Abstract:
:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 > nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 > nicorandil in human arteria mammaria. These data demonstrate that K(+)-channel openers are effective vasorelaxant agents in human coronary artery and human arteria mammaria. Bimakalim and EMD 56431 were more potent than nicorandil, a drug that also activates guanylate cyclase.
journal_name
J Cardiovasc Pharmacoljournal_title
Journal of cardiovascular pharmacologyauthors
Bossaller C,Auch-Schwelk W,Graf K,Gräfe M,Catadelgirmen G,Ennker J,Fleck Edoi
10.1097/00005344-199206203-00004subject
Has Abstractpub_date
1992-01-01 00:00:00pages
S13-6eissn
0160-2446issn
1533-4023journal_volume
20 Suppl 3pub_type
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journal_title:Journal of cardiovascular pharmacology
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更新日期:1995-01-01 00:00:00
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