Contrasting cardiovascular responses from intrathecal administration of epinephrine and norepinephrine in conscious rats: role of alpha 1- and alpha 2-adrenoceptors.

abstract：BACKGROUND:Factor Xa (FXa) has been a target of considerable interest for drug development efforts aimed at suppressing thrombosis. In this report, a new orally active, small molecule, active-site directed FXa inhibitor, GW813893, has been profiled in a succession of in vitro and in vivo assays involved in its preclini...

journal_title：Journal of cardiovascular pharmacology

authors： Abboud MA,Needle SJ,Burns-Kurtis CL,Valocik RE,Koster PF,Amour AJ,Chan C,Brown D,Chaudry L,Zhou P,Patikis A,Patel C,Pateman AJ,Young RJ,Watson NS,Toomey JR

更新日期：2008-07-01 00:00:00

abstract：:The cardiovascular effects of intracerebroventricular (i.c.v.) administration of choline were studied in endotoxin-treated rats. Intravenous (i.v.) endotoxin (20 mg/kg) caused a moderate hypotension and tachycardia within 10 min of treatment. Choline (50, 100, and 150 microg; i.c.v.) increased blood pressure and decre...

journal_title：Journal of cardiovascular pharmacology

authors： Savci V,Ulus IH

更新日期：1997-11-01 00:00:00

abstract：:The vasodilator action of organic nitrates can be severely impaired by induction of drug tolerance. A critical depletion of sulfhydryl groups has been proposed to play a key role in impairment of the biotransformation of organic nitrates to nitric oxide (NO). We studied the effects of the new cysteine-containing nitra...

journal_title：Journal of cardiovascular pharmacology

authors： Zanzinger J,Feelisch M,Bassenge E

更新日期：1994-05-01 00:00:00

abstract：:Neuropeptide Y (NPY) and ATP are considered cotransmitters with norepinephrine (NE) in sympathetic neurons innervating some blood vessels, including those of the mesentery. A prominent action of NPY is to potentiate the postjunctional contractile effect of NE as well as that of other vasoactive agents. We wished to in...

journal_title：Journal of cardiovascular pharmacology

authors： Westfall TC,Yang CL,Curfman-Falvey M

更新日期：1995-11-01 00:00:00

abstract：:Establishing the overall efficacy or safety of a drug requires a unified methodological approach and analysis of all clinical trials that are intended to be summarized. As an example, this article presents the aggregated dose-response relationship and a subgroup analysis (by age) over all studies of the antihypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Stienen U

更新日期：1992-01-01 00:00:00

abstract：:Serotonin, applied to helical strips of larger vessels such as coronary arteries, acts as a potent vasoconstrictor in vitro. In contrast, in vivo serotonin causes a remarkable decrease in total peripheral resistance. To differentiate the influence of serotonin on resistances of large and small vessels, experiments wer...

journal_title：Journal of cardiovascular pharmacology

authors： Meschig R,Breuer J,Arnold G

更新日期：1985-01-01 00:00:00

abstract：:Compound LY249933 and its component diastereomers, (RR) and (SR), were studied for their vascular and cardiac effects in vitro and in vivo. In guinea pig cardiac ventricular membranes, LY249933, (RR), and (SR) potently displaced bound [3H]nitrendipine (Kd values = 2-6 nM). In isolated guinea pig right ventricular stri...

journal_title：Journal of cardiovascular pharmacology

authors： Holland DR,Wikel JH,Kauffman RF,Smallwood JK,Zimmerman KM,Utterback BG,Turk JA,Steinberg MI

更新日期：1989-09-01 00:00:00

abstract：:Forty patients (aged 28-66 years) with essential hypertension were randomized to 14 weeks of treatment with diltiazem or hydrochlorothiazide (HCTZ) in a double-blind, parallel study design. A significant reduction in supine body weight (-6.0 +/- 1.5 lb; p less than 0.001) and increase in pulse (+6 +/- 2 beats/min; p l...

journal_title：Journal of cardiovascular pharmacology

authors： Swartz SL

更新日期：1987-04-01 00:00:00

abstract：:During recent years, small conductance Ca-activated K (SK) channels have been reported to play a role in cardiac electrophysiology. SK channels seem to be expressed in atria and ventricles, but from a functional perspective, atrial activity is predominant. A general notion seems to be that cardiac SK channels are pred...

journal_title：Journal of cardiovascular pharmacology

authors： Diness JG,Kirchhoff JE,Sheykhzade M,Jespersen T,Grunnet M

更新日期：2015-09-01 00:00:00

abstract：:We studied the effects of orally administered ibutilide, a class III antiarrhythmic agent, in a model of reentrant atrial flutter in conscious dogs. After baseline determination of atrial effective refractory period (AERP) and demonstration of reproducible induction of atrial flutter by rapid atrial pacing, 8 dogs rec...

journal_title：Journal of cardiovascular pharmacology

authors： Buchanan LV,Turcotte UM,Kabell GG,Gibson JK

更新日期：1993-07-01 00:00:00

abstract：:A mathematical model has been developed that relates wall tension in resistance vessels to changes in both distending pressure and flow; the effect of alterations in wall: lumen ratio is taken into account. The model indicates that increased autoregulatory activity in the forearm circulation of patients with primary h...

journal_title：Journal of cardiovascular pharmacology

authors： Robinson BF,Benjamin N

更新日期：1988-01-01 00:00:00

abstract：:The purpose of this study was to determine the receptor subtype mediating enhanced contractile responses of aortae and mesenteric arteries from diabetic rats to the alpha-adrenoceptor agonists, norepinephrine, clonidine, and methoxamine and to establish whether the enhanced responses are associated with increased rele...

journal_title：Journal of cardiovascular pharmacology

authors： Abebe W,Harris KH,MacLeod KM

更新日期：1990-08-01 00:00:00

abstract：:Artemisinin is an endoperoxide sesquiterpene lactone from Artemisia annua L with multiple beneficial effects, including anti-inflammation, antioxidant, and vascular protection. Recent studies have found that inflammation along with autophagy deficiency in macrophages is the possible reason for foam cell accumulation i...

journal_title：Journal of cardiovascular pharmacology

authors： Cao Q,Du H,Fu X,Duan N,Liu C,Li X

更新日期：2020-04-01 00:00:00

abstract：:Diabetes is a devastating disease with multiple adverse effects on the vasculature. Moreover, hypertension is a prerequisite for patients with diabetes to progress to end-stage renal disease and to develop cardiovascular complications. Adequate control of blood glucose and blood pressure are the two most important fac...

journal_title：Journal of cardiovascular pharmacology

authors： Makrilakis K,Bakris G

更新日期：1998-01-01 00:00:00

abstract：:Formation of oxygen free radicals during heart transplantation seems to be related to the alterations occurring during ischemia and reperfusion and could explain the short preservation time of donor hearts. The aim of our study was (a) to analyze the protective effects of pyruvate during cold cardioplegia and ischemia...

journal_title：Journal of cardiovascular pharmacology

authors： Dobsak P,Courderot-Masuyer C,Zeller M,Vergely C,Laubriet A,Assem M,Eicher JC,Teyssier JR,Wolf JE,Rochette L

更新日期：1999-11-01 00:00:00

abstract：:Anakinra is a recombinant human interleukin 1 receptor antagonist that competes and blocks the biologic effects of interleukin 1, reducing systemic inflammatory responses. In the 2015 guidelines for the diagnosis and management of pericardial diseases of the European Society of Cardiology, anakinra was established as ...

journal_title：Journal of cardiovascular pharmacology

authors： Correia ETO,Dos Santos Barbetta LM,de Almeida JPCL,Mesquita ET

更新日期：2020-07-01 00:00:00

abstract：:Recent evidence has shown that the kidneys produce and secrete a member of the atrial natriuretic peptide family, named urodilatin. This 32-amino acid peptide does not circulate in blood, but is secreted into urine. Urodilatin excretion closely parallels renal sodium excretion under various conditions that influence b...

journal_title：Journal of cardiovascular pharmacology

authors： Gerzer R,Drummer C

更新日期：1993-01-01 00:00:00

abstract：:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 > nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >...

journal_title：Journal of cardiovascular pharmacology

authors： Bossaller C,Auch-Schwelk W,Graf K,Gräfe M,Catadelgirmen G,Ennker J,Fleck E

更新日期：1992-01-01 00:00:00

abstract：:Inflammation plays a central role in the pathogenesis of atherosclerosis. This study investigated whether the proteasome inhibitor has the same preventive effect on the formation of accelerated atherosclerosis in rabbits with uremia compared with a NF-kappaB inhibitor. New Zealand white rabbits were subjected to five-...

journal_title：Journal of cardiovascular pharmacology

authors： Feng B,Zhang Y,Mu J,Ye Z,Zeng W,Qi W,Luo Z,Guo Y,Yang X,Yuan F

更新日期：2010-02-01 00:00:00

abstract：:The effect of lidocaine on the conduction of extrasystoles was studied in 8 open-chest dogs after atrioventricular nodal block. Simultaneous recording of endocardial and epicardial activation provided separate measures of endocardial (Purkinje) conduction as well as myocardial (muscle) conduction. Lidocaine (1.25--10....

journal_title：Journal of cardiovascular pharmacology

authors： Carson DL,Dresel PE

更新日期：1981-09-01 00:00:00

abstract：:Adenosine protects the ischemic myocardium by coronary vasodilation and the depression of heart rate and contractility, improving myocardial energy balance. Adenosine effects on the myocardium are mediated predominantly by the type A1 receptors. Atrial natriuretic peptide (ANP), a vasodilator and regulator of blood vo...

journal_title：Journal of cardiovascular pharmacology

authors： Salman H,Bergman M,Schlesinger H,Zahavi I,Kessler-Icekson G

更新日期：1999-07-01 00:00:00

abstract：:Pentoxifylline possesses vasodilator properties, but little information is available on the mechanism of action explaining this vasodilator effect. The present experiments were designed to determine the effects of the compound on vascular smooth muscle, endothelium, and adrenergic nerves in rings of isolated canine bl...

journal_title：Journal of cardiovascular pharmacology

authors： Hoeffner U,Aarhus LL,Katusic ZS,Vanhoutte PM

更新日期：1989-12-01 00:00:00

abstract：:Sarcosyl1, cysteinyl-S-methyl8-angiotensin II [(Sar1, Cys-Me8) Ang II] was examined for antagonism of angiotensin (Ang) responses in isolated rabbit atrial and aortic tissues. (Sar1, Cys-Me8) Ang II competitively antagonized Ang II responses in aorta at a concentration of 5 nM. Concentrations of the antagonist greater...

journal_title：Journal of cardiovascular pharmacology

authors： Trachte GJ,Peach MJ

更新日期：1983-11-01 00:00:00

abstract：:Several mechanisms have been suggested for the absence of reflex tachycardia in response to the hypotensive effect of the selective alpha 1-adrenoceptor antagonist indoramin, including, in animals, membrane-stabilising activity, prolongation of repolarisation time, and reduction in baroreflex sensitivity. The present ...

journal_title：Journal of cardiovascular pharmacology

authors： Deering AH,Riddell JG,Harron DW,Shanks RG

更新日期：1988-03-01 00:00:00

abstract：:To assess the comparative effects of benazepril and nitrendipine monotherapies on left ventricular mass index (LVMI) in hypertensive patients with echocardiographically determined left ventricular hypertrophy, patients with diastolic blood pressure (BP) > or = 100 mm Hg were randomized to benazepril, 10 mg, or nitrend...

journal_title：Journal of cardiovascular pharmacology

authors： Gaudio C,Tanzilli G,Ferri FM,Villatico Campbell S,Bertocchi F,Motolese M,Campa PP

更新日期：1998-11-01 00:00:00

abstract：:We investigated the effect of apstatin (an aminopeptidase P inhibitor) on bradykinin-induced inositol 1,4,5-triphosphate (IP3) formation and glucose uptake in isolated neonatal rat cardiomyocytes. Apstatin enhanced bradykinin-induced IP3 formation in a dose-dependent manner. We found that 1 microM Hoe 140 (a bradykini...

journal_title：Journal of cardiovascular pharmacology

authors： Kudoh A,Kudoh E,Katagai H,Takazawa T

更新日期：2001-05-01 00:00:00

abstract：:The electrophysiologic effects of acutely and chronically administered amiodarone on canine Purkinje fibers were assessed using microelectrode techniques to record intracellular action potentials. Chronically treated dogs received amiodarone for 3 weeks (serum levels, 0.91 +/- 0.09 microgram/ml or 1.42 X 10(-6) M). Ac...

journal_title：Journal of cardiovascular pharmacology

authors： Gallagher JD,Bianchi J,Gessman LJ

更新日期：1989-05-01 00:00:00

abstract：:Mikania laevigata, popularly known in Brazil as guaco, is widely used for respiratory disorders. As this plant is rich in coumarins, there is evidence of indications that it may cause bleeding and therefore should not be used concomitantly with anticoagulants. The basis of this information is very theoretical, with no...

journal_title：Journal of cardiovascular pharmacology

authors： Leite PM,Miranda APN,Amorim JM,Duarte RCF,Bertolucci SKV,Carvalho MDG,Castilho RO

更新日期：2019-12-01 00:00:00

abstract：:Antihypertensive medications are the most efficient drugs in achieving regression of myocardial hypertrophy in both clinical studies and animal models of hypertension. Nevertheless, there is a lack of clear and concise comparative study of their effects on the modulation of cardiomyocyte morphology and function. Here,...

journal_title：Journal of cardiovascular pharmacology

authors： Cagalinec M,Kyselovic J,Blaskova E,Bacharova L,Chorvat D Jr,Chorvatova A

更新日期：2006-04-01 00:00:00

abstract：:Vasoconstrictor actions of endothelin-1 (ET) were compared between endothelium-removed strips of cerebral (basilar, posterior cerebral, and middle cerebral) and peripheral (coronary and mesenteric) arteries of the dog. ET produced a concentration-dependent contraction in these arteries. A threshold concentration and E...

journal_title：Journal of cardiovascular pharmacology

authors： Tanoi C,Suzuki Y,Shibuya M,Sugita K,Masuzawa-Ito K,Asano M

更新日期：1992-04-01 00:00:00