Pharmacodynamic studies in normal volunteers with MDL-899, a new arteriolar vasodilator.

abstract：:Adenosine and verapamil have successfully been used in the treatment of clinical no-reflow after direct angioplasty for acute myocardial infarction. However, their effects on anatomic perfusion defects in experimental myocardial ischemia/reperfusion are unknown. Thus the area of no-reflow (ANR), visualized after in-vi...

journal_title：Journal of cardiovascular pharmacology

authors： Reffelmann T,Kloner RA

更新日期：2004-04-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitors are widely used for treatment of heart failure after myocardial infarction (MI). The beneficial effects consist of a combination of hemodynamic effects and interference with cardiac structural alterations. These effects are believed to depend on inhibition of angiotensin ...

journal_title：Journal of cardiovascular pharmacology

authors： Smits JF,van Krimpen C,Schoemaker RG,Cleutjens JP,Daemen MJ

更新日期：1992-01-01 00:00:00

abstract：:beta 2-Adrenoceptor function may be decreased in primary hypertension, resulting in increased peripheral resistance. To study the beta 2-adrenoceptor function, we used circulating mononuclear leukocytes (MNL) as a model system. Twenty untreated hypertensive subjects [(HT) 10 men and 10 women] and 20 age- and sex-match...

journal_title：Journal of cardiovascular pharmacology

authors： Blankesteijn WM,Willems PH,Graafsma SJ,de Pont JJ,Thien T

更新日期：1993-11-01 00:00:00

abstract：:We studied the influence of various inflammatory reactions on the survival rate and occurrence of arrhythmias in the acute phase of experimental myocardial infarction in conscious male Sprague--Dawley CFY rats. Chronic disseminated inflammatory disease was induced by subplantar injection of Freund complete adjuvant, w...

journal_title：Journal of cardiovascular pharmacology

authors： Koltai M,Leprán I,Nemecz G,Szekeres L

更新日期：1982-05-01 00:00:00

abstract：:To study the effects of chronic in vivo inhibition of NO synthase on endothelium-dependent hyperpolarization, cell-membrane potential (in individual vascular smooth-muscle cells) and changes in tension (in isolated rings) were recorded from isolated canine coronary arteries and guinea-pig carotid arteries and aortas. ...

journal_title：Journal of cardiovascular pharmacology

authors： Corriu C,Félétou M,Puybasset L,Bea ML,Berdeaux A,Vanhoutte PM

更新日期：1998-12-01 00:00:00

abstract：:We investigated the effects of aranidipine, a dihydropyridine-type Ca2+ channel blocker, on contractile responses to KCl and spontaneous contractions in isolated rat portal veins in comparison with those of the Ca2+ channel blockers, nifedipine, nicardipine, nitrendipine, diltiazem, and verapamil, and of the K+ channe...

journal_title：Journal of cardiovascular pharmacology

authors： Okumura K,Ichihara K,Nagasaka M

更新日期：1997-02-01 00:00:00

abstract：:Since minoxidil was previously shown to raise plasma renin activity (PRA) but not the plasma aldosterone concentration (PAC), the effect of minoxidil on the rate of aldosterone metabolic clearance was studied. After the addition of minoxidil to the antihypertensive regimen of 7 hypertensive patients, the aldosterone m...

journal_title：Journal of cardiovascular pharmacology

authors： Pratt JH,Yager CJ,Grim CE,Parkinson CA

更新日期：1980-01-01 00:00:00

abstract：:Endothelial cell (EC) and vascular smooth muscle cell (VSMC) interactions play critical roles in restenosis following vascular injury. We examined the effects of intracellular iron chelation on endothelial cell cycle progression and VSMC modulation of endothelial cell growth. A diffusible, lipid-soluble iron chelator ...

journal_title：Journal of cardiovascular pharmacology

authors： Hodges YK,Reese SM,Pahl PM,Horwitz LD

更新日期：2005-06-01 00:00:00

abstract：:The volatile anesthetics halothane, isoflurane, and sevoflurane depress myocardial contractility by decreasing transsarcolemmal Ca2+ influx, Ca2+ release from the sarcoplasmic reticulum, Ca2+ sensitivity of the contractile proteins, and cross-bridge performance. The aim of this study is to assess and compare the effec...

journal_title：Journal of cardiovascular pharmacology

authors： Housmans PR,Bartunek AE

更新日期：2001-08-01 00:00:00

abstract：:The new converting enzyme inhibitor cilazapril, or RO 31-2848, was evaluated in 14 healthy male volunteers. In a pilot study in two subjects, the inhibiting capacity of single oral doses of 5 and 10 mg on the pressure and heart rate response to exogenous angiotensin I was assessed. Both doses reduced the blood pressur...

journal_title：Journal of cardiovascular pharmacology

authors： Fasanella d'Amore T,Bussien JP,Nussberger J,Waeber B,Turini GA,Brunner HR,Kler L,Francis RJ

更新日期：1987-01-01 00:00:00

abstract：:The distribution of catecholamine (CA)-containing neurones and tissue noradrenaline (NA) concentration was investigated in pig hearts with and without myocardial ischemia. All hearts were shock-frozen using a Wollenberger clamp, and tissue samples were obtained from the mid- and apical left ventricular wall (nonischem...

journal_title：Journal of cardiovascular pharmacology

authors： Hirche H,McDonald FM,Polwin W,Addicks K

更新日期：1985-01-01 00:00:00

abstract：:We examined the involvement of the oxidative stress in high glucose-induced suppression of human aortic endothelial cell proliferation. Chronic glucose treatment for 72 h concentration-dependently (5.6-22.2 mol/l) inhibited human coronary endothelial cell proliferation. Temocaprilat, an angiotensin-converting enzyme i...

journal_title：Journal of cardiovascular pharmacology

authors： Yasunari K,Maeda K,Watanabe T,Nakamura M,Asada A,Yoshikawa J

更新日期：2003-12-01 00:00:00

abstract：:Plasma homocysteine levels increase in humans treated with fibrates but the molecular mechanisms are unknown. The goal of the present study was to determine the mechanism of this increase using animal models. Firstly, an increase in homocysteine was observed in mice treated with fenofibrate irrespective of the genetic...

journal_title：Journal of cardiovascular pharmacology

authors： Luc G,Jacob N,Bouly M,Fruchart JC,Staels B,Giral P

更新日期：2004-03-01 00:00:00

abstract：:The effects of a new nitrate ester derivative, ITF 296, on large conductance and small resistance coronary arteries were investigated and compared with those of nitroglycerin and isosorbide dinitrate in chronically instrumented conscious dogs with an intact or with a deendothelialized large coronary artery. In a wide ...

journal_title：Journal of cardiovascular pharmacology

authors： Ghaleh B,Dubois-Randé JL,Hittinger L,Berdeaux A,Giudicelli JF

更新日期：1995-01-01 00:00:00

abstract：:The signaling impact of a human beta1-adrenergic receptor (beta1 AR) polymorphism at residue 49 of the aminoterminus (Ser-to-Gly substitution) was studied by recombinantly expressing each receptor. The two receptors displayed identical agonist and antagonist binding affinities. Furthermore, basal and agonist-stimulate...

journal_title：Journal of cardiovascular pharmacology

authors： Rathz DA,Brown KM,Kramer LA,Liggett SB

更新日期：2002-02-01 00:00:00

abstract：:The "Oxford" system for continuous monitoring of the ambulatory blood pressure was used to assess the changes in blood pressure following therapy with the calcium ion antagonists verapamil and nifedipine in two separate groups of patients. In the first group 16 patients were studied on both no therapy and following a ...

journal_title：Journal of cardiovascular pharmacology

authors： Gould BA,Hornung RS,Mann S,Balasubramanian V,Raftery EB

更新日期：1982-01-01 00:00:00

abstract：:To evaluate the interaction between renal nerves, the atrial natriuretic peptide (ANP), and the renin-angiotensin system (RAS), electrical stimulation of renal nerves was performed in spontaneously hypertensive rats (SHR) and in their normotensive controls, Wistar Kyoto rats (WKY), before and after pharmacologic treat...

journal_title：Journal of cardiovascular pharmacology

authors： Golin R,Protasoni G,Wjinmaalen P,Sala C,Monopoli A,Casati C,Zanchetti A,Stella A

更新日期：1996-11-01 00:00:00

abstract：:Inclacumab is a novel monoclonal antibody directed against P-selectin in development for the prevention and treatment of atherosclerotic cardiovascular diseases. It is likely to be used concomitantly with heparin in patients undergoing percutaneous coronary intervention. Coadministration of both drugs may potentially ...

journal_title：Journal of cardiovascular pharmacology

authors： Schmitt C,Mudie N,Ciorciaro C,Gaudreault J

更新日期：2015-04-01 00:00:00

abstract：:One of the earliest structural changes in the heart adapting to hypertension is left ventricular hypertrophy, which can now be exactly measured by echocardiography. Left ventricular hypertrophy increases the incidence of coronary artery disease, heart failure, and sudden death severalfold, independent of the blood pre...

journal_title：Journal of cardiovascular pharmacology

authors： Schmieder RE

更新日期：1992-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of hypercholesterolemia on the angiotensin II-induced contractions in the isolated aorta and iliac artery of the rabbit, with respect to the role of arachidonate metabolites. Furthermore, the effect of the angiotensin-converting enzyme inhibitor ramipril was studied ...

journal_title：Journal of cardiovascular pharmacology

authors： Dam JP,Vleeming W,Riezebos J,Post MJ,Porsius AJ,Wemer J

更新日期：1997-07-01 00:00:00

abstract：:This study was undertaken to determine and confer the cardioprotective effects of the adenosine A2 receptor (A2AR) and its impact on myocardial autophagy in the setting of reperfusion. We established a rat ischemia model by subjecting rats to 30 minutes of ischemia (I) and 120 minutes of reperfusion (R). The A2AR agon...

journal_title：Journal of cardiovascular pharmacology

authors： Ke J,Yao B,Li T,Cui S,Ding H

更新日期：2015-07-01 00:00:00

abstract：:Reversal of left ventricular hypertrophy (LVH) is an important target of antihypertensive therapy. Nonpharmacological approaches such as weight reduction and exercise training have favorable effects on other risk factors. However, there are few data on their effects on LVH. Athletes have eccentric rather than concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Jennings G,Dart A,Meredith I,Korner P,Laufer E,Dewar E

更新日期：1991-01-01 00:00:00

abstract：:We have previously shown that amiloride suppresses the induction of sustained ventricular tachycardia both in dogs late following myocardial infarction and in patients. In those studies the only electrophysiologic correlate of amiloride's antiarrhythmic activity observed was prolongation of ventricular effective refra...

journal_title：Journal of cardiovascular pharmacology

authors： Duff HJ,Brown CE,Cragoe EJ,Rahmberg M

更新日期：1991-06-01 00:00:00

abstract：:Cardiovascular effects of Nifekalant were examined using halothane-anesthetized dogs, and its proarrhythmic potential was estimated with chronic complete atrioventricular block dogs. Nifekalant was intravenously administered to the halothane-anesthetized dogs in three doses of 0.03, 0.3, and 3 mg/kg/10 minutes with a ...

journal_title：Journal of cardiovascular pharmacology

authors： Satoh Y,Sugiyama A,Takahara A,Chiba K,Hashimoto K

更新日期：2004-05-01 00:00:00

abstract：:Formation of oxygen free radicals during heart transplantation seems to be related to the alterations occurring during ischemia and reperfusion and could explain the short preservation time of donor hearts. The aim of our study was (a) to analyze the protective effects of pyruvate during cold cardioplegia and ischemia...

journal_title：Journal of cardiovascular pharmacology

authors： Dobsak P,Courderot-Masuyer C,Zeller M,Vergely C,Laubriet A,Assem M,Eicher JC,Teyssier JR,Wolf JE,Rochette L

更新日期：1999-11-01 00:00:00

abstract：:In this study the effects of a new calcium entry blocking agent, 2,6-dimethyl-3-methoxycarbonyl-4-(2-nitrophenyl)-5-(2-furoyl)-1, 4-dihydropyridine (MDL 72567), were compared with those of nifedipine on blood pressure, heart rate, ECG, and cardiac contractility indices in conscious sinoaortic baroreceptor-denervated (...

journal_title：Journal of cardiovascular pharmacology

authors： Petty MA,Spedding M,Di Francesco GF

更新日期：1987-10-01 00:00:00

abstract：:In this study, we compared the effect of the essential oil of Citrus bergamia Risso [bergamot, bergamot essential oil (BEO)] on the intracellular Ca levels in vascular endothelial (EA) and mouse vascular smooth muscle (MOVAS) cells, using the fura-2 fluorescence technique. BEO caused an initial transient increase in i...

journal_title：Journal of cardiovascular pharmacology

authors： You JH,Kang P,Min SS,Seol GH

更新日期：2013-04-01 00:00:00

abstract：:Since the end of 1976 ten orally active converting enzyme inhibitors [SQ 14,225 (captopril), MK 421 (enalapril), MK 422, MK 521 (lysinopril), RHC 3659, CGS 13945, CGS 13928C, CGS 14824A, Hoe 498, S 9490-3, and Ro 31-2848] have been evaluated by our group in normal volunteers. Their ability to blunt the pressor respons...

journal_title：Journal of cardiovascular pharmacology

authors： Brunner HR,Nussberger J,Waeber B

更新日期：1985-01-01 00:00:00

abstract：:The effects of noradrenaline (NA, 10(-5) M) and [arginine8]vasopressin (AVP, 10(-7) M) on tension in Ca2+-free medium and on membrane potential, and the inhibition of NA- and AVP-induced contractions by isradipine, have been compared in mesenteric resistance vessels (MRVs) from Wistar-Kyoto (WKY) rats. The release of ...

journal_title：Journal of cardiovascular pharmacology

authors： Cauvin C,Weir SW,Wallnöfer A,Rüegg U

更新日期：1988-01-01 00:00:00

abstract：:The ongoing COVID-19 pandemic has produced serious turmoil world-wide. Lung injury causing acute respiratory distress syndrome seems to be a most dreaded complication occurring in ∼30%. Older patients with cardiovascular comorbidities and acute respiratory distress syndrome have an increased mortality. Although the pr...

journal_title：Journal of cardiovascular pharmacology

authors： Manolis AS,Manolis TA,Manolis AA,Melita H

更新日期：2020-10-01 00:00:00