Prophylactic effect of intravenous nicorandil on perioperative myocardial damage in patients undergoing off-pump coronary artery bypass surgery.


:Nicorandil, ATP sensitive potassium channel opener, is shown to reduce coronary events for patients with stable angina. The present study was designed to examine the protective potential of nicorandil for patients undergoing off-pump coronary artery bypass grafting. Twenty-four patients undergoing off-pump coronary artery bypass grafting were randomly assigned to two groups, one receiving continuous infusion of nicorandil (1.0 (n = 12) through anesthesia to next day and the other receiving no nicorandil for control (n = 12). For assessing myocardial injury, heart type fatty acid binding protein, troponin T, and creatine kinase MB isoform were determined during the first 15 hours after reperfusion. The concentration of heart type fatty acid binding protein in the nicorandil group was significantly lower than that in the control group. On the other hand, the concentrations of troponin T and creatine kinase MB isoform in the nicorandil group were lower than those in the control group, but the differences did not reach statistical significance. Furthermore, nicorandil did not affect the patients' hemodynamic variables. Our data suggest that the infusion of nicorandil provides small myocardial protection without affecting hemodynamic parameters during perioperative treatment of patients undergoing off-pump coronary artery bypass grafting.


J Cardiovasc Pharmacol


Ito I,Hayashi Y,Kawai Y,Kamibayashi T,Matsumiya G,Takahashi T,Matsuda H,Mashimo T




Has Abstract


2004-10-01 00:00:00














  • Blunted renal response to atrial natriuretic peptide in congestive heart failure rats is reversed by the alpha 2-adrenergic agonist clonidine.

    abstract::We wished to determine whether pharmacologic inhibition of the exaggerated sympathetic nerve activity in congestive heart failure (CHF) could restore the renal response to exogenous atrial natriuretic peptide (ANP) administration. Left ventricular (LV) myocardial infarction was induced in Sprague-Dawley rats (n = 16) ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Feng QP,Hedner T,Hedner J,Pettersson A

    更新日期:1990-11-01 00:00:00

  • Effects of angiotensin II AT1-receptor blockade on coronary dynamics, function, and structure in postischemic heart failure in rats.

    abstract::Angiotensin II AT1-receptor blockers (AT1-s) prolong survival in experimental postischemic (coronary artery ligation) heart failure (CHF) in rats. The goal of this study was to investigate whether potential beneficial effects of short- and/or long-term treatment with AT1-s on coronary dynamics, function, and structure...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Gervais M,Fornes P,Richer C,Nisato D,Giudicelli JF

    更新日期:2000-09-01 00:00:00

  • Alpha-adrenoreceptor blockade with indoramin in hypertension.

    abstract::We have evaluated the effects of indoramin, an alpha-adrenoreceptor blocking drug, used as sole therapy in a group of 27 patients with essential hypertension. Blood pressure and heart rate were measured continuously over prolonged ambulatory periods using an established invasive technique before and after six weeks of...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gould BA,Mann S,Davies AB,Altman DG,Raftery EB

    更新日期:1983-05-01 00:00:00

  • Positive inotropic effect of DPI 201-106 in spontaneously hypertensive rats: lack of inhibition by adenosine and cholinergic agents.

    abstract::The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Böhm M,Diet F,Erdmann E

    更新日期:1988-04-01 00:00:00

  • Distinct role of nox1, nox2, and p47phox in unstimulated versus angiotensin II-induced NADPH oxidase activity in human venous smooth muscle cells.

    abstract::Human saphenous veins (SV) are used for coronary bypass surgery despite the higher rate of graft failure observed as compared to arteries. A higher production of reactive oxygen species (ROS) in SV than in internal mammary artery (IMA) has been incriminated as possibly implicated in graft failure. NADPH oxidase, invol...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Chose O,Sansilvestri-Morel P,Badier-Commander C,Bernhardt F,Fabiani JN,Rupin A,Verbeuren TJ

    更新日期:2008-02-01 00:00:00

  • Role of the sympathoadrenal axis in the cardiovascular response to cocaine in conscious unrestrained rats.

    abstract::We investigated the role of peripheral sympathetic neurons and the adrenal medulla in the cardiovascular responses to cocaine in conscious, unrestrained Sprague-Dawley rats. Surgical adrenal demedullation (ADM) and/or chemical peripheral sympathectomy was used to eliminate one or both components of the sympathoadrenal...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Chen BX,Myles J,Wilkerson RD

    更新日期:1995-05-01 00:00:00

  • Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently.

    abstract::The mode of action of Crataegus extracts in the treatment of heart failure is still under examination. WS 1442, a standardized special extract from Crataegus leaves with flowers, exerts direct positive inotropic effects. This study was designed to investigate the mode of inotropic action of WS 1442 in human myocardium...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Schwinger RH,Pietsch M,Frank K,Brixius K

    更新日期:2000-05-01 00:00:00

  • Extracellular ATP increases [Ca2+]i in primarily cultured pig coronary smooth muscle cells via a P2Y purinoceptor subtype.

    abstract::In primarily cultured pig coronary smooth muscle cells, extracellular adenosine triphosphate (ATP; 10(-9) to 10(-3) M) dose-dependently increases intracellular calcium ([Ca2+]i). The [Ca2+]i transients measured by fura-2 fluorescence consist of peak and plateau phases with [Ca2+]i values of 191.84 +/- 5.67 nM (n = 10)...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Seiler L,Matyas S,Fleckenstein-Grün G

    更新日期:1999-05-01 00:00:00

  • Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031.

    abstract::Clobutinol has been clinically reported to induce long QT syndrome. To clarify its cardiac electrophysiological properties, we compared effects of clobutinol on the isolated myocardium and anesthetized guinea pig heart with those of a hERG K channel blocker, E-4031. In isolated guinea pig ventricular tissues, clobutin...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Takahara A,Sasaki R,Nakamura M,Sendo A,Sakurai Y,Namekata I,Tanaka H

    更新日期:2009-12-01 00:00:00

  • Roscovitine Protects From Arterial Injury by Regulating the Expressions of c-Jun and p27 and Inhibiting Vascular Smooth Muscle Cell Proliferation.

    abstract:PURPOSE:Roscovitine (Rosc) is a selective inhibitor of cyclin-dependent kinases (CDKs) and a promising therapy for various cancers. However, limited information is available on the biological significance of Rosc in vascular smooth muscle cells (VSMCs), the cell type critical for the development of proliferative vascul...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Liu Y,Li YF,Chang H,Zhao JS,Hou JM,Yu K,Sun JH,Wang H,Li AY

    更新日期:2017-03-01 00:00:00

  • Efficacy and safety of spirapril in mild-to-moderate hypertension.

    abstract::Spirapril is a new angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug with a resorption of about 50%. The active metabolite spiraprilat reaches maximal plasma concentration within 2-3 h after oral administration. Spirapril can be administered once daily because of its long duration of action caused by an e...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Hayduk K,Kraul H

    更新日期:1999-08-01 00:00:00

  • Contribution of endogenous endothelin-1 and endothelin-A-receptors to the hypertensive state of endothelin-B heterozygous (+/-) knockout mice.

    abstract::We observed that heterozygous knockout (+/-, KO) of either endothelin-A- (ET(A)) or -B- (ET(B)) receptors significantly reduced the pressor responses to systemically administered endothelin-1 (ET-1) in ET(A) or ET(B) (+/-) KO mice when compared to wild-type (WT) mice (data not shown). Also, we observed that basal mean...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Berthiaume N,Yanagisawa M,D'Orléans-Juste P

    更新日期:2000-11-01 00:00:00

  • Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking.

    abstract::The signaling impact of a human beta1-adrenergic receptor (beta1 AR) polymorphism at residue 49 of the aminoterminus (Ser-to-Gly substitution) was studied by recombinantly expressing each receptor. The two receptors displayed identical agonist and antagonist binding affinities. Furthermore, basal and agonist-stimulate...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Rathz DA,Brown KM,Kramer LA,Liggett SB

    更新日期:2002-02-01 00:00:00

  • Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study.

    abstract::The mechanisms by which tolerance to organic nitrates develops are still poorly understood. Enhanced oxidative stress, i.e., increased free radical production following organic nitrate administration, has been recently suggested as a possible mechanism. A randomized, double-blind, crossover study assessed in 18 health...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Keimer R,Stutzer FK,Tsikas D,Troost R,Gutzki FM,Frölich JC

    更新日期:2003-02-01 00:00:00

  • Long Noncoding RNA Taurine-Upregulated Gene 1 Knockdown Protects Cardiomyocytes Against Hypoxia/Reoxygenation-induced Injury Through Regulating miR-532-5p/Sox8 Axis.

    abstract:BACKGROUND:Long noncoding RNA taurine-upregulated gene 1 (TUG1) has been reported to involve in the processing of cardiac ischemia/reperfusion injury after myocardial infarction. Thus, this study further investigates the underlying mechanisms of TUG1 in hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury in vitro....

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Cai X,Wang S,Hong L,Yu S,Li B,Zeng H,Yang X,Zhang P,Shao L

    更新日期:2020-11-01 00:00:00

  • Effect of captopril treatment on total and central vascular capacitance in dogs with chronic heart failure.

    abstract::Chronic rapid right ventricular pacing (RRVP) at 250 beats/min produces low cardiac output (CO) heart failure, marked reduction in total vascular capacitance, and a shift in volume centrally. The effect of converting enzyme inhibition with captopril on cardiac preload was investigated in this model of heart failure. E...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Ogilvie RI,Zborowska-Sluis D

    更新日期:1994-09-01 00:00:00

  • Emerging pathophysiological concepts in hypertension.

    abstract::Essential hypertension is now considered a disease of pressure regulation implicating a multiplicity of physiological mechanisms. It is probably genetically predisposed and is associated with altered sensitivity to the sodium ion and a more than chance association with other clinical diseases. New concepts are emergin...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Frohlich ED

    更新日期:1984-01-01 00:00:00

  • Effects of concentration and steric configuration of propranolol on AV conduction and ventricular repolarization in the dog.

    abstract::To investigate the electrophysiological effects of propranolol in vivo over a wide range of plasma concentrations and to distinguish effects due to beta-blockade from those due to a direct membrane action, His bundle electrograms were recorded, and ventricular effective refractory periods (VERP) and monophasic action ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Brorson L,Reele S,Dupont W,Woosley R,Shand D,Smith R

    更新日期:1981-07-01 00:00:00

  • Positive inotropic effects of calcium sensitizers on normal and failing cardiac myocytes.

    abstract::Calcium sensitizers increase myocardial contractile function without affecting Ca2+ homeostasis, which might be beneficial in the treatment of patients with heart failure. However, it remains uncertain whether Ca sensitizers induce quantitatively similar inotropic responses in control and failing hearts. To compare th...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Tsutsui H,Kinugawa S,Ide T,Hayashidani S,Suematsu N,Satoh S,Nakamura R,Egashira K,Takeshita A

    更新日期:2001-01-01 00:00:00

  • The efficacy and tolerability of azilsartan in mice with left ventricular pressure overload or acute myocardial infarction.

    abstract::Angiotensin II receptor blockers (ARBs) are used for the treatment of patients with heart failure and hypertension. Yet their safety has been questioned by some who observed delayed cardiac healing and scar thinning after myocardial infarction (MI). To clarify potential efficacy and safety of ARBs, we administered Azi...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Quinn Baumann P,Zaman AK,McElroy-Yaggy K,Sobel BE

    更新日期:2013-05-01 00:00:00

  • Development and application of three radioimmunoassays of endothelin of varying specificities.

    abstract::We have developed three radioimmunoassays (RIAs) of varying specificities toward the endothelin (ET) isoforms. The assays are called the endothelin-1,2[125I] assay system (RPA535), the endothelin 1-21 Specific [125I] assay system (RPA555), and the endothelin-1,2 high-sensitivity [125I] assay system (RPA545). We have f...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Capper SJ,Ella SJ,Kalinka S

    更新日期:1991-01-01 00:00:00

  • Blood pressure response to the first 36 hours of heart failure therapy with perindopril versus captopril. French General Hospitals National College of Cardiologists.

    abstract::An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Haïat R,Piot O,Gallois H,Hanania G

    更新日期:1999-06-01 00:00:00

  • Relationship between the sympatholytic action of nebivolol and hypotension.

    abstract::Nebivolol, a chemically novel beta 1-adrenoceptor antagonist, acutely lowers blood pressure in spontaneously hypertensive rats, anaesthetised normotensive dogs, and hypertensive patients. We have investigated the actions of dl-nebivolol in five conscious normotensive rabbits (sham, mean blood pressure (BP) of 82.2 +/-...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Ward JE,Coles P,Cox H,Eisenhofer G,Angus JA

    更新日期:1992-07-01 00:00:00

  • Antithrombotic activity of NSP-513, a novel selective phosphodiesterase 3 inhibitor, on femoral arterial thrombosis induced by physical stenosis and electrical current: comparison of antithrombotic and hemodynamic effects.

    abstract::NSP-513, a novel potent and selective phosphodiesterase 3 (PDE 3) inhibitor, and cilostazol, a previously developed PDE 3 inhibitor, were compared with respect to antiplatelet, antithrombotic, and hemodynamic effects. In the in vitro antiplatelet aggregation studies, NSP-513 and cilostazol inhibited collagen-induced c...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Hirose H,Mashiko S,Kimura T,Ishida F,Mochizuki N,Nishibe T,Nishikibe M

    更新日期:2000-04-01 00:00:00

  • SC-36602, a new antiarrhythmic agent: comparison of its cardiovascular profile with that of other antiarrhythmic drugs.

    abstract::The cardiovascular profile of SC-36602, a new class 1A/1B antiarrhythmic agent, was compared to those of disopyramide, lidocaine, mexiletine, flecainide, encainide, lorcainide, and quinidine. These drugs were compared at their respective canine antiarrhythmic doses in a hemodynamic evaluation using anesthetized dogs. ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Frederick LG,Hatley FR,McDonald SJ,Stamm MH,Garthwaite SM

    更新日期:1988-06-01 00:00:00

  • Role of endothelin in the development of Dahl hypertension.

    abstract::To evaluate the possible role of endothelin in the development and/or maintenance of hypertension in Dahl rats, we examined the responsiveness of isolated vascular smooth muscle and glomerular mesangial cells, as well as deendothelialized vascular ring preparations to endothelin-1 (ET-1). Production of immunoreactive ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Goligorsky MS,Iijima K,Morgan M,Yanagisawa M,Masaki T,Lin L,Nasjletti A,Kaskel F,Frazer M,Badr KF

    更新日期:1991-01-01 00:00:00

  • NADPH oxidase inhibitors: new antihypertensive agents?

    abstract::NADPH oxidases have recently been shown to contribute to the pathogenesis of hypertension. The development of specific inhibitors of these enzymes has focused attention on their potential therapeutic use in hypertensive disease. Two of the most specific inhibitors, gp91ds-tat and apocynin, have been shown to decrease ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Williams HC,Griendling KK

    更新日期:2007-07-01 00:00:00

  • Effect of ouabain on the responses to vasoconstrictor agents in isolated perfused rat tail arteries.

    abstract::In isolated rat tail arteries perfused with Krebs-Henseleit solution, ouabain, in concentrations of less than 10(-5) M, caused a concentration-dependent, noncompetitive inhibition of the vasoconstrictor response to phenylephrine. Concentrations of 10(-8) and 10(-6) M caused 30 and 61% inhibition, respectively. The inh...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Armsworth SJ,Marwood JF,Stokes GS

    更新日期:1985-07-01 00:00:00

  • Comparison of the effects of angiotensin II, losartan, and enalapril on baroreflex control of heart rate in conscious rabbits.

    abstract::We compared the effects of angiotensin II (AII), enalapril, and losartan given by acute intravenous (i.v.) injection, on cardiac baroreflex sensitivity in two groups of conscious normotensive rabbits bred for high gain [> 5 beats/min/mm Hg] (group I) and low gain [< 4 beats/min/mm Hg] (group II) of the mean arterial b...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Weinstock M,Gorodetsky E

    更新日期:1995-03-01 00:00:00

  • Contrasting cardiovascular responses from intrathecal administration of epinephrine and norepinephrine in conscious rats: role of alpha 1- and alpha 2-adrenoceptors.

    abstract::In conscious rats, intrathecal (i.t.) administration of norepinephrine (NE) produced pressor responses, whereas i.t. epinephrine (Epi) caused depressor responses at low doses (0.1-1 microgram) and pressor responses at a higher dose (10 micrograms). Epi administered i.t. produced bradycardia; however, NE caused tachyca...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Gradin K,Nicholas AP,Hjemdahl P,Svensson T,Hökfelt T

    更新日期:1992-09-01 00:00:00