinacidil is one of a number of new antihypertensive agents possessing an action that involves an enhanced potassium efflux in cardiac and vascular smooth muscle. An associated feature of pinacidil is a shortening of the cardiac action potential duration, which may constitute a potentially proarrhythmic effect. The pr...

journal_title：Journal of cardiovascular pharmacology

authors： Chi L,Uprichard AC,Lucchesi BR

更新日期：1990-03-01 00:00:00

abstract：:Imipramine, amitriptyline, mianserine, maprotiline, and trazodone are five widely used antidepressant drugs with different chemical structures. Imipramine and amitriptyline are tricyclics, mianserine and maprotiline are tetracyclics, and trazodone is a triazolopyridine derivative. We studied the effects of these drugs...

journal_title：Journal of cardiovascular pharmacology

authors： Casis O,Sánchez-Chapula JA

更新日期：1998-10-01 00:00:00

abstract：:Currently used antiplatelet drugs including aspirin, ticlopidine, and others are effective against certain but not all of the many endogenous platelet activators. Because of their limited efficacy, a significant number of serious thromboembolic complications still occur, highlighting the need for a more effective ther...

journal_title：Journal of cardiovascular pharmacology

authors： Mousa SA,Forsythe M,Wityak J,Bozarth J,Mu DX

更新日期：1998-03-01 00:00:00

abstract：:The role of delta-opioid receptors in mediating ischemic preconditioning (IPC) in rats, rabbits, and pigs has been well-established; however, no studies have been performed in dogs. Therefore, the purpose of the present study was to determine if activation of delta-opioid receptors can mimic the cardioprotective effec...

journal_title：Journal of cardiovascular pharmacology

authors： Peart JN,Patel HH,Gross GJ

更新日期：2003-07-01 00:00:00

abstract：:MCI-154 is a potent nonglycoside and non-sympathomimetic cardiotonic agent with a pyridazinone structure. We assessed its cardiac and coronary vasodilator effects by use of isolated, blood-perfused papillary muscle, sinoatrial (SA) node, and atrioventricular (AV) node preparations of dogs. The drug (1-100 nmol) was in...

journal_title：Journal of cardiovascular pharmacology

authors： Hosono M,Taira N

更新日期：1987-12-01 00:00:00

abstract：:The majority of patients with implanted cardioverter defibrillators (ICD) require antiarrhythmic (AR) drugs. ARs may increase defibrillation energy requirements. This study investigated the effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy needs. In 24 isolated rabbit hearts, the 50 an...

journal_title：Journal of cardiovascular pharmacology

authors： Anvari A,Mast F,Schmidinger H,Schuster E,Allessie M

更新日期：1997-04-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is generally thought to be a central nervous system depressant; however, GHB also has sympathomimetic cardiovascular actions. Radio telemetry was used to record the cardiovascular responses elicited by GHB (180-1000 mg/kg IV) in conscious rats. GHB elicited increases in mean arterial pressu...

journal_title：Journal of cardiovascular pharmacology

authors： Hicks AR,Kapusta DR,Varner KJ

更新日期：2004-12-01 00:00:00

abstract：:Forty patients (aged 28-66 years) with essential hypertension were randomized to 14 weeks of treatment with diltiazem or hydrochlorothiazide (HCTZ) in a double-blind, parallel study design. A significant reduction in supine body weight (-6.0 +/- 1.5 lb; p less than 0.001) and increase in pulse (+6 +/- 2 beats/min; p l...

journal_title：Journal of cardiovascular pharmacology

authors： Swartz SL

更新日期：1987-04-01 00:00:00

abstract：:The different intervention trials in elderly hypertensive subjects are compatible with the hypothesis that antihypertensive drug treatment decreases cardiovascular mortality, mainly by a reduction of cerebrovascular mortality. Antihypertensive drug treatment in elderly hypertensive subjects also leads to a decrease in...

journal_title：Journal of cardiovascular pharmacology

authors： Staessen J,Fagard R,Van Hoof R,Amery A

更新日期：1988-01-01 00:00:00

abstract：:We studied the effects of felodipine [4-(2,3-dichlorophenyl)-1,4-dihydropyridine-2,6-dimethyl 3,5-dicarboxylic 3-ethylester and 5-methylester] on the coronary vascular bed of pig hearts with an ischemic region in the left ventricle following ligation of the left anterior descending coronary artery. At an infusion rate...

journal_title：Journal of cardiovascular pharmacology

authors： Sjöquist PO,Adler G,Duker G,Almgren O

更新日期：1983-03-01 00:00:00

abstract：:beta 2-Adrenoceptor function may be decreased in primary hypertension, resulting in increased peripheral resistance. To study the beta 2-adrenoceptor function, we used circulating mononuclear leukocytes (MNL) as a model system. Twenty untreated hypertensive subjects [(HT) 10 men and 10 women] and 20 age- and sex-match...

journal_title：Journal of cardiovascular pharmacology

authors： Blankesteijn WM,Willems PH,Graafsma SJ,de Pont JJ,Thien T

更新日期：1993-11-01 00:00:00

abstract：:To study the effects of chronic in vivo inhibition of NO synthase on endothelium-dependent hyperpolarization, cell-membrane potential (in individual vascular smooth-muscle cells) and changes in tension (in isolated rings) were recorded from isolated canine coronary arteries and guinea-pig carotid arteries and aortas. ...

journal_title：Journal of cardiovascular pharmacology

authors： Corriu C,Félétou M,Puybasset L,Bea ML,Berdeaux A,Vanhoutte PM

更新日期：1998-12-01 00:00:00

abstract：:LC3B is a marker of autophagic activity, and growing evidence supports its importance in myocardial hypertrophy. Thus, regulating LC3B expression may provide an important avenue to inhibit autophagy and protect against or inhibit pathological myocardial hypertrophy. To address this question, we investigated the effect...

journal_title：Journal of cardiovascular pharmacology

authors： Huang J,Pan W,Ou D,Dai W,Lin Y,Chen Y,Chen X

更新日期：2015-12-01 00:00:00

abstract：:The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Erdmann E

更新日期：1988-04-01 00:00:00

abstract：:Neuropeptide Y (NPY) and ATP are considered cotransmitters with norepinephrine (NE) in sympathetic neurons innervating some blood vessels, including those of the mesentery. A prominent action of NPY is to potentiate the postjunctional contractile effect of NE as well as that of other vasoactive agents. We wished to in...

journal_title：Journal of cardiovascular pharmacology

authors： Westfall TC,Yang CL,Curfman-Falvey M

更新日期：1995-11-01 00:00:00

abstract：:Hemodynamic responses to sarafotoxin (SFTX6) peptides and endothelin-1 (ET-1) were compared in the anesthetized cat. SFTX6a and ET-1 at a dose of 0.3 nmol/kg i.v. produced a biphasic change in arterial pressure characterized by an initial decrease followed by a secondary increase in pressure. In contrast, similar dose...

journal_title：Journal of cardiovascular pharmacology

authors： Minkes RK,Kadowitz PJ

更新日期：1991-01-01 00:00:00

abstract：:The electromechanical effects of UK-68,798 (UK), a novel class III antiarrhythmic drug, were studied in guinea pig and rat papillary muscles (PMs) and atria in vitro using conventional microelectrode technique. UK (10(-8)-10(-6) M) prolonged the action potential duration (APD) by 21-58% and effective refractory period...

journal_title：Journal of cardiovascular pharmacology

authors： Tande PM,Bjørnstad H,Yang T,Refsum H

更新日期：1990-09-01 00:00:00

abstract：:In response to acetylcholine, endothelial cells were shown to release a nonprostanoid factor, called endothelium-derived relaxing factor (EDRF), which caused relaxation of vascular smooth muscle. Since this discovery in 1980, many additional agents have been shown to stimulate release of EDRF from endothelium. Biologi...

journal_title：Journal of cardiovascular pharmacology

authors： Furchgott RF

更新日期：1993-01-01 00:00:00

abstract：:Coronary heart disease secondary to atherosclerosis is the leading cause of death for men in the United States. Using a new, nontransgenic, non-fat-fed mouse model of hyperlipidemia and atherosclerosis developed in our laboratory, we investigated the effect of sex on lipid profiles and subsequent aortic atheroscleroti...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Coker JW,Paigen BJ,Tawfik O

更新日期：2002-03-01 00:00:00

abstract：:The renin-angiotensin system (RAS) has been proposed to play a major role in causing the heart to hypertrophy during pressure overload. We examined whether blockade of this system by the angiotensin-converting enzyme (ACE) inhibitors enalapril (0.5 to 20 mg/kg p.o.) or ramipril (1.0 mg/kg p.o.) or the angiotensin rece...

journal_title：Journal of cardiovascular pharmacology

authors： Mohabir R,Young SD,Strosberg AM

更新日期：1994-02-01 00:00:00

abstract：:Diabetes mellitus is associated with significant morbidity and mortality caused by the micro- and macro-vascular complications that all too frequently develop during the lifetime of the diabetic patient. In attempts to treat the complications of diabetes, several different treatment strategies have been investigated. ...

journal_title：Journal of cardiovascular pharmacology

authors： Savage S,Miller LA,Schrier RW

更新日期：1991-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR) play a critical physiological role in energy homeostasis, in inflammation, and a protective role in cardiovascular function. We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated receptor alpha (PPARα) stimulation on ischemic myoca...

journal_title：Journal of cardiovascular pharmacology

authors： Ibarra-Lara L,Hong E,Soria-Castro E,Torres-Narváez JC,Pérez-Severiano F,Del Valle-Mondragón L,Cervantes-Pérez LG,Ramírez-Ortega M,Pastelín-Hernández GS,Sánchez-Mendoza A

更新日期：2012-10-01 00:00:00