Calcium antagonists combined with beta-blockers or ACE inhibitors in the treatment of hypertension.

abstract：:To study the role of medullary alpha-adrenoceptors in hypertension, we compared specific binding of [3H]prazosin and [3H]clonidine in different brain regions of spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and normotensive Wistar-Kyoto rats (WKY). As compared with age-matched WKY, Bmax values for s...

journal_title：Journal of cardiovascular pharmacology

authors： Yamada S,Ashizawa N,Nakayama K,Tomita T,Hayashi E

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the effect of a combination of bone marrow mononuclear cell (BM-MNC) implantation and sarpogrelate, a selective 5-HT(2A) antagonist, on endothelial function in patients with critical limb ischemia (CLI). METHODS:We evaluated the leg blood flow (LBF) responses to ac...

journal_title：Journal of cardiovascular pharmacology

authors： Higashi Y,Miyazaki M,Goto C,Sanada H,Sueda T,Chayama K

更新日期：2010-01-01 00:00:00

abstract：:In an 8-week, double-blind, randomized, active-controlled, multicenter study with three parallel treatment groups, we compared the efficacy and safety of once-daily 20 mg quinapril plus 12.5 mg hydrochlorothiazide (HCTZ) with each drug as monotherapy in patients with moderate to severe hypertension. Hypertensive out-p...

journal_title：Journal of cardiovascular pharmacology

authors： Romero R,Castellote E,Ocón J,Wagner B

更新日期：1995-07-01 00:00:00

abstract：:In addition to the hemodynamic components, the roles of various humoral factors have been emphasized in the progression of vascular and renal injury in hypertension. Radical scavenging properties have attracted much attention in this field. This article discusses the implication of antioxidant properties of the antihy...

journal_title：Journal of cardiovascular pharmacology

authors： Uehara Y,Kawabata Y,Shirahase H,Wada K,Hashizume Y,Morishita S,Numabe A,Iwai J

更新日期：1993-01-01 00:00:00

abstract：:Selection of the appropriate dose of a new drug for initiation of treatment and then for maintenance is a complicated task. It requires the careful assessment and weighing of benefit vs. risk. A series of studies was carried out with lacidipine to determine the optimal initial dose in a general hypertensive population...

journal_title：Journal of cardiovascular pharmacology

authors： Perelman M

更新日期：1991-01-01 00:00:00

abstract：:We studied 12 patients receiving either chronic oral (p.o.) maintenance bretylium and/or acute intravenous (i.v.) bretylium to evaluate drug efficacy and pharmacokinetics. All patients were survivors of ventricular tachycardia or fibrillation. A new assay for bretylium was applied, and it proved sensitive and reliable...

journal_title：Journal of cardiovascular pharmacology

authors： Anderson JL,Patterson E,Wagner JG,Johnson TA,Lucchesi BR,Pitt B

更新日期：1981-05-01 00:00:00

abstract：:Endothelial cell (EC) and vascular smooth muscle cell (VSMC) interactions play critical roles in restenosis following vascular injury. We examined the effects of intracellular iron chelation on endothelial cell cycle progression and VSMC modulation of endothelial cell growth. A diffusible, lipid-soluble iron chelator ...

journal_title：Journal of cardiovascular pharmacology

authors： Hodges YK,Reese SM,Pahl PM,Horwitz LD

更新日期：2005-06-01 00:00:00

abstract：:There is general agreement that the sympathetic nervous system is involved in the development of hypertension in spontaneously hypertensive rats (SHR). However, in a previous study we established that chronic administration of the selective alpha 1-adrenoceptor antagonist terazosin to SHR failed to prevent this phenom...

journal_title：Journal of cardiovascular pharmacology

authors： Young RL,Jonsson JR,Mano MT,Frewin DB,Head RJ

更新日期：1993-05-01 00:00:00

abstract：:Patients with untreated hypertension have been shown to be resistant to insulin-stimulated glucose uptake. They are also hyperinsulinemic and hypertriglyceridemic when compared with matched control groups with normal blood pressure. In addition, insulin resistance, hyperinsulinemia, and hypertriglyceridemia have been ...

journal_title：Journal of cardiovascular pharmacology

authors： Reaven GM

更新日期：1990-01-01 00:00:00

abstract：:We investigated the effects of aranidipine, a dihydropyridine-type Ca2+ channel blocker, on contractile responses to KCl and spontaneous contractions in isolated rat portal veins in comparison with those of the Ca2+ channel blockers, nifedipine, nicardipine, nitrendipine, diltiazem, and verapamil, and of the K+ channe...

journal_title：Journal of cardiovascular pharmacology

authors： Okumura K,Ichihara K,Nagasaka M

更新日期：1997-02-01 00:00:00

abstract：:Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of ca...

journal_title：Journal of cardiovascular pharmacology

authors： de Leiris J,de Lorgeril M,Boucher F

更新日期：2009-11-01 00:00:00

abstract：:We wished to determine whether angiotensin-converting enzyme (ACE) inhibition alters the effect of hypoxia and reoxygenation directly on the cardiac myocyte; to compare two different ACE inhibitors, one with and one without a sulfhydryl group (i.e., captopril and cilazapril), and to examine the potential interaction o...

journal_title：Journal of cardiovascular pharmacology

authors： Rabkin SW

更新日期：1992-03-01 00:00:00

abstract：:[125I]Endothelin-1 (ET-1) was administered intravenously into rats, and binding sites in various tissues were examined by electron-microscopic radioautography. Labeling was observed predominantly on the glomerular fenestrated endothelial cells of kidney, alveolar capillary endothelial cells of lung, fat-storing cells ...

journal_title：Journal of cardiovascular pharmacology

authors： Furuya S,Naruse S,Nakayama T,Furuya K,Nokihara K

更新日期：1991-01-01 00:00:00

abstract：:In primarily cultured pig coronary smooth muscle cells, extracellular adenosine triphosphate (ATP; 10(-9) to 10(-3) M) dose-dependently increases intracellular calcium ([Ca2+]i). The [Ca2+]i transients measured by fura-2 fluorescence consist of peak and plateau phases with [Ca2+]i values of 191.84 +/- 5.67 nM (n = 10)...

journal_title：Journal of cardiovascular pharmacology

authors： Seiler L,Matyas S,Fleckenstein-Grün G

更新日期：1999-05-01 00:00:00

abstract：:Bay k 8644, a new dihydropyridine calcium channel activator has been shown to have positive inotropic and vasoconstrictor properties following intravenous (i.v.) administration. In the present study, intracoronary administration of Bay k 8644 was used to isolate drug effects on regional myocardial blood flow and contr...

journal_title：Journal of cardiovascular pharmacology

authors： Pelc LR,Gross GJ,Brooks HL,Warltier DC

更新日期：1986-11-01 00:00:00

abstract：:The purpose of the present study was to assess the effects of chronic treatment with an orally active chymase inhibitor, 4-[1-(naphthylmethyl)benzimidazol-2-ylthio]butanoic acid (TEI-E548), in a hamster myocardial infarction model. In the first experiment, after confirming the biochemical inhibitory action of TEI-E548...

journal_title：Journal of cardiovascular pharmacology

authors： Hoshino F,Urata H,Inoue Y,Saito Y,Yahiro E,Ideishi M,Arakawa K,Saku K

更新日期：2003-01-01 00:00:00

abstract：:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 > nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >...

journal_title：Journal of cardiovascular pharmacology

authors： Bossaller C,Auch-Schwelk W,Graf K,Gräfe M,Catadelgirmen G,Ennker J,Fleck E

更新日期：1992-01-01 00:00:00

abstract：:In a double blind, randomized placebo-controlled crossover study we characterized how terbutaline affects the mean and short-term fluctuations of peripheral vascular resistance and arterial compliance. The study was carried out in six young and healthy male subjects in the supine and upright positions by recording con...

journal_title：Journal of cardiovascular pharmacology

authors： Kuusela TA,Jartti TT,Tahvanainen KU,Kaila TJ

更新日期：2004-07-01 00:00:00

abstract：:Kinins locally synthesized in the cardiovascular tissue are believed to contribute to the regulation of cardiovascular homeostasis by stimulating the endothelial cells to release nitric oxide, prostacyclin, or a hyperpolarizing factor via autocrine-paracrine mechanisms. This study was designed to investigate the actio...

journal_title：Journal of cardiovascular pharmacology

authors： Kanna T,Akata T,Izumi K,Nakashima M,Yonemitsu Y,Hashizume M,Takahashi S

更新日期：2002-11-01 00:00:00

abstract：:This presentation has reviewed evidence from our laboratory that both structural and functional changes participate in the initiation and maintenance of hypertension in spontaneously hypertensive rats (SHR). Structural changes are present in the muscular arteries of the mesenteric and renal vasculature at 3- to 5-week...

journal_title：Journal of cardiovascular pharmacology

authors： Daniel EE,Kwan CY,Lee RM,Smeda J

更新日期：1984-01-01 00:00:00

abstract：:We studied the influence of prostacyclin (PGI2) on the contractile performance of isolated mammalian ventricular muscle. PGI2 had no direct influence on myocardial contractility, as evidenced by experiments on single cardiac cells and papillary muscle. Moreover, PGI2 did not interfere with the inotropic action of isop...

journal_title：Journal of cardiovascular pharmacology

authors： Couttenye MM,De Clerck NM,Herman AG,Brutsaert DL

更新日期：1985-09-01 00:00:00

abstract：:Acetazolamide (ACTZ) vasodilating properties are used for the assessment of cerebral vasodilatory reserve not only in cerebral pathology investigation, but also in clinical pharmacology studies. However, the kinetics of these vasodilating properties are not clearly established; moreover, the cerebral selectivity of AC...

journal_title：Journal of cardiovascular pharmacology

authors： Démolis P,Chalon S,Giudicelli JF

更新日期：1995-11-01 00:00:00

abstract：:beta-Adrenoceptor antagonists such as propranolol and atenolol ameliorate the symptoms of human hyperthyroidism. We wished to define whether the cardiac changes of hyperthyroidism are attenuated by treatment with the beta-adrenoceptor antagonist atenolol. Rats were treated with triiodothyronine (T3) [1 mg/kg/day subcu...

journal_title：Journal of cardiovascular pharmacology

authors： Amos G,Kerr D,Sernia C,Brown L

更新日期：1994-08-01 00:00:00

abstract：:Angiotensin II receptor blockers (ARBs) are used for the treatment of patients with heart failure and hypertension. Yet their safety has been questioned by some who observed delayed cardiac healing and scar thinning after myocardial infarction (MI). To clarify potential efficacy and safety of ARBs, we administered Azi...

journal_title：Journal of cardiovascular pharmacology

authors： Quinn Baumann P,Zaman AK,McElroy-Yaggy K,Sobel BE

更新日期：2013-05-01 00:00:00

abstract：:The cardioprotective effects of betaxolol were studied in a rat model with heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization, Lewis rats were divided into four groups; 0.1 mg/kg betaxolol per day (group 0.1), 1.0 mg/kg betaxolol per day (group 1), 10 mg/kg betaxolol per day (group 1...

journal_title：Journal of cardiovascular pharmacology

authors： Watanabe K,Juan W,Narasimman G,Ma M,Inoue M,Saito Y,Wahed MI,Nakazawa M,Hasegawa G,Naito M,Tachikawa H,Tanabe N,Kodama M,Aizawa Y,Yamamoto T,Yamaguchi K,Takahashi T

更新日期：2003-01-01 00:00:00

abstract：:This article presents selected aspects of the presynaptic modulation of noradrenaline release from the heart. Several presynaptic effector systems that mediate either inhibition or facilitation of noradrenaline release are discussed. In particular, the potencies of muscarinic agonists and antimuscarinic drugs in musca...

journal_title：Journal of cardiovascular pharmacology

authors： Fuder H

更新日期：1985-01-01 00:00:00

abstract：:Clinical trials in patients with congestive heart failure have shown a wide disparity in the hemodynamic responses to chronic therapy with newer positive inotropic drugs. Therefore, the long-term efficacy of enoximone was studied in 10 patients with severe congestive heart failure. Patients were evaluated clinically, ...

journal_title：Journal of cardiovascular pharmacology

authors： Gilfrich HJ,Witzke-Gross J,Römer A

更新日期：1989-01-01 00:00:00

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:We investigated the endothelin (ET) receptors involved in the vasoconstrictor responses to ET-1 in rat pulmonary arteries and arterioles and the effect of endothelium removal, nitric oxide (NO) synthase inhibition, and hypoxia on ET-1-induced responses in the arteries. In isolated rat pulmonary artery rings (2-3 mm ID...

journal_title：Journal of cardiovascular pharmacology

authors： MacLean MR,McCulloch KM,Baird M

更新日期：1994-05-01 00:00:00

abstract：:We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-induced myocardial systolic shortening and malonylaldehyde production an...

journal_title：Journal of cardiovascular pharmacology

authors： Kim YD,Farhat MY,Myers AK,Kouretas P,DeGroot KW,Pacquing A,Ramwell PW,Suyderhoud JP,Lees DE

更新日期：1998-09-01 00:00:00