KATP channel activation mediates nicorandil-induced relaxation of nitrate-tolerant coronary arteries.

abstract：:PPARgamma agonists ameliorate insulin resistance and lower blood pressure. Volume expansion/edema has been observed in susceptible patients treated with these agents. Alterations of renal hemodynamics affect renal tubular reabsorption, and thus may contribute to volume expansion. This study seeks to determine whether ...

journal_title：Journal of cardiovascular pharmacology

authors： Yang B,Clifton LG,McNulty JA,Chen L,Brown KK,Baer PG

更新日期：2003-09-01 00:00:00

abstract：:According to the standard model of G protein-coupled receptor (GPCR) signaling, GPCRs are localized to the cell membrane where they respond to extracellular signals. Stimulation of GPCRs leads to the activation of heterotrimeric G proteins and their intracellular signaling pathways. However, this model fails to accomm...

journal_title：Journal of cardiovascular pharmacology

authors： Campden R,Audet N,Hébert TE

更新日期：2015-02-01 00:00:00

abstract：:Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young N(ω)-nitro-L-arginine methyl ester (L-NAME)-treated Wistar rats and 10-month-old spontaneously hypertensive rats (SHR) alone and after chronic treatment with feru...

journal_title：Journal of cardiovascular pharmacology

authors： Alam MA,Sernia C,Brown L

更新日期：2013-03-01 00:00:00

abstract：:We investigated the effects of endothelin (ET) and thrombin on the production of interleukin 6 (IL-6) in human umbilical vein endothelial cells (HUVECs). ET-1 increased IL-6 production twofold in HUVECs incubated for 18 h with 10(-10) M ET-1. Thrombin also significantly increased IL-6 production. However, stimulation ...

journal_title：Journal of cardiovascular pharmacology

authors： Stanková J,Rola-Pleszczynski M,D'Orléans-Juste P

更新日期：1995-01-01 00:00:00

abstract：:beta 2-Adrenoceptor function may be decreased in primary hypertension, resulting in increased peripheral resistance. To study the beta 2-adrenoceptor function, we used circulating mononuclear leukocytes (MNL) as a model system. Twenty untreated hypertensive subjects [(HT) 10 men and 10 women] and 20 age- and sex-match...

journal_title：Journal of cardiovascular pharmacology

authors： Blankesteijn WM,Willems PH,Graafsma SJ,de Pont JJ,Thien T

更新日期：1993-11-01 00:00:00

abstract：:The propyl derivative of ajmaline, N-n-propylajamaline (prajmalium), is an antiarrhythmic compound that lacks the commonly reported negative inotropic effects of all others under clinical use. The present study was undertaken to establish and understand its effects at the cellular level in mammalian preparations. Elec...

journal_title：Journal of cardiovascular pharmacology

authors： Alvarez JL,Rubio L,Garrido G,Vassort G

更新日期：1992-07-01 00:00:00

abstract：:Beraprost sodium is a stable analog of the vasodilator, platelet antiaggregatory eicosanoid, prostacyclin. Experiments were performed to determine whether long-term therapy with beraprost produces vascular protective effects in saline-drinking stroke-prone spontaneously hypertensive rats (SHRSPs). Oral beraprost at 30...

journal_title：Journal of cardiovascular pharmacology

authors： Stier CT Jr,Chander PN,Belmonte A,Inamdar RS,Mistry M

更新日期：1997-09-01 00:00:00

abstract：:Sinoaortic deafferentation (SAD) is characterized by arterial pressure lability, without sustained hypertension. Although SAD rats did not become hypertensive, their isolated aortas exhibit RCs. We have investigated whether these RCs are influenced by endothelium. Aortic rings were placed in an organ chamber, and the ...

journal_title：Journal of cardiovascular pharmacology

authors： Rocha ML,Bendhack LM

更新日期：2007-11-01 00:00:00

abstract：:Atrial Fibrillation (AF) is accompanied by an increased risk for thromboembolic events in most affected patients. Current guidelines therefore recommend antithrombotic therapy with vitamin K antagonist (VKA) or non VKA oral anticoagulant (NOAC) in the majority of AF patients. Current AF treatment guidelines recommend ...

journal_title：Journal of cardiovascular pharmacology

authors： Hammwöhner M,Goette A

更新日期：2015-12-01 00:00:00

abstract：:Using selective endothelin (ET) receptor antagonists, we investigated which ET receptor subtypes mediate the changes in blood pressure and hematocrit produced by intraarterial injection of ET-1 in the anesthetized rabbit. In addition, the receptor through which ET-1 stimulates the release of prostacyclin (PGI2) and, h...

journal_title：Journal of cardiovascular pharmacology

authors： McMurdo L,Lidbury PS,Corder R,Thiemermann C,Vane JR

更新日期：1993-01-01 00:00:00

abstract：:This study investigated the ability of angiotensin II (Ang II) to facilitate the stimulation-induced release of [3H]norepinephrine [( 3H]NE) from two cardiovascular regulatory areas in normal and sodium-restricted rats. Ang II (10(-7) M) facilitated the field-stimulation-induced release of [3H]NE from the A2 area of t...

journal_title：Journal of cardiovascular pharmacology

authors： Meldrum MJ,Xue CS,Badino L,Westfall TC

更新日期：1984-11-01 00:00:00

abstract：:In helical strips of dog cerebral, coronary, mesenteric, and renal arteries treated with ONO3708, an inhibitor of vasoconstricting prostaglandin (PG) receptors, and previously contracted with serotonin, PGF2 alpha, PGD2 and epithio-methano thromboxane A2 (sTxA2), a TxA2 analog, caused a relaxation. The cerebral arteri...

journal_title：Journal of cardiovascular pharmacology

authors： Toda N,Inoue S,Okamura T,Okunishi H

更新日期：1988-03-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:The object of this study was to differentiate losartan, an AT1-selective angiotensin II (ANG II) receptor antagonist, from enalapril, an angiotensin-converting enzyme (ACE) inhibitor, by measuring forearm vascular responses to AI, AII, and bradykinin. Eight healthy men were studied in a randomised, 4-period crossover ...

journal_title：Journal of cardiovascular pharmacology

authors： Cockcroft JR,Sciberras DG,Goldberg MR,Ritter JM

更新日期：1993-10-01 00:00:00

abstract：:The terminal phases of volume-overload heart failure are characterised by eccentric ventricular hypertrophy. Relatively little attention has been directed to exploring the mechanisms involved in this development. The increase in diastolic wall stress leads to replication of the sarcomeres in series. The hypertrophied ...

journal_title：Journal of cardiovascular pharmacology

authors： Taylor SH

更新日期：1987-01-01 00:00:00

abstract：:Biological aging is an independent risk factor for many cardiovascular diseases; some are treated with beta-blockers that may protect dysfunctional endothelium during aging by increasing NO, decreasing ONOO, and restoring NO/ONOO balance. A nanotechnological approach was used to simultaneously monitor NO and ONOO prod...

journal_title：Journal of cardiovascular pharmacology

authors： Funovic P,Korda M,Kubant R,Barlag RE,Jacob RF,Mason RP,Malinski T

更新日期：2008-02-01 00:00:00

abstract：:Effects of FK409 were investigated in perfused guinea-pig Langendorff hearts subjected to ischemia and reperfusion. Nitric oxide electrode, fluorometry, and 31P nuclear magnetic resonance imaging were used to monitor changes in cellular high-phosphorous energy and nitric oxide and Ca2+ content in the heart together wi...

journal_title：Journal of cardiovascular pharmacology

authors： Cao Y,Hotta Y,Shioi K,Nagata Y,Kawai N,Ishikawa N

更新日期：2001-10-01 00:00:00

abstract：:The use of calcium antagonists as cardioprotective agents is based on the assumption that uncontrolled Ca2+ gain is a key factor in causing cell death and tissue necrosis. This uncontrolled gain in Ca2+ is the ultimate expression of a series of metabolic events triggered by inadequate perfusion. One of the early event...

journal_title：Journal of cardiovascular pharmacology

authors： Nayler WG

更新日期：1991-01-01 00:00:00

abstract：:Endothelium-derived relaxing factor (EDRF) and donors of nitric oxide (NO) (glyceryl trinitrate, SIN-1--a metabolite of molsidomine--S-nitroso-N-acetyl-penicillamine, and sodium nitroprusside) but not prostacyclin and its analog, iloprost, relax strips of rabbit aorta. Strips of human coronary artery also relax when e...

journal_title：Journal of cardiovascular pharmacology

authors： Gryglewski RJ,Korbut R,Trabka-Janik E,Zembowicz A,Trybulec M

更新日期：1989-01-01 00:00:00

abstract：:Arterial hypertension complicating acute myocardial infarction (AMI) may aggravate myocardial damage, possibly through an increase in myocardial oxygen demand. This study reports the effects of clonidine in patients with hypertension complicating acute myocardial infarction. Forty patients (37 men and three women, ave...

journal_title：Journal of cardiovascular pharmacology

authors： Foresti A,Massari FM,Lotto A

更新日期：1986-01-01 00:00:00

abstract：:Poor compliance may be responsible for symptomatic decompensation or neurohormonal "escape" in patients with heart failure treated over the long term with angiotensin-converting enzyme-1 (ACEI) drugs. Serum ACE activity is a poor index of neurohormonal suppression or haemodynamic effect after ACE-inhibitor treatment. ...

journal_title：Journal of cardiovascular pharmacology

authors： MacFadyen RJ,Struthers AD

更新日期：1997-01-01 00:00:00

abstract：:The functional and anatomical abnormalities of the right ventricle may occur in hypertensive patients with left ventricular hypertrophy (LVH). The present study was designed to assess the functional and structural changes in both left and right ventricles induced by chronic antihypertensive therapy. Doppler and standa...

journal_title：Journal of cardiovascular pharmacology

authors： Cuspidi C,Sampieri L,Angioni L,Boselli L,Bragato R,Leonetti G,Zanchetti A

更新日期：1991-01-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors have been extensively studied and established in the treatment of hypertension, heart failure, and ventricular dysfunction. They have various cardiac and vascular protective effects, but the relevant mechanisms of action in these areas remain to be fully understood. Possible ef...

journal_title：Journal of cardiovascular pharmacology

authors： Sharpe N

更新日期：1993-01-01 00:00:00

abstract：:Late sodium channel current (late INa) is considered to be an antiarrhythmic target. The prime antiarrhythmic mechanisms of late INa inhibition have been suggested to be (1) suppression of intracellular calcium [Cai]-mediated rhythmic activity (through reduction in Cai secondary to the decrease in intracellular sodium...

journal_title：Journal of cardiovascular pharmacology

authors： Burashnikov A

更新日期：2017-09-01 00:00:00

abstract：:Inotropic effects of histamine have been studied extensively in many species, but data on porcine myocardium, often used as a model for human heart, are not available. We investigated inotropic effects of histamine on atrial and ventricular trabeculae obtained from porcine hearts. For comparison, we also evaluated the...

journal_title：Journal of cardiovascular pharmacology

authors： Du XY,Schoemaker RG,X462P6,Bos E,Saxena PR

更新日期：1993-09-01 00:00:00

abstract：:Rapamycin (RP; rapamune, sirolimus) is a potent inhibitor of vascular smooth muscle cell proliferation and migration. RP was demonstrated to reduce vascular neointimal formation in different animal models of vascular smooth muscle cell proliferation, and clinical use of RP-eluting stents promotes significant reduction...

journal_title：Journal of cardiovascular pharmacology

authors： Neto Mde M,Di Marco GS,Casarini DE,Lima VC,Campos AH

更新日期：2007-02-01 00:00:00

abstract：:It has previously been shown that endothelin (ET)-receptor antagonists protect the myocardium from ischemia and reperfusion (I/R) injury. The mechanism behind this effect is unclear. The aim of this study was to elucidate the possible interaction between ET(A)-receptor antagonism and nitric oxide (NO) during I/R. Anes...

journal_title：Journal of cardiovascular pharmacology

authors： Gonon AT,Gourine AV,Pernow J

更新日期：2000-09-01 00:00:00

abstract：:The goal of this study was to determine the effects of trimetazidine on all-cause mortality and heart failure hospitalizations in patients with ischemic cardiomyopathy. We performed an extension to 48 months and a post-hoc analysis of the Villa Pini d'Abruzzo trimetazidine trial; in this single-center, open-label, ran...

journal_title：Journal of cardiovascular pharmacology

authors： Di Napoli P,Di Giovanni P,Gaeta MA,Taccardi AA,Barsotti A

更新日期：2007-11-01 00:00:00

abstract：:We tested the hypothesis that the 5-HT transporter (5-HTT) is present and functional in peripheral arterial smooth muscle. In aorta and mesenteric resistance arteries, real time RT-PCR and western analyses indicated the presence of 5-HTT mRNA and a 74 kDa 5-HTT protein. Immunohistochemistry localized the transporter t...

journal_title：Journal of cardiovascular pharmacology

authors： Ni W,Thompson JM,Northcott CA,Lookingland K,Watts SW

更新日期：2004-06-01 00:00:00

abstract：:Besides generating renal damage, hypertension plays an important role in the progression of diabetic nephropathy. The fructose-fed rat is a well-established model both of high blood pressure and renal impairment, which is similar to diabetic nephropathy. To clarify the relationship between hypertension, glucose metabo...

journal_title：Journal of cardiovascular pharmacology

authors： Bernobich E,Cosenzi A,Campa C,Zennaro C,Sasso F,Paoletti S,Bellini G

更新日期：2004-09-01 00:00:00