Platelet serotonin in essential hypertension and in mental depression.

abstract：:Increased levels of endothelin (ET) have been demonstrated in the ischemic brain, and ET receptor antagonism has been shown to improve outcome in cerebral ischemia. However, no previous work has been carried out evaluating the role of ET and its antagonism in brain trauma as compared to experimental stroke. In this st...

journal_title：Journal of cardiovascular pharmacology

authors： Barone FC,Ohlstein EH,Hunter AJ,Campbell CA,Hadingham SH,Parsons AA,Yang Y,Shohami E

更新日期：2000-11-01 00:00:00

abstract：:We studied the effects of maprotiline, a tetracyclic antidepressant agent, on transmembrane potentials recorded from papillary muscles of guinea pigs and sinoatrial nodes of rabbits, using standard microelectrode techniques. Maprotiline (10-100 microM) produced dose-dependent decreases in the maximum rate of rise (Vma...

journal_title：Journal of cardiovascular pharmacology

authors： Igawa O,Kotake H,Kurata Y,Saitoh M,Fujimoto Y,Hasegawa J,Mashiba H

更新日期：1988-02-01 00:00:00

abstract：:The new converting enzyme inhibitor cilazapril, or RO 31-2848, was evaluated in 14 healthy male volunteers. In a pilot study in two subjects, the inhibiting capacity of single oral doses of 5 and 10 mg on the pressure and heart rate response to exogenous angiotensin I was assessed. Both doses reduced the blood pressur...

journal_title：Journal of cardiovascular pharmacology

authors： Fasanella d'Amore T,Bussien JP,Nussberger J,Waeber B,Turini GA,Brunner HR,Kler L,Francis RJ

更新日期：1987-01-01 00:00:00

abstract：:During ischemia-reperfusion an imbalance between endothelin (ET) and nitric oxide (NO) can be responsible for microcirculatory disturbances. The aim of this study was to restore the ET/NO balance to reduce the ischemia-reperfusion injury. Hepatic ischemia was induced for 30 min in 56 Wistar rats. Sham operation, ische...

journal_title：Journal of cardiovascular pharmacology

authors： Uhlmann D,Uhlmann S,Spiegel HU

更新日期：2000-11-01 00:00:00

abstract：:We studied 12 patients receiving either chronic oral (p.o.) maintenance bretylium and/or acute intravenous (i.v.) bretylium to evaluate drug efficacy and pharmacokinetics. All patients were survivors of ventricular tachycardia or fibrillation. A new assay for bretylium was applied, and it proved sensitive and reliable...

journal_title：Journal of cardiovascular pharmacology

authors： Anderson JL,Patterson E,Wagner JG,Johnson TA,Lucchesi BR,Pitt B

更新日期：1981-05-01 00:00:00

abstract：:The vasodilator action of organic nitrates can be severely impaired by induction of drug tolerance. A critical depletion of sulfhydryl groups has been proposed to play a key role in impairment of the biotransformation of organic nitrates to nitric oxide (NO). We studied the effects of the new cysteine-containing nitra...

journal_title：Journal of cardiovascular pharmacology

authors： Zanzinger J,Feelisch M,Bassenge E

更新日期：1994-05-01 00:00:00

abstract：:The benefit of thrombolytic agents to reduce myocardial infarct size, improve left ventricular (LV) function, and prolong survival in human subjects is generally recognized, although the precise mechanism is poorly defined. This study was designed to evaluate the cardioprotective effects of streptokinase (SK) in rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Smith EF 3rd,Nichols AJ,Sellers TS,O'Brien SR,Griswold DE,Egan JW,Hillegass LM,Vasko JA,Slivjak MJ,Davis PA

更新日期：1991-11-01 00:00:00

abstract：:The calcium channel blocker nifedipine and the new phosphodiesterase (PDE) inhibitor enoximone are used in the treatment of cardiovascular diseases. Since both substances are acting on slow calcium channels and because systemic elimination of these two agents is dependent on oxidative drug metabolizing enzyme activity...

journal_title：Journal of cardiovascular pharmacology

authors： Boldt J,Kling D,Dietevich HA,Hempelmann G

更新日期：1990-01-01 00:00:00

abstract：:Using selective endothelin (ET) receptor antagonists, we investigated which ET receptor subtypes mediate the changes in blood pressure and hematocrit produced by intraarterial injection of ET-1 in the anesthetized rabbit. In addition, the receptor through which ET-1 stimulates the release of prostacyclin (PGI2) and, h...

journal_title：Journal of cardiovascular pharmacology

authors： McMurdo L,Lidbury PS,Corder R,Thiemermann C,Vane JR

更新日期：1993-01-01 00:00:00

abstract：:We previously showed that preoperative nicorandil, a hybrid potassium channel opener and nitrate compound, conferred cardioprotective effects in a hypoxia/reoxygenation model of isolated human atrial muscle by using functional recovery as an end point, and that ischaemic preconditioning surprisingly abolished the prot...

journal_title：Journal of cardiovascular pharmacology

authors： Imagawa J,Baxter GF,Yellon DM

更新日期：1998-01-01 00:00:00

abstract：:Depression of myocardial contractility by muscarinic agonists is dependent on underlying beta-adrenergic tone. The negative inotropic effect of muscarinic agonists is enhanced by previous beta-adrenergic stimulation, an action that has been termed accentuated antagonism. We wished to determine whether accentuated anta...

journal_title：Journal of cardiovascular pharmacology

authors： Thurston TA,Mathew BP

更新日期：1995-12-01 00:00:00

abstract：:The effect of the new vasodilatory and antianginal compound, bepridil (CERM-1978), was examined on the electrical activity of the vascular smooth muscle of isolated dog coronary arteries. Tetraethylammonium (10 mM) was used to induce excitability in the muscle in the form of Ca2+-dependent overshooting action potentia...

journal_title：Journal of cardiovascular pharmacology

authors： Harder DR,Sperelakis N

更新日期：1981-07-01 00:00:00

abstract：:The actions of prostacyclin and its synthetic analog iloprost on the release and action of platelet-derived serotonin (5-HT) and thromboxane (TX) A2 were studied in vitro. Washed human platelet suspensions (WPS) (4 X 10(8) platelets/ml) were stimulated with arachidonic acid (AA) (30 mumol/L) and the incubate transferr...

journal_title：Journal of cardiovascular pharmacology

authors： Schrör K,Verheggen R

更新日期：1986-05-01 00:00:00

abstract：:The mechanism by which nicotine causes peripheral vasoconstriction and its relationship to the increased risk of peripheral vascular disease in smokers are unknown. To study the peripheral vascular effects of nicotine, we measured hemodynamic responses and oxygen consumption of the in situ gracilis muscle during intra...

journal_title：Journal of cardiovascular pharmacology

authors： Rooney MW,Hirsch LJ

更新日期：1991-10-01 00:00:00

abstract：:Reperfusion of ischemic myocardium is accompanied by intracellular Ca overload, leading to cardiac dysfunction. However, the mechanisms underlying intracellular Ca overload have yet to be fully elucidated. The mechanism may involve the activation of store-operated Ca entry, which is primarily mediated through the tran...

journal_title：Journal of cardiovascular pharmacology

authors： Kojima A,Fukushima Y,Ito Y,Ding WG,Kitagawa H,Matsuura H

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The sympathetic nervous system (SNS) of the whole body, including cardiac sympathetic nerves, is activated in patients with severe congestive systolic heart failure (CHF). Carvedilol can improve clinical status in such patients. This study aimed to determine how carvedilol acts on the SNS to improve CHF. ME...

journal_title：Journal of cardiovascular pharmacology

authors： Machida M,Takechi S,Fujimoto T,Kakinoki S,Nomura A

更新日期：2012-02-01 00:00:00

abstract：:Phosphoinositide (PI) turnover, chronotropic and inotropic responses to alpha 1-adrenoceptor activation, and alpha 1-adrenoceptor density were studied in atria from rats with left ventricular myocardial infarction (LVMI) and noninfarcted rats. LVMI was produced after surgical ligation of the left coronary artery in 8-...

journal_title：Journal of cardiovascular pharmacology

authors： Rowley KG,Tung LH,Hodsman GP,Howes LG,Jarrott B,Beart PM,Louis WJ

更新日期：1991-03-01 00:00:00

abstract：:The hypothesis that local release of prostanoids may contribute to the pharmacologic effect of nitroglycerin (NTG) has long been debated. Results of prostanoid blockade by indomethacin on NTG-induced effects, to date, have been inconclusive. To quantitate the effects of intravenous indomethacin on NTG-induced myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Bednarcyzk EM,Furniss SM,Green JA,Munger MA

更新日期：1997-12-01 00:00:00

abstract：:We undertook a systematic comparison of the effects of diltiazem and nifedipine and a nonspecific vasodilator, sodium nitroprusside, on renal perfusion, function, and activation of potentially relevant neurohormonal systems in the anesthetized dog. These agents were employed to reduce blood pressure to two levels, a m...

journal_title：Journal of cardiovascular pharmacology

authors： Blackshear JL,Orlandi C,Williams GH,Hollenberg NK

更新日期：1986-01-01 00:00:00

abstract：:The purpose of this study was to compare the acute hypotensive efficacy of different types of inhibitor of the renin-angiotensin system. A renin inhibitor (RI), CGP 44,099 A, a converting enzyme inhibitor (CEI), enalaprilat, a peptidic angiotensin II (Ang II) antagonist, [Sar1, Ile8]Ang II (P-Ang IIA), and a nonpeptid...

journal_title：Journal of cardiovascular pharmacology

authors： Wood JM,Mah SC,Schnell C

更新日期：1990-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a 21-residue peptide isolated from the conditioned medium of cultured porcine endothelial cells and is widely distributed throughout the body, with relatively high levels in the kidney and lung. In this study we examined the influence of thyroid hormone status on immunoreactive endothelin (ir-ET...

journal_title：Journal of cardiovascular pharmacology

authors： Lam HC,Wang JP,Lee JK,Ho LT,Han TM,Lu CC,Chiang HT,Cheng DL

更新日期：1993-01-01 00:00:00

abstract：:A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or ...

journal_title：Journal of cardiovascular pharmacology

authors： Gardes J,Evin G,Castro B,Corvol P,Menard J

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Adequate folate status supports endothelial structure and function. Folic acid (FA), an oxidized synthetic folate, which is present in the plasma of patients consuming fortified food or FA supplements, may impair cellular uptake of physiological, reduced folates. We studied the effect of FA on uptake of the ...

journal_title：Journal of cardiovascular pharmacology

authors： Smith D,Hornstra J,Rocha M,Jansen G,Assaraf Y,Lasry I,Blom H,Smulders YM

更新日期：2017-10-01 00:00:00

abstract：:The antiarrhythmic effects of R56865 were characterized both in vivo and in vitro. Four groups (n = 12 per group) of anesthetized rats, subjected to 5- or 30-min coronary artery ligation and reperfusion, were studied: saline, dimethyl sulfoxide (DMSO) carrier, and R56865 (0.5 or 2 mg/kg) were administered as an intrav...

journal_title：Journal of cardiovascular pharmacology

authors： Garner JA,Hearse DJ,Bernier M

更新日期：1990-09-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is generally thought to be a central nervous system depressant; however, GHB also has sympathomimetic cardiovascular actions. Radio telemetry was used to record the cardiovascular responses elicited by GHB (180-1000 mg/kg IV) in conscious rats. GHB elicited increases in mean arterial pressu...

journal_title：Journal of cardiovascular pharmacology

authors： Hicks AR,Kapusta DR,Varner KJ

更新日期：2004-12-01 00:00:00

abstract：:One of the earliest structural changes in the heart adapting to hypertension is left ventricular hypertrophy, which can now be exactly measured by echocardiography. Left ventricular hypertrophy increases the incidence of coronary artery disease, heart failure, and sudden death severalfold, independent of the blood pre...

journal_title：Journal of cardiovascular pharmacology

authors： Schmieder RE

更新日期：1992-01-01 00:00:00

abstract：:We wished to determine whether angiotensin-converting enzyme (ACE) inhibition alters the effect of hypoxia and reoxygenation directly on the cardiac myocyte; to compare two different ACE inhibitors, one with and one without a sulfhydryl group (i.e., captopril and cilazapril), and to examine the potential interaction o...

journal_title：Journal of cardiovascular pharmacology

authors： Rabkin SW

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Paraquat poisoning is one of leading intoxication worldwide without an effective antidote and treatment protocol. Among the other organs, cardiotoxicity of paraquat has been frequently reported. AIM:The protective effects of atorvastatin (STN) on paraquat-induced cardiotoxicity and the role of peroxisome pr...

journal_title：Journal of cardiovascular pharmacology

authors： Malekinejad M,Masoumi Verki M,Khoramjouy M,Alenabi A,Hallaj-Salahipour M,Malekinejad H

更新日期：2019-11-01 00:00:00

abstract：:Cardiac endothelial nitric oxide synthase (ecNOS) was suppressed and inducible NOS (iNOS) enhanced at the decompensated heart failure stage in 18-week-old Dahl salt-sensitive (DS) hypertensive rats to which a high-salt diet had been administered from the age of 6 weeks. Nicorandil (NIC) enhanced ecNOS by activating Ad...

journal_title：Journal of cardiovascular pharmacology

authors： Horinaka S,Kobayashi N,Yagi H,Mori Y,Matsuoka H

更新日期：2006-05-01 00:00:00

abstract：:Arrhythmias occur 24 h after occlusion of the left anterior descending (LAD) coronary artery in the canine heart and have been attributed to the abnormal spontaneous activity in subendocardial Purkinje fibers, which are markedly depolarized. The major current underlying normal automaticity in these fibers is i(f). Alt...

journal_title：Journal of cardiovascular pharmacology

authors： Lasker SM,Han D,Kline RP

更新日期：1997-05-01 00:00:00