Antihypertensive therapy with MK 421: angiotensin II--renin relationships to evaluate efficacy of converting enzyme blockade.

abstract：:The distribution of catecholamine (CA)-containing neurones and tissue noradrenaline (NA) concentration was investigated in pig hearts with and without myocardial ischemia. All hearts were shock-frozen using a Wollenberger clamp, and tissue samples were obtained from the mid- and apical left ventricular wall (nonischem...

journal_title：Journal of cardiovascular pharmacology

authors： Hirche H,McDonald FM,Polwin W,Addicks K

更新日期：1985-01-01 00:00:00

abstract：:Cardiac electrophysiologic effects of PK 10139 (PK), a new quinoleic antiarrhythmic agent, were compared with those of quinidine sulphate (Q) after three cumulative intravenous doses of 0.75, 1.5, and 3 mg/kg of PK and 5, 10, and 20 mg/kg of Q in anesthetized dogs. A control group of animals received saline solution o...

journal_title：Journal of cardiovascular pharmacology

authors： Heckle J,Jaillon P,Jozefczak C,Cheymol G

更新日期：1985-01-01 00:00:00

abstract：:The complementary antihypertensive effects of the beta-blocker/calcium antagonist combination has to be weighed against their additive and potentially detrimental negative inotropic, chronotropic, and dromotropic effects inherent in both classes of drugs. We reviewed the main adversity, particularly electrophysiologic...

journal_title：Journal of cardiovascular pharmacology

authors： Brouwer RM,Follath F,Bühler FR

更新日期：1985-01-01 00:00:00

abstract：:A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or ...

journal_title：Journal of cardiovascular pharmacology

authors： Gardes J,Evin G,Castro B,Corvol P,Menard J

更新日期：1980-09-01 00:00:00

abstract：:The vascular effects of cardamonin and alpinetin from Alpinia henryi K. Schum. were examined in the rat isolated mesenteric arteries. 1H and 13C nuclear magnetic resonance spectra showed that cardamonin is present in trans-form, and single-crystal radiographic structure revealed that alpinetin is present in S configur...

journal_title：Journal of cardiovascular pharmacology

authors： Wang ZT,Lau CW,Chan FL,Yao X,Chen ZY,He ZD,Huang Y

更新日期：2001-05-01 00:00:00

abstract：:Compound LY249933 and its component diastereomers, (RR) and (SR), were studied for their vascular and cardiac effects in vitro and in vivo. In guinea pig cardiac ventricular membranes, LY249933, (RR), and (SR) potently displaced bound [3H]nitrendipine (Kd values = 2-6 nM). In isolated guinea pig right ventricular stri...

journal_title：Journal of cardiovascular pharmacology

authors： Holland DR,Wikel JH,Kauffman RF,Smallwood JK,Zimmerman KM,Utterback BG,Turk JA,Steinberg MI

更新日期：1989-09-01 00:00:00

abstract：:Coronary heart disease secondary to atherosclerosis is the leading cause of death for men in the United States. Using a new, nontransgenic, non-fat-fed mouse model of hyperlipidemia and atherosclerosis developed in our laboratory, we investigated the effect of sex on lipid profiles and subsequent aortic atheroscleroti...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Coker JW,Paigen BJ,Tawfik O

更新日期：2002-03-01 00:00:00

abstract：:This study investigated the effect of pioglitazone, an insulin sensitizer, on metabolic abnormalities and oxidative stress as a cause of myocardial collagen accumulation in prediabetic rat hearts. Twenty male diabetic rats and 9 male nondiabetic age-matched rats were used. The diabetic rats were divided into two group...

journal_title：Journal of cardiovascular pharmacology

authors： Tsuji T,Mizushige K,Noma T,Murakami K,Ohmori K,Miyatake A,Kohno M

更新日期：2001-12-01 00:00:00

abstract：:Apolipoprotein (apo) E and C-I are plasma apolipoproteins that have been implicated in the etiology of atherosclerosis and obesity, respectively. Both proteins are synthesized and secreted by macrophages, though pharmacological regulation of their production is poorly understood. The authors compared the effect of 2 H...

journal_title：Journal of cardiovascular pharmacology

authors： Castilho LN,Chamberland A,Boulet L,Davignon J,Cohn JS,Bernier L

更新日期：2003-08-01 00:00:00

abstract：:We studied the effects of maprotiline, a tetracyclic antidepressant agent, on transmembrane potentials recorded from papillary muscles of guinea pigs and sinoatrial nodes of rabbits, using standard microelectrode techniques. Maprotiline (10-100 microM) produced dose-dependent decreases in the maximum rate of rise (Vma...

journal_title：Journal of cardiovascular pharmacology

authors： Igawa O,Kotake H,Kurata Y,Saitoh M,Fujimoto Y,Hasegawa J,Mashiba H

更新日期：1988-02-01 00:00:00

abstract：:The nitric oxide (NO) synthase activity present in murine J774.2 monocyte/macrophages was characterized in terms of its intracellular localization, substrate specificity, and Ca2+ dependency. Traces of constitutive NO synthase activity were found in the microsomal fraction from noninduced J774.2 cells, whereas no NO s...

journal_title：Journal of cardiovascular pharmacology

authors： Hecker M,Walsh DT,Vane JR

更新日期：1992-01-01 00:00:00

abstract：:The acute, 60 min blood pressure and plasma renin responses to an oral test dose of captopril given to a quietly seated patient can be used to gain information quickly on renin dependency or lack of it in a hypertensive situation. This information is verified by a baseline renin sodium profile test. These two diagnost...

journal_title：Journal of cardiovascular pharmacology

authors： Laragh JH

更新日期：1985-01-01 00:00:00

abstract：:We investigated the role of peripheral sympathetic neurons and the adrenal medulla in the cardiovascular responses to cocaine in conscious, unrestrained Sprague-Dawley rats. Surgical adrenal demedullation (ADM) and/or chemical peripheral sympathectomy was used to eliminate one or both components of the sympathoadrenal...

journal_title：Journal of cardiovascular pharmacology

authors： Chen BX,Myles J,Wilkerson RD

更新日期：1995-05-01 00:00:00

abstract：:The vasoactive effects of calcium antagonist drugs were compared using a multi-organ functional imaging technique with thallium-201 (Tl-201). Four drugs were tested at two different doses: nifedipine (10 and 25 micrograms/kg), verapamil (100 and 250 micrograms/kg), diltiazem (100 and 250 micrograms/kg), and bepridil (...

journal_title：Journal of cardiovascular pharmacology

authors： Moins N,Gachon P,Maublant J,Duchêne-Marullaz P

更新日期：1983-11-01 00:00:00

abstract：:The phosphodiesterase inhibitor UK 61260 exhibits positive inotropic activity in animal studies and is under clinical investigation for treatment of congestive heart failure (CHF). We examined the lusitropic and inotropic responses to UK 61260 in electrically driven (1 Hz, 37 degrees C) human auricular trabeculae (AUT...

journal_title：Journal of cardiovascular pharmacology

authors： Schwinger RH,Böhm M,La Rosée K,Schmidt U,Erdmann E

更新日期：1992-06-01 00:00:00

abstract：:We briefly review and compare the current knowledge of growth mechanisms for the mitogenic response of endothelial cells and smooth-muscle cells to injury. For the endothelium, this focuses on the evidence that growth control involves two components: an endogenous inhibition mechanism, which can be overcome either by ...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz SM,Liaw L

更新日期：1993-01-01 00:00:00

abstract：:We established a real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) system for the analysis of rat endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 gene expression. We used this technique to examine the expression levels in rat in 16 different organs. ET-1 gene expressio...

journal_title：Journal of cardiovascular pharmacology

authors： Uchide T,Adur J,Fukamachi T,Saida K

更新日期：2000-11-01 00:00:00

abstract：:We examined a relation between cyclic guanosine monophosphate (cGMP) production in thoracic aorta, as an indicator probably reflecting the vascular response, and the vascular as well as plasma levels of nicorandil administered orally to rats. Nicorandil (3 mg/kg) given orally was rapidly absorbed, reaching the maximal...

journal_title：Journal of cardiovascular pharmacology

authors： Sakai K,Moriyasu M,Kitajima S,Akima M,Kamachi S,Tanikawa M

更新日期：1998-04-01 00:00:00

abstract：:Effects of amiodarone injected intravenously (i.v.) at two doses (10 and 20 mg/kg) on perfused isovolumic rat hearts were assessed by P-31 nuclear magnetic resonance (NMR). P-31 NMR is used to measure intracellular myocardial pH, phosphocreatine (PCr), and ATP contents time evolutions. Myocardial mechanical function i...

journal_title：Journal of cardiovascular pharmacology

authors： Vander Elst L,Goudemant JF,Mouton J,Chatelain P,Van Haverbeke Y,Muller RN

更新日期：1990-03-01 00:00:00

abstract：:There is no systematic study in which the effects of vasoactive substances were investigated on pulmonary vascular resistance (PVR) in in vivo mouse by directly measuring cardiac output and the inflow and outflow pressures in the pulmonary circulation. We determined the responses of PVR, total peripheral resistance (T...

journal_title：Journal of cardiovascular pharmacology

authors： Wang M,Shibamoto T,Shinomiya S,Yamamoto Y,Kurata Y,Kuda Y,Tanida M,Toga H

更新日期：2015-04-01 00:00:00

abstract：:We studied the short-term effects of oral administration of nisoldipine (10 mg) and propranolol (80 mg) alone and in combination in 14 patients with chronic exertional angina pectoris in a double-blind, randomized, cross-over study. The 14 patients (13 men and 1 woman, mean age 56 +/- 7 years) performed symptoms-limit...

journal_title：Journal of cardiovascular pharmacology

authors： De Caprio L,Papa M,Acanfora D,Abete P,Gallucci F,Covelluzzi F,Cicatiello AM,Rengo F

更新日期：1990-08-01 00:00:00

abstract：:Activity in central sympathetic pathways can be modified by stimulating central alpha 2-adrenoceptors, e.g., with clonidine, or, more recently, by stimulating central 5-hydroxytryptamine (5-HT1A) receptors. Stimulation of 5-HT1A receptors causes central sympathoinhibition and an increase in cardiac vagal drive, which ...

journal_title：Journal of cardiovascular pharmacology

authors： Ramage AG

更新日期：1990-01-01 00:00:00

abstract：:Monophasic action potentials (MAPs) were utilized to examine the basis for cesium-induced arrhythmia in the dog. Cesium chloride (1 mmol/kg i.v.) produced an immediate prolongation of MAP (250 +/- 11 to 396 +/- 34 ms, p less than 0.05). Coupled premature ventricular beats (345 +/- 46 ms) and polymorphic ventricular ta...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Szabo B,Scherlag BJ,Lazzara R

更新日期：1990-02-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in the modulation of renal O2 consumption in dogs with pacing-induced congestive heart failure (CHF). O2 consumption in the renal cortex (C) and medulla (M) of normal dogs and dogs with CHF was measured under control conditions and in the presence of increasing concentrati...

journal_title：Journal of cardiovascular pharmacology

authors： Adler S,Huang H,Loke K,Xu X,Laumas A,Hintze TH

更新日期：2001-03-01 00:00:00

abstract：:The binding of [3H]ketanserin and [125I]BE 2254 [( beta-(4-hydroxyphenyl)ethylaminomethyl]tetralone) was characterized in human brain cortex membranes. As observed in saturation experiments, [3H]ketanserin (a reportedly selective serotonin 5-HT2 ligand) and [125I]BE 2254 (a selective alpha 1-adrenergic antagonists) la...

journal_title：Journal of cardiovascular pharmacology

authors： Hoyer D,Vos P,Closse A,Palacios JM,Engel G,Davies H

更新日期：1987-01-01 00:00:00

abstract：:Results of previous studies indicate that monophosphoryl lipid A (MLA) reduces myocardial infarct size when administered 24 but not 1 h before a prolonged period of regional ischemia in dogs and rabbits. This cardioprotective effect of MLA could be reversed by the administration of the adenosine triphosphate (ATP)-sen...

journal_title：Journal of cardiovascular pharmacology

authors： Elliott GT,Mei DA,Gross GJ

更新日期：1998-07-01 00:00:00

abstract：:Exposure of endothelial cells (ECs) to thrombin or cytokines leads to major changes in their biochemical properties, which confer procoagulant activities. Stimulated ECs express the procoagulant glycoprotein tissue factor (TF). Although some TF is expressed on the apical surface of the cells, most is deposited as a cr...

journal_title：Journal of cardiovascular pharmacology

authors： Leclerc NE,Haan-Archipoff G,Lenoble M,Beretz A

更新日期：1995-01-01 00:00:00

abstract：:Severe pulmonary arterial hypertension (PAH) is characterized by clustered proliferation of endothelial cells (ECs) in the lumina of small size pulmonary arteries resulting in concentric obliteration of the lumina and formation of complex vascular structures known as plexiform lesions. This debilitating disease occurs...

journal_title：Journal of cardiovascular pharmacology

authors： Tofovic SP

更新日期：2010-12-01 00:00:00

abstract：:Apoptosis of vascular cells is observed in vivo in normal vessel development and a variety of vascular pathologies. Apoptosis occurs in all cell types within the vessel wall, the consequences of which depend on both cell type and the pathology under study. The death receptor Fas is expressed throughout the vessel wall...

journal_title：Journal of cardiovascular pharmacology

authors： Stoneman VE,Bennett MR

更新日期：2009-02-01 00:00:00

abstract：:The aim of this study was to investigate whether the HMG-CoA reductase inhibitor cerivastatin alters the nitric oxide (NO) bioavailability of porcine aortic endothelial cell cultures and of native porcine coronary endothelium, after short-term (minutes) and long-term (24-hour) treatment with cerivastatin (electrochemi...

journal_title：Journal of cardiovascular pharmacology

authors： Berkels R,Nouri SK,Taubert D,Bartels H,Roesen P,Roesen R,Klaus W

更新日期：2003-09-01 00:00:00