Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d'Abruzzo Trimetazidine Trial.

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:Interest in the cardiovascular protective effects of calcium channel antagonists has increased in the past decade. We investigated prevention of vascular wall remodeling by the long-acting calcium channel antagonist pranidipine in 12-week-old Dahl salt-sensitive (SS) rats with high-salt-induced (4% NaCl) hypertension....

journal_title：Journal of cardiovascular pharmacology

authors： Uehara Y,Kawabata Y,Ohshima N,Hirawa N,Takada S,Numabe A,Nagata T,Goto A,Yagi S,Omata M

更新日期：1994-06-01 00:00:00

abstract：:Endothelin-1[1-31] is a recently discovered member of the endothelin family with vasoactive properties in several animal models and in man in vivo. It is generated from big endothelin-1 by human mast cell chymase and may be a novel intermediary peptide in the production of endothelin-1[1-21]. Given that both big endot...

journal_title：Journal of cardiovascular pharmacology

authors： Leslie SJ,Johnston N,Strachan FE,Bagnall A,Gray GA,Newby DE,Denvir MA,Webb DJ

更新日期：2004-11-01 00:00:00

abstract：:The effect of canrenone, an antialdosterone and partial ouabain-agonist drug, was studied in rats that developed volume expansion and hypertension after renal mass reduction and excess Na+ intake (RRM-salt). The RRM-salt was characterized by: (1) increased endogenous "digitalis-like" compounds in plasma [cross reactiv...

journal_title：Journal of cardiovascular pharmacology

authors： de Mendonça M,Grichois ML,Pernollet MG,Wauquier I,Trouillet-Thormann B,Meyer P,Devynck MA,Garay R

更新日期：1988-01-01 00:00:00

abstract：:We wished to determine the action of prostaglandins (PG) and to analyze pharmacologically the mechanisms of their action in isolated human uterine arteries in special reference to mediators liberated from the endothelium and subendothelial tissues. Helical strips of the human uterine artery with and without the endoth...

journal_title：Journal of cardiovascular pharmacology

authors： Kimura T,Okamura T,Yoshida Y,Toda N

更新日期：1995-08-01 00:00:00

abstract：:Calcium sensitizers increase myocardial contractile function without affecting Ca2+ homeostasis, which might be beneficial in the treatment of patients with heart failure. However, it remains uncertain whether Ca sensitizers induce quantitatively similar inotropic responses in control and failing hearts. To compare th...

journal_title：Journal of cardiovascular pharmacology

authors： Tsutsui H,Kinugawa S,Ide T,Hayashidani S,Suematsu N,Satoh S,Nakamura R,Egashira K,Takeshita A

更新日期：2001-01-01 00:00:00

abstract：:Nebivolol, a chemically novel beta 1-adrenoceptor antagonist, acutely lowers blood pressure in spontaneously hypertensive rats, anaesthetised normotensive dogs, and hypertensive patients. We have investigated the actions of dl-nebivolol in five conscious normotensive rabbits (sham, mean blood pressure (BP) of 82.2 +/-...

journal_title：Journal of cardiovascular pharmacology

authors： Ward JE,Coles P,Cox H,Eisenhofer G,Angus JA

更新日期：1992-07-01 00:00:00

abstract：:At present, endothelin (ET) receptor classification remains controversial. We investigated the presence of atypical ETA receptors in human saphenous veins (SV). Human SV was obtained from 24 patients undergoing coronary artery bypass grafting. Vessels were set up in organ baths, stretched to a tension of 6 g, and left...

journal_title：Journal of cardiovascular pharmacology

authors： Pate MA,Chester AH,Brown TJ,Roach AG,Yacoub MH

更新日期：1998-01-01 00:00:00

abstract：:The pharmacokinetics of losartan and EXP3174, an active metabolite of losartan, were evaluated in the anesthetized pig after both a single intravenous dose (3 mg/kg) and during constant intravenous infusion. The pharmacodynamic activities of losartan and EXP3174 were determined during constant intravenous infusion as ...

journal_title：Journal of cardiovascular pharmacology

authors： Lankford SM,Plummer D,Hellyer P,Christ DD,Bai SA

更新日期：1997-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a 21-amino-acid local and circulating factor whose plasma concentrations are increased in advanced atherosclerosis. ET-1 is cleaved from a prohormone (big ET-1) by endothelin-converting enzymes (ECEs) into the biologically active mature form which mediates vasoconstriction and cell proliferation...

journal_title：Journal of cardiovascular pharmacology

authors： Grantham JA,Schirger JA,Williamson EE,Heublein DM,Wennberg PW,Kirchengast M,Muenter K,Subkowski T,Burnett JC Jr

更新日期：1998-01-01 00:00:00

abstract：:Endothelin (ET) receptor subtypes in human prostate with benign prostatic hyperplasia were investigated by binding and functional studies. In the displacement experiment, LU224332 [endothelin-A/-B (ET(A)/ET(B)) nonselective antagonist] competed for [125I]ET-1 binding with a monophasic curve. On the other hand, LU13525...

journal_title：Journal of cardiovascular pharmacology

authors： Hiraoka Y,Oshita M,Morikawa K,Nagata O,Hahn KJ,Hahn A,Okada K,Taniguchi T,Muramatsu I

更新日期：2000-11-01 00:00:00

abstract：:Carvedilol (20 mg/kg, bid) or vehicle was given to rats surviving a myocardial infarction (MI) 24 h (n = 409). In rats with large MI, carvedilol partially preserved left ventricular (LV) function and intrinsic myocardial contractility and reactivity to beta-adrenergic stimulation. Carvedilol led to scar thickening, in...

journal_title：Journal of cardiovascular pharmacology

authors： Sia YT,Parker TG,Tsoporis JN,Liu P,Adam A,Rouleau JL

更新日期：2002-01-01 00:00:00

abstract：:To determine whether nitrate tolerance is attenuated on aortas isolated from rats treated in the long term with an angiotensin-converting enzyme (ACE) inhibitor, five groups of rats were studied in parallel. Group 1 received ramipril, 1 mg/ kg/day, p.o., for 6 weeks; group 2 received ramipril at the same dose for 4 we...

journal_title：Journal of cardiovascular pharmacology

authors： Berkenboom G,Fontaine D,Unger P,Baldassarre S,Preumont N,Fontaine J

更新日期：1999-10-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play key physiological roles and represent a significant target for drug development. However, historically, drugs were developed with the understanding that GPCRs as a therapeutic target exist solely on cell surface membranes. More recently, GPCRs have been detected on intracellula...

journal_title：Journal of cardiovascular pharmacology

authors： Branco AF,Allen BG

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Telmisartan is an angiotensin II receptor blocker, which acts as a partial agonist of peroxisome proliferator activator receptor-γ (PPAR-γ). Because PPAR-γ initiates a variety of antiinflammatory responses, the effect on myocardial ischemia is to be elucidated. METHODS AND RESULTS:The left anterior descendi...

journal_title：Journal of cardiovascular pharmacology

authors： Nagashima A,Watanabe R,Ogawa M,Suzuki J,Masumura M,Hishikari K,Shimizu T,Takayama K,Hirata Y,Nagai R,Isobe M

更新日期：2012-08-01 00:00:00

abstract：:The study was designed to assess the antihypertensive effect of combined angiotensin-converting enzyme (ACE) inhibition and angiotensin II type 1 receptor (AT1) antagonism in patients with essential hypertension. Twenty patients with uncontrolled ambulatory diastolic blood pressure (BP) after 6 weeks of ACE inhibitor ...

journal_title：Journal of cardiovascular pharmacology

authors： Stergiou GS,Skeva II,Baibas NM,Roussias LG,Kalkana CB,Achimastos AD,Mountokalakis TD

更新日期：2000-06-01 00:00:00

abstract：:The adrenal medulla and pheochromocytomas are known to secrete various neuropeptides and vasoactive peptides. On the other hand, the production and secretion of peptides by adrenocortical tumors have not been studied in detail. The study reported here therefore set out to examine these two functions for two vasoactive...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Yoshinoya A,Murakami O,Totsune K,Shibahara S

更新日期：2000-11-01 00:00:00

abstract：:The objective of this study was to characterize angiotensin II (AII) receptors in cerebral capillary endothelium and to examine whether the first step in AII responsiveness, namely AII receptor binding, is aberrant in cerebral microvessels obtained from adult spontaneously hypertensive rats (SHR). The binding of [3H]a...

journal_title：Journal of cardiovascular pharmacology

authors： Grammas P,Diglio C,Giacomelli F,Wiener J

更新日期：1989-02-01 00:00:00

abstract：:Centrally acting agents and the beta-adrenergic antagonists represent two classes of antihypertensive agents recommended for initial monotherapy. Comparisons of the efficacy and safety of the centrally acting agent, guanabenz, with those of propranolol and pindolol in patients with mild to moderately severe hypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Morgan TO

更新日期：1984-01-01 00:00:00

abstract：:The function of presynaptic angiotensin II receptors at postganglionic sympathetic terminal axons under conditions of uninterrupted sympathetic impulse traffic was studied in anesthetized rabbits (alfadolone + alfaxalone). Mean arterial pressure, postganglionic renal sympathetic firing rate, the arterial plasma noradr...

journal_title：Journal of cardiovascular pharmacology

authors： Szabo B,Hedler L,Schurr C,Starke K

更新日期：1990-06-01 00:00:00

abstract：:Conversion of sustained ventricular tachycardia (VT) to nonsustained VT may be a potent mode of antiarrhythmic drug action, whereas a drug's conversion of nonsustained VT to sustained VT could produce serious clinical complications. We tested the effects of two class Ic drugs [encainide (1, 2, and 4 microM) and propaf...

journal_title：Journal of cardiovascular pharmacology

authors： Hill BC,Summers RA,Courtney KR

更新日期：1992-04-01 00:00:00

abstract：:In patients on chronic hemodialysis hypotensive episodes are frequently encountered during the course of treatment and the prevalence of atherosclerosis is increased. Endothelin-1 (ET-1), an endothelium-derived peptide with vasoconstrictive and mitogenic effects on smooth muscles, is involved in vascular tone regulati...

journal_title：Journal of cardiovascular pharmacology

authors： Stefanidis I,Wurth P,Mertens PR,Ikonomov V,Philippidis G,Golphinopoulos S,Makropoulos V,Liakopoulos V,Mann H,Heintz B

更新日期：2004-11-01 00:00:00

abstract：:We investigated the potential role of atorvastatin, given at reperfusion, to improve survival of the ischemic/reperfused myocardium by activation of p44/42 MAPK and p38 MAPK with its downstream effector, HSP27. We have previously shown that atorvastatin attenuates lethal reperfusion-induced injury via activation of th...

journal_title：Journal of cardiovascular pharmacology

authors： Efthymiou CA,Mocanu MM,Yellon DM

更新日期：2005-03-01 00:00:00

abstract：:To evaluate the role of intracellular calcium and particularly Ca2+-uptake in the initiation of lymphocyte mitogenesis, the effect of mibefradil, which blocks both L- and T-type calcium channels with a more selective blockade of T-type channels, on the proliferation of human peripheral blood mononuclear cells (PBMCs) ...

journal_title：Journal of cardiovascular pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-04-01 00:00:00

abstract：:Disorders of the cardiac conduction system occur frequently and may cause life-threatening arrhythmias requiring medication or electronic pacemaker implantation. Repair or regeneration of conduction system components is currently not possible due to limited knowledge of the molecular regulation of pacemaker myocardium...

journal_title：Journal of cardiovascular pharmacology

authors： Bakker ML,Christoffels VM,Moorman AF

更新日期：2010-07-01 00:00:00

abstract：:This study investigated whether intrarenal endothelin-1(ET-1) contributes to sodium excretion in aged rats. Metabolic function studies were performed in male Wistar rats (3 and 24 months) treated with placebo or the orally active ET(A) receptor antagonist darusentan (20 mg/kg/d) for 4 weeks. Mean arterial pressure was...

journal_title：Journal of cardiovascular pharmacology

authors： Traupe T,Ortmann J,Haas E,Münter K,Parekh N,Hofmann-Lehmann R,Baumann K,Barton M

更新日期：2006-03-01 00:00:00

abstract：:Left ventricular (LV) function and end-diastolic dimensions were determined during antegrade and retrograde perfusions, respectively. Isolated hearts from spontaneously hypertensive rats (SHRs) and renal hypertensive rats and SHRs to which either feldopine, nifedipine, alpha-methyldopa, or a combination of felodipine ...

journal_title：Journal of cardiovascular pharmacology

authors： Nordlander M,Wåhlander H,Friberg P

更新日期：1987-01-01 00:00:00

abstract：:Since minoxidil was previously shown to raise plasma renin activity (PRA) but not the plasma aldosterone concentration (PAC), the effect of minoxidil on the rate of aldosterone metabolic clearance was studied. After the addition of minoxidil to the antihypertensive regimen of 7 hypertensive patients, the aldosterone m...

journal_title：Journal of cardiovascular pharmacology

authors： Pratt JH,Yager CJ,Grim CE,Parkinson CA

更新日期：1980-01-01 00:00:00

abstract：:Since the end of 1976 ten orally active converting enzyme inhibitors [SQ 14,225 (captopril), MK 421 (enalapril), MK 422, MK 521 (lysinopril), RHC 3659, CGS 13945, CGS 13928C, CGS 14824A, Hoe 498, S 9490-3, and Ro 31-2848] have been evaluated by our group in normal volunteers. Their ability to blunt the pressor respons...

journal_title：Journal of cardiovascular pharmacology

authors： Brunner HR,Nussberger J,Waeber B

更新日期：1985-01-01 00:00:00

abstract：:The role of pressure-sensitive mechanoreceptors (PSMRs) in histamine-stimulated nitric oxide release from cultured human endothelial cells was investigated, using our new method (helium pack method). PSMRs were stimulated by various levels of pressure applied in addition to atmospheric pressure (40, 80, 120, and 160 m...

journal_title：Journal of cardiovascular pharmacology

authors： Hishikawa K,Nakaki T,Suzuki H,Saruta T,Kato R

更新日期：1992-01-01 00:00:00