Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel Ik blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium.

abstract：:The objective of this study was to investigate the cardioactive properties of oxybutynin, a drug that is widely prescribed for management of voiding dysfunction. Membrane currents were recorded from whole-cell-configured guinea pig ventricular myocytes, and action potentials were recorded from guinea pig and rabbit pa...

journal_title：Journal of cardiovascular pharmacology

authors： Jones SE,Kasamaki Y,Shuba LM,Ogura T,McCullough JR,McDonald TF

更新日期：2000-02-01 00:00:00

abstract：:Atherosclerosis (AS), known as the chronic inflammatory disease, results from the dysfunction of vascular endothelial cells (VECs). Transforming growth factor-β1 (TGF-β1) has been reported to be induced by oxidized low-density lipoprotein (ox-LDL) and contribute to AS-related vascular endothelial cell damage. This wor...

journal_title：Journal of cardiovascular pharmacology

authors： He Z,Xue H,Liu P,Han D,Xu L,Zeng X,Wang J,Yang B,Luo B

更新日期：2020-05-01 00:00:00

abstract：:Our recent studies have shown that the nonpeptide angiotensin II (Ang II) antagonist losartan interacts with thromboxane A2/prostaglandin H2 receptors and inhibits the thromboxane A2 (TxA2) analog U46619-induced vasoconstriction in canine coronary arteries. In this study, we further investigated whether losartan preve...

journal_title：Journal of cardiovascular pharmacology

authors： Li P,Ferrario CM,Brosnihan KB

更新日期：1998-08-01 00:00:00

abstract：:Coronary artery disease is the most important cause of morbidity and mortality in Western countries. Its pathogenesis is unknown but involves an enhanced vasoconstriction and increased interaction of platelets and monocytes with the vessel wall, as well as proliferation, migration, and extracellular matrix formation o...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Noll G

更新日期：1994-01-01 00:00:00

abstract：:We have previously reported the production of endothelin-1 (ET-1) by the cerebral microvessel endothelia and suggested an important role of ET-1 and microvessel endothelia in the regulation of local blood flow within the brain. In the present study, radioimmunoassay of ET-1 revealed that ET-1, produced by cultured cer...

journal_title：Journal of cardiovascular pharmacology

authors： Yoshimoto S,Ishizaki Y,Mori A,Sasaki T,Takakura K,Murota S

更新日期：1991-01-01 00:00:00

abstract：:Reviewed herein are data supporting the hypothesis that insulin and the sympathoadrenal system are involved in the pathogenesis of hypertension in the obese. Data from the Normative Aging Study, a population-based cohort followed in Boston, confirm other epidemiologic reports of a direct relationship between upper-bod...

journal_title：Journal of cardiovascular pharmacology

authors： Landsberg L

更新日期：1994-01-01 00:00:00

abstract：:Phosphatidylinositol 4,5-bisphosphate hydrolysis at the plasma membrane by phospholipase C is one of the major hormone regulated intracellular signaling systems. The system generates the diffusible second messenger IP3 and the membrane bound messenger diacylglycerol. Spatial regulation of this system has been thought ...

journal_title：Journal of cardiovascular pharmacology

authors： Smrcka AV

更新日期：2015-03-01 00:00:00

abstract：:The effects of the adrenergic antihypertensive drugs propranolol, clonidine, alpha-methyldopa, urapidil, indoramin, and prazosin on the relative rate of sterol synthesis were studied in freshly isolated human mononuclear leukocytes. Incubation of cells for 6 h in a medium containing lipid-depleted serum led to a three...

journal_title：Journal of cardiovascular pharmacology

authors： Krone W,Müller-Wieland D,Greten H

更新日期：1985-11-01 00:00:00

abstract：:Before the withdrawal of 2 COX-2 selective agents (COX-2s) from the market, many rheumatoid arthritis patients were using these products regularly, with disease-modifying antirheumatic agents. Clinical trials have shown benefit of COX-2s equivalent to nonselective nonsteroidal anti-inflammatory drugs (NS-NSAIDs) in rh...

journal_title：Journal of cardiovascular pharmacology

authors： Strand V

更新日期：2006-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a 21-residue peptide isolated from the conditioned medium of cultured porcine endothelial cells and is widely distributed throughout the body, with relatively high levels in the kidney and lung. In this study we examined the influence of thyroid hormone status on immunoreactive endothelin (ir-ET...

journal_title：Journal of cardiovascular pharmacology

authors： Lam HC,Wang JP,Lee JK,Ho LT,Han TM,Lu CC,Chiang HT,Cheng DL

更新日期：1993-01-01 00:00:00

abstract：:A randomized, double-blind, crossover trial was carried out in 17 hypertensive patients to evaluate the hypotensive efficacy and safety of verapamil. Verapamil in doses of 120 mg thrice daily was compared with pindolol in doses of 7.5 mg twice daily. A thiazide diuretic was given with both drugs. Blood pressure fell a...

journal_title：Journal of cardiovascular pharmacology

authors： Anavekar SN,Christophidis N,Louis WJ,Doyle AE

更新日期：1981-03-01 00:00:00

abstract：:KATP channels are a complex of regulatory sulfonylurea receptor subunits and the pore-forming inward rectifiers such as Kir6.1. Using the whole-cell patch-clamp technique, we investigated the interaction of nicotine with the Kir6.1 subunit as well as the underlying mechanism. Stable expression of Kir6.1 in HEK-293 cel...

journal_title：Journal of cardiovascular pharmacology

authors： Hanna ST,Cao K,Sun X,Wang R

更新日期：2005-05-01 00:00:00

abstract：:Angiotensin II AT1-receptor blockers (AT1-s) prolong survival in experimental postischemic (coronary artery ligation) heart failure (CHF) in rats. The goal of this study was to investigate whether potential beneficial effects of short- and/or long-term treatment with AT1-s on coronary dynamics, function, and structure...

journal_title：Journal of cardiovascular pharmacology

authors： Gervais M,Fornes P,Richer C,Nisato D,Giudicelli JF

更新日期：2000-09-01 00:00:00

abstract：:Pro-arrhythmia by noncardiac drugs has become an important safety concern in the pharmaceutical industry. The most common underlying mechanism for induction of arrhythmias by noncardiac drugs is off-target block of the native cardiac repolarizing current, I Kr. The pore-forming subunit of I Kr is encoded by the human ...

journal_title：Journal of cardiovascular pharmacology

authors： Margulis M,Sorota S

更新日期：2008-06-01 00:00:00

abstract：:Since the end of 1976 ten orally active converting enzyme inhibitors [SQ 14,225 (captopril), MK 421 (enalapril), MK 422, MK 521 (lysinopril), RHC 3659, CGS 13945, CGS 13928C, CGS 14824A, Hoe 498, S 9490-3, and Ro 31-2848] have been evaluated by our group in normal volunteers. Their ability to blunt the pressor respons...

journal_title：Journal of cardiovascular pharmacology

authors： Brunner HR,Nussberger J,Waeber B

更新日期：1985-01-01 00:00:00

abstract：:Currently used antiplatelet drugs including aspirin, ticlopidine, and others are effective against certain but not all of the many endogenous platelet activators. Because of their limited efficacy, a significant number of serious thromboembolic complications still occur, highlighting the need for a more effective ther...

journal_title：Journal of cardiovascular pharmacology

authors： Mousa SA,Forsythe M,Wityak J,Bozarth J,Mu DX

更新日期：1998-03-01 00:00:00

abstract：:The terminal phases of volume-overload heart failure are characterised by eccentric ventricular hypertrophy. Relatively little attention has been directed to exploring the mechanisms involved in this development. The increase in diastolic wall stress leads to replication of the sarcomeres in series. The hypertrophied ...

journal_title：Journal of cardiovascular pharmacology

authors： Taylor SH

更新日期：1987-01-01 00:00:00

abstract：:In this study, we used the spontaneously beating, isolated rat right atrium as an in vitro model to study arrhythmogenic effects of electrical stimulation. A tetrapolar platinum electrode was used for stimulation and recording of atrial electrical activity at 36.5 degrees C (spontaneous rate, 4.9+/-0.3 Hz). A flutter-...

journal_title：Journal of cardiovascular pharmacology

authors： Godoy CM,Bassani RA,Bassani JW

更新日期：1999-10-01 00:00:00

abstract：:It has been suggested that isosorbide dinitrate (ISDN)-induced venodilation could be ascribed to preferential accumulation of the agent in venous tissues, resulting in higher concentrations of nitric oxide (NO). Here, the authors investigated whether the venodilating effect of ISDN is associated with a preferential in...

journal_title：Journal of cardiovascular pharmacology

authors： Ishibashi T,Himeno M,Kubota K,Matsubara T,Hori T,Ozaki K,Yamazoe M,Aizawa Y,Yoshida J,Nishio M

更新日期：2003-01-01 00:00:00

abstract：:We wished to determine whether pharmacologic inhibition of the exaggerated sympathetic nerve activity in congestive heart failure (CHF) could restore the renal response to exogenous atrial natriuretic peptide (ANP) administration. Left ventricular (LV) myocardial infarction was induced in Sprague-Dawley rats (n = 16) ...

journal_title：Journal of cardiovascular pharmacology

authors： Feng QP,Hedner T,Hedner J,Pettersson A

更新日期：1990-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) influences vascular function by modulating intracellular free Ca2+ concentration ([Ca2+]i) in smooth muscle. This study investigated the effects of ET-1 on [Ca2+]i and contractile responses in resistance vessels of young prehypertensive (5 week) and adult hypertensive (17 week) spontaneously hypert...

journal_title：Journal of cardiovascular pharmacology

authors： Touyz RM,Deng LY,Schiffrin EL

更新日期：1995-01-01 00:00:00

abstract：:The present article reviews the experience with amiodarone therapy in life-threatening ventricular tachyarrhythmias. In 13 studies, 1,594 patients were treated with amiodarone in average doses of 300 mg/day. The mean annual death rate was 6.2%; the annual withdrawal rate averaged 8%. Risk factors for arrhythmia recurr...

journal_title：Journal of cardiovascular pharmacology

authors： Burckhardt D

更新日期：1992-01-01 00:00:00

abstract：:Hyperinsulinemia, lipid abnormalities, and impaired fibrinolytic capacity may accompany hypertension, and comprise the metabolic cardiovascular syndrome. They are all independent risk factors for coronary artery disease. Lifestyle modifications can reduce the coronary artery risk. Physical activity has been shown to i...

journal_title：Journal of cardiovascular pharmacology

authors： Westheim A,Os I

更新日期：1992-01-01 00:00:00

abstract：:We examined whether the activation of the renin-angiotensin system after intramuscular isoprenaline injection contributes to the simultaneous increase in vasopressin release. Plasma concentrations of vasopressin and angiotensin II were measured in conscious rats using specific radioimmunoassays. Intravenous infusions ...

journal_title：Journal of cardiovascular pharmacology

authors： Knepel W,Meyer DK

更新日期：1980-11-01 00:00:00

abstract：:Nitric oxide (NO) is a potent inhibitor of platelet aggregation. However, the benefits of NO-based therapies can be confounded by concomitant hypotension. Monophosphoryl lipid A (MLA) is a nontoxic derivative of endotoxin that purportedly increases nitric oxide synthase (NOS) activity and, presumably, NO production, y...

journal_title：Journal of cardiovascular pharmacology

authors： Przyklenk K,Hata K,Whittaker P,Elliott GT

更新日期：2000-03-01 00:00:00

abstract：:Establishing the overall efficacy or safety of a drug requires a unified methodological approach and analysis of all clinical trials that are intended to be summarized. As an example, this article presents the aggregated dose-response relationship and a subgroup analysis (by age) over all studies of the antihypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Stienen U

更新日期：1992-01-01 00:00:00

abstract：:The new anti-anginal drug ranolazine causes a slight (<10 milliseconds) prolongation of the QT interval, raising the concern that its use may be associated with an increased incidence of torsades de pointes ventricular tachyarrhythmias. The goal of this study was to show that ranolazine inhibits the late component of ...

journal_title：Journal of cardiovascular pharmacology

authors： Song Y,Shryock JC,Wu L,Belardinelli L

更新日期：2004-08-01 00:00:00

abstract：:The purpose of the two double-blind studies summarized in this article was to compare the antianginal and anti-ischemic effects of nicorandil with those of two different nitrate preparations. A total of 129 patients with stable New York Heart Association functional class II or III coronary heart disease were enrolled ...

journal_title：Journal of cardiovascular pharmacology

authors： Döring G

更新日期：1992-01-01 00:00:00

abstract：:Serotonin, applied to helical strips of larger vessels such as coronary arteries, acts as a potent vasoconstrictor in vitro. In contrast, in vivo serotonin causes a remarkable decrease in total peripheral resistance. To differentiate the influence of serotonin on resistances of large and small vessels, experiments wer...

journal_title：Journal of cardiovascular pharmacology

authors： Meschig R,Breuer J,Arnold G

更新日期：1985-01-01 00:00:00

abstract：:This study investigated whether glibenclamide exerts a defibrillatory action and if this action is mediated by a blockade of ATP-sensitive K+ channels (K(ATP)) or by an anti-free radical mechanism. Aerobically perfused isolated rat hearts were subjected to 10 min of pacing-induced ventricular fibrillation (VF) followe...

journal_title：Journal of cardiovascular pharmacology

authors： Csonka C,Onody A,Csont T,Ferdinandy P

更新日期：2003-06-01 00:00:00