Pulmonary vascular reactivity to endothelin-1 in normal and chronically pulmonary hypertensive rats.

abstract：:The cholinergic anti-inflammatory pathway has been found to exert a protective role in myocardial ischemia-reperfusion injury (MIRI). Alpha7 nicotinic acetylcholine receptor (α7nAChR) is a regulator of cholinergic anti-inflammatory pathway; however, little information is available on the effect of α7nAChR on MIRI. In ...

journal_title：Journal of cardiovascular pharmacology

authors： Li H,Zhang ZZ,Zhan J,He XH,Song XM,Wang YL

更新日期：2012-06-01 00:00:00

abstract：:The distribution of catecholamine (CA)-containing neurones and tissue noradrenaline (NA) concentration was investigated in pig hearts with and without myocardial ischemia. All hearts were shock-frozen using a Wollenberger clamp, and tissue samples were obtained from the mid- and apical left ventricular wall (nonischem...

journal_title：Journal of cardiovascular pharmacology

authors： Hirche H,McDonald FM,Polwin W,Addicks K

更新日期：1985-01-01 00:00:00

abstract：:The effects of various doses of creatine phosphate have been examined in a rat model of acute myocardial ischaemia. When given directly into the lumen of the left ventricle in pentobarbitone-anaesthetised male rats, creatine phosphate (50 and 100 mg/kg) markedly reduced the incidence of ventricular ectopic beats, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Fagbemi O,Kane KA,Parratt JR

更新日期：1982-01-01 00:00:00

abstract：:Activating IK1 channels is considered to be a promising antiarrhythmic strategy. Zacopride has been identified as a selective IK1 channel agonist and can suppress triggered arrhythmias. Whether this drug also exerts a beneficial effect on cardiac remodeling is unknown, and the present study sought to address this ques...

journal_title：Journal of cardiovascular pharmacology

authors： Liu CF,Liu QH,Liu EL,Zhai XW,Zhang L,Luo TE,Zhang WF,Feng QL,Cui XL,Zhao ZQ,Cao JM,Wu BW

更新日期：2014-10-01 00:00:00

abstract：:We examined the effects of tiapamil, a Ca2+ antagonist, on infarct size, lymphatic enzyme release, and arrhythmias in reperfused, ischemic canine hearts. Three-hour reperfusion of the left anterior descending coronary artery, which had been ligated for 3 h, significantly increased cardiac lymphatic release of lactate ...

journal_title：Journal of cardiovascular pharmacology

authors： Matsuura A,Ishihara T,Nakamura K,Himori N,Nakamura K

更新日期：1986-01-01 00:00:00

abstract：:This study was performed to determine if cardiodepression can be dissociated from cardioprotection with calcium antagonists and which one (diltiazem, nifedipine, or verapamil) can maximally protect ischemic myocardium at a given level of cardiodepression. Isolated rat hearts were subjected to 0.1, 0.5, or 1.0 microM d...

journal_title：Journal of cardiovascular pharmacology

authors： Grover GJ,Sleph PG

更新日期：1989-08-01 00:00:00

abstract：:: Interstitial fibrosis is a common pathological change in various heart diseases, especially cardiac hypertrophy. Arginine vasopressin (AVP), one of the hallmarks of heart failure, exhibits a profibrotic effect by promoting the proliferation and differentiation of cardiac fibroblasts (CFs). In contrast, angiotensin-(...

journal_title：Journal of cardiovascular pharmacology

authors： Niu X,Xue Y,Li X,He Y,Zhao X,Xu M,Zhao L

更新日期：2014-12-01 00:00:00

abstract：:Doxazosin has been shown to lower serum cholesterol levels in the cholesterol-fed (0.75% in a synthetic diet that contains sucrose and cholic acid) C57BR/cdJ mouse. These studies show that the drug's main effect is to lower low-density lipoprotein (LDL) cholesterol and leave high-density lipoprotein (HDL) cholesterol ...

journal_title：Journal of cardiovascular pharmacology

authors： Krupp MN,Hoover KW,Valentine JJ

更新日期：1989-01-01 00:00:00

abstract：:The influence of intravenous diltiazem on hemodynamics and left ventricular function indices was studied in 14 patients with severe coronary artery disease at rest and during atrial pacing. We used a tip manometer catheter for recording left ventricular pressure tracings and a nuclear probe for measuring left ventricu...

journal_title：Journal of cardiovascular pharmacology

authors： van Dijk RB,Blanksma PK,van Gilst WH,Lie KI

更新日期：1993-08-01 00:00:00

abstract：:The pharmacokinetics of losartan and EXP3174, an active metabolite of losartan, were evaluated in the anesthetized pig after both a single intravenous dose (3 mg/kg) and during constant intravenous infusion. The pharmacodynamic activities of losartan and EXP3174 were determined during constant intravenous infusion as ...

journal_title：Journal of cardiovascular pharmacology

authors： Lankford SM,Plummer D,Hellyer P,Christ DD,Bai SA

更新日期：1997-11-01 00:00:00

abstract：:The relation between insulin resistance/ hyperinsulinemia and cardiovascular disease may be related to one of the cardiovascular effects of insulin. In acute experiments in humans, systemic euglycemic hyperinsulinemia induced vasodilation in skeletal muscle. Furthermore, the sympathetic nervous system is activated, al...

journal_title：Journal of cardiovascular pharmacology

authors： Tack CJ,Heeremans M,Thien T,Lutterman JA,Smits P

更新日期：1996-08-01 00:00:00

abstract：:Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are importan...

journal_title：Journal of cardiovascular pharmacology

authors： Passariello CL,Li J,Dodge-Kafka K,Kapiloff MS

更新日期：2015-03-01 00:00:00

abstract：:Bucindolol is a nonselective beta-adrenergic receptor antagonist that has additional vasodilating properties. Because some beta-adrenergic receptor antagonists such as cyanopindolol are used as 5-HT1A/5-HT1B receptor antagonists, we tested the hypothesis that bucindolol can interact with 5-HT receptors. Both in vitro ...

journal_title：Journal of cardiovascular pharmacology

authors： Watts SW,Fink GD,Silver PJ,Cushing DJ

更新日期：2000-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) not only causes potent vasoconstriction but also leads to fluid retention, both actions mediated by ET(A)- and/or ET(B)-receptors. Selective ET(A)- and combined ET(A)/ET(B)-receptor antagonists improve hemodynamics in heart failure; however, it is also important to evaluate the effects of these ant...

journal_title：Journal of cardiovascular pharmacology

authors： Ohnishi M,Wada A,Tsutamoto T,Sawaki M,Fujii M,Matsumoto T,Kinoshita M

更新日期：2000-11-01 00:00:00

abstract：:Myocardial infarction (MI) is one of cardiovascular diseases with high incidence and mortality. MicroRNAs, as posttranscriptional regulators of genes, are involved in many diseases, including cardiovascular diseases. The aim of the present study was to determine whether miR-203 was functional in MI therapy and how it ...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang J,Pan J,Yang M,Jin X,Feng J,Wang A,Chen Z

更新日期：2019-11-01 00:00:00

abstract：:As cyclic 3',5'-guanosine monophosphate (cGMP) is still discussed as a possible mediator of the negative inotropic effects of cholinergic agents, the influence of acetylcholine (ACh) on force of contraction and cGMP tissue levels was studied in isolated, electrically driven guinea pig auricles in the presence of methy...

journal_title：Journal of cardiovascular pharmacology

authors： Groschner K,Holzmann S,Kukovetz WR

更新日期：1986-11-01 00:00:00

abstract：:Cardiovascular function is regulated by short-term and long-term neurohormonal and autocrine-paracrine mechanisms that act synergistically or sequentially. Structural adaptive changes that occur progressively over time also contribute to the long-term outcome. The renin-angiotensin system (RAS) can operate as both an ...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1989-01-01 00:00:00

abstract：:We investigated the hemodynamic and inotropic effects of the new class III antiarrhythmic drug melperone. In eight pentobarbital-anesthetized dogs, the effects of intravenous melperone 0.5, 2.5, and 12.5 mg/kg-1 were tested. During atrial pacing we measured cardiac output (CO), mean aortic blood pressure (MAP), right ...

journal_title：Journal of cardiovascular pharmacology

authors： Platou ES,Smiseth OA,Refsum H,Rouleau JL,Chuck LH

更新日期：1982-07-01 00:00:00

abstract：:The prevention of coronary disease in hypertensive patients will see progress in the years to come. It is clearly too much, however, to expect this progress to come exclusively from the application of new therapies, as the incidence of coronary disease in hypertensive patients depends on several factors, which are, es...

journal_title：Journal of cardiovascular pharmacology

authors： Djian J

更新日期：1990-01-01 00:00:00

abstract：:We examined the electromechanical effects of two class III antiarrhythmic agents, dofetilide (UK-68,798) and D-sotalol, in acidic myocardium. Right ventricular papillary muscle preparations isolated from guinea pigs were divided into three groups (n = 6 per group): (a) drug-free, (b) dofetilide (10 nM), and (c) D-sota...

journal_title：Journal of cardiovascular pharmacology

authors： Yang T,Tande PM,Refsum H

更新日期：1992-12-01 00:00:00

abstract：:In strip preparations from the rabbit main pulmonary artery, it was not possible to differentiate convincingly between alpha 1- and alpha 2-adrenoceptors, when selective agonists such as methoxamine, St 587, B-HT 920, and clonidine, as well as selective antagonists such as prazosin and yohimbine were used for receptor...

journal_title：Journal of cardiovascular pharmacology

authors： Haeusler G,de Peyer JE,Yajima M,Schultz G

更新日期：1986-01-01 00:00:00

abstract：:We have studied the effect of ramipril (10 mg/kg daily by gastric gavage) on the development of neointima 2 and 14 days after injury to rat aorta with a balloon catheter. In treated animals, there was no significant inhibition of the early mitotic reaction after injury (synthesis of DNA, as reflected by aortic thymidi...

journal_title：Journal of cardiovascular pharmacology

authors： Capron L,Heudes D,Chajara A,Bruneval P

更新日期：1991-08-01 00:00:00

abstract：:Nicorandil, ATP sensitive potassium channel opener, is shown to reduce coronary events for patients with stable angina. The present study was designed to examine the protective potential of nicorandil for patients undergoing off-pump coronary artery bypass grafting. Twenty-four patients undergoing off-pump coronary ar...

journal_title：Journal of cardiovascular pharmacology

authors： Ito I,Hayashi Y,Kawai Y,Kamibayashi T,Matsumiya G,Takahashi T,Matsuda H,Mashimo T

更新日期：2004-10-01 00:00:00

abstract：:Left ventricular (LV) function and end-diastolic dimensions were determined during antegrade and retrograde perfusions, respectively. Isolated hearts from spontaneously hypertensive rats (SHRs) and renal hypertensive rats and SHRs to which either feldopine, nifedipine, alpha-methyldopa, or a combination of felodipine ...

journal_title：Journal of cardiovascular pharmacology

authors： Nordlander M,Wåhlander H,Friberg P

更新日期：1987-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) produced by vascular endothelial cells has been proposed to act in a paracrine manner on adjacent smooth muscle cells (SMCs) in vivo, exerting a variety of short- and long-term effects. Although some of the in vitro ET-1-mediated effects are related to growth-promoting events, the physiological sig...

journal_title：Journal of cardiovascular pharmacology

authors： Hahn AW,Resink TJ,Kern F,Bühler FR

更新日期：1992-01-01 00:00:00

abstract：:ATP-sensitive potassium (KATP) channels link membrane excitability to metabolic state to regulate a series of biological activities including the vascular tone. However, their ability to influence hypertension is controversial. Here we aim to investigate possible alteration of KATP channel in vascular smooth muscles (...

journal_title：Journal of cardiovascular pharmacology

authors： Liu X,Duan P,Hu X,Li R,Zhu Q

更新日期：2016-08-01 00:00:00

abstract：:The electrophysiologic stability of isolated perfused rabbit hearts was evaluated over a period of 5 h. Hearts perfused with protein-free buffer deteriorated over time, with significant shortening of the ventricular effective refractory period (ERP) and development of ventricular fibrillation. When serum albumin (6.01...

journal_title：Journal of cardiovascular pharmacology

authors： Kates RE,Yee YG,Hill I

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether upregulation of OX40-OX40 ligand (OX40L) system is related to stability of coronary atherosclerotic plaque in patients with coronary heart diseases. METHODS:Thirty normal controls and 250 patients, including 80 with stable angina (SA), 110 with unstable angina (UA), and 60 with acute m...

journal_title：Journal of cardiovascular pharmacology

authors： Yan J,Chen G,Gong J,Wang C,Du R

更新日期：2009-11-01 00:00:00

abstract：:Adenosine A1 receptor (A1AR) activation contracts smooth muscle, although signaling mechanisms are not thoroughly understood. Activation of A1AR leads to metabolism of arachidonic acid, including the production of 20-hydroxyeicosatetraenoic acid (20-HETE) by cytochrome P4504a (CYP4a). The 20-HETE can activate protein ...

journal_title：Journal of cardiovascular pharmacology

authors： Kunduri SS,Mustafa SJ,Ponnoth DS,Dick GM,Nayeem MA

更新日期：2013-07-01 00:00:00

abstract：:Sixteen nonhospitalized men, average age 41.3 years with essential hypertension (WHO I-II) were given nifedipine slow-release tablets of 20 mg twice daily for 48 weeks. Both supine and standing blood pressure values were significantly reduced, but heart rate was not significantly changed by the drug. A significant dec...

journal_title：Journal of cardiovascular pharmacology

authors： Landmark K

更新日期：1985-01-01 00:00:00