Circadian variation of ischemic cardiac events.

abstract：:The cardiovascular profile of a novel calcium antagonist, MPC-1304 and its active metabolites were investigated in experimental animals in vitro and in vivo, and were compared with those of other calcium antagonists or nitroglycerin (NTG). The ratio of negative chronotropic/negative inotropic effect of MPC-1304 was 23...

journal_title：Journal of cardiovascular pharmacology

authors： Kanda A,Haruno A,Miyoshi K,Tanahashi Y,Miyake H,Ichihara K,Okumura K,Nagasaka M

更新日期：1993-07-01 00:00:00

abstract：:This investigation demonstrates an increase in endothelin (ET)-mediated vascular tone in peri-ischemic areas after experimental focal cerebral ischemia (middle cerebral artery occlusion) in the cat. Adventitial application of the butenolide antagonist PD155080 (30 microM), after MCA occlusions resulted in marked incre...

journal_title：Journal of cardiovascular pharmacology

authors： Patel TR,Galbraith SL,McAuley MA,Doherty AM,Graham DI,McCulloch J

更新日期：1995-01-01 00:00:00

abstract：:A significant reduction of maximal vasodilation capacity at the calf in relation to the severity of the hypertensive state has been demonstrated in essential hypertension. The aim of this study was to evaluate the behavior of calf blood flow and vascular resistance in borderline hypertensives (BH) in comparison with n...

journal_title：Journal of cardiovascular pharmacology

authors： Novo S,Pinto A,Alaimo G,Galati D,Strano A

更新日期：1986-01-01 00:00:00

abstract：:We aim to develop warfarin dosing algorithm for African-Americans. We explored demographic, clinical, and genetic data from a previously collected cohort of 163 African-American patients with a stable warfarin dose. We explored 2 approaches to develop the algorithm: multiple linear regression and artificial neural net...

journal_title：Journal of cardiovascular pharmacology

authors： Alzubiedi S,Saleh MI

更新日期：2016-01-01 00:00:00

abstract：:It is known that adenosine decreases blood pressure (BP) level as well as blood pressure variability (BPV). However, there is little information about the effect of adenosine on BPV. With a computerized analytic system for BP and heart rate (HR) that could sample the data continuously in conscious, freely moving rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Shen FM,Su DF

更新日期：2000-11-01 00:00:00

abstract：:The antiarrhythmic agent propafenone and its primary electropharmacologically active metabolite, 5-hydroxypropafenone, are known inhibitors of cardiac myocyte repolarizing currents. We recently documented potent propafenone inhibition of the transient outward potassium current (Ito) in human atrial myocytes from patie...

journal_title：Journal of cardiovascular pharmacology

authors： Cahill SA,Kirshenbaum LA,Gross GJ

更新日期：2001-09-01 00:00:00

abstract：:Spirapril (SCH 33844; 7-N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-(S)-alanyl-1,4-dithia- 7-azaspiro[4,4]-nonane-8(S)-carboxylic acid) is a new angiotensin-converting enzyme (ACE) inhibitor. SCH 33844 diacid inhibited hydrolysis of hip-his-leu by rabbit lung ACE in a potent (Ki = 0.74 nM), selective, and noncompetitive fa...

journal_title：Journal of cardiovascular pharmacology

authors： Sybertz EJ,Watkins RW,Ahn HS,Baum T,La Rocca P,Patrick J,Leitz F

更新日期：1987-01-01 00:00:00

abstract：:Metformin has been used for the treatment of some metabolic diseases during gestation and the beneficial effects of metformin to the vascular system have been described in diabetic and obese animal models. Nevertheless, the long-term consequences to the vascular system of offsprings maternally exposed to metformin hav...

journal_title：Journal of cardiovascular pharmacology

authors： Novi DRBS,Forcato S,Vidigal CB,Loiola GH,Gerardin DCC,Ceravolo GS

更新日期：2017-11-01 00:00:00

abstract：:The antihypertensive efficacy and tolerability of amlodipine in combination with enalapril were assessed in this two-center study. Patients with moderate to severe hypertension and with diastolic blood pressure > 95 mm Hg after 4 weeks of treatment with open-label enalapril 5-10 mg daily were randomized to receive aml...

journal_title：Journal of cardiovascular pharmacology

authors： Davies J,Jensen H,Garsdal P

更新日期：1991-01-01 00:00:00

abstract：:The actions of prostacyclin and its synthetic analog iloprost on the release and action of platelet-derived serotonin (5-HT) and thromboxane (TX) A2 were studied in vitro. Washed human platelet suspensions (WPS) (4 X 10(8) platelets/ml) were stimulated with arachidonic acid (AA) (30 mumol/L) and the incubate transferr...

journal_title：Journal of cardiovascular pharmacology

authors： Schrör K,Verheggen R

更新日期：1986-05-01 00:00:00

abstract：:Vascular serotonin 5-HT1 receptors have quiescent constrictor activity that is activated by other vasoactive agents such as histamine. Previously, we observed that the 5-HT1-selective agonist 5-carboxamidotryptamine (5-CT) potentiated histamine-stimulated arachidonic acid (AA) mobilization and prostaglandin production...

journal_title：Journal of cardiovascular pharmacology

authors： Kilbourne EJ

更新日期：2004-11-01 00:00:00

abstract：:A randomized open-label clinical trial was conducted to determine whether mortality, readmission, or quality of life differed between heart failure patients managed with captopril plus diuretics and those with digoxin plus diuretics. A total of 345 heart failure patients in New York Heart Association functional classe...

journal_title：Journal of cardiovascular pharmacology

authors： Cosín-Aguilar J,Marrugat J,Sanz G,Massó J,Gil M,Vargas R,Pérez-Casar F,Simarro E,De Armas D,García-García J,Azpitarte J,Diago JL,Rodrigo-Trallero G,Lekuona I,Domingo E,Marin-Huerta E

更新日期：1999-05-01 00:00:00

abstract：:During recent years, small conductance Ca-activated K (SK) channels have been reported to play a role in cardiac electrophysiology. SK channels seem to be expressed in atria and ventricles, but from a functional perspective, atrial activity is predominant. A general notion seems to be that cardiac SK channels are pred...

journal_title：Journal of cardiovascular pharmacology

authors： Diness JG,Kirchhoff JE,Sheykhzade M,Jespersen T,Grunnet M

更新日期：2015-09-01 00:00:00

abstract：:Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. However, this hormone has a ubiquitous influence and has specific effects on the heart. Although diff...

journal_title：Journal of cardiovascular pharmacology

authors： Pelletier JS,Dicken B,Bigam D,Cheung PY

更新日期：2014-07-01 00:00:00

abstract：:The in vivo vasoconstrictor effect of endothelin-1 (ET-1) was investigated on feline and canine basilar arteries. The basilar artery caliber was angiographically measured after either vertebral artery perfusion or cisternal injection of the peptide. In both cats and dogs, ET-1 (5-500 pmol) induced a dose-dependent bas...

journal_title：Journal of cardiovascular pharmacology

authors： Shigeno T,Mima T,Takakura K,Yanagisawa M,Saito A,Goto K,Masaki T

更新日期：1989-01-01 00:00:00

abstract：:Studies were undertaken to establish the regional hemodynamic profile and dose-response relation of the adenosine triphosphate (ATP)-dependent potassium channel activator lemakalim in anesthetized rats. In addition, the ability of the sulphonylurea potassium channel blocker glybenclamide to reverse the hemodynamic eff...

journal_title：Journal of cardiovascular pharmacology

authors： Smits GJ,Perrone MH,Cox BF

更新日期：1997-01-01 00:00:00

abstract：:We investigated the endothelin (ET) receptors involved in the vasoconstrictor responses to ET-1 in rat pulmonary arteries and arterioles and the effect of endothelium removal, nitric oxide (NO) synthase inhibition, and hypoxia on ET-1-induced responses in the arteries. In isolated rat pulmonary artery rings (2-3 mm ID...

journal_title：Journal of cardiovascular pharmacology

authors： MacLean MR,McCulloch KM,Baird M

更新日期：1994-05-01 00:00:00

abstract：:The electrophysiologic actions of the class III antiarrhythmic agents, GLG-V-13 and d,l-sotalol, were examined in superfused normal and ischemically injured epicardium. Both drugs produced concentration and reverse-use dependent prolongation of the action potential duration in normal myocardium without altering restin...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Scherlag BJ,Lazzara R,Garrison GL,Berlin KD

更新日期：2007-09-01 00:00:00

abstract：:The effects of R 56,865, a compound with unusual calcium antagonistic properties, on altered left ventricular (LV) diastolic properties were studied during pacing-induced ischemia in dogs with coronary stenosis. Severe coronary artery stenosis was produced on both the left anterior descending (LAD) and circumflex (Cx)...

journal_title：Journal of cardiovascular pharmacology

authors： Vandeplassche G,Hermans C,Wouters L,Borgers M

更新日期：1991-04-01 00:00:00

abstract：:Biological aging is an independent risk factor for many cardiovascular diseases; some are treated with beta-blockers that may protect dysfunctional endothelium during aging by increasing NO, decreasing ONOO, and restoring NO/ONOO balance. A nanotechnological approach was used to simultaneously monitor NO and ONOO prod...

journal_title：Journal of cardiovascular pharmacology

authors： Funovic P,Korda M,Kubant R,Barlag RE,Jacob RF,Mason RP,Malinski T

更新日期：2008-02-01 00:00:00

abstract：:Efficacy of flecainide was investigated in 50 patients with sustained ventricular tachycardia (n = 38) or ventricular fibrillation (n = 12) during a 4-week in-hospital and 1-year follow-up period. Furthermore, the predictive value of programmed electrical stimulation, Holter monitoring, and exercise testing on outcome...

journal_title：Journal of cardiovascular pharmacology

authors： van Wijk LM,Crijns HJ,Kingma HJ,van Gilst WH,van Gelder IC,Wesseling H,Lie KI

更新日期：1990-06-01 00:00:00

abstract：:The acute hemodynamic, hormonal, and pharmacokinetic responses to the oral angiotensin-converting enzyme (ACE) inhibitor spirapril were studied in 15 patients with moderate to severe congestive heart failure in a baseline controlled dose-ranging study. Doses of 0.3, 1.0, 1.5, 3.125, and 6.25 mg were investigated for 2...

journal_title：Journal of cardiovascular pharmacology

authors： van den Broek SA,van Bruggen A,de Graeff PA,Hillege H,van Gilst WH,Wesseling H,Lie KI

更新日期：1991-10-01 00:00:00

abstract：:Several reports suggest that when diuretics are added to nifedipine (N), they do not exert any additional hypotensive effect to that produced by N alone. We present the first double-blind, crossover trial to investigate this interaction. Twenty-four black patients with moderate to severe essential hypertension entered...

journal_title：Journal of cardiovascular pharmacology

authors： Poulter N,Thompson AV,Sever PS

更新日期：1987-01-01 00:00:00

abstract：:Acute angiotensin-converting enzyme inhibitors (ACEIs) have been found to induce natriuresis in humans as well as in experimental animals. However, the tubular sites involved have not been precisely evaluated in humans. Using both free-water and lithium clearance, the latter as a marker of proximal tubular reabsorptio...

journal_title：Journal of cardiovascular pharmacology

authors： Hannedouche T,Delgado A,Gnionsahe A,Lacour B,Grunfeld JP

更新日期：1989-01-01 00:00:00

abstract：:Nebivolol, a chemically novel beta 1-adrenoceptor antagonist, acutely lowers blood pressure in spontaneously hypertensive rats, anaesthetised normotensive dogs, and hypertensive patients. We have investigated the actions of dl-nebivolol in five conscious normotensive rabbits (sham, mean blood pressure (BP) of 82.2 +/-...

journal_title：Journal of cardiovascular pharmacology

authors： Ward JE,Coles P,Cox H,Eisenhofer G,Angus JA

更新日期：1992-07-01 00:00:00

abstract：:Results of previous studies indicate that monophosphoryl lipid A (MLA) reduces myocardial infarct size when administered 24 but not 1 h before a prolonged period of regional ischemia in dogs and rabbits. This cardioprotective effect of MLA could be reversed by the administration of the adenosine triphosphate (ATP)-sen...

journal_title：Journal of cardiovascular pharmacology

authors： Elliott GT,Mei DA,Gross GJ

更新日期：1998-07-01 00:00:00

abstract：:Transgenic mice are often used to study the physiologic role of a known gene. The design of experiments with transgenic mice usually does not take into account strain and sex differences, at least in isolated vessels. Therefore, we have compared the contractile response of isolated aortae and isolated pulmonary arteri...

journal_title：Journal of cardiovascular pharmacology

authors： Knapp J,Aleth S,Balzer F,Gergs U,Schmitz W,Neumann J

更新日期：2006-07-01 00:00:00

abstract：:Beside its antiarrhythmic properties, which in particular are used for the treatment of atrial fibrillation, quinidine is known to have alpha-adrenoceptor blocking properties. On the other hand, atrial fibrillation is reported to cause activation of the sympathetic nervous system which, in turn, reduces coronary blood...

journal_title：Journal of cardiovascular pharmacology

authors： Schipke J,Schulz R,Tölle T,Heusch G,Thämer V

更新日期：1987-12-01 00:00:00

abstract：:To study the effects of chronic in vivo inhibition of NO synthase on endothelium-dependent hyperpolarization, cell-membrane potential (in individual vascular smooth-muscle cells) and changes in tension (in isolated rings) were recorded from isolated canine coronary arteries and guinea-pig carotid arteries and aortas. ...

journal_title：Journal of cardiovascular pharmacology

authors： Corriu C,Félétou M,Puybasset L,Bea ML,Berdeaux A,Vanhoutte PM

更新日期：1998-12-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is increasingly used in the clinical evaluation of hypertension. However, a number of limitations restrict its routine use. One of the limitations is a lack of definite conclusions about ambulatory blood pressure normality, because of the shortcomings of previous studies on ...

journal_title：Journal of cardiovascular pharmacology

authors： Sega G,Bravi C,Cesana G,Valagussa F,Mancia G,Zanchetti A

更新日期：1994-01-01 00:00:00