Abstract:
:A significant reduction of maximal vasodilation capacity at the calf in relation to the severity of the hypertensive state has been demonstrated in essential hypertension. The aim of this study was to evaluate the behavior of calf blood flow and vascular resistance in borderline hypertensives (BH) in comparison with normotensive control subjects (CS). We studied 32 BH, with average age of 47.31 +/- 16.78 years and blood pressure 140-160/90-95 mm/Hg, in comparison with 20 CS, with average age of 47.24 +/- 11.75 years and blood pressure values below 140/85 mm Hg. Calf rest flow (RF) and peak flow (PF) were evaluated by strain-gauge plethysmography, and basal vascular resistance (BVR) and minimal vascular resistance (MVR) were calculated by the ratio between mean blood pressure and RF and PF, respectively. Mean blood pressure was significantly higher in BH in comparison with CS. RF and PF did not differ significantly in BH in comparison with CS. BVR did not differ in BHs in comparison with CS. In contrast, MVR were significantly higher in BH in comparison with CS. These results show that in BH, arterial flow at the calf is normal, whereas MVR are higher, indicating an impairment of maximal vasodilation capacity despite the modest blood pressure elevation.
journal_name
J Cardiovasc Pharmacoljournal_title
Journal of cardiovascular pharmacologyauthors
Novo S,Pinto A,Alaimo G,Galati D,Strano Adoi
10.1097/00005344-198608005-00025subject
Has Abstractpub_date
1986-01-01 00:00:00pages
S122-4eissn
0160-2446issn
1533-4023journal_volume
8 Suppl 5pub_type
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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