The effect of desipramine on ischemia-induced changes in extracellular K+, Na+, and H+ concentrations and noradrenaline release in the isolated rat heart during global ischemia.

Abstract:

:Isolated Langendorff-perfused rat hearts set up to allow measurement of mechanical myocardial function (according to Bardenheuer and Schrader) were subjected to 60 min of global ischemia (gI). The hearts were perfused with a modified Krebs-Henseleit solution (KHS; control group) or KHS with desipramine (DMI group) 100 nM. Extracellular concentrations of K+, Na+, and H+ were determined using ion-selective membrane polyvinyl chloride (PVC) minielectrodes. The noradrenaline (NA) release was estimated by analyzing the NA overflow during a 10-min reperfusion period, using high pressure liquid chromatography (HPLC). Control hearts and DMI-treated hearts showed no differences in mechanical performance prior to gI. In control hearts, the onset of gI resulted in a rapid triphasic [K+]e accumulation (an increase from 4.25 +/- 0.25 to 8.76 +/- 0.37 mmol/L during the first 3.5 min, a decrease to 8.06 +/- 0.34 mmol/L until the seventh min, and a further increase to 33.0 +/- 2.42 mmol/L at 60 min), a rapid increase in [H+]e (45.9 +/- 2.3 to 1314.5 +/- 214 nmol/L during 23 min), and a slight initial increase of [Na+]e (138.8 +/- 0.4 to 141.9 +/- 0.8 mmol/L within 8 min) followed by a long-lasting decrease (119.1 +/- 4.5 mmol/L at 60 min). Treatment with DMI had only slight effects on ionic redistribution during the course of ischemia. The [K-]e and [H-]e accumulation tended to be diminished, whereas [Na-]e values were slightly higher in the course of gI compared to the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Cardiovasc Pharmacol

authors

Knopf H,Theising R,Hirche H

doi

10.1097/00005344-198806121-00003

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

S8-14

eissn

0160-2446

issn

1533-4023

journal_volume

12 Suppl 1

pub_type

杂志文章
  • Nitric oxide-dependent vasodilation and the regulation of arterial blood pressure.

    abstract::Conflicting evidence has been reported on the hypothesis that vascular nitric oxide (NO) release is modulated by autonomic influences. Another controversial question is whether an insufficient degree of NO-dependent vasodilation may play a contributory role in the genesis of arterial hypertension. To address these que...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-200111002-00006

    authors: Ferrari AU,Radaelli A,Mori T,Mircoli L,Perlini S,Meregalli P,Fedele L,Mancia G

    更新日期:2001-11-01 00:00:00

  • Endothelium-derived relaxing factor modulates the atherothrombogenic effects of homocysteine.

    abstract::Hyperhomocysteinemia is a risk factor for atherosclerosis, and is found in the heterozygous form in approximately one-third of all individuals with coronary artery disease. The sulfhydryl group of homocysteine has been viewed as contributing to the atherogenic effects of this low-molecular-weight thiol, largely as a c...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199204002-00057

    authors: Stamler JS,Loscalzo J

    更新日期:1992-01-01 00:00:00

  • Resolvin D1 Reduces Infarct Size Through a Phosphoinositide 3-Kinase/Protein Kinase B Mechanism.

    abstract::This study was designed to determine if Resolvin D1 (RvD1), a pro-resolution metabolite of the omega-3 polyunsaturated fatty acid docosahexaenoic acid, could decrease myocardial infarct size with delivered at the onset of ischemia. Male Sprague Dawley rats underwent 40 minutes of myocardial ischemia followed by reperf...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/FJC.0000000000000245

    authors: Gilbert K,Bernier J,Bourque-Riel V,Malick M,Rousseau G

    更新日期:2015-07-01 00:00:00

  • Effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy requirements in isolated rabbit heart.

    abstract::The majority of patients with implanted cardioverter defibrillators (ICD) require antiarrhythmic (AR) drugs. ARs may increase defibrillation energy requirements. This study investigated the effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy needs. In 24 isolated rabbit hearts, the 50 an...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199704000-00001

    authors: Anvari A,Mast F,Schmidinger H,Schuster E,Allessie M

    更新日期:1997-04-01 00:00:00

  • Alpha-adrenoceptor blockade in patients with mild to moderate hypertension: long-term renal effects of doxazosin.

    abstract::Using constant infusion technique and a water-loading procedure, we investigated renal hemodynamic and excretional variables in 15 essential hypertensive patients [diastolic blood pressure (DBP) 102 +/- 10 mm Hg] after 3 weeks of placebo and after 16 weeks of treatment with a postjunctional alpha 1-adrenoceptor-antago...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00005344-199209000-00015

    authors: Krusell LR,Christensen CK,Pedersen OL

    更新日期:1992-09-01 00:00:00

  • Extracellular Ca2+ influx and endothelin-1-induced intracellular mitogenic cascades in rabbit internal carotid artery vascular smooth muscle cells.

    abstract::Endothelin-1 (ET-1) has been proven to activate two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC) in rabbit internal carotid artery vascular smooth muscle cells (ICA VSMCs). Ca2+ influx through these channels plays an essential role for ET-...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-200208000-00016

    authors: Kawanabe Y,Hashimoto N,Masaki T

    更新日期:2002-08-01 00:00:00

  • Differential effect of a selective cyclooxygenase-2 inhibitor versus indomethacin on renal blood flow in conscious volume-depleted dogs.

    abstract::Renal effects of a selective cyclooxygenase-2 (COX-2) inhibitor [MF-Tricyclic; 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone] were studied in control and volume-depleted conscious dogs. MF-Tricyclic was compared with the nonselective COX-1/COX-2 inhibitor indomethacin. Six instrumented male dogs ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199811000-00002

    authors: Black SC,Brideau C,Cirino M,Belley M,Bosquet J,Chan CC,Rodger IW

    更新日期:1998-11-01 00:00:00

  • Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently.

    abstract::The mode of action of Crataegus extracts in the treatment of heart failure is still under examination. WS 1442, a standardized special extract from Crataegus leaves with flowers, exerts direct positive inotropic effects. This study was designed to investigate the mode of inotropic action of WS 1442 in human myocardium...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-200005000-00004

    authors: Schwinger RH,Pietsch M,Frank K,Brixius K

    更新日期:2000-05-01 00:00:00

  • Characterization of distinct angiotensin II binding sites in rat adrenal gland and bovine cerebellum using selective nonpeptide antagonists.

    abstract::We investigated the characteristics of 125I-AII binding to rat adrenal and bovine cerebellar membranes in the presence and absence of new nonpeptide angiotensin II (AII) receptor ligands. The imidazole AII ligands, DUP753 and WL19, both produced biphasic competition curves to 125I-AII binding in rat adrenal glomerulos...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199102000-00001

    authors: Wiest SA,Rampersaud A,Zimmerman K,Steinberg MI

    更新日期:1991-02-01 00:00:00

  • Upregulation of OX40-OX40 ligand system on T lymphocytes in patients with acute coronary syndromes.

    abstract:OBJECTIVE:To investigate whether upregulation of OX40-OX40 ligand (OX40L) system is related to stability of coronary atherosclerotic plaque in patients with coronary heart diseases. METHODS:Thirty normal controls and 250 patients, including 80 with stable angina (SA), 110 with unstable angina (UA), and 60 with acute m...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/FJC.0b013e3181be7578

    authors: Yan J,Chen G,Gong J,Wang C,Du R

    更新日期:2009-11-01 00:00:00

  • Possible existence of novel endothelium-derived relaxing factor in the endothelium of rat mesenteric arterial bed.

    abstract::Both acetylcholine (ACh) and cyclopiazonic acid (CPA) caused vasodilation of the mesenteric arterial bed in a concentration-dependent manner. When the mesenteric arterial bed was perfused with 0.1% Triton X-100 for 30 s, ACh- or CPA-induced vasodilation was almost abolished. ACh-induced vasodilation was significantly ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199604000-00022

    authors: Kamata K,Umeda F,Kasuya Y

    更新日期:1996-04-01 00:00:00

  • Cocoa flavanols and brain perfusion.

    abstract::Foods and beverages rich in flavonoids are being heralded as potential preventive agents for a range of pathologic conditions, ranging from hypertension to coronary heart disease to stroke and dementia. We and others have demonstrated that short-term ingestion of cocoa, particularly rich in the subclass of flavonoids ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-200606001-00017

    authors: Fisher ND,Sorond FA,Hollenberg NK

    更新日期:2006-01-01 00:00:00

  • Inhibitory effects of diltiazem, verapamil, nifedipine, and nicardipine on sympathetic tachycardia in decentralized hearts of anesthetized dogs.

    abstract::Intravenous diltiazem (10-300 micrograms/kg), verapamil (10-300 micrograms/kg), nifedipine (1-100 micrograms/kg) and nicardipine (1-100 micrograms/kg) inhibited the tachycardia caused by cardiac sympathetic nerve stimulation (SNS, 0.5-4 Hz) in decentralized hearts of anesthetized dogs. The dose range of each drug requ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:

    authors: Satoh E,Mukaiyama O,Kimura T,Satoh S

    更新日期:1990-10-01 00:00:00

  • Management of hypertension in the young: role of antihypertensive medications.

    abstract::Traditionally, antihypertensive medications were used in few children or adolescents, usually just those with underlying renal or other organ system disease. However, with recent data suggesting that the incidence of primary hypertension may be increasing in the young, it is possible that more children and adolescents...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1097/FJC.0b013e31820d1b89

    authors: Flynn JT

    更新日期:2011-08-01 00:00:00

  • Left ventricular hypertrophy: a pressure-independent cardiovascular risk factor.

    abstract::Left ventricular hypertrophy (LVH), an increase in the muscle mass of the left ventricle, has been identified as a powerful risk factor for future cardiovascular morbidity and mortality. The risk of acute myocardial infarction, congestive heart failure, sudden death, and other cardiovascular events increases sixfold t...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审

    doi:

    authors: Messerli FH,Ketelhut R

    更新日期:1993-01-01 00:00:00

  • Comparison of hemodynamic effects of nitric oxide (NO) donors with different NO-releasing properties in rats.

    abstract::The aim of this study was to compare the hemodynamic effects of three nitric oxide (NO) donors [i.e., (+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409), (+/-)-N-[(E)-4-ethyl-3-[(Z)-hydroxyimino]-6-methyl-5-nitro-3-he ptenyl]-3-pyridinecarboxamide (FR 146801) and isosorbide dinitrate (ISDN)] in rats. In...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199708000-00011

    authors: Kita Y,Hirasawa Y,Kato Y,Ohkubo K,Ohno M,Nishino S,Kato M,Fukuyama S

    更新日期:1997-08-01 00:00:00

  • Uncoupling the coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria seen in aldosteronism.

    abstract::Intracellular [Ca2+]i overloading in cardiomyocytes is a fundamental pathogenic event associated with chronic aldosterone/salt treatment (ALDOST) and accounts for an induction of oxidative stress that leads to necrotic cell death and consequent myocardial scarring. This prooxidant response to Ca2+ overloading in cardi...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/FJC.0b013e3181cf0090

    authors: Kamalov G,Ahokas RA,Zhao W,Zhao T,Shahbaz AU,Johnson PL,Bhattacharya SK,Sun Y,Gerling IC,Weber KT

    更新日期:2010-03-01 00:00:00

  • Tetrachlorodecaoxygen, a wound healing agent, produces vascular relaxation through hemoglobulin-dependent inactivation of serotonin and norepinephrine.

    abstract::We investigated the vasoactive actions of the wound-healing agent tetrachlorodecaoxygen (TCDO). TCDO (20 microM) had no direct effect on tone in isolated calf pulmonary arteries precontracted with potassium with or without 1 microM reduced hemoglobin under O2 or N2 atmosphere. However, TCDO, in a reduced hemoglobin-de...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199404000-00022

    authors: Wolin MS,Kleber E,Mohazzab KM,Elstner EF

    更新日期:1994-04-01 00:00:00

  • The development and regression of vascular hypertrophy.

    abstract::Genetic hypertension [essential hypertension (EH) in humans and spontaneous hypertension in rats (SHRs)] is associated with an altered vascular structure, expressed in resistance vessels (small arteries) as an increased media:lumen ratio. The vascular smooth muscle cells appear normal and there is no cellular hypertro...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.1097/00005344-199219002-00006

    authors: Mulvany MJ

    更新日期:1992-01-01 00:00:00

  • Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice.

    abstract::To examine the role of sulfhydryl (-SH) group in improvement of endothelial dysfunction with angiotensin-converting enzyme (ACE) inhibitors in experimental high dose of methionine dieted rats. We compared the effects of Captopril (an ACE inhibitor with -SH group), enalapril (an ACE-inhibitor without -SH group), N-acet...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/01.fjc.0000195306.61719.64

    authors: Liu YH,Liu LY,Wu JX,Chen SX,Sun YX

    更新日期:2006-01-01 00:00:00

  • Positive inotropic effect of DPI 201-106 in spontaneously hypertensive rats: lack of inhibition by adenosine and cholinergic agents.

    abstract::The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-198804000-00012

    authors: Böhm M,Diet F,Erdmann E

    更新日期:1988-04-01 00:00:00

  • Cerebrovascular angiotensin II receptors in spontaneously hypertensive rats.

    abstract::The objective of this study was to characterize angiotensin II (AII) receptors in cerebral capillary endothelium and to examine whether the first step in AII responsiveness, namely AII receptor binding, is aberrant in cerebral microvessels obtained from adult spontaneously hypertensive rats (SHR). The binding of [3H]a...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-198902000-00008

    authors: Grammas P,Diglio C,Giacomelli F,Wiener J

    更新日期:1989-02-01 00:00:00

  • Neuropeptide-Y-ATP interactions at the vascular sympathetic neuroeffector junction.

    abstract::Neuropeptide Y (NPY) and ATP are considered cotransmitters with norepinephrine (NE) in sympathetic neurons innervating some blood vessels, including those of the mesentery. A prominent action of NPY is to potentiate the postjunctional contractile effect of NE as well as that of other vasoactive agents. We wished to in...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199511000-00002

    authors: Westfall TC,Yang CL,Curfman-Falvey M

    更新日期:1995-11-01 00:00:00

  • Impaired vasodilatation response to amrinone in the forearm of patients with congestive heart failure: role of endothelium-derived nitric oxide.

    abstract::Recent in vitro experiments have shown that amrinone enhances the release of nitric oxide (NO) from the endothelium and induces NO mediated vasodilatation. This in vivo study examined whether amrinone causes vasodilatation mediated by endothelium-derived NO, and whether this effect is attenuated in patients with endot...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00005344-200008000-00008

    authors: Sakane T,Ishibashi Y,Shimada T,Takahashi N,Sugamori T,Hirano Y,Ohata S,Inoue SI,Nakamura K,Murakami Y

    更新日期:2000-08-01 00:00:00

  • Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats.

    abstract::Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young N(ω)-nitro-L-arginine methyl ester (L-NAME)-treated Wistar rats and 10-month-old spontaneously hypertensive rats (SHR) alone and after chronic treatment with feru...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/FJC.0b013e31827cb600

    authors: Alam MA,Sernia C,Brown L

    更新日期:2013-03-01 00:00:00

  • Influence of short-term experimental diabetes on blood pressure and heart rate in response to norepinephrine and angiotensin II in the conscious rat.

    abstract::Hypertension, atherosclerosis, arteriosclerosis, and cardiomyopathy account for 80% of all diabetic deaths. A paucity of data exists concerning reactivity of the diabetic vasculature to vasopressor substances. The purpose of this investigation was to determine the influence of short-term (4-5 weeks) diabetes on the re...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-198303000-00016

    authors: Jackson CV,Carrier GO

    更新日期:1983-03-01 00:00:00

  • Endothelium-dependent hyperpolarization in isolated arteries taken from animals treated with NO-synthase inhibitors.

    abstract::To study the effects of chronic in vivo inhibition of NO synthase on endothelium-dependent hyperpolarization, cell-membrane potential (in individual vascular smooth-muscle cells) and changes in tension (in isolated rings) were recorded from isolated canine coronary arteries and guinea-pig carotid arteries and aortas. ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199812000-00011

    authors: Corriu C,Félétou M,Puybasset L,Bea ML,Berdeaux A,Vanhoutte PM

    更新日期:1998-12-01 00:00:00

  • Long-term results of the Spanish trial on treatment and survival of patients with predominantly mild heart failure.

    abstract::A randomized open-label clinical trial was conducted to determine whether mortality, readmission, or quality of life differed between heart failure patients managed with captopril plus diuretics and those with digoxin plus diuretics. A total of 345 heart failure patients in New York Heart Association functional classe...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00005344-199905000-00009

    authors: Cosín-Aguilar J,Marrugat J,Sanz G,Massó J,Gil M,Vargas R,Pérez-Casar F,Simarro E,De Armas D,García-García J,Azpitarte J,Diago JL,Rodrigo-Trallero G,Lekuona I,Domingo E,Marin-Huerta E

    更新日期:1999-05-01 00:00:00

  • Mechanism of block of cardiac transient outward K+ current (I(to)) by antidepressant drugs.

    abstract::Imipramine, amitriptyline, mianserine, maprotiline, and trazodone are five widely used antidepressant drugs with different chemical structures. Imipramine and amitriptyline are tricyclics, mianserine and maprotiline are tetracyclics, and trazodone is a triazolopyridine derivative. We studied the effects of these drugs...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199810000-00004

    authors: Casis O,Sánchez-Chapula JA

    更新日期:1998-10-01 00:00:00

  • Distribution of alpha1-adrenergic receptor mRNA species in rat heart.

    abstract::Radioligand binding studies have detected alpha1A- and alpha1B-adrenergic receptors (AR) in rat heart, but the ligands available for these studies lack the sensitivity and specificity needed to map possible differences in alpha1-AR subtype expression. We therefore used competitive reverse transcriptase-polymerase chai...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章

    doi:10.1097/00005344-199807000-00018

    authors: Wolff DW,Dang HK,Liu MF,Jeffries WB,Scofield MA

    更新日期:1998-07-01 00:00:00