Clinical efficacy of long-term treatment with amiodarone for life-threatening arrhythmias.

abstract：:Interest in the cardiovascular protective effects of calcium channel antagonists has increased in the past decade. We investigated prevention of vascular wall remodeling by the long-acting calcium channel antagonist pranidipine in 12-week-old Dahl salt-sensitive (SS) rats with high-salt-induced (4% NaCl) hypertension....

journal_title：Journal of cardiovascular pharmacology

authors： Uehara Y,Kawabata Y,Ohshima N,Hirawa N,Takada S,Numabe A,Nagata T,Goto A,Yagi S,Omata M

更新日期：1994-06-01 00:00:00

abstract：:Cilostazol, a potent phosphodiesterase 3 inhibitor and anti-thrombotic agent, was recently shown to inhibit adenosine uptake into cardiac myocytes and vascular cells. In the present studies, cilostazol inhibited [ H]-adenosine uptake in both platelets and erythrocytes with a median inhibitory concentration (IC ) of 7 ...

journal_title：Journal of cardiovascular pharmacology

authors： Sun B,Le SN,Lin S,Fong M,Guertin M,Liu Y,Tandon NN,Yoshitake M,Kambayashi J

更新日期：2002-10-01 00:00:00

abstract：:The effects of potent coronary vasodilator, 2- phenylaminoadenosine (CV-1808), on coronary circulatory failure and thromboxane (TX) A2 release were studied during coronary occlusion (for 60 min) and subsequent reperfusion (for 60 min) in anesthetized dogs. During coronary reperfusion, reactive hyperemic response was a...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe M,Terashita Z,Nishikawa K,Hirata M

更新日期：1984-05-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH), an increase in the muscle mass of the left ventricle, has been identified as a powerful risk factor for future cardiovascular morbidity and mortality. The risk of acute myocardial infarction, congestive heart failure, sudden death, and other cardiovascular events increases six- to e...

journal_title：Journal of cardiovascular pharmacology

authors： Messerli FH,Ketelhut R

更新日期：1991-01-01 00:00:00

abstract：:We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-induced myocardial systolic shortening and malonylaldehyde production an...

journal_title：Journal of cardiovascular pharmacology

authors： Kim YD,Farhat MY,Myers AK,Kouretas P,DeGroot KW,Pacquing A,Ramwell PW,Suyderhoud JP,Lees DE

更新日期：1998-09-01 00:00:00

abstract：:Coronary heart disease secondary to atherosclerosis is the leading cause of death for men in the United States. Using a new, nontransgenic, non-fat-fed mouse model of hyperlipidemia and atherosclerosis developed in our laboratory, we investigated the effect of sex on lipid profiles and subsequent aortic atheroscleroti...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Coker JW,Paigen BJ,Tawfik O

更新日期：2002-03-01 00:00:00

abstract：:We have previously demonstrated that endothelin-1 (ET-1) is essential to the development of neural crest-derived craniofacial and cardiovascular structures. In this study we evaluated the intrauterine growth and development of the thyroid and thymus glands in Edn1-/- homozygous mice. Edn1-/- homozygous mice were small...

journal_title：Journal of cardiovascular pharmacology

authors： Kurihara Y,Kurihara H,Maemura K,Kuwaki T,Kumada M,Yazaki Y

更新日期：1995-01-01 00:00:00

abstract：:Relationships between lipoprotein fractions, lipoprotein lipase activities, thyroid hormones, and coronary lesion growth were studied among 35 male patients with severe coronary atherosclerosis, who had participated in the Leiden Intervention Trial, a lipid-lowering dietary intervention program. Coronary arteriography...

journal_title：Journal of cardiovascular pharmacology

authors： Barth JD,Jansen H,Kromhout D,Reiber JH,Birkenhäger JC,Arntzenius AC

更新日期：1987-01-01 00:00:00

abstract：:Oxidative stress plays a critical role in diabetic cardiomyopathy. Transient receptor potential ankyrin subtype 1 (TRPA1) has antioxidative property. In this study, we tested whether activation of TRPA1 with cinnamaldehyde protects against high-glucose-induced cardiomyocyte injury. Cinnamaldehyde remarkably decreased ...

journal_title：Journal of cardiovascular pharmacology

authors： Wang D,Hou J,Yang Y,Zhou P,Liu S,Wan J,Wang P

更新日期：2019-07-01 00:00:00

abstract：:The renin-angiotensin system affects blood pressure and regional blood flow through endocrine, paracrine, and autocrine influences. The circulating endocrine renin-angiotensin system (RAS) is activated for acute cardiovascular homeostasis. The recent demonstration of a local renin-angiotensin system in the blood vesse...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1987-01-01 00:00:00

abstract：:To establish a model of hypertension in marmosets, increasing doses of the immune-modulator cyclosporin (from 3 to 30 mg/kg/day) were given orally to marmosets for 31 days. Cyclosporin consistently induced hypertension with doses greater than or equal to 10 mg/kg/day. Time course and level of hypertension reached were...

journal_title：Journal of cardiovascular pharmacology

authors： Clozel JP,Fischli W

更新日期：1989-07-01 00:00:00

abstract：:Although evidence has been accumulated to support a role of endothelin-1 (ET-1) in cardiac hypertrophy, details of the pathophysiological significance of ET-1 in cardiac hypertrophy remain to be elucidated. In the present study, we investigated the effects of the vasodilator hydralazine on the blood pressure, cardiac ...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe A,Naruse M,Adachi C,Seki T,Yoshimoto T,Takagi S,Naruse K,Takano K

更新日期：2000-11-01 00:00:00

abstract：:The effect of two calcium antagonists on left ventricular (LV) relaxation and diastolic filling was evaluated in 16 randomized patients. Isradipine and nifedipine were administered intravenously in a maximum dose of 60 micrograms/min for isradipine and 63 micrograms/min for nifedipine. Heart rate was increased signifi...

journal_title：Journal of cardiovascular pharmacology

authors： Hoppeler H,Hess OM,Hug R,Turina J,Krayenbühl HP

更新日期：1990-01-01 00:00:00

abstract：:The vascular endothelium has a number of functions that may mediate many of the ischemia-reperfusion (IR) phenomena. The gatekeeper function is disturbed and increased capillary permeability results in edema and organ dysfunction. Vasomotor function is altered, with impairment of relaxation and augmentation of constri...

journal_title：Journal of cardiovascular pharmacology

authors： Verrier E

更新日期：1996-01-01 00:00:00

abstract：:Endothelial cells and smooth muscle cells are the major cells that constitute blood vessels, and endothelial cells line the lumen of blood vessels. These 2 types of cells also play an integral role in the regional specialization of vascular structure. On the basis of these observations, we designed our study to invest...

journal_title：Journal of cardiovascular pharmacology

authors： Bertrand-Thiebault C,Masson C,Siest G,Batt AM,Visvikis-Siest S

更新日期：2007-05-01 00:00:00

abstract：:The cardiopulmonary profile of three different rat strains was compared after exposure to hypoxia (9% O2) for 0, 7, or 14 days. In Sprague-Dawley (SD), Wistar (W), and high altitude-sensitive (HAS) rats, pulmonary arterial pressure (PAP) rose 30, 58, and 85% respectively, after 7 days of hypoxia, and by 108, 116, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Underwood DC,Bochnowicz S,Osborn RR,Louden CS,Hart TK,Ohlstein EH,Hay DW

更新日期：1998-01-01 00:00:00

abstract：:Spirapril is a new angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug with a resorption of about 50%. The active metabolite spiraprilat reaches maximal plasma concentration within 2-3 h after oral administration. Spirapril can be administered once daily because of its long duration of action caused by an e...

journal_title：Journal of cardiovascular pharmacology

authors： Hayduk K,Kraul H

更新日期：1999-08-01 00:00:00

abstract：:Therapeutic response to angiotensin-converting enzyme (ACE) inhibitors was reported to be better related to tissular than to circulating levels of ACE inhibition, especially during chronic therapy. We studied the relations between plasma concentrations of angiotensin I (AI), plasma renin activity (PRA), angiotensin II...

journal_title：Journal of cardiovascular pharmacology

authors： Schaison FH,Fernando Ramirez-Gil J,Ciferri S,Bernard M,Baudin B,Mougenot N,Carayon A,Lechat P

更新日期：1996-07-01 00:00:00

abstract：:Efficacy of flecainide was investigated in 50 patients with sustained ventricular tachycardia (n = 38) or ventricular fibrillation (n = 12) during a 4-week in-hospital and 1-year follow-up period. Furthermore, the predictive value of programmed electrical stimulation, Holter monitoring, and exercise testing on outcome...

journal_title：Journal of cardiovascular pharmacology

authors： van Wijk LM,Crijns HJ,Kingma HJ,van Gilst WH,van Gelder IC,Wesseling H,Lie KI

更新日期：1990-06-01 00:00:00

abstract：:Lidocaine and tocainide had no effect on ventricular conduction of extrasystoles with coupling intervals longer than 500 msec in isolated blood-perfused dog hearts, but caused interval-related increases in conduction time of extrasystoles in the range of 250--400 msec, here called mid-range extrasystoles (MRE). Quinid...

journal_title：Journal of cardiovascular pharmacology

authors： Man RY,Dresel PE

更新日期：1979-05-01 00:00:00

abstract：:This article reviews the relation of cardiac cellular Na+ load and increased force of contraction. Digitalis glycosides and naturally occurring Na+ channel activators are considered. DPI201-106 was described as the first synthetic organic molecule with cardioselective Na+ channel-activating properties and investigated...

journal_title：Journal of cardiovascular pharmacology

authors： Scholtysik G

更新日期：1989-01-01 00:00:00

abstract：:In a previous experiment, (-)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine-induced locomotor activity and stereotyped behaviors and inhibited caffeine-induced neuronal stimulant activity. This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant effects in animals...

journal_title：Journal of cardiovascular pharmacology

authors： Han JY,Kim CS,Lim KH,Kim JH,Kim S,Yun YP,Hong JT,Oh KW

更新日期：2011-10-01 00:00:00

abstract：:Beraprost sodium is a stable analog of the vasodilator, platelet antiaggregatory eicosanoid, prostacyclin. Experiments were performed to determine whether long-term therapy with beraprost produces vascular protective effects in saline-drinking stroke-prone spontaneously hypertensive rats (SHRSPs). Oral beraprost at 30...

journal_title：Journal of cardiovascular pharmacology

authors： Stier CT Jr,Chander PN,Belmonte A,Inamdar RS,Mistry M

更新日期：1997-09-01 00:00:00

abstract：:Activation of adrenoceptors of the alpha 2-subtype can cause an inhibitory or an excitatory response, depending on the cellular system affected. At the plasma membrane, where the extracellular signal is transduced via the alpha 2-adrenoceptor into an intracellular signal, only one transduction process has clearly been...

journal_title：Journal of cardiovascular pharmacology

authors： Jakobs KH

更新日期：1985-01-01 00:00:00

abstract：:Antecubital venous plasma neuropeptide Y-like immunoreactivity (NPY-LI) and catecholamines were analyzed in six healthy volunteers performing a graded bicycle exercise without medication and after acute administration of clonidine, phentolamine, and nifedipine. During the control exercise, plasma noradrenaline (NA), a...

journal_title：Journal of cardiovascular pharmacology

authors： Pernow J,Lundberg JM,Kaijser L

更新日期：1988-01-01 00:00:00

abstract：:The cardioprotective effects on myocardial ischemia of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) inhibitor, cyclopiazonic acid (CPA), were studied. We used the isolated arterially perfused interventricular septum of the rabbit heart submitted to 30-min global ischemia/30-min reperfusion. Mechanical [maximal ...

journal_title：Journal of cardiovascular pharmacology

authors： Avellanal M,Rodriguez P,Barrigon S

更新日期：1998-11-01 00:00:00

abstract：:The evolutionary relationships among 17 protein and nucleic acid sequences from the sarafotoxin/endothelin/endothelin-like superfamily of peptides were studied. The endothelin/endothelin-like gene family has diverged from an ancestral gene that has experienced an exon duplication event followed by two complete gene du...

journal_title：Journal of cardiovascular pharmacology

authors： Landan G,Bdolah A,Wollberg Z,Kochva E,Graur D

更新日期：1991-01-01 00:00:00

abstract：:In helical strips of dog cerebral, coronary, mesenteric, and renal arteries treated with ONO3708, an inhibitor of vasoconstricting prostaglandin (PG) receptors, and previously contracted with serotonin, PGF2 alpha, PGD2 and epithio-methano thromboxane A2 (sTxA2), a TxA2 analog, caused a relaxation. The cerebral arteri...

journal_title：Journal of cardiovascular pharmacology

authors： Toda N,Inoue S,Okamura T,Okunishi H

更新日期：1988-03-01 00:00:00

abstract：:This study examines the acute effects of the antianginal drug carbocromene (chromonar) in dogs (20 mg/kg p.o., twice daily for 8 weeks) on mortality, hemodynamics, coronary collateral blood flow, and myocardial infarct size. Following the chronic pretreatment and during acute phase of the experiments, the animals rece...

journal_title：Journal of cardiovascular pharmacology

authors： Fiedler VB,Nitz RE,Buchheim S

更新日期：1982-01-01 00:00:00

abstract：:Diabetes is a devastating disease with multiple adverse effects on the vasculature. Moreover, hypertension is a prerequisite for patients with diabetes to progress to end-stage renal disease and to develop cardiovascular complications. Adequate control of blood glucose and blood pressure are the two most important fac...

journal_title：Journal of cardiovascular pharmacology

authors： Makrilakis K,Bakris G

更新日期：1998-01-01 00:00:00