Protective effects of cyclopiazonic acid on ischemia-reperfusion injury in rabbit hearts.

abstract：:Angiotensin-converting enzyme (ACE) inhibitors are widely used for treatment of heart failure after myocardial infarction (MI). The beneficial effects consist of a combination of hemodynamic effects and interference with cardiac structural alterations. These effects are believed to depend on inhibition of angiotensin ...

journal_title：Journal of cardiovascular pharmacology

authors： Smits JF,van Krimpen C,Schoemaker RG,Cleutjens JP,Daemen MJ

更新日期：1992-01-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is known to alter the pharmacokinetics of several antiarrhythmic agents. To study the effects of AMI on the kinetics of mexiletine (MEX), a single intravenous dose of 200 mg MEX HCl was infused over 30 min in 11 patients with AMI. The study was performed within 24 h of the onset of pa...

journal_title：Journal of cardiovascular pharmacology

authors： Pentikäinen PJ,Halinen MO,Helin MJ

更新日期：1984-01-01 00:00:00

abstract：:The major aim of treatment of arterial hypertension is to reduce the increased risks of cardio-cerebrovascular morbidity and mortality that are associated with elevated blood pressure (BP). A direct relationship can be found between the level of BP and risk, even down to what is normally considered to be the "normoten...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson L

更新日期：1987-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play key physiological roles and represent a significant target for drug development. However, historically, drugs were developed with the understanding that GPCRs as a therapeutic target exist solely on cell surface membranes. More recently, GPCRs have been detected on intracellula...

journal_title：Journal of cardiovascular pharmacology

authors： Branco AF,Allen BG

更新日期：2015-02-01 00:00:00

abstract：:Carvedilol (20 mg/kg, bid) or vehicle was given to rats surviving a myocardial infarction (MI) 24 h (n = 409). In rats with large MI, carvedilol partially preserved left ventricular (LV) function and intrinsic myocardial contractility and reactivity to beta-adrenergic stimulation. Carvedilol led to scar thickening, in...

journal_title：Journal of cardiovascular pharmacology

authors： Sia YT,Parker TG,Tsoporis JN,Liu P,Adam A,Rouleau JL

更新日期：2002-01-01 00:00:00

abstract：:Roughly 40% of all diabetics, whether insulin dependent or not, develop persistent albuminuria, a decline in their glomerular filtration rate, and elevated blood pressure, i.e., diabetic nephropathy. Diabetic nephropathy is the single most important cause of end-stage renal disease in the Western world, accounting for...

journal_title：Journal of cardiovascular pharmacology

authors： Parving HH

更新日期：1992-01-01 00:00:00

abstract：:We produced transgenic mice overexpressing Na+/ H+ exchanger as a model of salt-sensitive hypertension and reported that dietary salt loading elevates blood pressure in these transgenic mice. We speculate that this blood pressure elevation may be attributed to the elevation of intraarterial smooth muscle Ca2+ concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Kiraku J,Sugiyama T,Ashida T,Takahashi N,Fujii J,Kuro-o M,Nagai R

更新日期：2000-03-01 00:00:00

abstract：:Twenty-four-hour urinary sodium excretion and plasma renin activity were monitored in 36 patients receiving bendrofluazide as sole antihypertensive therapy. There was no increase in urinary sodium output compared with pretreatment values during a 2-year period, and there is therefore no evidence that an increase in sa...

journal_title：Journal of cardiovascular pharmacology

authors： Swales JD,Bing RF,Swart S,Thurston H

更新日期：1984-01-01 00:00:00

abstract：:Chronic uremia and metabolic acidosis impair vascular responses to norepinephrine (NE) and also cause multiple metabolic defects in skeletal muscle. These studies were conducted to determine whether decreased vascular responsiveness resulted from putative second messenger metabolism. Tail arteries were used from rats ...

journal_title：Journal of cardiovascular pharmacology

authors： Fox AW,May RE,Mitch WE

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:The goal of this study was to determine whether an Angiotensin II receptor antagonist, candesartan, prevents myocardial fibrosis more effectively than enalapril in animals with a non-ACE pathway during the progression of congestive heart failure (CHF). METHODS AND RESULTS:Dogs were randomly assigned to one ...

journal_title：Journal of cardiovascular pharmacology

authors： Onishi K,Dohi K,Koji T,Funabiki K,Kitamura T,Imanaka-Yoshida K,Ito M,Nobori T,Nakano T

更新日期：2004-06-01 00:00:00

abstract：:Reperfusion of ischemic myocardium is accompanied by intracellular Ca overload, leading to cardiac dysfunction. However, the mechanisms underlying intracellular Ca overload have yet to be fully elucidated. The mechanism may involve the activation of store-operated Ca entry, which is primarily mediated through the tran...

journal_title：Journal of cardiovascular pharmacology

authors： Kojima A,Fukushima Y,Ito Y,Ding WG,Kitagawa H,Matsuura H

更新日期：2018-04-01 00:00:00

abstract：:Cardiac electrophysiologic effects of PK 10139 (PK), a new quinoleic antiarrhythmic agent, were compared with those of quinidine sulphate (Q) after three cumulative intravenous doses of 0.75, 1.5, and 3 mg/kg of PK and 5, 10, and 20 mg/kg of Q in anesthetized dogs. A control group of animals received saline solution o...

journal_title：Journal of cardiovascular pharmacology

authors： Heckle J,Jaillon P,Jozefczak C,Cheymol G

更新日期：1985-01-01 00:00:00

abstract：:Previous studies have suggested that racial differences may exist in beta-adrenoceptor-mediated responsiveness. However, no clear conclusions can be drawn based on these studies because of the confounding effect of the parasympathetic nervous system on responses to isoproterenol bolus doses. In this study, we blocked ...

journal_title：Journal of cardiovascular pharmacology

authors： Johnson JA,Burlew BS,Stiles RN

更新日期：1995-01-01 00:00:00

abstract：:Celiprolol is a selective beta(1)-adrenoceptor antagonist with antihypertensive actions, which causes renal vasodilation by increasing tissue nitric oxide (NO) levels. The authors tested whether celiprolol increases coronary blood flow (CBF) by increasing cardiac NO release in the ischemic heart in vivo. In open-chest...

journal_title：Journal of cardiovascular pharmacology

authors： Asanuma H,Node K,Minamino T,Sanada S,Takashima S,Ueda Y,Sakata Y,Asakura M,Kim J,Ogita H,Tada M,Hori M,Kitakaze M

更新日期：2003-04-01 00:00:00

abstract：:Both acetylcholine (ACh) and cyclopiazonic acid (CPA) caused vasodilation of the mesenteric arterial bed in a concentration-dependent manner. When the mesenteric arterial bed was perfused with 0.1% Triton X-100 for 30 s, ACh- or CPA-induced vasodilation was almost abolished. ACh-induced vasodilation was significantly ...

journal_title：Journal of cardiovascular pharmacology

authors： Kamata K,Umeda F,Kasuya Y

更新日期：1996-04-01 00:00:00

abstract：:Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the effects of torasemi...

journal_title：Journal of cardiovascular pharmacology

authors： Harada K,Izawa H,Nishizawa T,Hirashiki A,Murase Y,Kobayashi M,Isobe S,Cheng XW,Noda A,Nagata K,Yokota M,Murohara T

更新日期：2009-06-01 00:00:00

abstract：:Nicorandil, a potent coronary vasorelaxant used in the treatment of angina, has differential effects on arteries and veins in vivo. To explain this phenomenon, experiments were designed to characterize the relaxant and inhibitory actions of this compound on canine isolated arteries and veins. Paired rings of canine co...

journal_title：Journal of cardiovascular pharmacology

authors： Morrison KJ,Flavahan NA,Vanhoutte PM

更新日期：1990-05-01 00:00:00

abstract：:Previous animal experiments suggest that the increase in the amplitude from the R-wave to the S-wave (RSh) may be more sensitive than other ECG measures to sodium channel blocking drug actions. We measured RSh of three orthogonal leads at baseline and during intravenous pharmacologic stimulation with adenosine, ajmali...

journal_title：Journal of cardiovascular pharmacology

authors： Wolzt M,Schmetterer L,Gouya G,Zanaschka G,Eichler HG

更新日期：1995-10-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH), an increase in the muscle mass of the left ventricle, has been identified as a powerful risk factor for future cardiovascular morbidity and mortality. The risk of acute myocardial infarction, congestive heart failure, sudden death, and other cardiovascular events increases sixfold t...

journal_title：Journal of cardiovascular pharmacology

authors： Messerli FH,Ketelhut R

更新日期：1993-01-01 00:00:00

abstract：:We briefly review and compare the current knowledge of growth mechanisms for the mitogenic response of endothelial cells and smooth-muscle cells to injury. For the endothelium, this focuses on the evidence that growth control involves two components: an endogenous inhibition mechanism, which can be overcome either by ...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz SM,Liaw L

更新日期：1993-01-01 00:00:00

abstract：:Cardiovascular effects of Nifekalant were examined using halothane-anesthetized dogs, and its proarrhythmic potential was estimated with chronic complete atrioventricular block dogs. Nifekalant was intravenously administered to the halothane-anesthetized dogs in three doses of 0.03, 0.3, and 3 mg/kg/10 minutes with a ...

journal_title：Journal of cardiovascular pharmacology

authors： Satoh Y,Sugiyama A,Takahara A,Chiba K,Hashimoto K

更新日期：2004-05-01 00:00:00

abstract：:To investigate the effects of ramipril, a new angiotensin converting enzyme inhibitor, on autonomic function, autonomic function tests were performed in eight healthy male subjects, aged 22-26 years, after single oral administration of 5 mg of ramipril or placebo, in a randomized, double-blind, crossover design. Measu...

journal_title：Journal of cardiovascular pharmacology

authors： Sugimoto K,Kumagai Y,Tateishi T,Seguchi H,Ebihara A

更新日期：1989-01-01 00:00:00

abstract：:This study investigated the role of perivascular adipose tissue (PVAT) in the beneficial effects of andrographolide on vascular reactivity in endotoxaemic rats. After being challenged by lipopolysaccharide (4 mg/kg intraperitoneally), the rats were treated with andrographolide (1 mg/kg intraperitoneally). The response...

journal_title：Journal of cardiovascular pharmacology

authors： Hai-Mei L,Song-Yin H,Run-Mei L,Xiao-Huang X,Le-Quan Z,Xiao-Ping L,Jin-Wen X

更新日期：2013-08-01 00:00:00

abstract：:Ghrelin is a novel growth hormone (GH)-releasing peptide, isolated from the stomach, which is identified as an endogenous ligand for GH secretagogues receptor. Although both ghrelin and its specific receptor are expressed in blood vessels, the cardiovascular effects of ghrelin remain unknown. To clarify whether ghreli...

journal_title：Journal of cardiovascular pharmacology

authors： Okumura H,Nagaya N,Enomoto M,Nakagawa E,Oya H,Kangawa K

更新日期：2002-06-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：:During the last few years, there has been a growing awareness that treated hypertensive patients are still at substantially increased risks for cardiovascular morbidity and mortality and that one conceivable explanation for this is that their blood pressure has not been lowered to strictly normotensive levels. To obta...

journal_title：Journal of cardiovascular pharmacology

authors： Dahlöf B,Eggertsen R,Hansson L

更新日期：1988-01-01 00:00:00

abstract：:Endothelin-1 reduces the chronotropic and inotropic effects of the beta-adrenoceptor agonist isoproterenol in rabbit isolated atria. Vascular interactions between endothelin-1 and isoproterenol have not been reported. Rings of the rabbit aorta without endothelium were mounted on myographs to measure isometric tension....

journal_title：Journal of cardiovascular pharmacology

authors： Gilbert P,Thorin E

更新日期：2003-10-01 00:00:00

abstract：:Despite today's standard of care, aimed at preventing homeostatic neurohormonal activation, one in every five patients recently hospitalized with congestive heart failure (CHF) will be readmitted within 30 days of discharge because of a recurrence of their symptoms and signs. In light of recent pathophysiological insi...

journal_title：Journal of cardiovascular pharmacology

authors： Kamalov G,Bhattacharya SK,Weber KT

更新日期：2010-09-01 00:00:00

abstract：:Cardiac hypertrophy occurs in response to increased workload, such as hypertension or valvular heart disease. Oxidative stress has been implicated in cardiac hypertrophy and in its transition to heart failure. This study was taken up with the objective to evaluate the role of oxidative stress in cardiomyoblast hypertr...

journal_title：Journal of cardiovascular pharmacology

authors： Sankar V,Pangayarselvi B,Prathapan A,Raghu KG

更新日期：2013-01-01 00:00:00

abstract：:Labedipinedilol-A is a novel 1, 4-dihydropyridine type calcium antagonist with alpha-receptor blocking activity. This study investigates the effects of labedipinedilol-A on mitogen-induced proliferation of rat vascular smooth muscle cells (VSMCs). Labedipinedilol-A's inhibition on cell proliferation was measured by th...

journal_title：Journal of cardiovascular pharmacology

authors： Liou SF,Yeh JL,Liang JC,Chiu CC,Lin YT,Chen IJ

更新日期：2004-11-01 00:00:00