Selection of initial and maintenance dosages for lacidipine, a new once-daily calcium antagonist for the treatment of hypertension.

Abstract:

:Selection of the appropriate dose of a new drug for initiation of treatment and then for maintenance is a complicated task. It requires the careful assessment and weighing of benefit vs. risk. A series of studies was carried out with lacidipine to determine the optimal initial dose in a general hypertensive population as well as in special populations in whom the pharmacokinetics may be different. The conclusions of these studies are that (a) in a general adult population, the initial dose should be 4 mg once daily; (b) in the elderly and in those with impaired liver function, the starting dose should be 2 mg once daily; and (c) renal dysfunction does not alter the usual starting dose of 4 mg once daily.

journal_name

J Cardiovasc Pharmacol

authors

Perelman M

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

S14-8; discussion S18-9

eissn

0160-2446

issn

1533-4023

journal_volume

17 Suppl 4

pub_type

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