Benazepril causes in hypertension a greater reduction in left ventricular mass than does nitrendipine: a randomized study using magnetic resonance imaging.

abstract：:This review deals with cellular factors that contribute to individualities of vascular smooth-muscle function in different organ systems and at different levels of the vascular tree. Particular attention has been given to: membrane receptors responsive to catecholamines, serotonin, angiotensin II, dopamine, and acetyl...

journal_title：Journal of cardiovascular pharmacology

authors： Bell DR,Webb RC,Bohr DF

更新日期：1985-01-01 00:00:00

abstract：:Sarcosyl1, cysteinyl-S-methyl8-angiotensin II [(Sar1, Cys-Me8) Ang II] was examined for antagonism of angiotensin (Ang) responses in isolated rabbit atrial and aortic tissues. (Sar1, Cys-Me8) Ang II competitively antagonized Ang II responses in aorta at a concentration of 5 nM. Concentrations of the antagonist greater...

journal_title：Journal of cardiovascular pharmacology

authors： Trachte GJ,Peach MJ

更新日期：1983-11-01 00:00:00

abstract：:Angiotensin II receptor blockers (ARBs) are used for the treatment of patients with heart failure and hypertension. Yet their safety has been questioned by some who observed delayed cardiac healing and scar thinning after myocardial infarction (MI). To clarify potential efficacy and safety of ARBs, we administered Azi...

journal_title：Journal of cardiovascular pharmacology

authors： Quinn Baumann P,Zaman AK,McElroy-Yaggy K,Sobel BE

更新日期：2013-05-01 00:00:00

abstract：:It is known that adenosine decreases blood pressure (BP) level as well as blood pressure variability (BPV). However, there is little information about the effect of adenosine on BPV. With a computerized analytic system for BP and heart rate (HR) that could sample the data continuously in conscious, freely moving rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Shen FM,Su DF

更新日期：2000-11-01 00:00:00

abstract：:Intravenous (i.v.) administration of bromocriptine (150 micrograms/kg) in conscious normotensive rats with chronic spinal cord transection (at T5-T7), pretreated or not with i.v. propranolol (0.5 mg/kg), induced significant decreases in mean arterial blood pressure (MAP) which were greater and longer lasting than thos...

journal_title：Journal of cardiovascular pharmacology

authors： Lahlou S,Demenge P

更新日期：1992-05-01 00:00:00

abstract：:Analysis of the circadian distributions of silent ischemic episodes and myocardial infarction has revealed a circadian variability with peak event incidences in the morning hours after awakening. This morning peak of ischemic events is paralleled by circadian variations of blood pressure and heart rate that reflect an...

journal_title：Journal of cardiovascular pharmacology

authors： Kiowski W,Osswald S

更新日期：1993-01-01 00:00:00

abstract：:The effects of nitrendipine, a new antihypertensive agent, have been examined using the isolated rabbit aortic strip stimulated with either noradrenaline (1.7 X 10(-8) - 1.7 X 10(-5) mol/L) or potassium (22.7-52.7 mmol/L). Nifedipine, verapamil, phentolamine, papaverine, and minoxidil were used as reference compounds....

journal_title：Journal of cardiovascular pharmacology

authors： Towart R

更新日期：1982-11-01 00:00:00

abstract：:We have previously demonstrated that endothelin-1 (ET-1) is essential to the development of neural crest-derived craniofacial and cardiovascular structures. In this study we evaluated the intrauterine growth and development of the thyroid and thymus glands in Edn1-/- homozygous mice. Edn1-/- homozygous mice were small...

journal_title：Journal of cardiovascular pharmacology

authors： Kurihara Y,Kurihara H,Maemura K,Kuwaki T,Kumada M,Yazaki Y

更新日期：1995-01-01 00:00:00

abstract：:Adenosine A1 receptor (A1AR) activation contracts smooth muscle, although signaling mechanisms are not thoroughly understood. Activation of A1AR leads to metabolism of arachidonic acid, including the production of 20-hydroxyeicosatetraenoic acid (20-HETE) by cytochrome P4504a (CYP4a). The 20-HETE can activate protein ...

journal_title：Journal of cardiovascular pharmacology

authors： Kunduri SS,Mustafa SJ,Ponnoth DS,Dick GM,Nayeem MA

更新日期：2013-07-01 00:00:00

abstract：:Calcium is a signaling element of general importance to cells. In muscle, its key function is the activation of troponin C, which is essential for the contraction of myofibrils in skeletal and heart muscles, and of myosin light chain kinase, which is essential for the contraction of smooth muscles. Calcium modulates t...

journal_title：Journal of cardiovascular pharmacology

authors： Carafoli E

更新日期：1988-01-01 00:00:00

abstract：:In response to acetylcholine, endothelial cells were shown to release a nonprostanoid factor, called endothelium-derived relaxing factor (EDRF), which caused relaxation of vascular smooth muscle. Since this discovery in 1980, many additional agents have been shown to stimulate release of EDRF from endothelium. Biologi...

journal_title：Journal of cardiovascular pharmacology

authors： Furchgott RF

更新日期：1993-01-01 00:00:00

abstract：:The effect of the new vasodilatory and antianginal compound, bepridil (CERM-1978), was examined on the electrical activity of the vascular smooth muscle of isolated dog coronary arteries. Tetraethylammonium (10 mM) was used to induce excitability in the muscle in the form of Ca2+-dependent overshooting action potentia...

journal_title：Journal of cardiovascular pharmacology

authors： Harder DR,Sperelakis N

更新日期：1981-07-01 00:00:00

abstract：:Since beta-adrenoceptor blocking drugs were originally discovered and shown to be important therapeutic agents in the management of both angina pectoris and hypertension, many other similar drugs have become available. These share the common property of beta-adrenoceptor antagonism, though they may vary in terms of po...

journal_title：Journal of cardiovascular pharmacology

authors： McDevitt DG

更新日期：1986-01-01 00:00:00

abstract：:Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young N(ω)-nitro-L-arginine methyl ester (L-NAME)-treated Wistar rats and 10-month-old spontaneously hypertensive rats (SHR) alone and after chronic treatment with feru...

journal_title：Journal of cardiovascular pharmacology

authors： Alam MA,Sernia C,Brown L

更新日期：2013-03-01 00:00:00

abstract：:Spirapril is a new angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug with a resorption of about 50%. The active metabolite spiraprilat reaches maximal plasma concentration within 2-3 h after oral administration. Spirapril can be administered once daily because of its long duration of action caused by an e...

journal_title：Journal of cardiovascular pharmacology

authors： Hayduk K,Kraul H

更新日期：1999-08-01 00:00:00

abstract：:Heart failure (HF) is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including an increase in betaAR kinase 1 (betaARK1) levels and activity. Gene therapy using a peptide inhibitor of betaARK1 (betaARKct) in infarcted rabbit hearts has improved compromised cardiac function. To determine...

journal_title：Journal of cardiovascular pharmacology

authors： Suzuki Y,Nakano K,Sugiyama M,Imagawa J

更新日期：2004-09-01 00:00:00

abstract：:The antihypertensive effect of the combination of ketanserin, a new antiserotonergic agent, and thiazide has been evaluated in 35 patients with arterial hypertension of mild to moderate degree in the greater than 50-year-old age group. Twenty patients were given ketanserin (20 mg) + hydrochlorothiazide (25 mg) (treatm...

journal_title：Journal of cardiovascular pharmacology

authors： Ferrara LA,Fasano ML,Soro S,Pasanisi F,Mancini M

更新日期：1987-01-01 00:00:00

abstract：:We investigated the effect of different ACE inhibitors on tissue injury in isolated rat hearts subjected to 30 minutes of ischemia followed by 120 minutes of reperfusion. Zofenoprilat (1-100 microM), but not enalaprilat or lisinopril, significantly reduced infarct size, as estimated on the basis of triphenyltetrazoliu...

journal_title：Journal of cardiovascular pharmacology

authors： Frascarelli S,Ghelardoni S,Ronca-Testoni S,Zucchi R

更新日期：2004-02-01 00:00:00

abstract：:The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris. Hemodynamic indices were measured by impedance cardiography and echocardiography and bicyc...

journal_title：Journal of cardiovascular pharmacology

authors： Andreyev N,Bichkov I,Skutelis A,Andreyeva T

更新日期：1991-01-01 00:00:00

abstract：:The effect of olmesartan medoxomil (OLM), an angiotensin II receptor blocker (ARB), on advanced nephropathy and mortality was evaluated in Zucker Diabetic Fatty (ZDF) rats, a type 2 diabetes model. OLM was administered from 36 weeks of age, when the animals developed advanced proteinuria. OLM effectively suppressed th...

journal_title：Journal of cardiovascular pharmacology

authors： Mizuno M,Sada T,Kato M,Fukushima Y,Terashima H,Koike H

更新日期：2006-10-01 00:00:00

abstract：:During the healing phase of evolving myocardial infarction, inflammatory cells invade the affected region and produce metabolites that may influence electrophysiological parameters and the genesis of malignant arrhythmias. We have recently shown an increased synthetic capacity within an evolving infarct for thromboxan...

journal_title：Journal of cardiovascular pharmacology

authors： Kramer JB,Davis AG,Dean R Jr,McCluskey ER,Needleman P,Corr PB

更新日期：1985-11-01 00:00:00

abstract：:The use of calcium antagonists as cardioprotective agents is based on the assumption that uncontrolled Ca2+ gain is a key factor in causing cell death and tissue necrosis. This uncontrolled gain in Ca2+ is the ultimate expression of a series of metabolic events triggered by inadequate perfusion. One of the early event...

journal_title：Journal of cardiovascular pharmacology

authors： Nayler WG

更新日期：1991-01-01 00:00:00

abstract：:Formation of oxygen free radicals during heart transplantation seems to be related to the alterations occurring during ischemia and reperfusion and could explain the short preservation time of donor hearts. The aim of our study was (a) to analyze the protective effects of pyruvate during cold cardioplegia and ischemia...

journal_title：Journal of cardiovascular pharmacology

authors： Dobsak P,Courderot-Masuyer C,Zeller M,Vergely C,Laubriet A,Assem M,Eicher JC,Teyssier JR,Wolf JE,Rochette L

更新日期：1999-11-01 00:00:00

abstract：:The effects of cibenzoline were examined in the dog with multifocal ventricular arrhythmias 24 h after ligation of the left anterior descending coronary artery, and on isolated, superfused canine cardiac tissues which were studied using standard microelectrode techniques. In the intact dog, 5 mg/kg cibenzoline consist...

journal_title：Journal of cardiovascular pharmacology

authors： Dangman KH

更新日期：1984-03-01 00:00:00

abstract：:To investigate the effects of endothelin blockade initiated immediately after the onset of myocardial infarction on survival and left ventricular remodeling, treatment with the nonselective receptor antagonist TAK-044 (n = 22) or saline (n = 19) for 3 weeks was initiated immediately after coronary ligation in rats. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi C,Kagaya Y,Namiuchi S,Takeda M,Fukuchi M,Otani H,Ninomiya M,Yamane Y,Kohzuki M,Watanabe J,Shirato K

更新日期：2001-07-01 00:00:00

abstract：:The equilibrating process of catecholamines (CAs) between plasma and red blood cells (RBC) was studied by measuring their erythrocyte/plasma concentration gradient (E/P ratio); ratio of E/P > 1 for a given amine was considered the consequence of its accumulation in or on RBC. We studied in vitro human blood obtained f...

journal_title：Journal of cardiovascular pharmacology

authors： Azoui R,Vignon D,Safar M,Cuche JL

更新日期：1994-04-01 00:00:00

abstract：:We observed that heterozygous knockout (+/-, KO) of either endothelin-A- (ET(A)) or -B- (ET(B)) receptors significantly reduced the pressor responses to systemically administered endothelin-1 (ET-1) in ET(A) or ET(B) (+/-) KO mice when compared to wild-type (WT) mice (data not shown). Also, we observed that basal mean...

journal_title：Journal of cardiovascular pharmacology

authors： Berthiaume N,Yanagisawa M,D'Orléans-Juste P

更新日期：2000-11-01 00:00:00

abstract：:With increasing age, cardiac beta-adrenoceptor function decreases. To study possible mechanisms underlying this process, we assessed in right atrial appendages from 52 patients of different ages (group A, < 20 years, mean age 3.7 +/- 1.0 years, n = 20; group B, 20-50 years, mean age, 37.9 +/- 2.3 years, n = 9; group C...

journal_title：Journal of cardiovascular pharmacology

authors： Brodde OE,Zerkowski HR,Schranz D,Broede-Sitz A,Michel-Reher M,Schäfer-Beisenbusch E,Piotrowski JA,Oelert H

更新日期：1995-07-01 00:00:00

abstract：:In humans, three endothelin (ET) isoforms are predicted to exist by analysis of genomic DNA. However, evidence for the presence of all three mature ET peptides and their precursors remains unclear. Our aim was to identify the ET isoforms present in human heart, using radioimmunoassay (RIA) and reverse-phase high-perfo...

journal_title：Journal of cardiovascular pharmacology

authors： Plumpton C,Champeney R,Ashby MJ,Kuc RE,Davenport AP

更新日期：1993-01-01 00:00:00

abstract：:It has been suggested that isosorbide dinitrate (ISDN)-induced venodilation could be ascribed to preferential accumulation of the agent in venous tissues, resulting in higher concentrations of nitric oxide (NO). Here, the authors investigated whether the venodilating effect of ISDN is associated with a preferential in...

journal_title：Journal of cardiovascular pharmacology

authors： Ishibashi T,Himeno M,Kubota K,Matsubara T,Hori T,Ozaki K,Yamazoe M,Aizawa Y,Yoshida J,Nishio M

更新日期：2003-01-01 00:00:00