Localization of [125I]endothelin-1 in rat tissues observed by electron-microscopic radioautography.

abstract：:Since beta-adrenoceptor blocking drugs were originally discovered and shown to be important therapeutic agents in the management of both angina pectoris and hypertension, many other similar drugs have become available. These share the common property of beta-adrenoceptor antagonism, though they may vary in terms of po...

journal_title：Journal of cardiovascular pharmacology

authors： McDevitt DG

更新日期：1986-01-01 00:00:00

abstract：:Anesthesia inhibits arterial baroreflex functions such as baroreflex sensitivity (BRS). The main objective of the present study was to determine the time course of BRS recovery from anesthesia and to determine whether BRS recovery is synchronous with the recovery of consciousness and blood pressure (BP). Experiments w...

journal_title：Journal of cardiovascular pharmacology

authors： Yi-Ming W,Shu H,Miao CY,Shen FM,Jiang YY,Su DF

更新日期：2004-01-01 00:00:00

abstract：:Alpha 2-adrenoceptor agonists are effective antihypertensive drugs that may provide particular advantages in the treatment of many types of patients. Of those now available, guanabenz has been shown to lower serum cholesterol concentration and not to cause sodium and water retention, offering additional protection aga...

journal_title：Journal of cardiovascular pharmacology

authors： Kaplan NM

更新日期：1985-01-01 00:00:00

abstract：:The adrenal medulla and pheochromocytomas are known to secrete various neuropeptides and vasoactive peptides. On the other hand, the production and secretion of peptides by adrenocortical tumors have not been studied in detail. The study reported here therefore set out to examine these two functions for two vasoactive...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Yoshinoya A,Murakami O,Totsune K,Shibahara S

更新日期：2000-11-01 00:00:00

abstract：:The pulmonary vascular reactivity to endothelin-1 (ET-1) was assessed in rats previously exposed to 11% O2 (hypoxic) or room air (controls) for 3 weeks. In isolated control lung preparations studied during conditions of increased tone by U46619 (50 pmol/min) and treated with meclofenamate (3 microM), low doses of ET-1...

journal_title：Journal of cardiovascular pharmacology

authors： Eddahibi S,Raffestin B,Braquet P,Chabrier PE,Adnot S

更新日期：1991-01-01 00:00:00

abstract：:The objective of the study was to inquire about the mechanism(s) involved in the catabolism of S-nitrosothiols by vascular tissue under in vitro conditions. Incubations of S-nitrosocysteine (CYSNO) or S-nitrosoglutathione (GSNO) with homogenates isolated from porcine aortic smooth muscle resulted in only a marginal de...

journal_title：Journal of cardiovascular pharmacology

authors： Kostka P,Xu B,Skiles EH

更新日期：1999-04-01 00:00:00

abstract：:Lactoferrin (LF) exerts a variety of biological effects, including the promotion of angiogenesis by increasing the expression of angiogenesis-related genes and reducing blood pressure via a nitric oxide-dependent mechanism. In this study, we investigated the effects of LF on angiogenesis using C57BL/6J mice that recei...

journal_title：Journal of cardiovascular pharmacology

authors： Ikeda Y,Tajima S,Izawa-Ishizawa Y,Kihira Y,Ishizawa K,Yoshida S,Aihara K,Tsuchiya K,Tamaki T

更新日期：2013-05-01 00:00:00

abstract：:Recent studies have suggested that central nervous mechanisms are involved in the enhanced sympathetic drive observed in heart failure (HF). Nitric oxide (NO) in the brainstem has been shown to reduce sympathetic nerve activity. The aim of this study was to determine whether the expression of neuronal nitric oxide syn...

journal_title：Journal of cardiovascular pharmacology

authors： Hirooka Y,Shigematsu H,Kishi T,Kimura Y,Ueta Y,Takeshita A

更新日期：2003-12-01 00:00:00

abstract：:Hyperinsulinemia, lipid abnormalities, and impaired fibrinolytic capacity may accompany hypertension, and comprise the metabolic cardiovascular syndrome. They are all independent risk factors for coronary artery disease. Lifestyle modifications can reduce the coronary artery risk. Physical activity has been shown to i...

journal_title：Journal of cardiovascular pharmacology

authors： Westheim A,Os I

更新日期：1992-01-01 00:00:00

abstract：:Chalcone is a class of flavonoid compounds that are widely biosynthesized in plants. Epidemiological studies suggest that increased intake of flavonoids from fruits and vegetables reduces the risk of cardiovascular disease. However, the effect of chalcone on cardiovascular diseases has not been fully investigated. The...

journal_title：Journal of cardiovascular pharmacology

authors： Liu CS,Chang CC,Du YC,Chang FR,Wu YC,Chang WC,Hsieh TJ

更新日期：2012-04-01 00:00:00

abstract：:The effects of 3 quinazoline alpha-adrenoreceptor antagonists, prazosin, trimazosin, and UK-33,274, on lying blood pressure (BP), BP response to 60 degrees tilt, pressor response to noradrenaline, phenylephrine, and exercise (isometric and dynamic) were measured in a double-blind study in 6 volunteers. There was no di...

journal_title：Journal of cardiovascular pharmacology

authors： Singleton W,Saxton CA,Hernandez J,Prichard BN

更新日期：1982-01-01 00:00:00

abstract：:Cyclosporine (CsA) treatment in solid organ transplantation has represented one of the greatest advances in the past 20 years, reducing acute rejection and increasing long-term survival. However, CsA has an important side effect, producing renal vasoconstriction and systemic hypertension. The main histological finding...

journal_title：Journal of cardiovascular pharmacology

authors： Rodicio JL

更新日期：2000-01-01 00:00:00

abstract：:The effects of exogenous guanosine 5'-triphosphate (GTP) and guanosine on nitroglycerin-, sodium nitrite- and SIN-1-induced guanosine 3',5'-cyclic monophosphate (cyclic GMP) accumulation and smooth muscle relaxation were studied using endothelium-denuded rat mesenteric artery rings precontracted with noradrenaline. Pr...

journal_title：Journal of cardiovascular pharmacology

authors： Vuorinen P,Pörsti I,Metsä-Ketelä T,Manninen V,Vapaatalo H,Laustiola KE

更新日期：1991-12-01 00:00:00

abstract：:We used strips of human pulmonary arteries from patients undergoing surgery for lung tumor to investigate whether or not this human tissue (like that of the rabbit) is endowed with inhibitory presynaptic alpha 2-adrenoceptors. The strips were incubated with [3H]noradrenaline and subsequently superfused with physiologi...

journal_title：Journal of cardiovascular pharmacology

authors： Hentrich F,Göthert M,Greschuchna D

更新日期：1986-05-01 00:00:00

abstract：:Endothelin-1 (ET-1) not only causes potent vasoconstriction but also leads to fluid retention, both actions mediated by ET(A)- and/or ET(B)-receptors. Selective ET(A)- and combined ET(A)/ET(B)-receptor antagonists improve hemodynamics in heart failure; however, it is also important to evaluate the effects of these ant...

journal_title：Journal of cardiovascular pharmacology

authors： Ohnishi M,Wada A,Tsutamoto T,Sawaki M,Fujii M,Matsumoto T,Kinoshita M

更新日期：2000-11-01 00:00:00

abstract：:Carvedilol (20 mg/kg, bid) or vehicle was given to rats surviving a myocardial infarction (MI) 24 h (n = 409). In rats with large MI, carvedilol partially preserved left ventricular (LV) function and intrinsic myocardial contractility and reactivity to beta-adrenergic stimulation. Carvedilol led to scar thickening, in...

journal_title：Journal of cardiovascular pharmacology

authors： Sia YT,Parker TG,Tsoporis JN,Liu P,Adam A,Rouleau JL

更新日期：2002-01-01 00:00:00

abstract：:Addition of endothelin-1 (ET-1) to primary cultures of bovine adrenal chromaffin cells causes a significant enhancement of norepinephrine and epinephrine efflux, with an EC50 of about 1 nM. A maximally effective concentration of endothelin (10 nM) gives a transient increase in noradrenaline release within 5 min. The a...

journal_title：Journal of cardiovascular pharmacology

authors： Boarder MR,Marriott DB

更新日期：1989-01-01 00:00:00

abstract：:Intracerebroventricular injections of endothelin-1 (ET-1) are reported to cause dose-related increases in sympathetic nerve activity and blood pressure in anesthetized normotensive rats. These studies were performed to determine the following: which endothelin receptor, A or B, is involved in mediating sympathetic and...

journal_title：Journal of cardiovascular pharmacology

authors： Nakamura K,Sasaki S,Moriguchi J,Morimoto S,Miki S,Kawa T,Itoh H,Nakata T,Takeda K,Nakagawa M

更新日期：1999-06-01 00:00:00

abstract：:Lisinopril (LIS) is a lysine analog of enalaprilat, the active metabolite of enalapril, an angiotensin-converting enzyme inhibitor (ACEI). Unlike enalapril, the precursor of enalaprilat, LIS is not a prodrug but has equal ACEI efficacy and potency and a slightly longer duration of action after oral administration. Sho...

journal_title：Journal of cardiovascular pharmacology

authors： Pool JL,Gennari J,Goldstein R,Kochar MS,Lewin AJ,Maxwell MH,McChesney JA,Mehta J,Nash DT,Nelson EB

更新日期：1987-01-01 00:00:00

abstract：:The aim of this study was to determine whether a quantitative relation exists between changes in regional myocardial blood flow (RMBF) and those in electrophysiologic determinants recorded via left ventricular endocardial and epicardial bipolar electrograms after administration of disopyramide (DP) and a class III ant...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe T,Iwamoto T,Iwata O,Aikawa M,Kusuzaki S,Handa S,Shinozaki Y,Mori H

更新日期：1999-08-01 00:00:00

abstract：:Fibric acid-shaped drugs raise high-density lipoprotein (HDL) cholesterol by upregulating the HDL-related genes through activating peroxisome proliferater activated receptor (PPAR)-alpha. We investigated the effects of fibrates to induce expression of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and ...

journal_title：Journal of cardiovascular pharmacology

authors： Hossain MA,Tsujita M,Gonzalez FJ,Yokoyama S

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:A substantial proportion of patients with heart failure have a normal ejection fraction and diastolic dysfunction. However, there are few data available to guide the therapy of these patients. The effects of statins on cardiac remodeling are well documented in animal models and it is reported that statin the...

journal_title：Journal of cardiovascular pharmacology

authors： Xu Z,Okamoto H,Akino M,Onozuka H,Matsui Y,Tsutsui H

更新日期：2008-01-01 00:00:00

abstract：:KATP channels are a complex of regulatory sulfonylurea receptor subunits and the pore-forming inward rectifiers such as Kir6.1. Using the whole-cell patch-clamp technique, we investigated the interaction of nicotine with the Kir6.1 subunit as well as the underlying mechanism. Stable expression of Kir6.1 in HEK-293 cel...

journal_title：Journal of cardiovascular pharmacology

authors： Hanna ST,Cao K,Sun X,Wang R

更新日期：2005-05-01 00:00:00

abstract：:This presentation has reviewed evidence from our laboratory that both structural and functional changes participate in the initiation and maintenance of hypertension in spontaneously hypertensive rats (SHR). Structural changes are present in the muscular arteries of the mesenteric and renal vasculature at 3- to 5-week...

journal_title：Journal of cardiovascular pharmacology

authors： Daniel EE,Kwan CY,Lee RM,Smeda J

更新日期：1984-01-01 00:00:00

abstract：:The mechanism by which enoximone, a reported phosphodiesterase inhibitor, inhibits the oxidation of long-chain fatty acids was studied in isolated rat heart mitochondria using a series of 14C-labeled substrates. Enoximone decreased palmitate oxidation in a time- and concentration-dependent manner. Fifty percent inhibi...

journal_title：Journal of cardiovascular pharmacology

authors： Abdel-aleem S,Youssef J,Badr M,Morgan P,Frangakis C

更新日期：1992-06-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is a widely used vehicle for water-insoluble substances and exerts a wide range of pharmacologic effects including anti-inflammatory and free radical scavenging properties. Additionally, in an animal model, DMSO inhibited cholesterol-induced atherosclerosis. Despite such profound pharmacologi...

journal_title：Journal of cardiovascular pharmacology

authors： Laskar A,Yuan XM,Li W

更新日期：2010-09-01 00:00:00

abstract：:The cardioprotective effects on myocardial ischemia of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) inhibitor, cyclopiazonic acid (CPA), were studied. We used the isolated arterially perfused interventricular septum of the rabbit heart submitted to 30-min global ischemia/30-min reperfusion. Mechanical [maximal ...

journal_title：Journal of cardiovascular pharmacology

authors： Avellanal M,Rodriguez P,Barrigon S

更新日期：1998-11-01 00:00:00

abstract：:A contribution by active vasodilation to the hypotensive effect of medroxalol was investigated in anesthetized dogs and reserpinized pithed rats. In anesthetized dogs, intravenous doses of medroxalol, which decreased blood pressure and heart rate, also produced a dose-related vasodilation in the isolated perfused grac...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Hsieh CP,Spedding M

更新日期：1983-01-01 00:00:00

abstract：:Intravenous (i.v.) administration of bromocriptine (150 micrograms/kg) in conscious normotensive rats with chronic spinal cord transection (at T5-T7), pretreated or not with i.v. propranolol (0.5 mg/kg), induced significant decreases in mean arterial blood pressure (MAP) which were greater and longer lasting than thos...

journal_title：Journal of cardiovascular pharmacology

authors： Lahlou S,Demenge P

更新日期：1992-05-01 00:00:00

abstract：:Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) ...

journal_title：Journal of cardiovascular pharmacology

authors： Ivanov AV,Alexandrin VV,Paltsyn AA,Virus ED,Nikiforova KA,Bulgakova PO,Sviridkina NB,Svetlana Alexandrovna Apollonova,Kubatiev AA

更新日期：2018-10-01 00:00:00