Abstract:
:Hemodynamic responses to sarafotoxin (SFTX6) peptides and endothelin-1 (ET-1) were compared in the anesthetized cat. SFTX6a and ET-1 at a dose of 0.3 nmol/kg i.v. produced a biphasic change in arterial pressure characterized by an initial decrease followed by a secondary increase in pressure. In contrast, similar doses of SFTX6b and SFTX6c produced mainly decreases in arterial pressure. Each peptide produced increases in central venous pressure, pulmonary arterial pressure, left atrial pressure, and cardiac output. Secondary decreases in cardiac output could be observed in response to SFTX6a and ET-1. SFTX6a and ET-1 produced biphasic changes, whereas SFTX6b and SFTX6c produced only decreases in systemic vascular resistance. In contrast, each peptide produced biphasic changes in pulmonary vascular resistance. The initial fall in pulmonary vascular resistance may be passively related to an increase in pulmonary blood flow because it occurs at a time when cardiac output is increased and no initial fall in pulmonary arterial pressure is observed. The present data show that the SFTX6 peptides can produce different patterns of responses in the systemic vascular bed of the cat, whereas responses in the pulmonary vascular bed are similar.
journal_name
J Cardiovasc Pharmacoljournal_title
Journal of cardiovascular pharmacologyauthors
Minkes RK,Kadowitz PJdoi
10.1097/00005344-199100177-00083subject
Has Abstractpub_date
1991-01-01 00:00:00pages
S293-6eissn
0160-2446issn
1533-4023journal_volume
17 Suppl 7pub_type
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journal_title:Journal of cardiovascular pharmacology
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abstract:BACKGROUND:S-equol is known as an estrogenic substance, but its ability to restore vascular endothelial function is unknown. The aim of this study was to investigate the impact of S-equol on endothelial function and intimal thickening under isoflavone- and estrogen-deficient circumstances. METHODS:Twelve-week-old fema...
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