Myocardial and vascular structural adaptation to chronic pressure overload.

abstract：:The cardiovascular effects of intracerebroventricular (i.c.v.) administration of choline were studied in endotoxin-treated rats. Intravenous (i.v.) endotoxin (20 mg/kg) caused a moderate hypotension and tachycardia within 10 min of treatment. Choline (50, 100, and 150 microg; i.c.v.) increased blood pressure and decre...

journal_title：Journal of cardiovascular pharmacology

authors： Savci V,Ulus IH

更新日期：1997-11-01 00:00:00

abstract：:Independent determinations of Ca2+ by two indicators showed that subcellular Ca2+ activity (intracellular free calcium concentration) was heterogeneous in rat myocardial cells. Arsenazo III (Az III), a membrane-impermeant absorbance indicator for Ca2+, was loaded into cardiac muscle via liposomes and calcium quantitat...

journal_title：Journal of cardiovascular pharmacology

authors： Hermsmeyer K,Mason R,Puga A,Erne P

更新日期：1991-01-01 00:00:00

abstract：:Inflammation induces cardiac fibrosis and hypertrophy in multiple cardiovascular diseases, contributing to cardiac dysfunction. We tested the hypothesis that pentoxifylline (PTX), a phosphodiesterase inhibitor with anti-inflammatory property, would attenuate cardiac fibrosis and hypertrophy, and prevent cardiac dysfun...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang X,Meng F,Song J,Zhang L,Wang J,Li D,Li L,Dong P,Yang B,Chen Y

更新日期：2016-01-01 00:00:00

abstract：:In conscious rats, intrathecal (i.t.) administration of norepinephrine (NE) produced pressor responses, whereas i.t. epinephrine (Epi) caused depressor responses at low doses (0.1-1 microgram) and pressor responses at a higher dose (10 micrograms). Epi administered i.t. produced bradycardia; however, NE caused tachyca...

journal_title：Journal of cardiovascular pharmacology

authors： Gradin K,Nicholas AP,Hjemdahl P,Svensson T,Hökfelt T

更新日期：1992-09-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR) play a critical physiological role in energy homeostasis, in inflammation, and a protective role in cardiovascular function. We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated receptor alpha (PPARα) stimulation on ischemic myoca...

journal_title：Journal of cardiovascular pharmacology

authors： Ibarra-Lara L,Hong E,Soria-Castro E,Torres-Narváez JC,Pérez-Severiano F,Del Valle-Mondragón L,Cervantes-Pérez LG,Ramírez-Ortega M,Pastelín-Hernández GS,Sánchez-Mendoza A

更新日期：2012-10-01 00:00:00

abstract：:We have studied the effects of bremazocine on the peripheral sympathetic nervous system and the arterial blood pressure of pithed rabbits with electrically (2 Hz) stimulated sympathetic outflow, and compared them with the effects of Leu-enkephalin and fentanyl. The 3H-noradrenaline plasma clearance and the plasma conc...

journal_title：Journal of cardiovascular pharmacology

authors： Ensinger H,Hedler L,Szabo B,Starke K

更新日期：1986-05-01 00:00:00

abstract：:Coronary artery reperfusion established by thrombolytic agents early in the evolution of an acute myocardial infarction is known to result in the salvage of otherwise jeopardized heart muscle. Recently, experimental evidence has suggested that reactive products of oxygen are formed as a result of reperfusion and can i...

journal_title：Journal of cardiovascular pharmacology

authors： Mickelson JK,Simpson PJ,Jackson CV,Lucchesi BR

更新日期：1988-08-01 00:00:00

abstract：:Experience with angiotensin converting enzyme (ACE) inhibitor drugs as with other antihypertensive agents, is limited in the elderly. Nevertheless, they appear effective and well tolerated but without evidence to suggest that they have any special role in the elderly compared to a younger age group. Most are excreted ...

journal_title：Journal of cardiovascular pharmacology

authors： Ball SG

更新日期：1988-01-01 00:00:00

abstract：:In congestive heart failure, the chronic sympathetic hyperactivity contributes to a poor prognosis. In this respect, clonidine, a centrally acting sympathoinhibitory drug, has previously been tested in clinical trials. The aim of the current study was to evaluate the effects of clonidine on morbidity and mortality in ...

journal_title：Journal of cardiovascular pharmacology

authors： Thomas L,Gasser B,Bousquet P,Monassier L

更新日期：2003-02-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in the modulation of renal O2 consumption in dogs with pacing-induced congestive heart failure (CHF). O2 consumption in the renal cortex (C) and medulla (M) of normal dogs and dogs with CHF was measured under control conditions and in the presence of increasing concentrati...

journal_title：Journal of cardiovascular pharmacology

authors： Adler S,Huang H,Loke K,Xu X,Laumas A,Hintze TH

更新日期：2001-03-01 00:00:00

abstract：:We previously showed that rat and cow blood vessels contain arginine vasopressin (AVP) of local origin. In the present study, to investigate potential roles for this locally produced peptide, we examined the effects of AVP on growth of cultured vascular endothelial and smooth muscle cells (EC, SMC). Treatment of cultu...

journal_title：Journal of cardiovascular pharmacology

authors： Simon JS,Baum JS,Moore SA,Kasson BG

更新日期：1995-03-01 00:00:00

abstract：:There is no systematic study in which the effects of vasoactive substances were investigated on pulmonary vascular resistance (PVR) in in vivo mouse by directly measuring cardiac output and the inflow and outflow pressures in the pulmonary circulation. We determined the responses of PVR, total peripheral resistance (T...

journal_title：Journal of cardiovascular pharmacology

authors： Wang M,Shibamoto T,Shinomiya S,Yamamoto Y,Kurata Y,Kuda Y,Tanida M,Toga H

更新日期：2015-04-01 00:00:00

abstract：:We investigated the effects of a newly synthesized dihydropyridine (DHP) derivative (NZ-105) on intracellular Ca transients and contraction in ferret ventricular muscles, using the aequorin method. Low concentrations of NZ-105 (10(-9)-10(-7) M) showed no significant effects on the light signal of aequorin and tension ...

journal_title：Journal of cardiovascular pharmacology

authors： Kurihara S,Hongo K,Tanaka T,Tanaka E

更新日期：1994-08-01 00:00:00

abstract：:Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) ...

journal_title：Journal of cardiovascular pharmacology

authors： Ivanov AV,Alexandrin VV,Paltsyn AA,Virus ED,Nikiforova KA,Bulgakova PO,Sviridkina NB,Svetlana Alexandrovna Apollonova,Kubatiev AA

更新日期：2018-10-01 00:00:00

abstract：:The acute effects of doxorubicin on coronary perfusion and left ventricular pressures and intracellular phosphate metabolite levels, the latter obtained by 31P nuclear magnetic resonance, were measured simultaneously in isolated, isovolumic rat hearts (Langendorf preparation) perfused at constant flow. Nineteen experi...

journal_title：Journal of cardiovascular pharmacology

authors： Pelikan PC,Weisfeldt ML,Jacobus WE,Miceli MV,Bulkley BH,Gerstenblith G

更新日期：1986-09-01 00:00:00

abstract：:The enantiomers of tocainide, a Class Ib antiarrhythmic agent, have recently been shown to exhibit differences in antiarrhythmic activity and pharmacokinetic characteristics. The present study examined the antiarrhythmic and electrophysiological effects of SR tocainide, S tocainide, and R tocainide on arrhythmias in a...

journal_title：Journal of cardiovascular pharmacology

authors： Uprichard AC,Allen JD,Harron DW

更新日期：1988-02-01 00:00:00

abstract：:We compared platelet function results obtained with the VerifyNow P2Y12 (VN-P2Y12) point-of-care device and the light transmission aggregometry (5 and 20 microM adenosine diphosphate) method using an integrated database of eight clinical trials with a total of 591 subjects. The study was performed in healthy subjects,...

journal_title：Journal of cardiovascular pharmacology

authors： Jakubowski JA,Li YG,Small DS,Payne CD,Tomlin ME,Luo J,Winters KJ

更新日期：2010-07-01 00:00:00

abstract：:We compared the vasodilator potencies of a number of Ca2+-entry blockers with glyceryl trinitrate (GTN) in isolated ring segments of dog coronary arteries contracted by a variety of substances. Rings were contracted to 80% of maximum by serotonin, phenylephrine (PE), noradrenaline (NA), K+ (KCl), or U46619 (stable thr...

journal_title：Journal of cardiovascular pharmacology

authors： Angus JA,Brazenor RM

更新日期：1983-03-01 00:00:00

abstract：:This study examined the effect of Vitis vinifera grape skin ACH09 extract (ACH09) on metabolic disorders and oxidative stress in adult offspring of rats fed a high-fat diet (HF) during lactation. Four groups of female rats were fed: control diet (7% fat); ACH09 (7% fat + 200 mg·kg·d ACH09 orally); HF (24% fat); HF+ AC...

journal_title：Journal of cardiovascular pharmacology

authors： Emiliano AF,de Cavalho LC,da Silva Cristino Cordeiro V,da Costa CA,de Oliveira PB,Queiroz EF,Col Moreira DD,Boaventura GT,de Moura RS,Resende AC

更新日期：2011-09-01 00:00:00

abstract：:NSP-513, a novel potent and selective phosphodiesterase 3 (PDE 3) inhibitor, and cilostazol, a previously developed PDE 3 inhibitor, were compared with respect to antiplatelet, antithrombotic, and hemodynamic effects. In the in vitro antiplatelet aggregation studies, NSP-513 and cilostazol inhibited collagen-induced c...

journal_title：Journal of cardiovascular pharmacology

authors： Hirose H,Mashiko S,Kimura T,Ishida F,Mochizuki N,Nishibe T,Nishikibe M

更新日期：2000-04-01 00:00:00

abstract：:Kinins elicit prostaglandin and inositol phosphate production in 3T3 fibroblasts through stimulation of B2 receptors. Prostaglandin synthesis is maximum by 5 min, whereas inositol phosphate production continues for longer than 30 min. Prostaglandin synthesis is stimulated by phospholipase A2, which releases arachidona...

journal_title：Journal of cardiovascular pharmacology

authors： Burch RM

更新日期：1990-01-01 00:00:00

abstract：:Since minoxidil was previously shown to raise plasma renin activity (PRA) but not the plasma aldosterone concentration (PAC), the effect of minoxidil on the rate of aldosterone metabolic clearance was studied. After the addition of minoxidil to the antihypertensive regimen of 7 hypertensive patients, the aldosterone m...

journal_title：Journal of cardiovascular pharmacology

authors： Pratt JH,Yager CJ,Grim CE,Parkinson CA

更新日期：1980-01-01 00:00:00

abstract：:We investigated the effects of the ATP-dependent K+ channel antagonist glyburide and the ATP-dependent K+ channel agonist pinacidil in a Langendorff-perfused rabbit isolated heart subjected to a period of global hypoxia. A class III antiarrhythmic drug, E-4031, also was studied in this model. These studies aimed to de...

journal_title：Journal of cardiovascular pharmacology

authors： Chi L,Black SC,Kuo PI,Fagbemi SO,Lucchesi BR

更新日期：1993-02-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:In patients on chronic hemodialysis hypotensive episodes are frequently encountered during the course of treatment and the prevalence of atherosclerosis is increased. Endothelin-1 (ET-1), an endothelium-derived peptide with vasoconstrictive and mitogenic effects on smooth muscles, is involved in vascular tone regulati...

journal_title：Journal of cardiovascular pharmacology

authors： Stefanidis I,Wurth P,Mertens PR,Ikonomov V,Philippidis G,Golphinopoulos S,Makropoulos V,Liakopoulos V,Mann H,Heintz B

更新日期：2004-11-01 00:00:00

abstract：:We wished to determine the action of prostaglandins (PG) and to analyze pharmacologically the mechanisms of their action in isolated human uterine arteries in special reference to mediators liberated from the endothelium and subendothelial tissues. Helical strips of the human uterine artery with and without the endoth...

journal_title：Journal of cardiovascular pharmacology

authors： Kimura T,Okamura T,Yoshida Y,Toda N

更新日期：1995-08-01 00:00:00

abstract：:Low density lipoprotein (LDL) oxidation plays a crucial role in the development and progression of atherosclerosis and is enhanced in patients with essential hypertension. This finding has stimulated a search for antihypertensive drugs with high intrinsic antioxidant properties. We investigated the antihypertensive an...

journal_title：Journal of cardiovascular pharmacology

authors： Maggi E,Marchesi E,Covini D,Negro C,Perani G,Bellomo G

更新日期：1996-04-01 00:00:00

abstract：:Endothelins (ETs) are a family of peptide hormones that act on G protein-coupled ET(A) and ET(B) receptors. ETs exert inotropic and chronotropic actions in the heart. Myocardial ischemia is associated with increased plasma levels of ET and cell swelling. We examined the effect of ETs on dog atrial swelling-induced chl...

journal_title：Journal of cardiovascular pharmacology

authors： Du XY,Sorota S

更新日期：2000-05-01 00:00:00

abstract：:Myocardial alpha 1-adrenoceptor number has been reported to increase during ischaemia in myocytes consequent to an increase in acyl carnitine levels. We investigated whether this phenomenon occurs in vivo and whether the novel antiischaemic agent ranolazine will protect against it. Thirty-minute occlusion of the left ...

journal_title：Journal of cardiovascular pharmacology

authors： Allely MC,Brown CM,Kenny BA,Kilpatrick AT,Martin A,Spedding M

更新日期：1993-06-01 00:00:00

abstract：:The hemodynamic effects of tetramethylpyrazine were examined in 27 anesthetized open chest dogs with electromagnetic flowmeter probes on the left circumflex coronary artery and ascending aorta. Tetramethylpyrazine, 2-15 mg/kg i.v., caused prominent systemic and coronary vasodilation, with a maximum reduction of mean a...

journal_title：Journal of cardiovascular pharmacology

authors： Dai XZ,Bache RJ

更新日期：1985-09-01 00:00:00