Cerebrospinal fluid norepinephrine levels in essential hypertension: effects of drug treatment and withdrawal.

abstract：BACKGROUND:Telmisartan is an angiotensin II receptor blocker, which acts as a partial agonist of peroxisome proliferator activator receptor-γ (PPAR-γ). Because PPAR-γ initiates a variety of antiinflammatory responses, the effect on myocardial ischemia is to be elucidated. METHODS AND RESULTS:The left anterior descendi...

journal_title：Journal of cardiovascular pharmacology

authors： Nagashima A,Watanabe R,Ogawa M,Suzuki J,Masumura M,Hishikari K,Shimizu T,Takayama K,Hirata Y,Nagai R,Isobe M

更新日期：2012-08-01 00:00:00

abstract：:Dobutamine is frequently used for acute therapy in heart failure. In the present study, the hemodynamic effects of long-term intermittent dobutamine therapy were investigated in conscious rats with heart failure. Rats with healed myocardial infarctions received two i.p. injections of dobutamine per day for 2 weeks. He...

journal_title：Journal of cardiovascular pharmacology

authors： Schoemaker RG,Debets JJ,Struyker-Boudier HA,Smits JF

更新日期：1991-06-01 00:00:00

abstract：:The aim of this study was to assess whether arterial chemoreceptors are activated in chronic heart failure and to appreciate whether this activation is related to the degree of cardiac dysfunction. We examined whether administration of pure oxygen for 30 min to 35 patients with chronic heart failure was followed by he...

journal_title：Journal of cardiovascular pharmacology

authors： Saadjian A,Paganelli F,Levy S

更新日期：1999-01-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:Endothelin (ET) receptor subtypes in human prostate with benign prostatic hyperplasia were investigated by binding and functional studies. In the displacement experiment, LU224332 [endothelin-A/-B (ET(A)/ET(B)) nonselective antagonist] competed for [125I]ET-1 binding with a monophasic curve. On the other hand, LU13525...

journal_title：Journal of cardiovascular pharmacology

authors： Hiraoka Y,Oshita M,Morikawa K,Nagata O,Hahn KJ,Hahn A,Okada K,Taniguchi T,Muramatsu I

更新日期：2000-11-01 00:00:00

abstract：:Both acetylcholine (ACh) and cyclopiazonic acid (CPA) caused vasodilation of the mesenteric arterial bed in a concentration-dependent manner. When the mesenteric arterial bed was perfused with 0.1% Triton X-100 for 30 s, ACh- or CPA-induced vasodilation was almost abolished. ACh-induced vasodilation was significantly ...

journal_title：Journal of cardiovascular pharmacology

authors： Kamata K,Umeda F,Kasuya Y

更新日期：1996-04-01 00:00:00

abstract：:Although myocardial ischemia is associated with regional cardiac sympathetic nerve deterioration, it remains unknown whether acute hindlimb ischemia impairs muscle sympathetic nerve function. In the study presented here we implanted dialysis probes in the adductor muscle of anesthetized rabbits and measured dialysate ...

journal_title：Journal of cardiovascular pharmacology

authors： Tokunaga N,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2003-12-01 00:00:00

abstract：:We investigated the effects of sodium 2[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (POCA) on regional myocardial function and metabolism in anesthetized, thoracotomized dogs subjected to a 53.5% reduction in flow through the circumflex branch of the left coronary artery (LCX). Regional function in the area suppl...

journal_title：Journal of cardiovascular pharmacology

authors： Seitelberger R,Kraupp O,Winkler M,Brugger G,Raberger G

更新日期：1985-03-01 00:00:00

abstract：:Atherosclerosis, like several other vascular diseases, exhibits structural and functional abnormalities resulting partially from an exaggerated proliferation of vascular smooth-muscle cells (VSMCs). Ca2+ channel blockers, such as amlodipine, have been suggested to retard or even prevent the progression of atherosclero...

journal_title：Journal of cardiovascular pharmacology

authors： Stepien O,Gogusev J,Zhu DL,Iouzalen L,Herembert T,Drueke TB,Marche P

更新日期：1998-05-01 00:00:00

abstract：:Previous animal experiments suggest that the increase in the amplitude from the R-wave to the S-wave (RSh) may be more sensitive than other ECG measures to sodium channel blocking drug actions. We measured RSh of three orthogonal leads at baseline and during intravenous pharmacologic stimulation with adenosine, ajmali...

journal_title：Journal of cardiovascular pharmacology

authors： Wolzt M,Schmetterer L,Gouya G,Zanaschka G,Eichler HG

更新日期：1995-10-01 00:00:00

abstract：:Chronic uremia and metabolic acidosis impair vascular responses to norepinephrine (NE) and also cause multiple metabolic defects in skeletal muscle. These studies were conducted to determine whether decreased vascular responsiveness resulted from putative second messenger metabolism. Tail arteries were used from rats ...

journal_title：Journal of cardiovascular pharmacology

authors： Fox AW,May RE,Mitch WE

更新日期：1992-08-01 00:00:00

abstract：:Besides generating renal damage, hypertension plays an important role in the progression of diabetic nephropathy. The fructose-fed rat is a well-established model both of high blood pressure and renal impairment, which is similar to diabetic nephropathy. To clarify the relationship between hypertension, glucose metabo...

journal_title：Journal of cardiovascular pharmacology

authors： Bernobich E,Cosenzi A,Campa C,Zennaro C,Sasso F,Paoletti S,Bellini G

更新日期：2004-09-01 00:00:00

abstract：:We have evaluated the effects of indoramin, an alpha-adrenoreceptor blocking drug, used as sole therapy in a group of 27 patients with essential hypertension. Blood pressure and heart rate were measured continuously over prolonged ambulatory periods using an established invasive technique before and after six weeks of...

journal_title：Journal of cardiovascular pharmacology

authors： Gould BA,Mann S,Davies AB,Altman DG,Raftery EB

更新日期：1983-05-01 00:00:00

abstract：:The use of calcium antagonists as cardioprotective agents is based on the assumption that uncontrolled Ca2+ gain is a key factor in causing cell death and tissue necrosis. This uncontrolled gain in Ca2+ is the ultimate expression of a series of metabolic events triggered by inadequate perfusion. One of the early event...

journal_title：Journal of cardiovascular pharmacology

authors： Nayler WG

更新日期：1991-01-01 00:00:00

abstract：:Intracellular calcium ([Ca]i) overload on reperfusion may be one of the mechanisms responsible for ischemia-induced regional myocardial dysfunction. Because inhibiting the Na-H exchanger (NHE) limits intracellular sodium ([Na]i) and subsequent [Ca]i accumulation, we hypothesized that NHE inhibition would attenuate reg...

journal_title：Journal of cardiovascular pharmacology

authors： Symons JD,Correa SD,Schaefer S

更新日期：1998-12-01 00:00:00

abstract：:The presence of endothelin (ET) receptors and the nature of the subtype and expression of ET were investigated in the human megakaryoblastic cell line MEG-01. By the RT-PCR procedure, we have shown that both ETA and ETB receptor subtype mRNAs are expressed in the cells. However, binding experiments have shown that the...

journal_title：Journal of cardiovascular pharmacology

authors： Hamroun D,Mathieu MN,Clain E,Germani E,Laliberté MF,Laliberté F,Chevillard C

更新日期：1995-01-01 00:00:00

abstract：:Numerous studies have demonstrated that immune effector mechanisms cause serious heart diseases, among which are heart transplant rejection, myocarditis, and the resulting dilated cardiomyopathy, as well as Chagas' disease. Whereas different effectors of the immune system can affect cardiac function, this review prima...

journal_title：Journal of cardiovascular pharmacology

authors： Binah O

更新日期：2001-08-01 00:00:00

abstract：:To assess dose-related effects of enalapril, we treated eight hospitalized hypertensive patients receiving constant sodium intake with incremental doses of this new angiotensin converting-enzyme blocking drug. After a few days of placebo treatment, enalapril was given in single daily doses, starting with 1.25 mg and i...

journal_title：Journal of cardiovascular pharmacology

authors： de Leeuw PW,Birkenhäger WH

更新日期：1986-01-01 00:00:00

abstract：:The present study was undertaken to investigate the interaction between endothelin-1 (ET-1) and norepinephrine (NE) on contractile regulation in dog ventricular myocardium. ET-1 alone did not elicit any inotropic response in isolated dog ventricular trabeculae (37 degrees C, 0.5 Hz). In the presence of NE at a high co...

journal_title：Journal of cardiovascular pharmacology

authors： Chu L,Endoh M

更新日期：2000-01-01 00:00:00

abstract：:To determine whether differential release of nitric oxide underlies the diversity of regional kidney blood flow responses to vasoactive agents, this study examined how nitric oxide synthase blockade with IV N(G)-nitro-L-arginine (L-NNA), and also IV L-NNA plus co-infusion of glyceryl trinitrate, affected responses to ...

journal_title：Journal of cardiovascular pharmacology

authors： Rajapakse NW,Oliver JJ,Evans RG

更新日期：2002-08-01 00:00:00

abstract：AIMS:To determine whether short-term treatment with trimetazidine (TMZ), an antiischemic agent that directly inhibits fatty acid oxidation and results in stimulation of glucose oxidation, may improve myocardial perfusion and left ventricular systolic function in diabetic patients with ischemic cardiomyopathy. METHODS ...

journal_title：Journal of cardiovascular pharmacology

authors： Belardinelli R,Cianci G,Gigli M,Mazzanti M,Lacalaprice F

更新日期：2008-06-01 00:00:00

abstract：:We compared the tolerance-inducing effects of nitroglycerin (NTG) and nicorandil (NIC) in porcine isolated coronary arteries and assessed the role of KATP channels in the response to NIC in nitrate-tolerant and nontolerant preparations. In coronary arteries contracted with U46619 (1-3 x 10(-9) M), NTG, NIC, sodium nit...

journal_title：Journal of cardiovascular pharmacology

authors： O'Rourke ST

更新日期：1996-06-01 00:00:00

abstract：:Bethanidine sulfate is a congener of bretylium tosylate, which has been reported to have antiarrhythmic and antifibrillatory effects. We studied the effects of bethanidine on transmembrane potentials recorded from canine Purkinje fibers and ventricular muscle cells, using standard microelectrode techniques. Normal Pur...

journal_title：Journal of cardiovascular pharmacology

authors： Dangman KH,Miura DS

更新日期：1985-01-01 00:00:00

abstract：:To assess the interaction of endothelin (ET) with nitric oxide (NO) and the effects on venous circulation and handling of renal water and electrolytes, ET (1.0 ng/kg/min) or saline was administered with or without three doses (0.27, 2.7 and 27 ng/kg/min for 40 min) of N omega-nitro-L-arginine methyl ester (L-NAME), an...

journal_title：Journal of cardiovascular pharmacology

authors： Ota K,Kimura T,Shoji M,Ota M,Funyu T,Mori T,Sahata T

更新日期：1998-01-01 00:00:00

abstract：:Vasopeptidase inhibitors are single molecules that inhibit neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) simultaneously. Omapatrilat, the first in this new class of cardiovascular agents, potentiates vasodilatory and cardioprotective peptides and represses angiotensin II. This study compared the ...

journal_title：Journal of cardiovascular pharmacology

authors： Trippodo NC,Fox M,Monticello TM,Panchal BC,Asaad MM

更新日期：1999-12-01 00:00:00

abstract：:The aim of this study was to comparatively assess the effects of irbesartan and amlodipine monotherapies on left ventricular mass index (LVMI) in patients with mild to moderate untreated hypertension and echocardiographically determined left ventricular hypertrophy (LVH). Sixty hypertensive patients (35 men, 25 women;...

journal_title：Journal of cardiovascular pharmacology

authors： Gaudio C,Ferri FM,Giovannini M,Pannarale G,Puddu PE,Vittore A,Fera MS,Vizza CD,Fedele F

更新日期：2003-11-01 00:00:00

abstract：:(+/-)-Dobutamine at concentrations < or =10(-5) M did not evoke contractions of rat gastric artery segments. However, when the tissues were contracted with methoxamine, (+/-)-dobutamine evoked concentration-dependent relaxation. The relaxant responses were not significantly affected by propranolol. In the same prepara...

journal_title：Journal of cardiovascular pharmacology

authors： Oriowo MA

更新日期：1999-11-01 00:00:00

abstract：:In primarily cultured pig coronary smooth muscle cells, extracellular adenosine triphosphate (ATP; 10(-9) to 10(-3) M) dose-dependently increases intracellular calcium ([Ca2+]i). The [Ca2+]i transients measured by fura-2 fluorescence consist of peak and plateau phases with [Ca2+]i values of 191.84 +/- 5.67 nM (n = 10)...

journal_title：Journal of cardiovascular pharmacology

authors： Seiler L,Matyas S,Fleckenstein-Grün G

更新日期：1999-05-01 00:00:00

abstract：:alpha-Adrenoceptor agonists and antagonists are widely used perioperatively for internal mammary artery (IMA)-coronary artery bypass operations. To determine subtypes of alpha-adrenoceptors in the human IMA, we studied responses of isolated human IMA segments to alpha-adrenoceptor agonists, antagonists, and electrical...

journal_title：Journal of cardiovascular pharmacology

authors： He GW,Shaw J,Hughes CF,Yang CQ,Thomson DS,McCaughan B,Hendle PN,Baird DK

更新日期：1993-02-01 00:00:00

abstract：:We conducted an intracardiac study of the electrophysiologic effects and kinetics of intravenous nicardipine (N) in 16 patients with or without impaired cardiac conduction, using a randomized, double-blind, crossover design versus placebo (P). N or P were infused intravenously over 5 min: the dose of N was 9.46 +/- 3....

journal_title：Journal of cardiovascular pharmacology

authors： David D,Guize L,Leheuzey JY,Lavergne T,Loria Y,Ourbak P

更新日期：1990-01-01 00:00:00