Interaction between NO donors and iloprost in human vascular smooth muscle, platelets, and leukocytes.

Abstract:

:Endothelium-derived relaxing factor (EDRF) and donors of nitric oxide (NO) (glyceryl trinitrate, SIN-1--a metabolite of molsidomine--S-nitroso-N-acetyl-penicillamine, and sodium nitroprusside) but not prostacyclin and its analog, iloprost, relax strips of rabbit aorta. Strips of human coronary artery also relax when exposed to NO donors and prostacyclin; in this artery, SIN-1 and iloprost exert additive but not synergistic relaxant action. In mildly activated human platelets and leukocytes, SIN-1 and iloprost have a synergistic suppressive action. A similar synergistic thrombolytic effect between NO and prostacyclin was observed in whole rabbit blood in interactions with rabbit aortic endothelium. These findings suggest that because of this cell-selective synergism between NO donors and prostacyclin analogs, the concomitant use of molsidomine and iloprost for the treatment of ischemic heart and peripheral vascular disease should be attempted.

journal_name

J Cardiovasc Pharmacol

authors

Gryglewski RJ,Korbut R,Trabka-Janik E,Zembowicz A,Trybulec M

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

S124-8

eissn

0160-2446

issn

1533-4023

journal_volume

14 Suppl 11

pub_type

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