ITF 296, a new endothelium-independent vasodilator: comparison with nitroglycerin and isosorbide dinitrate.

abstract：:The regulation of coronary hemodynamics is a complex process. One important factor that interferes with the regulation of coronary tone is the pathophysiological state of the vessels: stimuli that in normal vessels provoke no or only a slight vasoconstriction may cause a severe vasoconstriction in diseased vessels. Th...

journal_title：Journal of cardiovascular pharmacology

authors： van Gilst WH,Tio RA,van Wijngaarden J,de Graeff PA,Wesseling H

更新日期：1992-01-01 00:00:00

abstract：:The degree of cardiac and vascular beta-adrenoceptor blockade of bisoprolol and atenolol was determined by the chronotropic dose 25 (CD25) of isoproterenol (the dose of an intravenous isoproterenol bolus required to increase resting heart rate by 25 beats/min) and by the increase in forearm blood flow (venous occlusio...

journal_title：Journal of cardiovascular pharmacology

authors： Bolli P,Müller FB,Linder L,Ji BH,Bühler FR

更新日期：1986-01-01 00:00:00

abstract：:Although evidence has been accumulated to support a role of endothelin-1 (ET-1) in cardiac hypertrophy, details of the pathophysiological significance of ET-1 in cardiac hypertrophy remain to be elucidated. In the present study, we investigated the effects of the vasodilator hydralazine on the blood pressure, cardiac ...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe A,Naruse M,Adachi C,Seki T,Yoshimoto T,Takagi S,Naruse K,Takano K

更新日期：2000-11-01 00:00:00

abstract：:A sodium/calcium exchange mechanism that mediates both Ca2+ exit and Ca2+ entry is present in the sarcolemma of most types of muscle including mammalian cardiac muscle and vascular smooth muscle (VSM). The rate and direction of Ca2+ transport mediated by the exchanger are normally regulated primarily by: (a) the intra...

journal_title：Journal of cardiovascular pharmacology

authors： Blaustein MP

更新日期：1988-01-01 00:00:00

abstract：:Sixteen nonhospitalized men, average age 41.3 years with essential hypertension (WHO I-II) were given nifedipine slow-release tablets of 20 mg twice daily for 48 weeks. Both supine and standing blood pressure values were significantly reduced, but heart rate was not significantly changed by the drug. A significant dec...

journal_title：Journal of cardiovascular pharmacology

authors： Landmark K

更新日期：1985-01-01 00:00:00

abstract：:The acute effects of daunomycin on the mechanical and energetic outputs of rabbit papillary muscles have been examined at 27 degrees C using a myothermic technique. Contrary to expectations, daunomycin, in concentrations ranging from 10 to 160 micrograms/ml, acted as a positive inotropic agent in terms of peak stress ...

journal_title：Journal of cardiovascular pharmacology

authors： Gibbs CL

更新日期：1985-05-01 00:00:00

abstract：:The usual drugs for migraine attacks carry risks of increased frequency, resistance to other treatment, drug dependency, and abuse. Ergotamines may also be vascular risk factors. Alternative drugs without these risks would be useful. Flunarizine could be an alternative. Migraine cannot be reduced to molecular pathophy...

journal_title：Journal of cardiovascular pharmacology

authors： Isler H

更新日期：1991-01-01 00:00:00

abstract：:Besides generating renal damage, hypertension plays an important role in the progression of diabetic nephropathy. The fructose-fed rat is a well-established model both of high blood pressure and renal impairment, which is similar to diabetic nephropathy. To clarify the relationship between hypertension, glucose metabo...

journal_title：Journal of cardiovascular pharmacology

authors： Bernobich E,Cosenzi A,Campa C,Zennaro C,Sasso F,Paoletti S,Bellini G

更新日期：2004-09-01 00:00:00

abstract：:Chronic stimulation of beta-adrenoceptors with isoproterenol induces alteration of vascular reactivity and increases local pro-inflammatory cytokines. We investigated whether fenofibrate and pioglitazone, PPAR-alpha and -gamma agonists, respectively, improve the changes in vascular reactivity induced by isoproterenol....

journal_title：Journal of cardiovascular pharmacology

authors： Fukuda LE,Davel AP,Verissimo-Filho S,Lopes LR,Cachofeiro V,Lahera V,Rossoni LV

更新日期：2008-11-01 00:00:00

abstract：:The cardiovascular effects of catecholamines and related substances after local application into the nucleus tractus solitarii (NTS) of the medulla oblongata of urethane anesthetized rats are summarized. The catecholamines in the nanomolar dose range appear to activate stereospecifically receptor sites in the NTS, res...

journal_title：Journal of cardiovascular pharmacology

authors： de Jong W,Petty M

更新日期：1982-01-01 00:00:00

abstract：:On the basis of animal studies, it has been proposed that calcium antagonists selectively interfere with the pressor response to alpha 2-adrenoceptor antagonists and have less direct action on alpha 1-adrenoceptor mechanisms. In placebo-controlled randomized studies in healthy normotensives, we have found that verapam...

journal_title：Journal of cardiovascular pharmacology

authors： Reid JL,Pasanisi F,Meredith PA,Elliott HL

更新日期：1985-01-01 00:00:00

abstract：:The human cutaneous microcirculation has so far been studied by rather crude methods, such as plethysmography and 133Xn clearance. New sophisticated and noninvasive techniques are now available, with which the microcirculation of the skin can be continuously studied and measured for hours. With two such methods, i.e.,...

journal_title：Journal of cardiovascular pharmacology

authors： Fagrell B

更新日期：1985-01-01 00:00:00

abstract：:The development of tolerance to the antihypertensive effect of clonidine and related imidazolines is clinically recognized. Here, we employed a restricted daytime (8:30 AM until 4:30 PM) clonidine regimen to establish a model of sustained hypotension in spontaneously hypertensive rats (SHRs). Blood pressure (BP), hear...

journal_title：Journal of cardiovascular pharmacology

authors： El-Mas MM,Abdel-Rahman AA

更新日期：2007-03-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF), a potent mitogen and chemoattractant for smooth muscle cells and fibroblasts in culture, is believed to play an important role in the formation of proliferative lesions of arterio-sclerosis. PDGF appears as three different dimeric isoforms: AA, AB, and BB. These were recently fou...

journal_title：Journal of cardiovascular pharmacology

authors： Hosang M,Rouge M

更新日期：1989-01-01 00:00:00

abstract：:Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. However, this hormone has a ubiquitous influence and has specific effects on the heart. Although diff...

journal_title：Journal of cardiovascular pharmacology

authors： Pelletier JS,Dicken B,Bigam D,Cheung PY

更新日期：2014-07-01 00:00:00

abstract：:Establishing the overall efficacy or safety of a drug requires a unified methodological approach and analysis of all clinical trials that are intended to be summarized. As an example, this article presents the aggregated dose-response relationship and a subgroup analysis (by age) over all studies of the antihypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Stienen U

更新日期：1992-01-01 00:00:00

abstract：:Nineteen hypertensive patients were treated with increasing doses of the new angiotensin-converting enzyme inhibitor MK 421. Twenty milligrams orally reduced blood pressure from 180/112 +/- 6.8/3.6 (mean +/- SEM) to 160/100 +/- 6.5/3.3 mm Hg (p less than 0.005) while heart rate increased from 75 +/- 2 to 87 +/- 3 beat...

journal_title：Journal of cardiovascular pharmacology

authors： Biollaz J,Brunner HR,Gavras I,Waeber B,Gavras H

更新日期：1982-11-01 00:00:00

abstract：:In a multicenter, randomized, double-blind, placebo-controlled study, we evaluated the efficacy and tolerability of the combination of benazepril, 10 mg, and amlodipine, 2.5 or 5 mg once daily, compared with benazepril, 10 mg, monotherapy in patients with hypertension inadequately controlled with angiotensin-convertin...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Corea L,Cardoni O,Cosmi F,Porcellati C,Innocenti P,Provvidenza M,Timio M,Bentivoglio M,Bertocchi F,Zoppi A

更新日期：1997-10-01 00:00:00

abstract：:Chronic rapid right ventricular pacing (RRVP) at 250 beats/min produces low cardiac output (CO) heart failure, marked reduction in total vascular capacitance, and a shift in volume centrally. The effect of converting enzyme inhibition with captopril on cardiac preload was investigated in this model of heart failure. E...

journal_title：Journal of cardiovascular pharmacology

authors： Ogilvie RI,Zborowska-Sluis D

更新日期：1994-09-01 00:00:00

abstract：:Cardiovascular responsiveness to stress conditions differs between men and women. It is not known to what extent this observation is explained by differences in the release of stress hormones like adrenaline, or by differences in the response to adrenaline. Therefore, we quantified the hemodynamic response to infusion...

journal_title：Journal of cardiovascular pharmacology

authors： Schouwenberg BJ,Rietjens SJ,Smits P,de Galan BE

更新日期：2006-01-01 00:00:00

abstract：:Using micropuncture techniques in euvolemic adult male Munich-Wistar rats, we assessed the functional role of renal beta-adrenoceptors in mediating neural control of glomerular filtration and proximal tubular reabsorption. The determinants of nephron filtration and rate of proximal tubular reabsorption were measured i...

journal_title：Journal of cardiovascular pharmacology

authors： Thomson SC,Tucker BJ,Blantz RC

更新日期：1991-03-01 00:00:00

abstract：:Trans-diclofurime has been shown to be a very potent class II calcium antagonist (see preceding report), and we have examined its molecular interactions with the different receptor sites at the Ca2+ channel. Trans-diclofurime did not affect [3H]nitrendipine binding to rat cortical membranes at 37 degrees C and showed ...

journal_title：Journal of cardiovascular pharmacology

authors： Mir AK,Spedding M

更新日期：1987-04-01 00:00:00

abstract：:Spontaneously hypertensive stroke-prone rats suffer spontaneous strokes partly as a result of abnormal cerebrovascular development. This model exhibits prehypertensive, typical hypertensive and malignant hypertensive stages. We had observed that vascular endothelial growth factor and its receptors, kinase domain regio...

journal_title：Journal of cardiovascular pharmacology

authors： Jesmin S,Sakuma I,Togashi H,Yoshioka M,Hattori Y,Kitabatake A,Miyauchi T

更新日期：2004-11-01 00:00:00

abstract：:In this study the contribution of alternating architecture and Ca2+ handling of mitochondria to cytosolic Ca2+ homeostasis was elucidated under normoglycemic and hyperglycemic (HGC) conditions in the human endothelial cell line EA.hy926. Exposure of endothelial cells to hyperglycemic medium elevated basal cytosolic fr...

journal_title：Journal of cardiovascular pharmacology

authors： Paltauf-Doburzynska J,Malli R,Graier WF

更新日期：2004-10-01 00:00:00

abstract：:Atherosclerosis is a complex vascular disease initiated by abnormal accumulation of plasma lipoproteins in the subendothelial space. Elevated levels of plasma triglycerides (TG) and low-density lipoprotein (LDL)-cholesterol as well as low concentrations of high-density lipoprotein (HDL) play a causal role in the devel...

journal_title：Journal of cardiovascular pharmacology

authors： Declercq V,Yeganeh B,Moshtaghi-Kashanian GR,Khademi H,Bahadori B,Moghadasian MH

更新日期：2005-07-01 00:00:00

abstract：:Measurements of cerebrospinal fluid (CSF) catecholamines (CA) were made in an attempt to estimate the activity of central CA neurons in essential hypertension (EHT). CSF norepinephrine (NE), epinephrine (EPI), and dopamine (DA) levels were measured in 12 normotensive (age 36 +/- 3 years; SBP = 116 +/- 4 and DBP = 79 +...

journal_title：Journal of cardiovascular pharmacology

authors： Cubeddu LX,Hoffman IS

更新日期：1987-01-01 00:00:00

abstract：:The role of delta-opioid receptors in mediating ischemic preconditioning (IPC) in rats, rabbits, and pigs has been well-established; however, no studies have been performed in dogs. Therefore, the purpose of the present study was to determine if activation of delta-opioid receptors can mimic the cardioprotective effec...

journal_title：Journal of cardiovascular pharmacology

authors： Peart JN,Patel HH,Gross GJ

更新日期：2003-07-01 00:00:00

abstract：:In response to acetylcholine, endothelial cells were shown to release a nonprostanoid factor, called endothelium-derived relaxing factor (EDRF), which caused relaxation of vascular smooth muscle. Since this discovery in 1980, many additional agents have been shown to stimulate release of EDRF from endothelium. Biologi...

journal_title：Journal of cardiovascular pharmacology

authors： Furchgott RF

更新日期：1993-01-01 00:00:00

abstract：:There has been some debate regarding the benefit of magnesium (Mg) in the treatment of acute myocardial infarction (AMI) because of conflicting results from recent clinical trials. Several different hypotheses have been advanced to explain the cardioprotective properties of Mg, including the influence of the timing of...

journal_title：Journal of cardiovascular pharmacology

authors： Serebruany VL,Herzog WR,Schlossberg ML,Edenbaum LR,Gurbel PA

更新日期：1996-12-01 00:00:00

abstract：:The similarity between the metabolic pathways of serotonin in platelets and serotoninergic nerve endings has often been emphasized. The turnover of serotonin was therefore investigated in two diseases: hypertension (as central serotoninergic neurones appear to modulate central sympathetic nervous activity) and depress...

journal_title：Journal of cardiovascular pharmacology

authors： Baudouin-Legros M,Le Quan-Bui KH,Guicheney P,Kamal LA,Meyer P

更新日期：1985-01-01 00:00:00